RERF · 2017. 9. 12. · Collaborative and Institutional Oral Presentations Annual Report 2014–2015page 94 Senior Scientist Kodama K. How large are the radiation doses and risks

Collaborative and Institutional Publications

Annual Report 2014–2015 page 92

Director Walsh L, Zhang W, Shore RE, Auvinen A, Laurier D,

Wakeford R, Jacob P, Gent N, Anspaugh LR, Schüz J, Kesminiene A, van Deventer E, Tritscher A, del Rosarion Pérez M: A framework for estimating radiation-related cancer risks in Japan from the 2011 Fukushima nuclear accident. Radiat Res 2014 (November); 182(5):556–72.

Clinical Studies, Hiroshima Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama

R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K: Differences in serum microRNA profiles in hepatitis B and C virus infection. J Infect Dis 2015 (March); 70(3):273–87. Fujino H, Hiroshima Liver Study Group (RERF: Ohishi

W): Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C. J Gastroenterol 2014 (December); 49(12):1548–56. Ohishi W, Chayama K: The relationship of elevated IL-6

and increased risk of hepatocellular carcinoma. Nippon Rinsho [Jpn J Clin Med] 2015 (January); 73(Suppl 1):217–21. (Japanese) Satoh M, Ohkubo T, Asayama K, Murakami Y, Sakurai

M, Nakagawa H, Iso H, Okayama A, Miura K, Imai Y, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group (RERF: Yamada M): Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan. Hypertension 2015 (March); 65(3):517–24.

Clinical Studies, Nagasaki Haraguchi A, Fujishima K, Ando T, Mori F, Imaizumi M,

Abiru N, Yamasaki H, Matsumoto K, Takamura N, Kawakami A: Multiple drug combination of anti-diabetic agents as a predictor for poor clinical response to liraglutide. Minerva Endocrinol 2014 (December); 39(4):289–97. Hayashida N, Imaizumi M, Shimura H, Furuya F, Okubo

N, Asari Y, Nigawara T, Midorikawa S, Kotani K, Nakaji S, Ohtsuru A, Akamizu T, Kitaoka M, Suzuki S, Taniguchi N, Yamashita S, Takamura N: Thyroid ultrasound findings in a follow-up survey of children from three Japanese prefectures: Aomori, Yamanashi, and Nagasaki. Sci Rep 2015 (March); 5:9046. doi: 10.1038/srep09046 Ikeoka T, Ando T, Imaizumi M, Ueki I, Usa T, Kawakami

A: Moderate to severe nausea in radioactive iodine (RAI) therapy is associated with the RAI dose per body weight and was not prevented by ramosetron. Endocrine 2014 (May); 46(1):131–7.


The following manuscripts are not based on research connected to specific protocols. Rather, they generally represent collaborative work, institutionally authored publications, or publications based on pilot studies. They are arranged by department.

Genetics Kodama Y: Genetic effects of atomic bomb radiation on

humans. Sutou S, ed. Fukushima Nuclear Accident: Global Implications, Long-Term Health Effects and Ecological Consequences. New York: Nova Science Publishers; 2015 (March), pp 77–88. Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y,

Osaki M, Oshimura M, Ishigaki Y, Hamasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H: Reprogramming suppresses premature senescence phenotypes of Werner Syndrome cells and maintains chromosomal stability over long-term culture. PLoS ONE; 2014 (November), 9(11): e112900.

Radiobiology/Molecular Epidemiology Kyoizumi S: T-cell receptor mutation assay for monitoring

human genotoxic exposure. Sierra LM, Gaivão I, eds. Genotoxicity and DNA Repair. A Practical Approach. New York: Humana Press; 2014, pp 159–67.

Epidemiology, Hiroshima Ito Y et al., the J-CANSIS Research Group (RERF:

Sugiyama H): Long-term survival and conditional survival of cancer patients in Japan using population-based cancer registry data. Cancer Sci 2014 (November); 105(11): 1480–6. Sakai A, Ohira T, Hosoya M, Ohtsuru A, Satoh H,

Kawasaki Y, Suzuki H, Takahashi A, Kobashi G, Ozasa K, Yasumura S, Yamashita S, Kamiya K, Abe M and for the Fukushima Health Management Survey Group: Life as an evacuee after the Fukushima Daiichi nuclear power plant accident is a cause of polycythemia: the Fukushima Health Management Survey. BMC Public Health 2014 (December); 14:1318. Sakai A, Ohira T, Hosoya M, Ohtsuru A, Satoh H,

Kawasaki Y, Suzuki H, Takahashi A, Kobashi G, Ozasa K, Yasumura S, Yamashita S, Kamiya K, Abe M and for the Fukushima Health Management Survey Group: White blood cell, neutrophil, and lymphocyte counts in individuals in the evacuation zone designated by the government after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey. J Epidemiol 2015 (January); 25(1):80–7.

Statistics Furukawa K: The importance of study designs and

statistical analysis in epidemiology. Clin Calcium 2014 (May); 24(5):703–10. (Japanese) Tekwe CD, Carter RL, Cullings HM, Carroll RJ: Multiple

indicators, multiple causes measurement error models. Stat Med 2014 (November); 33(10):4469–81.



Manuscript in Pressa Crowley KD, Cullings HM, Landes RD, Shore RE, Ullrich

RL: Comments on estimating risks of low radiation doses—A critical review of the BEIR VII Report and use of the linear no-threshold (LNT) hypothesis by Edward J. Calabrese and Michael K. O’Connor [Letter to the editor]. Radiat Res.

