Revised Abridged CV Adeneye AA - LASUCOMlasucom.edu.ng/.../Revised-Abridged-CV_Adeneye-AA.pdf · 3 3. Published article “Hypoglycemic and hypolipidemic effects of fresh leaf aqueous

CURRICULUM VITAE

A. PERSONAL DATA:

(a). Name (Surname underlined): ADENEYE, Adejuwon Adewale

(b). Date of Birth: 28th July 1974

(c). Place of Birth: Lagos, Nigeria

(d). Marital Status: Married

(e). Nationality: Nigerian

(f). Contact Addresses: Department of Pharmacology & Dean’s

Office, Faculty of Basic Medical Sciences,

Lagos State University College of Medicine,

1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos

State, Nigeria

(g). E-mail contacts: [email protected],

[email protected]

(h). Telephone (mobile): +2348020690946, +2348035835589

(i). Current Position held: Associate Professor of Pharmacology,

Therapeutics and Toxicology &

Ag. Dean, Faculty of Basic Medical

Sciences, Lagos State University College of

Medicine, Ikeja, Lagos State, Nigeria

B. ACADEMIC QUALIFICATIONS AND AWARDING

INSTITUTIONS (WITH DATES):

1. D.Sc. (Alternative Medicine) Sep. 2013 Indian Board of Alternative

Medicines, Kolkata, India

(affiliated to The Open

International University,

Colombo, Sri Lanka)

2. Ph.D. (Pharmacology) Jun. 2010 University of Lagos, Akoka,

Lagos, Nigeria

3. M.Sc. (Pharmacology) Sept. 2006 Usmanu Danfodiyo

University, Sokoto, Nigeria

4. M.B;B.S. Oct. 1998 University of Ilorin, Kwara,

Nigeria

2

E. SCHOLARSHIPS, FELLOWSHIPS, PRIZES AND TRAVEL

GRANTS WON (WITH DATES):

1. Awarded Young Affiliate for The World Academy of Sciences Regional

Office for Sub-Saharan Africa (TWAS-ROSSA) by the African Academy of

Sciences (AAS) on behalf of The World Academy of Sciences, 2014 to 2018

tenure track.

2. Awarded 2013 Best Young Scientists National Award in the Basic Sciences,

Technology and Innovation category of the African Union-The World

Academy of Sciences (AU-TWAS) National Award, tagged to the prize

money of Five Thousand US Dollars ($5000). The AU-TWAS Young

Scientists National Award is a partnership between the African National

Academies, TWAS, African Union, National Science Academies and National

Ministries of Science and Technology.

http://www.nas.org.ng/index.php?option=com_content&view=section&layout

=blog&id=1&Itemid=3

3. Norvatis/AiBST Training Scholarship Award to participate in

Pharmacometrics Course and Workshop on Drug Discovery and Development

– Modeling and Simulation, at the African Institute of Biomedical Science and

Technology (AiBST), Harare, Zimbabwe, 26th – 30th November, 2012

4. Fulbright Junior Scholar Development Scholarship Award as a Visiting

Research Scholar to the College of Pharmacy, University of Kentucky,

U.S.A.; August 2010 - May 2011.

5. Federal Government Scholarship Award for Studies in Nigerian Tertiary

Institutions: Postgraduate (2001/2002). Award No. FSBA/FGSS: /PG/276AI.

F. RATINGS OF PUBLISHED ARTICLES:

1 Published article “Ethnopharmacological survey of herbal treatment of

malaria in Lagos, Southwest Nigeria. Journal of Herbal Medicine 4, 224-

234, by I.O. Ishola, I.A. Oreagba, A.A. Adeneye, C. Adirije, K.A.

Oshikoya, O.O. Ogunleye” was rated the 11th of 25 Most Downloaded

Journal of Herbal Medicine articles on ScienceDirect, January – March,

2015. http://www.journals.elsevier.com/journal-of-herbal-medicine/most-

downloaded-articles/

2. Published article “Hypoglycemic and antidiabetic activities of the stem

bark aqueous and alcohol extracts of Musanga cecropioides in normal and

alloxan-induced diabetic rats by A.A. Adeneye, O.P. Ajagbonna, O.W.

Ayodele” was rated the 22nd Hottest Article of the Top 25 Hottest Articles

in Fitoterapia Journal, October – December, 2007.

3

3. Published article “Hypoglycemic and hypolipidemic effects of fresh leaf

aqueous extract of Cymbopogon citratus Stapf. in rats by A.A. Adeneye,

E.O. Agbaje” was rated the 18th Hottest Article of the Top 25 Hottest

Articles in the Journal of Ethnopharmacology, July – September, 2007.

