Resveratrolo. Ligand Induces a Conformational Change in the LBD that Repositions helix 12 No LigandAgonist.

ResveratroloResveratrolo

Ligand Induces a Conformational Change in the LBD that Repositions helix 12

No Ligand Agonist

NR Antagonists Alter the Position of Helix 12

No Ligand Agonist(ER)

Antagonist(ER)

PHENOL

OH

•>100,000 Compounds>100,000 Compounds

•classified according to basic classified according to basic skeletal structureskeletal structure

•acidicacidic

•Participates in oxidation-Participates in oxidation-reduction reactions reduction reactions

Polyphenol content

Total polyphenolsTotal polyphenols

Red grape, Red grape, aveave. . 5500 mg/kg5500 mg/kg

Red wineRed wine 700–4000 700–4000 mg/Lmg/L

White grape, White grape, aveave. . 4000 mg/kg4000 mg/kg

White wineWhite wine 150-400 150-400 mg/Lmg/L

Vascular benefits Quercetin, catechin, resveratrolQuercetin, catechin, resveratrol

• Inhibition of platelet aggregationInhibition of platelet aggregation

• Inhibition of LDL oxidation (plaque)Inhibition of LDL oxidation (plaque)

•

• Vasodilation

• Inhibition of vasoconstriction (tannins)

Anti-carcinogenic propertiesAnti-carcinogenic properties

• Stilbenes inhibit cell proliferationStilbenes inhibit cell proliferation

• Association with decreased colon Association with decreased colon cancercancer

• Inhibition of non-melanoma skin cancer Inhibition of non-melanoma skin cancer -resveratrol-resveratrol

• Estrogenic effect-resveratrol +/-Estrogenic effect-resveratrol +/-

Resveratrolo