Collaborative and Institutional Oral Presentations


Senior Scientist Kodama K. How large are the radiation doses and risks

from Fukushima? 47th Annual Meeting of the Society for Epidemiologic Research, 25–26 June 2014, Seattle, Washington, USA

Genetics Satoh Y, Fujimoto A, Asakawa J. Mutations identified in

cell clones derived from X-irradiated human cultured cells by whole genome sequencing. 60th Annual Meeting of the Radiation Research Society, 21–24 September 2014, Las Vegas, Nevada, USA Asakawa J, Fujimoto A, Satoh Y, Miura A, Nakamoto Y,

Nishikori E, Imanaka M, Kodaira M. Mutations identified by whole genome sequencing of DNA samples derived from X-irradiated human cell clones. 57th Annual Meeting of the Japan Radiation Research Society, 1–3 October 2014, Kagoshima Kodaira M, Miura A, Imanaka M, Tsuji T, Kitamura J,

Nakamoto Y, Kamiguchi Y, Nakamura N, Asakawa J. Estimation of genetic ef fects of radiation in immature oocytes of rats: Characteristics of mutations detected by using high-density microarray. 57th Annual Meeting of the Japan Radiation Research Society, 1–3 October 2014, Kagoshima

Epidemiology, Hiroshima Ozasa K, Sadakane A, Fukushima W, Oofuji S. Advocacy

of the prevention and control of influenza by vaccination. 73rd Annual Meeting of the Japanese Society of Public Health, 5–7 November 2014, Utsunomiya

Collaborative and Institutional Oral Presentations

The following oral presentations were not linked to specific research protocols but based on pilot studies, or represent collaborative work with outside organizations and general research activities. They are arranged by department.

Statistics Nakashima E. Modified GEE1 for the analysis of

multivariate heterogeneous variances gaussian data. FY2014 Annual Meeting of the Japanese Biometric Society, 23–24 May 2014, Tokyo Kim YM. A simple method of power analysis based on

“Proportion Explained” to assess mediated effects for a dichotomous outcome. 2014 WNAR/IMS Conference, 15–18 June 2014, Honolulu, Hawaii, USA Landes RD. Recommendations for interval estimators of

relative potency. 2014 WNAR/IMS Conference, 15–18 June 2014, Honolulu, Hawaii, USA Nakashima E. The modified GEE1 and the linear mixed

effect models for the longitudinal heteroscedastic gaussian data: Application to the longitudinal systolic blood pressure data from age 9 to 14 years of A-bomb survivors exposed in utero. FY2014 Japan Joint Statistical meeting, 13–16 September 2014, Tokyo Cullings HM. Evaluation of the risk of de novo variation

in offspring due to parental radiation exposure in the cohort of Japanese A-bomb survivors. 21st International Meeting Conference on Radiation and Health, 21–24 September 2014, Las Vegas, Nevada, USA

Scienti�c Lectures and Seminars Presented at RERF


18 April 2014, Akihiro Fujimoto, Senior Scientist, Laboratory for Medical Science Mathematics RIKEN, Center for Integrative Medical Sciences (IMS), Yokohama: “Comprehensive analysis of genetic variation by whole genome sequencing”

21 April 2014, Tony Riddell, Data Manager, Epidemiology Depar tment, Centre for Radiation, Chemicals and Environmental, Hazards, Public Health England, U.K.: “The Past, Present and Future of the Assessment of Plutonium Exposure Risks”

25 April 2014, Munechika Misumi, Research Scientist, Department of Statistics, Radiation Ef fects Research Foundation, The 282nd Hiroshima Statistics Study Group Meeting: “Application of simulation-extrapolation (SIMEX) to the RERF Life Span Study data”

12 May 2014, John B. Little, Professor Emeritus, Department of Genetics and Complex Diseases, Harvard University, U.S.A.: “How May ‘Non-Targeted’ Effects of Radiation Influence the Risk of Low Dose Exposures”

12 May 2014, Zhi-Min Yuan, Professor, Department of Genetics and Complex Diseases, Harvard University, U.S.A.: “The Metabolic Response to Low Dose Irradiation”

6 June 2014, Shinpei Imori, Department of Mathematics, Graduate School of Science, Hiroshima University, The 283rd Hiroshima Statistics Study Group Meeting: “Two-step model selection method in high-dimensional data”

7 July 2014, Jorge Leon-Cruz, M.S. Biostatistics, College of Public Health, University of Iowa, U.S.A.: “Predicting change in hearing ability over time using clustering and multinomial logistic regression”

18 July 2014, Hiroko Kato Solvang, Institute of Marine Research, Norway, The 284th Hiroshima Statistics Study Group Meeting: “Estimation of an optimum threshold related to T-category of breast cancer by differential gene expression”

13 August 2014, Kaitlin E. Kelly-Reif, Japan Society for the Promotion of Science (JSPS) Summer Program Fellow, Department of Epidemiology, University of North Carolina at Chapel Hill, U.S.A.: “Geostatistical estimation of residual radiation from the Hiroshima atomic bomb”

1 September 2014, William F. Morgan, Director of Radiation Biology and Biophysics, Biological Sciences Division, Pacific Northwest National Laboratory, U.S.A.: “Issues in Low Dose Radiation Research”

3 September 2014, Curtis C. Harris, Chief, Laboratory of Human Carcinogenesis, Center for Cancer Research,

Scientific Lectures and Seminars Presented at RERF1 April 2014–31 March 2015

The following presentations were made during the fiscal year by researchers internal and external to RERF at the Hiroshima Laboratory. They appear in chronological order.

