Feb 06, 2016
Research Institute
For
Endocrine Sciences
Tehran, I.R. Iran
Research Institute for Endocrine Sciences
SBUMS
10Research Centers
Research
Laboratories
Tehran Lipid and
Glucose Study
Endocrine
Clinics
Department Of
Endocrinology
Research Centers of Research Institute for Endocrine Science
1. The Endocrine and Metabolism Research Center2. The Research Center for the Prevention of Metabolic Disorders3. The Research Center for Prevention and Treatment of Obesity4. The Research Center for Reproductive Endocrinology5. The Research Center of Nutrition and Endocrine6. The Research Center of Cellular and Molecular Endocrinenology7. The Research Center of Endocrine Physiology8. The Research Center for Determinants of Health
9. Research Development Center for Endocrinology
10. Medical Laws and Ethics Research Center
WHO Collaborating Center for Research and Training on Endocrine Science (2003)
The Terms of References:
1. To attain, upgrade and expand new knowledge in various aspects of
endocrine sciences.
2. To compile, upgrade and classify latest information related to
endocrinology in particular IDD and DM.
3. To train qualified personnel for education and research in endocrinology.
4. To collaborate with national, regional and international health
organizations and scientific centers in research and training in
endocrinology.
TOR 1
To attain, upgrade and expand new
knowledge in various aspects of endocrine
sciences.
Scientific Achievements of ERC Published Articles (Total): 1128
Published in International English Journals 568
Published in Scientific Farsi Journals 560
Guidelines and country programs 12
Books Published in English 6
Books Published in Farsi 25
Research Proposals (ongoing) 115
Research Proposals (accomplished) 600
International Research collaboration 30
TOR 2
To compile, upgrade and classify latest
information related to endocrinology in
particular IDD and DM.
The RIES SBMU Research laboratories
The RIES Research Lab is divided into three labs:
1) Biochemistry Lab: Routine and specialized bio-
chemistry tests, including bio-chemical analyses and
enzyme activities
2) Endocrinology Lab: Classic endocrines tests
3) Basic Research Lab : Endocrine receptors, cytokines,
metal ions etc.
Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Seciences
National Endocrine Laboratory
• Acting as:
• Reference laboratory for national programs of IDD &
DM
• Designing and preparation of endocrine diagnostic kits
• Training of endocrine laboratory personnel both
nationally and regionally
Total goiter rate in 4 national surveys in the I.R. Iran
1989 1996 2001 20070
50
100
150
200
250
Med
ian
urin
ary
iodi
ne (µ
g/L
)
Before After iodine supplementation
Median urinary iodine excretion in 4 national surveys in the I.R.Iran
Azizi F. Thyroid International 2009;4:1
Tehran Lipid
and
Glucose Study
TLGS Cohort
1380-1377 1384-1380 1387-1384
Phase 1 Phase 2 Phase 3
15005 57.9 % 71.9 %
15005
9474 63.2 %
1390-1387
Phase 4
71.0 %
Continuous NCD outcomes follow-up
1390 -….
Phase 5
?
Fat and sweet group6.4 ± 3.0
(Not recommended)
Milk and Dairy products1.1 ± 0.8
(2-3 servings)
Vegetable group3.6 ± 2.0
(3-5 servings)
Meat and its alternatives1.2 ± 0.7
(2-3 servings)
Fruits group3.1 ± 3.0
(2-4 servings)
Bread Group
7.8 ± 3.7( 9-11
servings)
Mean servings of intakes of various food groups in TLGS population in comparison with Food Guide Pyramid
Male Female Total0
10
20
30
40
50
60
70
33 32.3 32.6
52.1
41.9
46.4
57.3
38.9
47.1
63.2
51.8
56.7
Frequency of central obesity Waist ≥ 90 dur-ing 12 years of follow up in Tehranian adults:
TLGS
Phase 1Phase 2Phase 3phase 4
(%)
Important in causality Important in public health
Hazard ratio, survival time ratio and population attributable fraction (PAF) for CHD risk factors
Risk factors Hazard Ratio (95% CI)
Time Ratio
(95% CI) Average PAF
(%)
Men
High risk age 3.7 (2.8-5.1) 0.45 (0.37-0.55) 40.1
Family history of cardiovascular diseases
1.4 (1.1-1.9) 0.81 (0.68-0.96) 2.4
Smoking 1.5 (1.2-1.9) 0.78 (0.68-0.89) 9.6
Hypertension 1.7 (1.4-2.2) 0.72 (0.62-0.83) 8.9
Diabetes Mellitus 2.0 (1.6-2.6) 0.66 (0.56-0.77) 6.5
High total cholesterol 1.7 (1.3-2.1) 0.74 (0.64-0.85) 7.3
Low HDL cholesterol 1.2 (1.0-1.5) 0.90 (0.78-1.03) 6.5
Modifiableriskfactors
Changes following
lifestyle modification
18
ResultsThe change in the prevalence of metabolic syndrome componentsOver the time in cases and controls
Cases Controls
0
10
20
30
40
50
60
70
80
90
1st phase 2nd phase
High FBS Low HDL-c Central obesity
High TGs High blood pressure
0
10
20
30
40
50
60
70
80
90
1st phase 2nd phase
Prev
alen
ce (%
)
Harati et al. Am J Prev Med. 2010 Jun;38(6):628-636.e1.
TOR 3
To train qualified personnel for
education and research in
endocrinology
Manpower Training
Subspecialty Training in Endocrinology
Graduate training program offered to 6 specialists in internal medicine for 2 years
PhD in Molecular Medicine
PhD in Research
Continuing Medical Education for:GP's & internists Weakly grand roundsWeakly journal clubsMonthly endocrine conferences
Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Sciences
Workshops (National and International)
Iodine Deficiency Disorders
Diabetes Mellitus
Obesity
Research methodology
Management of endocrine disorders
Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Seciences
TOR 4
To collaborate with national, regional
and international health organizations
and scientific centers in research and
training in endocrinology
پژوهشي علمي آمتياز با
Research Institute for Endocrine Sciences (SBUMS)
Main office for scientific and professional societies:
Iran Endocrine Society
Iran Obesity Society
Association of Editors of Iranian Medical
Journals
RIES-SBUMS, has been in close collaboration with WHO EMRO during the last 35 years. The main activities include:
1. Two regional training courses on monitoring and evaluation of IDD elimination program held for 23
representatives from 12 countries of EMR in 2001 and for 39 representatives from 20 countries of EMR, East
Europe and Central Asia in 2002
2. The “Tehran Glucose and Lipid Study” (TLGS) conducted from 1998 to 2001, and initiation of “Interventions for
change of life style’’ in a population sample of Tehran. The findings have been presented at WHO sponsored
meetings in Isfahan 2001 Beirut 2002 and Cairo 2013
3. Participation of the director of the ERC-SBUMS as WHO-EMRO advisor and consultant on multiple occasions to
address IDD, diabetes, NCD and medical education in various countries of the region, EMRO and Geneva
meetings
4. Publication of the book “Assessment, Monitoring and Evaluation of IDD in the Middle East and Eastern
Mediterranean countries” 2002
5. Participation in the Regional Consultation in Diabetes Prevention and Control
6. Participation in NCD control, EMRO
7. Participation in consultations of WHO-Geneva (NCD, childhood obesity, IDD, Nutrition)
8. Training for many countries of the region
Collaboration with WHO
28