4. Published article “Hypoglycemic and hypocholesterolemic activities of the

aqueous leaf and seed extract of Phyllanthus amarus in mice by A.A.

Adeneye, O.O. Amole, A.K. Adeneye” was rated the 19th Hottest Article

of the Top 25 Hottest Articles in Fitoterapia Journal, October – December

2006.

G. INTERNATIONAL RESEARCH GRANTS AWARDED (WITH

TITLE AND DATES):

1. Names of Investigators: O. P. Akinwale (Principal Investigator)

J. O. Oyefara (Co-Investigator)

P. E. Adejoh (Co-Investigator)

K. S. O. Oyedeji (Co-Investigator)

A. A. Adeneye (Co-Investigator)

A. K. Adeneye (Co-Investigator)

M.A. Sulyman (Co-Investigator)

Z. A. Musa (Co-Investigator)

Project Title: Intervention study on non-communicable

diseases and preventable lifestyle risk

factors in three slums in Lagos, Nigeria.

Amount in US Dollars: $56,000 (USD)

Grant Type: Research seed grant

Awarding Institution: International Association of National Public

Health Institutes (IANPHI), Finland

Project Duration: 2010 – 2012 (Completed)

URL: http://www.ianphi.org/what-we-do/project-

detail.cfm/proj_id/2BC7D265-D461-0A55-

4E0A89A615A497A4

4

H. HONORS, DISTINCTIONS AND MEMBERSHIP OF LEARNED

SOCIETIES:

1. Nigerian Medical Association (Nigeria) Member

2. West African Society for Pharmacology Member

3. International Society for Development of Natural Products Member

4. Society for Medicinal Plant and Natural Products Research

(Germany) Member

5. American Association of Clinical Endocrinologist (U.S.A.) Member

6. Fulbright Alumni Association of Nigeria (Nigeria) Member

7. Association for African Medicinal Plants Standards (R.S.A.) Member

8. The Physiological Society (United Kingdom) Member

9. Nigerian Young Academy (Nigeria) Member

10. Institute of Public Management (Nigeria) Fellow

I. RESEARCH ORIENTATION

In the last 10 years, I have been actively involved in the identification,

pharmacological screening and evaluation of the therapeutic benefits inherent in

the local medicinal plants locally used by Yoruba traditional healers in the local

management of diabetes mellitus, obesity, hyperlipidemia and other endocrine

disorders. The reason for this was borne of out the fact that the incidence and

prevalence of diabetes mellitus and its associated neuro-endocrine disorders in the

world and indeed, in developing nations, such as Nigeria, is fast increasing at an

alarming rate. For example, in the year 2000, the global prevalence of diabetes

mellitus was estimated to be 170 million sufferers and this figure is expected to

double by the year 2030 (Wild et al., 2004). In addition to this, the attendant

complications of diabetes mellitus account for the high mortality and morbidity

associated with the disease. However, despite the scientific breakthrough that has

been recorded with the orthodox management of the disease, the prevalence,

morbidity and mortality of the disease continue to rise. This necessitated the

setting up of a fact-finding expert committee by the World Health Organization

(WHO) in 1979 which was mandated to investigate and form policies that would

help in stemming the prevalence of diabetes mellitus globally. The WHO expert

committee then recommended that indigenous medicinal plants in different

countries of the world should be investigated for their antihyperglycemic

potentials (WHO, 1980). Also, many of the conventional antihyperglycemic

remedies are associated with intolerable and sometimes, life-threatening side-

effects which often result in poor drug adherence. For all these stated reasons,

over the last half a decade, I have been involved in the screening and

identification of indigenous medicinal plants with antihyperglycemic, anti-obesity

5

and antihyperlipidemic activities using standard pharmacological procedures. In

addition, efforts have been channeled towards investigating the antihyperglycemic

mechanisms and standardizing the appropriate and effective dosages of these

medicinal plants, particularly, flora that are of Southwest Nigeria origin. Further

to these, I have also been involved in drug discovery and development from some

of these plants. One of particular interest is the recent discovery of a new

antihyperglycemic compound named erinidine. Erinidine is a bisindole alkaloid

isolated from the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier

f. (family: Apocynaeceae) and whose chemical structure as well as its

antihyperglycemic profile has been investigated. This compound’s

pharmacokinetic and pharmacodynamic profile in an animal model is currently

being investigated, after which clinical trials of it will begin.

