REVOLUTIONAL PEPTIDES DERMAL FILLER 1. REVOFIL has both biphasic and monophasic physical characteristics introduced by combination of cutting edged peptide technology and crossed linked HA which bring upgraded quality in gel viscosity and elasticity with softer operation. 2. REVOFIL contains higher concentration of free HAs, linked with peptide, instead of PBS among cross-linked HA molecules which results in increased stability of HA gel. 3. Strong inhibition of endogenous Hyaluronidase increases duration of the gel in skin. 4. REVOFIL makes up-regulation of endogenous collagen and hyaluronic acid and to increase skin tightness and lifting. In overall, peptide technology has endowed higher viscosity and elasticity, increased efficacy of sculpturing with longer lasting, increased gel stability and softer injection of HA gel. Advantages of REVOFIL es of REVOFIL ntag
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REVOLUTIONAL PEPTIDES DERMAL FILLER
1. REVOFIL has both biphasic and monophasic physical characteristics introduced by combination of cutting edged peptide technology
and crossed linked HA which bring upgraded quality in gel viscosity and elasticity with softer operation.
2. REVOFIL contains higher concentration of free HAs, linked with peptide, instead of PBS among cross-linked HA molecules which results
in increased stability of HA gel.
3. Strong inhibition of endogenous Hyaluronidase increases duration of the gel in skin.
4. REVOFIL makes up-regulation of endogenous collagen and hyaluronic acid and to increase skin tightness and lifting.
In overall, peptide technology has endowed higher viscosity and elasticity, increased efficacy of sculpturing with longer lasting, increased
gel stability and softer injection of HA gel.
Advantages of REVOFILes of REVOFILntag
Reticulated Hyaluronic acid (23 mg/ml) :
Cross-linked hyaluronic acid, non-animal origin
Biodegradable gel which is slowly absorbed over the time
Monophasic and homogeneous gel
Oligopeptide-72 (CG-Boostrin) :
Strong inhibition of Hyaluronidase
Oligopeptide-50 (CG-Glamerin) :
Increasing endogenous collagen and Hyaluronic acid
Active ingredients
Stay Longer, Stay Active and Stay Spectacular
Cross-linked HA and peptide
HA
Cross-linked HA sphere
Cross linkage bond
Amide bond formation between Free HA and Cross-linked HA
Free HAs are connected to peptide mediated disulfide bond
REVOFIL gel
linked
Viscoelastic properties of REVOFIL
REVOFIL Ultra, Plus, Fine shows high
shear storage modulus (G’) and stable
shear loss modulus (G”) in Dynamic
mechanical analysis. The result shows
high elasticity, duration and stable fluidity
of REVOFIL gels.
REVOFIL Fine
REVOFIL Plus
REVOFIL Ultra
Rheological Properties
Molecular Structure of reticulated HA gel in REVOFIL
REVOLUTIONAL PEPTIDES DERMAL FILLER
Elasticity and Fluidity of REVOFIL Fine, Plus, Ultra
1
1.2
1.4
1.6
1.8
2
2.2
2.4
2.6
2.8
3
2
2.1
2.2
2.3
2.4
2.5
2.6
2.7
2.8
2.9
3
0.01 0.1 1.0
Frequency (Hz)
REVOFIL Plus
REVOFIL Ultra
REVOFIL Fine
High
logG
Fluidity
High
logG
Elasticity
120
0
20
40
60
80
100
0 10 20 30 40 50 60
Interaction of Hyaluronidase and CG-Boostrin Inhibition of Hyaluronidase Activity
REVOFIL has shown positive regulation of endogenous collagen and hyaluronic acid synthesis in human fibroblast cell.
REVOFIL contains a strong inhibitor of hyaluronidase. CG-Boostrin, a patented peptide, binds to the enzyme strongly and down-regulatesthe degradation of reticulated hyaluronic acid which implies increased duration of the gel in skin.
Anti-oxidative Stress Recovery Photo-induced Cell death Protection
REVOFIL shows strong anti-oxidant effect against oxidative chemical and photo-damage induced UV in human dermal fibroblasts.
UVB+REVOFILUVBControl
Concentration of Hyaluronidase: 25unit/ml
Incubation temperature: 37
Vis
cosi
ty o
f Fille
r (R
elat
ive
rate
%)
UVB: 20mj/cm2
Competitor 1
REVOFIL
Competitor 2
REVOFIL showed strong resistance to the enzyme which implies longer lasting in skin compared to competitors. The result indicates that the duration of REVOFIL is much longer than other HA Dermal fillers.
100
145
105 103
Control REVOFIL Competitor 1 Competitor 2
Rel
ativ
e ra
te o
f HA
Syn
thes
is(%
)
45%
0
50
150
100
200
100
181
113
105
Control REVOFIL Competitor 1 Competitor 2
Rel
ativ
e ra
te o
f Colla
gen
Syn
thes
is(%
)
81%
0
50
150
100
200
Fold
incr
ease
Control CG-Boostrin0
0.5
1.5
1
2
2.5
2.1 fold
CG-BoostrinHyaluronidase +
-+ +
++
100
1510R
elat
ive
rate
(%)
0
50
100
150
-90%
Control Menadione Menadione
+REVOFIL
Rel
ativ
e ra
te(%
)
100 105
0
50
100
45
+60%
Direct Inhibition of Hyaluronidase Activity: Decreased 90% Hyaluronidase Activity
Mid, Deep dermisSuperficial dermis Deep, Subcutaneous dermis
UltraPlusFine
Fore Head:
REVOFIL Plus, Ultra
Nose Bridge:
REVOFIL Plus, Ultra
Nasolabial Folds, Smile lines:
REVOFIL Plus, Ultra
Marionette lines:
REVOFIL Plus, Ultra
Eyelid Tear Troughs:
REVOFIL Fine, Plus
Fine lines, Temporal region:
REVOFIL Fine, Plus
Upper Cheeks:
REVOFIL Fine, Plus
Cheek, Hollow Cheek:
REVOFIL Fine, Plus, Ultra
Lip Lifting, Augmentation:
REVOFIL Ultra, Plus
Jaw, Chin, Mandibular region:
REVOFIL Ultra, Plus
※ Average duration depends on several factors: Patient’s skin type, severity of the wrinkles to be corrected, type of injection and the injected volume.
Deep Touch FillerSub Touch FillerSoft Touch Filler