National Cancer Institute, National Institutes of Health, U.S.A.: “Interweaving the threads of microRNA inflammation and p53 networks in the tapestry of cancer and aging”

19 September 2014, Fukiko Mitsui, Visiting Research Associate, Department of Clinical Studies, Radiation Effects Research Foundation: “Importance of serum concentration of Adefovir for Lamivudine-Adefovir combination therapy in patients with Lamivudine-resistant chronic hepatitis B”

3 October 2014, Reid D. Landes, Senior Scientist, Department of Statistics, Radiation Ef fects Research Foundation, The 285th Hiroshima Statistics Study Group Meeting: “A Bayesian calibration involving nonlinear mixed effects models”

24 October 2014, Ginji Endo, Professor, Osaka City University Graduate School of Medicine: “Epidemiological elucidation and analysis of the cause of cholangiocarcinoma among printing workers”

28 October 2014, Yueh-Yun Chi, Assistant Professor, Department of Biostatistics, University of Florida, U.S.A.: “Statistical Considerations for Longitudinal Design and Data Analysis”

31 October 2014, Yasunori Fujikoshi, Emeritus Professor of Hiroshima University, Advisor of the Hiroshima University Statistical Science Research Core, The 286th Hiroshima Statistics Study Group Meeting: “Estimation methods of the rank of a mean parameter matrix in multivariate linear model and their high-dimensional consistency properties”

18 November 2014, Gregory D. Sempowski, Professor, Departments of Medicine and Pathology, Scientific Director for Shared Resources, Duke Human Vaccine Institute, U.S.A.: “Enhancing your research with multiplex cytokine profiling”

18 November 2014, Nan-ping Weng, Senior Investigator and Chief, Lymphocyte Differentiation Section, Laboratory of Immunology, National Institute on Aging (NIH), U.S.A.: “Genetic and epigenetic factors in aging of human immune system”

28 November 2014, Hiroshi Yamada, Professor, Department of Economics, Hiroshima University, The 287th Hiroshima Statistics Study Group Meeting: “Selecting the Tuning Parameter of the l1 Trend Filter”

12 December 2014, Eiji Nakashima, Assistant Department Chief, Department of Statistics, Radiation Effects Research Foundation, The 288th Hiroshima Statistics Study Group Meeting: “Linear Regression with Classical and Berkson Independent Additive Covariate Measurement Errors”

Scienti�c Lectures and Seminars Presented at RERF


14 January 2015, Kismet (Anna) Cordova, Applied Biostatistics & Bioinformatics, Colorado School of Public Health, U.S.A.: “The Impact of Marijuana Use on the Relationship between Personality and Anxiety/Depression”

23 January 2015, Inge Koch, Associate Professor, School of Mathematical Sciences, The University of Adelaide, Australia, The 289th Hiroshima Statistics Study Group Meeting: “Analysis of Spatial Data from Proteomics Imaging Mass Spectrometry”

RERF Colloquia, Awards Received by RERF Employees


RERF Colloquia

Rather than formal seminars, RERF Colloquia are presentations mainly focused on preliminary or ongoing studies, with the aim of obtaining constructive ideas from RERF researchers.

18 April 2014, Eric J. Grant, Assistant Department Chief, Department of Epidemiology, Hiroshima, “Risk of death among the children of the atomic bomb survivors: an update after 62 years of follow-up”

16 May 2014, Eiji Nakashima, Assistant Department Chief, Department of Statistics, “Modified GEE1 for the analysis of multivariate heteroscedastic variances gaussian data: Application to the longitudinal systolic blood pressure data from Age 9 to 14 years of A-bomb survivors exposed in utero”

18 July 2014, Mieko Kodaira, Adjunct Specialist (Research Scientist), Laboratory of Biochemical Genetics, Department of Genetics, “Can we distinguish radiation-associated mutations from spontaneous mutations? Molecular characterization of spontaneous and radiation-associated mutations in mouse germ cells”

22 August 2014, Masataka Taga, Research Scientist, Laboratory of Cell Biology, Department of Radiobiology/Molecular Epidemiology, “Analysis of ALK fusion genes in lung cancer among atomic-bomb survivors”

19 September 2014, Michiko Yamada, Chief, Division of Radiology, Department of Clinical Studies, Hiroshima, “Longitudinal analyses of the AHS measurements”

17 October 2014, Eric J. Grant, Assistant Department Chief, Department of Epidemiology, Hiroshima, “Solid cancer incidence among atomic bomb survivors, updated analysis through 2009”

21 November 2014, Reid D. Landes, Senior Scientist, Department of Statistics, “Examples of bootstrap and Bayesian methods to estimate ratios”

19 December 2014, Yasunari Satoh, Research Scientist, Department of Genetics, “Mutations identified in cell clones derived from X-irradiated human cultured cells by whole genome sequencing”

16 January 2015, Junko Kajimura, Fixed-Term Scientist, Laboratory of Immunology, Department of Radiobiology/Molecular Epidemiology, “Effects of radiation exposure and aging on human circulating dendritic cells (DCs)”

Awards Received by RERF Employees1 April 2014–31 March 2015

13 June 2014, Michio Sunamoto, Assistant Section Chief, Pathology Laborator y, Department of Epidemiology, Hiroshima, and Akiko Nagayoshi, Assistant Section Chief, Tumor and Tissue Registry Office, Department of Epidemiology, Nagasaki, received the 2014 Distinguished Clerical Service Award, which is presented to those who have achieved a certain level of technical skill in regional cancer registry operations, at the 23rd meeting of the Japanese Association of Cancer Registries, held in the city of Tsu, Mie prefecture.

13 October 2014, RERF was presented with an honorary award by the Latvian Republican Union Chernobyl for its contributions over many years, including the provision of training for medical workers and researchers from Latvia as well as its cooperation in health management of the military veterans who worked at the Chernobyl nuclear accident site. On behalf of RERF, Tomonori Hayashi, PhD, Assistant Chief, RERF Department of Radiobiology/Molecular Epidemiology, attended the award ceremony held in Riga, Latvia.

22 October 2014, Toshiteru Okubo, PhD, RERF Chair-man, received the 2014 Distinguished Service Award of the Japan Industrial Safety and Health Association (JISHA) at the general conference of the 73rd National Industrial Safety and Health Convention, held in Hiroshima. For many years, he has worked on research in the field of occupational hygiene and industrial medicine, contributing to the devel-opment of occupational health indices and the establish-ment of basic theories on industrial health activities.

