Rheumatoid arthritis and seronegative spondylarthritides

Rheumatoid arthritis and seronegative

spondylarthritides

Nov 24, 2017

György Nagy

Rheumatoid arthritis

Rheumatoid arthritis

Chronic, progressive, autoimmune disorder of the joints with extra-articular features.

Prevalence: 1% (0.3-2.1%)

Female/male = 3:1

Age at onset 30-40 years

Early RA

Advanced RA

End stage RA

Extra-articular features

Extra-articular features

Iain B. McInnes, F.R.C.P., Ph.D., and Georg Schett, M.D. N Engl J Med 2011;

The pathogenesis of rheumatoid arthritis

The pathogenesis of rheumatoid arthritis

Iain B. McInnes, F.R.C.P., Ph.D., and Georg Schett, M.D. N Engl J Med 2011;

Autoantibodies in RA

Rheumatoid factor

- against the Fc portion of IgG

- occurs in 70% of the RA patients

- not specific for RA

Autoantibodies targeting citrullinated proteins

- highly specific for RA

- occurs in 70% of the RA patients

Baka Z, Buzás E, Nagy G - Arthritis Res. Ther. (2009)

The pathogenesis of rheumatoid arthritis

DAS 28 = disease activity score

Swollen and tender joints, patient’s global opininion, CRP or We

Philip S. Hench and

Edward C. Kendall

Mayo Clinic, 1950

Nobel Prize

Synthetic DMARD, NSAID and steroid

therapy in RA

Ronald F. van Vollenhoven

Nature Reviews Rheumatology 7, 205-215 (April

2011)

Biological therapy in RA & side effects

Ankylosing spondylitis

Ankylosing spondylitis

Thank you for your attention