Dr. Tillie-Louise Hackett Department of Anesthesiology, Pharmacology and Therapeutics University of British Columbia Associate Head, Centre of Heart Lung Innovation, St Paul’s Hospital [email protected]Respiratory Pharmacology: Pulmonary vascular diseases
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Respiratory Pharmacology: Pulmonary vascular diseases€¦ · Department of Anesthesiology, Pharmacology and Therapeutics . University of British Columbia. Associate Head, Centre
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Dr. Tillie-Louise HackettDepartment of Anesthesiology, Pharmacology and Therapeutics
University of British Columbia
Associate Head, Centre of Heart Lung Innovation, St Paul’s [email protected]
Effect of Pulmonary edema Interstitial edema Generally little effect on lung function Some evidence that lung compliance is reduced
Alveolar Edema Lung compliance is reduced Airway compliance is reduced Seriously reduced O2 – CO2 transfer
Pathogenesis of Pulmonary Edema
1) Increased Capillary Hydrostatic Pressure
Caused by Myocardial Infarction Heart attack, left atrium fails, increase in pressure
2) Increased Capillary Permeability
Caused by capillary wall abnormalities Inhaled or circulating toxins (chlorine gas) Radiation (Breast cancer treatment)
Treatment for Pulmonary Edema
Oxygen Therapy: Most influential
Preload reducers: Use nitroglycerin and diuretics, such as furosemide (Lasix), to decrease the pressure caused by fluid going into your heart and lungs.
Afterload reducers: These drugs dilate your blood vessels and take a pressure load off your heart's left ventricle e.g. Nitropress, Vasotec.
Substances metabolized by the lung
Biological activation: Angiotensin I is converted to the vasoconstrictor, angiotensin II via ACE