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re to

th

e m

ouse

fetu

s

JSPS

Gra

nt-in

-Aid

for

Scie

ntifi

c R

esea

rch

Youn

g Sc

ient

ists

(B

)K

anya

Ham

asak

i, R

esea

rch

Scie

ntis

t, C

ytog

enet

ics

Labo

rato

ry,

Dep

artm

ent o

f Gen

etic

s, R

ER

F

1 A

pril

2014

–31

Mar

ch 2

015

Dir

ect c

ost

¥1,0

00,0

00In

dire

ct c

ost

¥300

,000



FY20

14 E

xter

nally

Fun

ded

Res

earc

h

Titl

e of

Res

earc

hN

ame

and

Loca

tion

of E

ntru

stin

g O

utsi

de O

rgan

izat

ion

and

C

hief

of R

esea

rch

Gro

up o

r Pr

inci

pal I

nves

tigat

or in

Cha

rge

Col

labo

rato

r(s)

at R

ER

FSt

udy

Peri

odR

esea

rch

Fund

s

Dep

artm

ent

of G

enet

ics

In v

ivo,

in s

itu m

utag

enic

ris

k ev

alua

tion

of r

adia

tion

and

envi

ronm

enta

l che

mic

als

usin

g ne

wly

dev

elop

ed k

nock

-in m

ouse

sy

stem

s

JSPS

Gra

nt-in

-Aid

for

Scie

ntifi

c R

esea

rch

Scie

ntifi

c R

esea

rch

(S)

Asa

o N

oda,

Ass

ista

nt C

hief

, Dep

artm

ent o

f Gen

etic

s, R

ER

F

Kan

ya H

amas

aki

1 A

pril

2014

–31

Mar

ch 2

015

Dir

ect c

ost

¥27,

200,

000

Indi

rect

cos

t¥8

,160

,000

The

abov

e am

ount

in

clud

es fu

nds

allo

cate

d to

the

colla

bora

tors

at

othe

r in

stitu

tes

(The

Uni

vers

ity

of T

okyo

, Osa

ka

Uni

vers

ity, a

nd

Ibar

aki

Uni

vers

ity).

Dev

elop

men

t of n

ew m

etho

ds th

at

spec

ifica

lly d

etec

t and

mea

sure

rad

iatio

n-in

duce

d un

repa

irab

le D

SBs

JSPS

Gra

nt-in

- Aid

for

Scie

ntifi

c R

esea

rch

Cha

lleng

ing

Exp

lora

tory

Res

earc

hA

sao

Nod

a, A

ssis

tant

Chi

ef, D

epar

tmen

t of G

enet

ics,

RE

RF

1 A

pril

2014

–31

Mar

ch 2

015

Dir

ect c

ost

¥800

,000

Indi

rect

cos

t¥2

40,0

00

Stud

y on

the

info

rmat

ion

of B

ikin

i hy

drog

en b

omb

MH

LW S

cien

tific

Res

earc

h G

rant

Sp

ecia

l Res

earc

h Pr

ojec

tM

akot

o A

kash

i, D

irec

tor,

Nat

iona

l Ins

titut

e of

Rad

iolo

gica

l Sci

ence

Yosh

iaki

Kod

ama

16 J

anua

ry 2

015–

31 M

arch

201

5¥2

00,0

0 0

Dep

artm

ent

of R

adio

biol

ogy/

Mol

ecula

r E

pide

mio

logy

Stud

ies

of im

mun

osen

esce

nce

and

othe

r la

te e

ffec

ts o

f acu

te io

nizi

ng r

adia

tion

expo

sure

in a

tom

ic-b

omb

surv

ivor

s

U.S

. Nat

iona

l Ins

titut

e of

Alle

rgy

and

Infe

ctio

us D

isea

ses

Prin

cipa

l Inv

estig

ator

: Kei

Nak

achi

, RE

RF

Con

sulta

ntC

o-pr

inci

pal I

nves

tigat

ors:

Yoic

hiro

Kus

unok

i, C

hief

, Dep

artm

ent o

f Rad

iobi

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y/M

olec

ular

E

pide

mio

logy

, RE

RF

Tom

onor

i Hay

ashi

, Ass

ista

nt C

hief

, Dep

artm

ent o

f Rad

iobi

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y/M

olec

ular

Epi

dem

iolo

gy, R

ER

F

Rob

ert

L. U

llric

h （A

ssoc

iate

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hief

of R

esea

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hi K

yoiz

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Rei

ko I

toJu

nko

Kaj

imur

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engo

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hida

Wak

a O

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i (D

epar

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C

linic

al S

tudi

es)

Kot

aro

Oza

sa (

Dep

artm

ent

of

Epi

dem

iolo

gy)

Kyo

ji Fu

ruka

wa

(Dep

artm

ent o

f St

atis

tics)

Mun

echi

ka M

isum

i (D

epar

t-m

ent o

f Sta

tistic

s)

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ctob

er 2

009–

30 S

epte

mbe

r 20

14D

irec

t cos

t¥1

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ct c

ost

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000



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14 E

xter

nally

Fun

ded

Res

earc

h

Titl

e of

Res

earc

hN

ame

and

Loca

tion

of E

ntru

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g O

utsi

de O

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ion

and

C

hief

of R

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Gro

up o

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inci

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nves

tigat

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rge

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at R

ER

FSt

udy

Peri

odR

esea

rch

Fund

s

Dep

artm

ent

of R

adio

biol

ogy/

Mol

ecula

r E

pide

mio

logy

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ecul

ar e

pide

mio

logy

stu

dy o

f in

flam

mat

ion-

asso

ciat

ed d

isea

se

deve

lopm

ent o

n th

e ba

sis

of lo

ng-te

rm

follo

w-u

p of

ato

mic

-bom

b su

rviv

ors

JSPS

Gra

nt-in

-Aid

for

Scie

ntifi

c R

esea

rch

Scie

ntifi

c R

esea

rch

(B)

Tom

onor

i Hay

ashi

, Ass

ista

nt C

hief

, Dep

artm

ent o

f Rad

iobi

olog

y/M

olec

ular

Epi

dem

iolo

gy, R

ER

F

Ass

ocia

te I

nves

tiga

tors

: K

ei

Nak

achi

(R

ER

F C

onsu

ltant

),

Taka

hiko

Oga

wa

1 A

pril

2014

–31

Mar

ch 2

015

Dir

ect c

ost

¥4,3

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dire

ct c

ost

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90,0

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e ab

ove

amou

nt

incl

udes

fund

s al

loca

ted

to th

e co

llabo

rato

r at

T

he U

nive

rsity

of

Toky

o.

