Micro RNAs From Basic Science to Disease Biology Edited by Krishnarao Appasani Forewords by Victor R. Ambros and Sidney Altman Pre-publication praise for MicroRNAs “This book contains much up-to-date information about the fast growing field of micro-RNA research. The book should be very useful to anyone interested in miRNA.” Marshall Nirenberg, Nobel Laureate “… a useful reference for researchers wanting to know the state-of-the art in microRNA research. Knowledge in the field has exploded so quickly that it is difficult to get a sense of what is known and what is not known … a timely summary of many important topics in microRNA research.” Dr. Peter Linsley, Executive Director Merck-Rosetta Inpharmatics LLC, Seattle, USA “MicroRNAs – From Basic Science to Disease Biology, is for people who are willing to continuously expand knowledge about microRNAs from their discovery, visualizing techniques, and relations with human diseases to how to apply to living creatures. The first of a comprehensive portfolio of mighty small microRNAs.” Dr. Mikiko Siomi Institute of Genome Research, University of Tokushima, Japan “… an excellent collection of reviews addressing most important aspects of miRNA research, including basics of miRNA biogenesis and function, bioinformatic approaches to target prediction, and connection of miRNAs with human pathologies … very valuable to those already involved in miRNA studies and to newcomers to the field.” Professor Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland “… a comprehensive compilation of articles on microRNAs that span methodological, detection, and biological implications. The well-written and thoughtful chapters in this book offer timely contributions to our current understanding of this fast moving and exciting field.” Dr. Kuan-Teh Jeang Head of Molecular Virology Section, National Institutes of Health, NIAID, Bethesda, USA “… excellent in covering not only the broad scope of the role of miRNAs in health and disease but also the history of the discovery of miRNAs and the emerging technologies in their computational analyses and their detection and quantitation in normal and disease tissues … an extremely valuable resource for any scientist interested in this rapidly evolving new research area and in developing innovative miRNA based drug discovery approaches.” Dr. Ekkehard Leberer Genomic Sciences, Sanofi-Aventis Pharma Gmbh, Germany Micro RNAs Appasani Cover illustration: Whole mount chick embryo in situ hybridization image indicating the expression of microRNA-1 in the somatic and cardiac myotome. Image courtesy of Dr Diana K. Darnell and Dr Parker B. Antin of the University of Arizona.