Jerome R. Lechien MD, PhD, MSc Department of Otolaryngology-Head & Neck Surgery, CHU Saint-Pierre, Brussels, Belgium Department of Thoracic – Head & Neck Surgery, Centre Oscar Lambret, Lille, France Department of Anatomy, School of Medicine, University of Mons, Mons, Belgium Research Committee of YO-IFOS: Laryngopharyngeal Reflux Study Group Tareck Ayad MD, FRCS Montreal Hospital, Chairman of Research Committee Jay Lechien MD, PhD, MS University of Mons, Vice-Chairman of Research Committee
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Research Committee of YO-IFOS: Laryngopharyngeal Reflux ... · Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018. Curr Opin Otolaryngol
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Jerome R. Lechien MD, PhD, MScDepartment of Otolaryngology-Head & Neck Surgery, CHU Saint-Pierre, Brussels, Belgium
Department of Thoracic – Head & Neck Surgery, Centre Oscar Lambret, Lille, France
Department of Anatomy, School of Medicine, University of Mons, Mons, Belgium
Research Committee of YO-IFOS:
Laryngopharyngeal Reflux Study Group
Tareck Ayad MD, FRCS
Montreal Hospital,
Chairman of Research
Committee
Jay Lechien MD, PhD, MS
University of Mons,
Vice-Chairman of Research
Committee
INTRODUCTION – DEFINITION OF REFLUX & CONTROVERSIES
Introduction-Inflammatory disease
-From 1996 to 2019:
Increased number of
publications
Current controversies & lack of consensus:
1. The diagnostic of LPR
2. The treatment (< poor superiority of PPIs over placebo)
Vaezi MF. Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review. Otolaryngol-Head Neck Surg, 2019
Acid LPR: diet + PPIs (2/d) + Gaviscon
Nonacid LPR: diet + Gaviscon/Riopan
Mixed LPR: diet + PPIs + Gaviscon (3/d)
STEP 3: DEVELOPMENT OF NEW CLINICAL TOOLS
RSS Acid
Evolution RSS & RSA (N=102)
RSS Nonacid RSS mixed
RSA Acid RSA Nonacid RSA mixed
P=0.001 P=0.015 P=0.042
P=0.013 P=0.036 P=0.004
Significant improvement of ENT & Digestive Symptoms and Laryngealand Extra-laryngeal signs. No difference between groups. 11
STEP 3: DEVELOPMENT OF NEW CLINICAL TOOLS
2/11SUMMARIZE
Step 1:
-Lechien, Schindler et al. Instruments Evaluating the Clinical Findings of Laryngopharyngeal Reflux: A Systematic Review. Laryngoscope. 2019
-Lechien, Askt et al. Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review. Otolaryngol Head Neck Surg, 2019.
-Lechien, Saussez et al. Clinical Outcomes of Laryngopharyngeal reflux Treatment: A Systematic review and Meta-analysis. Laryngoscope.
-Lechien, Saussez, et al. Association between Laryngopharyngeal Reflux and Benign Vocal Folds Lesions: A Systematic Review. Laryngoscope, 2019
-Lechien, Dapri et al. Surgical treatment for laryngopharyngeal reflux disease: A systematic review of 2,190 patients. JAMA Otolaryngol Head Neck Surg. 2019.
-Lechien, Muls et al. Management of Patients with recalcitrant Laryngopharyngeal Reflux: Contemporary Review. Clin Otolaryngol, 2019.
-Lechien, Saussez & Karkos. Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018. Curr Opin Otolaryngol Head Neck Surg, 2018.
Step 2:
Lechien, Mouawad et al. Awareness of European Otolaryngologists and General Practitioners Towards Laryngopharyngeal Reflux. Accepted for publication in Ann Otol Rhinol Laryngol, 2019
Step 3:Lechien, Bobin et al. Validity and reliability of the Reflux Symptom Score. Laryngoscope. 2019Lechien, Rodriguez et al. Validity and reliability of the Reflux Sign Assessment. Under review. 2019
Step 4: In process => Next IFOS Congress, Vancover, Canada.
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INTRODUCTION – LPR STUDY GROUP
LPR Study Group of YO IFOS: Systematic Review of Controversies in reflux