Mol

ecul

ar e

pide

mio

logy

stu

dy o

f cig

aret

te

smok

ing

effe

cts

on im

mun

ity- a

nd

infla

mm

atio

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late

d bi

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and

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Res

earc

h Fo

unda

tion

Tom

onor

i Hay

ashi

, Ass

ista

nt C

hief

, Dep

artm

ent o

f Rad

iobi

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olec

ular

Epi

dem

iolo

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ER

F

1 A

pril

2014

–31

Mar

ch 2

015

¥2,0

00,0

00

Can

low

er-d

ose

radi

atio

n ca

use

card

iova

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ar d

isea

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Ass

essm

ent u

sing

an

imal

mod

els

Nuc

lear

Saf

ety

Res

earc

h A

ssoc

iatio

nM

OE

Res

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h Pr

ojec

t for

Nuc

lear

-pow

er D

isas

ter

Influ

ence

in F

Y20

14

(Res

earc

h R

egar

ding

the

Hea

lth E

ffec

ts o

f Rad

iatio

n)Ya

suha

ru N

iwa,

Ass

ocia

te S

enio

r Sc

ient

ist,

Cel

l Bio

logy

Lab

orat

ory,

D

epar

tmen

t of R

adio

biol

ogy/

Mol

ecul

ar E

pide

mio

logy

, RE

RF

Coo

pera

tive

In

vest

igat

ors:

N

orio

Tak

ahas

hi (

Con

sulta

nt

atta

ched

to A

ssoc

iate

Chi

ef o

f R

esea

rch ’

s O

ffice

)W

aka

Ohi

shi

(Dep

artm

ent

of

Clin

ical

Stu

dies

)M

unec

hika

Mis

umi

(Dep

art-

men

t of S

tatis

tics)

Res

earc

h P

arti

cipa

nt:

Hid

eko

Mur

akam

i

1 A

pril

2014

–10

Mar

ch 2

015

¥4,4

19,1

63

Bio

logi

cal s

igni

fican

ce o

f EM

L4-A

LK

fusi

on g

ene

in r

adia

tion

thyr

oid

carc

inog

enes

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JSPS

Gra

nt-in

-Aid

for

Scie

ntifi

c R

esea

rch

Scie

ntifi

c R

esea

rch

(C)

Kiy

ohir

o H

amat

ani,

Res

earc

h Sc

ient

ist,

Cel

l Bio

logy

Lab

orat

ory,

D

epar

tmen

t of R

adio

biol

ogy/

Mol

ecul

ar E

pide

mio

logy

, RE

RF

Rei

ko I

to1

Apr

il 20

14–

31 M

arch

201

5D

irec

t cos

t¥1

,200

,000

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rect

cos

t¥3

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00Th

e ab

ove

amou

nt

incl

udes

fund

s al

loca

ted

to th

e co

llabo

rato

r at

Sa

itam

a M

edic

al

Uni

vers

ity.



FY20

14 E

xter

nally

Fun

ded

Res

earc

h

Titl

e of

Res

earc

hN

ame

and

Loca

tion

of E

ntru

stin

g O

utsi

de O

rgan

izat

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and

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hief

of R

esea

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Gro

up o

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inci

pal I

nves

tigat

or in

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rge

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labo

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at R

ER

FSt

udy

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odR

esea

rch

Fund

s

Dep

artm

ent

of R

adio

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ecula

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logy

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ecul

ar e

pide

mio

logi

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tudy

on

gyne

colo

gic

canc

er a

nd it

s co

rrel

atio

n w

ith

radi

othe

rapy

out

com

e in

Kor

ean

and

Japa

nese

pop

ulat

ions

JSPS

Bila

tera

l Pro

gram

sJa

pan-

Kor

ea J

oint

Res

earc

h Pr

ojec

t (N

RF)

Tom

onor

i Hay

ashi

, Ass

ista

nt C

hief

, Dep

artm

ent o

f Rad

iobi

olog

y/M

olec

ular

Epi

dem

iolo

gy, R

ER

F

Ass

ocia

te I

nves

tigat

ors:

Wak

a O

hish

i (D

epar

tmen

t of

Clin

i-ca

l St

udie

s),

Kei

Nak

achi

(R

ER

F C

onsu

ltant

)C

oope

rativ

e In

vest

igat

ors:

Hu

Yiq

un

, K

im

You

ng

M

in

(Dep

artm

ent o

f Sta

tistic

s)

1 A

pril

2014

–31

Mar

ch 2

015

¥1,2

00,0

00

Tra

nscr

ipto

me

and

mol

ecul

ar p

athw

ay

anal

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hara

cter

ize

phen

otyp

es o

f hu

man

imm

unol

ogic

al a

ging

Nat

iona

l Ins

titut

e of

Gen

etic

s (J

apan

)FY

2014

Col

labo

rativ

e R

esea

rch

and

Res

earc

h M

eetin

gR

esea

rch

Org

aniz

atio

n of

Inf

orm

atio

n an

d Sy

stem

sC

olla

bora

tive

Res

earc

h (A

)K

engo

Yos

hida

, Res

earc

h Sc

ient

ist,

Imm

unol

ogy

Labo

rato

ry, D

epar

tmen

t of

Rad

iobi

olog

y/M

olec

ular

Epi

dem

iolo

gy, R

ER

F

Yoic

hiro

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unok

iTo

mon

ori H

ayas

hiM

unec

hika

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umi

(Dep

art-

men

t of S

tatis

tics)