J. SELECTED RESEARCH PUBLICATIONS

(i). Books already published:

1. A.A. Adeneye (2014). Herbal Pharmacotherapy For Hypertension

Management (November 2014). Published by Lambert Academic

Publishing GmbH & Co. KG, Saarbrücken, Germany; ISBN: 978-3-659-

63763-6.

2. A. Adeneye (2011). Diabetes Mechanisms and Management: Glucose

Metabolizing & Homeostasis Machinery and Application of Medicinal

Plants in Diabetes Management (March 2011). Published by Lambert

Academic Publishing GmbH & Co. KG, Saarbrücken, Germany; ISBN:

978-3-8443-2094-7. Available online at:

http://www.bod.com/index.php?id=3435&objk_id=488346

3. A. Adeneye (2010). Evaluation of Hunteria umbellata seed:

Pharmacological and Toxicological Approaches (Dec. 2010). Published by

Lambert Academic Publishing GmbH & Co. KG, Saarbrücken, Germany;

ISBN: 978-3-8433-8163-5. Available online at:

http://www.bod.com/index.php?id=3435&objk_id=445937

(ii). Chapters in Books already published:

4. A.A. Adeneye (2014). Subchronic and chronic toxicities of African

medicinal plants. In: Toxicological Survey of African Medicinal Plants

(edited by V. Kuete). Elsevier Science, London; pp. 99-133.

5. D.N. Ghista, U.R. Acharya, K.D. Desai, S. Dittakavi, A.A. Adeneye, L.K.

Meng (2012). Diabetes Mechanisms, Detection and Complications

Monitoring. In: Biomedical Science, Engineering and Technology (edited

by D.N. Ghista). Published by INTECH Open Access Publisher, 51000

6

Rijeka, Crotia; ISBN: 978-953-307-471-9; pp. 419-446. Published online:

20 January, 2012; Published in print edition: January, 2012

www.intechopen.com, www.clbme.bg/../newbooks_6.pdf and

http://www.intechopen.com/books/biomedical-science-engineering-and-

technology/diabetes-mechanisms-detection-and-complications-monitoring

(iii). Articles that have already appeared in Learned Journals:

6. A.A. Adeneye, P.A. Crooks (2015). Weight losing, antihyperlipidemic

and cardioprotective effects of the alkaloid fraction of Hunteria umbellata

seed extract in normal and triton-induced hyperlipidemic rats. Asian

Pacific Journal of Tropical Biomedicine 5(5), 387-394.

7. A.A. Adeneye, O. Awodele, S.A. Aiyeola, A.S. Benebo (2015).

Modulatory potentials of the aqueous stem bark extract of Mangifera

indica on carbon tetrachloride-induced hepatotoxicity in rats. Journal of

Traditional & Complementary Medicine 5, 106-115.

8. A.A. Adeneye, S.O. Adenekan, O.O. Adeyemi, E.O. Agbaje (2014).

Glucose utilization and anti-oxidative mechanisms of Hunteria umbellata

aqueous seed extract in alloxan-induced diabetic rats. Nigerian Journal of

Physiological Sciences 9(1), 71-79.

9. A.A. Adeneye, P.A. Crooks, Z. Fadhel-Albayati, A.F. Miller, S.W. Zito,

O.O. Adeyemi, E.O. Agbaje (2013). Antihyperglycemic profile of

erinidine isolated from Hunteria umbellata seed. African Journal of

Traditional, Complementary and Alternative Medicine 10(2), 189-202.

10. A.A. Adeneye, O.O. Adeyemi, E.O. Agbaje, M.O. Sofidiya (2012). The

novel antihyperglycemic action of Hunteria umbellata seed fractions

mediated via intestinal glucose uptake inhibition. African Journal of

Traditional, Complementary and Alternative Medicine 9(1), 17-24.

11. A.A. Adeneye, P.A. Crooks, A.F. Miller, J. Goodman, O.O. Adeyemi,

E.O. Agbaje (2012). Isolation and structure elucidation of a new indole

alkaloid, erinidine, from Hunteria umbellata seeds. Pharmacologia 3(7),

204-214.

7

12. A.A. Adeneye, O.O. Adeyemi, E.O. Agbaje (2010). Anti-obesity and

antihyperlipidemic effects of the seed extract of Hunteria umbellata (K.

Schum.) Hallier f. in experimental hyperlipidemia. Journal of

Ethnopharmacology 130(2), 307-314.