1 A

pril

2014

–31

Mar

ch 2

015

¥176

,000

Ana

lysi

s of

rad

iatio

n ef

fect

s on

the

form

atio

n of

fusi

on g

enes

invo

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in lu

ng

canc

er

JSPS

Gra

nt-in

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for

Scie

ntifi

c R

esea

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Scie

ntifi

c R

esea

rch

(C)

Mas

atak

a Ta

ga, R

esea

rch

Scie

ntis

t, C

ell B

iolo

gy L

abor

ator

y, D

epar

tmen

t of

Rad

iobi

olog

y/M

olec

ular

Epi

dem

iolo

gy, R

ER

F

Kiy

ohir

o H

amat

ani

Rei

ko I

to1

Apr

il 20

14–

31 M

arch

201

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irec

t cos

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rect

cos

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Dep

artm

ent

of E

pide

mio

logy

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him

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ppor

t for

epi

dem

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gica

l stu

dies

of

canc

er a

mon

g at

omic

bom

b su

rviv

ors

U.S

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iona

l Can

cer

Inst

itute

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CI)

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trac

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nal C

ance

r In

stitu

te, B

ethe

sda,

Mar

ylan

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CI

Con

trac

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aro

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hief

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artm

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f Epi

dem

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ER

F

Proj

ect M

anag

ers:

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c J.

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nt,

Har

ry M

. C

ullin

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art-

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tatis

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1 A

pril

2014

–31

Jul

y 20

19D

irec

t cos

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0In

dire

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00

Imm

unoh

isto

logi

cal e

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mio

logi

c st

udy

of

brea

st c

ance

r am

ong

atom

ic-b

omb

surv

ivor

s

JSPS

Gra

nt-in

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for

Scie

ntifi

c R

esea

rch

Scie

ntifi

c R

esea

rch

(C)

Kot

aro

Oza

sa, C

hief

, Dep

artm

ent o

f Epi

dem

iolo

gy, R

ER

F

1 A

pril

2014

–31

Mar

ch 2

015

Dir

ect c

ost

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dire

ct c

ost

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ith e

xten

sion

of

the

fund

ed te

rm,

the

unex

ecut

ed

amou

nt fo

r FY

2013

(¥

289,

124)

was

us

ed. N

o gr

ant

was

pro

vide

d fo

r FY

2014

.



FY20

14 E

xter

nally

Fun

ded

Res

earc

h

Titl

e of

Res

earc

hN

ame

and

Loca

tion

of E

ntru

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utsi

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and

C

hief

of R

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ER

FSt

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s

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rant

Res

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Em

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e-em

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In

fluen

zaYo

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Hir

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Dir

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linic

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pide

mio

logy

Res

earc

h C

ente

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edic

al

Co.

LTA

Kot

aro

Oza

sa1

Apr

il 20

14–

31 M

arch

201

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00

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y to

gra

sp tr

ends

of c

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are

for

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atio

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or c

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Reg

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veill

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ter

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cer

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trol

and

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orm

atio

n Se

rvic

es, N

atio

nal C

ance

r C

ente

r

Kot

aro

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il 20

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31 M

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Dep

artm

ent

of I

nfor

mat

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nolo

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onst

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e in

tegr

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dat

abas

e of

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epi

dem

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lysi

s fo

r th

e pe

ople

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ing

in S

emip

alat

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test

site

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a

JSPS

Gra

nt-in

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for

Scie

ntifi

c R

esea

rch

Scie

ntifi

c R

esea

rch

(B)

Hir

oaki

Kat

ayam

a, C

hief

, Dep

artm

ent o

f Inf

orm

atio

n Te

chno

logy

, RE

RF

1 A

pril

2014

–31

Mar

ch 2

015

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ect c

ost

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dire

ct c

ost

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00Th

e ab

ove

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nt

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udes

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e co

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rs a

t ot

her

inst

itute

s (H

iros

him

a U

nive

rsity

, K

anaz

awa

Uni

vers

ity,

Shim

ane

Uni

vers

ity, a

nd

Tsu

kuba

U

nive

rsity

).

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ioac

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pe

ople

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idin

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Sem

ipal

atin

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ects̶

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nt-in

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ntifi

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ahar

u H

oshi

, Pro

fess

or E

mer

itus,

Ins

titut

e fo

r Pe

ace

Scie

nce,

H

iros

him

a U

nive

rsity

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oaki

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esea

rch

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er O

ffice

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n in

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rdio

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ease

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Eva

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odel

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dies

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nt-in

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Scie

ntifi

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esea

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Scie

ntifi

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esea

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akah

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nt a

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Ass

ocia

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hief

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esea

rch ’

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ffice

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RF

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linic

al S

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haru

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ogy/

Mol

ecul

ar E

pi-

dem

iolo

gy)

Ass

ocia

te I

nves

tigat

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eko

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akam

i (D

epar

tmen

t of

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adio

biol

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Mol

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pi-

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FY20

14 C

olla

bora

tive

Stud

ies

(With

out E

xter

nal F

unds

)

Titl

e of

Res

earc

hN

ame

of C

hief

of R

esea

rch

Gro

upIn

vest

igat

or(s

) at

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RF

Inve

stig

ator

(s)

outs

ide

RE

RF

Initi

atio

n Ye

ar

Dep

artm

ent

of C

linic

al S

tudi

es,

Hir

oshi

ma

NI-H

ON

-SE

A (

Nip

pon-

Hon

olul

u-Se

attle

) St

udy

(Pre

vale

nce

and

inci

denc

e of

dem

entia

)Ya

mad

a M

Kas

agi F

(R

adia

tion

Eff

ects

Ass

ocia

tion)

Sasa

ki H

(Ya

suda

Wom

en’s

Uni

vers

ity)

Mim

ori Y

(H

iros

him

a In

tern

atio

nal

Uni

vers

ity)

Whi

te L

(H

onol

ulu

Agi

ng S

tudy

)La

rson

E (

Cen

ter

for

Hea

lth S

tudi

es a

t G

roup

Hea

lth C

oope

rativ

e, S

eattl

e, U

SA)

1992

A n

este

d ca

se-c

ontr

ol s

tudy

of b

reas

t and

en

dom

etri

al c

ance

r in

the

coho

rt o

f Jap

anes

e at

omic

-bom

b su

rviv

ors

Ohi

shi W

Gra

nt E

J (D

epar

tmen

t of E

pide

mio

logy

)C

olog

ne J

B (

Dep

artm

ent o

f Sta

tistic

s)O

zasa

K (

Dep

artm

ent o

f Epi

dem

iolo

gy)

Nak

achi

K (

RE

RF

Con

sulta

nt)

Nak

ashi

ma

E (

Dep

artm

ent o

f Sta

tistic

s)

Shar

p G

B (

U.S

. Nat

iona

l Ins

titut

e of

Alle

rgy

and

Infe

ctio

us D

isea

ses)

E

guch

i H (

Saita

ma

Med

ical

Uni

vers

ity)

Izum

i S (

Oita

Uni

vers

ity)

Key

TJ

(Im

peri

al C

ance

r R

esea

rch

Fund

, U

K)

Stev

ens

RG

(U

nive

rsity

of C

onne

ctic

ut

Hea

lth C

ente

r, U

SA)

Ber

ring

ton

de G

onza

lez

A (

U.S

. Nat

iona

l C

ance

r In

stitu

te)

2002

A c

ase-

cont

rol s

tudy

of a

trop

hic

gast

ritis

and

ga

stri

c ca

ncer

usi

ng fr

ozen

ser

a an

d ge

nom

e D

NA

: Ide

ntifi

catio

n of

new

bio

mar

kers

for

chro

nic

gast

ritis

ass

ocia

ted

with

gas

tric

can

cer

Ohi

shi W

Ued

a K

Cul

lings

HM

(D

epar

tmen

t of S

tatis

tics)

Hay

ashi

T (

Dep

artm

ent o

f Rad

iobi

olog

y/M

olec

ular

Epi

dem

iolo

gy)

Mits

ui F

Hid

a A

(D

epar

tmen

t of C

linic

al S

tudi

es,

Nag

asak

i)O

zasa

K (

Dep

artm

ent o

f Epi

dem

iolo

gy)

Fujiw

ara

S (H

iros

him

a A

tom

ic B

omb

Cas

ualty

Cou

ncil)

Ta

hara

E (

Hir

oshi

ma

Can

cer

Sem

inar

)

2004

Cou

ld g

enet

ic fa

ctor

s ca

use

popu

latio

n bi

as

amon

g pr

oxim

al A

-bom

b su

rviv

ors?̶

A te

st o

f w

heth

er th

e sa

me

gene

tic fa

ctor

s ar

e ri

sk

fact

ors

for

high

infla

mm

ator

y st

atus

and

m

yoca

rdia

l inf

arct

ion

amon

g A

-bom

b su

rviv

ors

40–5

0 ye

ars

late

r

Ohi

shi W

Taka

hash

i IC

olog

ne J

B (

Dep

artm

ent o

f Sta

tistic

s)H

ida

A (

Dep

artm

ent o

f Clin

ical

Stu

dies

, N

agas

aki)

Fujiw

ara

S (H

iros

him

a A

tom

ic B

omb

Cas

ualty

Cou

ncil)

2005

Infla

mm

atio

n an

d ca

ncer

inci

denc

e in

ato

mic

-bo

mb

surv

ivor

sTa

tsuk

awa

YC

olog

ne J

B (

Dep

artm

ent o

f Sta

tistic

s)N

akas

him

a E

(D

epar

tmen

t of S

tatis

tics)

Oza

sa K

(D

epar

tmen

t of E

pide

mio

logy

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da M

(D

epar

tmen

t of E

pide

mio

logy

, N

agas

aki)

Yam

ada

M

Littl

e M

P (N

atio

nal I

nstit

utes

of H

ealth

, U

SA)

2005



FY20

14 C

olla

bora

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Stud

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(With

out E

xter

nal F

unds

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Titl

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earc

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ame

of C

hief

of R

esea

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Gro

upIn

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igat

or(s

) at

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RF

Inve

stig

ator

(s)

outs

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RE

RF

Initi

atio

n Ye

ar

Dep

artm

ent

of C

linic

al S

tudi

es,

Hir

oshi

ma

Ass

essm

ent o

f sta

tistic

al m

etho

ds fo

r in

term

edia

te r

isk

fact

ors

in n

on-c

ance

r di

seas

e an

d m

orta

lity

Will

iam

L (

Uni

vers

ity o

f W

ashi

ngto

n, U

SA)

Taka

hash

i IC

olog

ne J

B (

Dep

artm

ent o

f Sta

tistic

s)K

odam

a K

(C

hief

Sci

entis

t)

Fujiw

ara

S (H

iros

him

a A

tom

ic B

omb

Cas

ualty

Cou

ncil)

Aka

hosh

i M (

Kei

ju H

ospi

tal)

Kop

ecky

KJ

(Uni

vers

ity o

f Was

hing

ton,

Fre

d H

utch

inso

n C

ance

r R

esea

rch

Cen

ter,

USA

)D

avis

S (

Uni

vers

ity o

f Was

hing

ton,

Fre

d H

utch

inso

n C

ance

r R

esea

rch

Cen

ter,

USA

)

2006

Bod

y m

ass

inde

x (B

MI)

and

mor

talit

yT

hun

M (

Am

eric

an C

ance

r So

ciet

y)O

hish

i WH

ida

A (

Dep

artm

ent o

f Clin

ical

Stu

dies

, N

agas

aki)

Shor

e R

E (

Vic

e C

hair

man

and

Exe

cutiv

e D

irec

tor)

2008

Eva

luat

ion

of r

etin

al a

rter

iolo

scle

rosi

s an

d ag

e-re

late

d m

acul

ar d

egen

erat

ion

usin

g st

ored

re

tina

imag

es w

ith s

tand

ardi

zed

mea

sure

men

ts

in r

elat

ion

to g

lauc

oma

deve

lopm

ent i

n at

omic

-bo

mb

surv

ivor

s an

d to

ass

ocia

tion

with

aor

tic

arte

rios

cler

osis

Taka

hash

i IM

isum

i M (

Dep

artm

ent o

f Sta

tistic

s)N

akas

him

a E

(D

epar

tmen

t of S

tatis

tics)