13. A.A. Adeneye, O.O. Adeyemi, E.O. Agbaje, A.A.F. Banjo (2010).

Evaluation of toxicity profile and reversibility of the aqueous seed extract

of Hunteria umbellata (K. Schum.) Hallier f. (Apocynaecea) in rodents.

African Journal of Traditional, Complementary and Alternative Medicine

7(4), 350-369 (Nigeria)

K. POSTGRADUATE SUPERVISION UNDERTAKEN:

1. M.Sc. (2015). Temitope F. OGUNDARE. Oral toxicity profile of the

aqueous stem bark extract of Morinda lucida in Wistar rats. School of

Postgraduate Studies of the University of Lagos, Akoka, Lagos State,

Nigeria. (Completed, examined and Awarded M.Sc. degree in

Pharmacology, February 2015)

2 M.Sc. (2014). Sheriff A. AIYEOLA. Protective effects of the aqueous

stem bark of Mangifera indica against CCl4-induced hepatic and renal

toxicities in rats. School of Postgraduate Studies of the University of

Lagos, Akoka, Lagos State, Nigeria. (Completed, examined and awarded

M.Sc. degree in Pharmacology)

3. M.Sc. (2012). Francis OLATOYE. Nephroprotective effect of calcium

channel blockers and phospholipase-A2 inhibitor on drug-induced renal

toxicity in rats. School of Postgraduate Studies of the University of Lagos,

Akoka, Lagos State, Nigeria. (Completed, examined, and awarded M.Sc.

degree in Pharmacology)

4. M.Sc. (2012). Saidi O. SALAU. Toxicity and toxicity reversibility profile

of the hydroethanolic leaf extract of Flabellaria paniculata in rodents.

School of Postgraduate Studies of the University of Lagos, Akoka, Lagos

State, Nigeria. (Completed, examined, and awarded M.Sc. degree in

Pharmacology)

8

L. POSTGRADUATE THESIS EXAMINED:

1. Ph.D. (2015). V. R. RAVIKKUMAR. Pharmacognostical, Phytochemical

and Pharmacological Evaluation of Zanthoxylum tetraspermum Wight &

Arn, (Rutaceae). Department of Pharmacy Centre for Advanced Research

in Indian System of Medicine (CARISM) SASTRA University, Thanjavur

– 613 401, Tamilnadu, India.

2. Ph.D. (2013). K. RASHMI. Studies on hepatoprotective property of

Barringtonia acutangula (L.) Gaertn. Department of Applied Zoology,

Mangalore University, Mangalagangothri-574199, Karnataka State, India.

M. ADMINISTRATIVE AND INSTITUTIONAL POSTS HELD:

i. Appointed Acting Dean, Faculty of Basic Medical Sciences, Lagos State

University College of Medicine, Ikeja, Lagos, Nigeria. 1st March, 2016 till

date;

ii. Appointed Acting Head, Department of Pharmacology, Lagos State

University College of Medicine, Ikeja, Lagos, Nigeria. 1st March, 2014 to

28th February 2016;

iii. Elected pioneering member (representing Academic Staff Assembly) of

the Lagos State University College of Medicine Court of Governors, Ikeja,

Lagos, Nigeria. 27th January, 2014 to date;

iv. Member, Lagos State University Senate, Ojo, Lagos. 1st March, 2014 to

date

v. Member, Academic Board of Lagos State University College of Medicine,

Ikeja, Lagos, Nigeria. 1st March, 2014 to date;

vi. Member, Faculty of Basic Medical Sciences Board, Lagos State

University College of Medicine, Ikeja, Lagos, Nigeria. 1st March, 2014 to

date;

vii. Member, Examination Misconduct Panel, Lagos State University College

of Medicine, Ikeja, Lagos, Nigeria. January, 2014 to date;

viii. Chairman, Animal House Committee, Lagos State University College of

Medicine, Ikeja, Lagos, Nigeria. November, 2012 to date;

ix. Member, Curriculum Committee of the Senate, Lagos State University,

Ojo, Lagos, Nigeria. 13th October, 2008 to date;

x. Member, Postgraduate Education Committee, Lagos State University

College of Medicine, Ikeja, Lagos, Nigeria. November, 2012 to date;

xi. Member, Research Grant and Ethics Committee of the Lagos State

University College of Medicine, Ikeja, Lagos, Nigeria. 1st December 2008

to date

9

N. OTHER ACTIVITIES OUTSIDE CURRENT EMPLOYMENT:

a. I served as a grant reviewer for Diabetes UK to consider the application

for funding from Dr. Opeolu Ojo for the research project titled

"Investigation of the actions of novel antihyperglycaemic peptides on

vascular dysfunction in experimental diabetes". Research Grant

Application Reference number: 16/0005442

b. I am a manuscript reviewer for the following journals:

(i) Expert Opinion on Therapeutic Targets (United Kingdom)

(ii). British Journal of Nutrition (United Kingdom)

(iii). Journal of Food Biochemistry (Canada)

(iv). Oriental Pharmacy and Experimental Medicine (Republic of Korea)

(v). Journal of Biomedical Research (formerly known as African Journal of

Biomedical Research, Nigeria)

(vi). Evidence Based Complementary and Alternative Medicine (Oxford

University Press, United Kingdom)

(vii). International Research Journal of Pharmacy and Pharmacology {formerly

African Journal of Pharmacy and Pharmacology (Egypt)}

(viii). Pharmaceutical Biology (Hawaii, USA)

(ix). African Journal of Biochemical Research (Egypt)

(x). Journal of Pharmacognosy and Phytotherapy (Nigeria)

(xi). Iranian Journal of Pharmacology (Iran)

(xii). African Journal of Traditional, Complementary and Alternative Medicine

(Nigeria)

(xiii). Methods and Findings in Experimental and Clinical Pharmacology (Spain)

(xiv). The Chinese Journal of Physiology (China)

(xv). Plant Foods for Human Nutrition (Mexico)

(xvi). Indian Journal of Experimental Biology (India)

(xvii). Regulatory Peptides (Germany)

(xviii). BMC Complementary and Alternative Medicine (United Kingdom)

(xix). Molecules (Switzerland)

(xx). West African Journal of Pharmacy (Nigeria)

(xxi). European Journal of Medicinal Plants (United Kingdom)

(xxii). British Journal of Medicine and Medical Research (United Kingdom)

(xxiii). Annals of Medical and Health Sciences Research (Nigeria)

(xxiv). Journal of King Saud University (Science) (Saudi-Arabia)

(xxv). International Journal of Green Pharmacy (India)

(xxvi). Food and Chemical Toxicology (USA)

(xxvii). Archiv der Pharmazie - Chemistry in Life Sciences (Germany)

(xxviii). Toxicology and Industrial Health (United Kingdom)

10

(xxix). Human and Experimental Toxicology (Finland)

(xxx). Diabetology and Metabolic Syndrome (U.S.A.)

(xxxi). Nutrition (U.S.A.)

c. I am also an editorial board member of the following peer review journals:

(i). Journal of Medicinal Plant Research (Nigeria)

Accessible online via: http://www.academicjournals.org/jmpr/Editors.htm

(ii). International Journal of Cell and Molecular Biology (U.S.A.)

Accessible online at: http://www.ijcmb.yola.com/services.php

(iii). Asian Journal of Biomedical and Pharmaceutical Sciences (Hong Kong)

Accessible at: http://jbiopharm.com/index.php/ajpsbr/pages/view/ed

(iv). Asian Pacific Journal of Tropical Biomedicine (Beijing, China)

Accessible at: http://www.apjtb.com/jianli4.htm

(v). Journal of Coastal Life Medicine (Wan Chai, Hong Kong.)

Accessible at: http://www.jclmm.com/index_files/f4.pdf

(vi). West African Journal of Pharmacology and Drug Research (An official

Journal of the West African Society for Pharmacology) (Nigeria)

d. I was appointed an editorial advisor to Science and Technology Group

(STG) Phytochemistry (A scientific journal published by Science and

Technology Group Publishers, Alexandria, Egypt). Accessible online via:

http://stg-publisher.com/index_files/Page 2102.htm

e. I was appointed a Guest Assistant Editor on “Herbal Remedies and

Phytochemicals: Focus on Safety and Toxicological Evaluation”, an

upcoming issue in “Frontiers In Pharmacology Research Topics” (A

scientific journal published by Frontiers Publishing, Lausanne,

Switzerland), 2014.

f. I was also appointed Managing Editor for the Journal: Frontiers in

Pharmacology, section Ethnopharmacology on the special topic “Herbal

Remedies and Phytochemicals: Focus on Safety and Toxicological

Evaluation” (A scientific journal published by Frontiers Publishing,

Lausanne, Switzerland), November 2014.

g. Appointed External Examiner to the Department of Pharmacology and

Therapeutics, College of Medicine, Ambrose Alli University, Ekpoma,

Edo State, Nigeria, for the Part II M.B;B.S. Main Examinations in

Pharmacology, 2015-2017.