Yana

gi M

(H

iros

him

a U

nive

rsity

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akur

a K

(H

iros

him

a U

nive

rsity

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awas

aki R

(Ya

mag

ata

Uni

vers

ity)

Yoko

yam

a T

(H

iros

him

a U

nive

rsity

)Ta

kam

atsu

M (

Hir

oshi

ma

Uni

vers

ity)

Kin

oshi

ta H

(N

agas

aki U

nive

rsity

)T

suik

i E (

Nag

asak

i Uni

vers

ity)

Uem

atsu

M (

Nag

asak

i Uni

vers

ity)

Kum

agam

i T (

Nag

asak

i Uni

vers

ity)

2010

Stud

y of

bod

y co

mpo

sitio

n of

the

Hir

oshi

ma

Adu

lt H

ealth

Stu

dy p

opul

atio

nTa

tsuk

awa

YM

isum

i M (

Dep

artm

ent o

f Sta

tistic

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hish

i WYa

mad

a M

Fujiw

ara

S (H

iros

him

a A

tom

ic B

omb

Cas

ualty

Cou

ncil)

Har

ris

TB

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.S. N

atio

nal I

nstit

ute

on A

ging

) K

asag

i F (

Rad

iatio

n E

ffec

ts A

ssoc

iatio

n)

2010

Dep

artm

ent

of C

linic

al S

tudi

es,

Nag

asak

iT

he a

ssoc

iatio

n be

twee

n su

bclin

ical

thyr

oid

dysf

unct

ion

and

card

iova

scul

ar d

isea

se a

nd

mor

talit

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n in

divi

dual

par

ticip

ant p

oole

d an

alys

is o

f lar

ge in

tern

atio

nal c

ohor

t stu

dies

Rod

ondi

N (

Inse

lspi

tal U

nive

rsity

H

ospi

tal,

Uni

vers

ity o

f Ber

n,

Switz

erla

nd)

Imai

zum

i MG

usse

kloo

J (

Leid

en U

nive

rsity

Med

ical

C

ente

r, th

e N

ethe

rlan

ds)

2008



FY20

14 C

olla

bora

tive

Stud

ies

(With

out E

xter

nal F

unds

)

Titl

e of

Res

earc

hN

ame

of C

hief

of R

esea

rch

Gro

upIn

vest

igat

or(s

) at

RE

RF

Inve

stig

ator

(s)

outs

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RE

RF

Initi

atio

n Ye

ar

Dep

artm

ent

of C

linic

al S

tudi

es,

Nag

asak

iT

he a

ssoc

iatio

n be

twee

n ch

roni

c ki

dney

dis

ease

an

d ca

rdio

vasc

ular

dis

ease

am

ong

atom

ic-b

omb

surv

ivor

s

Har

uta

DTa

kaha

shi I

(D

epar

tmen

t of C

linic

al

Stud

ies,

Hir

oshi

ma)

Hid

a A

Imai

zum

i MYa

mad

a M

(D

epar

tmen

t of C

linic

al

Stud

ies,

Hir

oshi

ma)

Ohi

shi W

(D

epar

tmen

t of C

linic

al S

tudi

es,

Hir

oshi

ma)

Tats

ukaw

a Y

(D

epar

tmen

t of C

linic

al

Stud

ies,

Hir

oshi

ma)

Nak

ashi

ma

E (

Dep

artm

ent o

f Sta

tistic

s)M

isum

i M (

Dep

artm

ent o

f Sta

tistic

s)

Tsu

neto

A (

Nag

asak

i Uni

vers

ity)

Sera

N (

Nag

asak

i Uni

vers

ity)

Ner

iishi

K (

Yach

iyo

Hos

pita

l)

Fujiw

ara

S (H

iros

him

a A

tom

ic B

omb

Cas

ualty

Cou

ncil)

Aka

hosh

i M (

Kei

ju H

ospi

tal)

2009

Stud

y on

the

gene

tic b

ackg

roun

d of

sho

rt Q

TM

akita

N (

Nag

asak

i Uni

vers

ity)

Har

uta

DO

hish

i W (

Dep

artm

ent o

f Clin

ical

Stu

dies

, H

iros

him

a)H

ida

A

Aka

hosh

i M (

Kei

ju H

ospi

tal)

Mae

mur

a K

(N

agas

aki U

nive

rsity

)20

11

Stud

y fo

r th

e ep

idem

iolo

gica

l and

gen

etic

bas

is

of p

rogr

essi

ve c

ardi

ac c

ondu

ctio

n de

fect

Mak

ita N

(N

agas

aki U

nive

rsity

)H

arut

a D

Ohi

shi W

(D

epar

tmen

t of C

linic

al S

tudi

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Hir

oshi

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Hid

a A

Nak

ashi

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Dep

artm

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f Sta

tistic

s)

Aka

hosh

i M (

Kei

ju H

ospi

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Mae

mur

a K

(N

agas

aki U

nive

rsity

)20

12

Wei

ght fl

uctu

atio

n an

d ca

ncer

and

ca

rdio

vasc

ular

dis

ease

inci

denc

e an

d m

orta

lity

in J

apan

ese

Nan

ri A

(N

atio

nal C

ente

r fo

r G

loba

l Hea

lth a

nd M

edic

ine)

Har

uta

DTa

kaha

shi I

(D

epar

tmen

t of C

linic

al

Stud

ies,

Hir

oshi

ma)

Soda

M (

Dep

artm

ent o

f Epi

dem

iolo

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Nag

asak

i)O

zasa

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Dep

artm

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f Epi

dem

iolo

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Col

ogne

JB

(D

epar

tmen

t of S

tatis

tics)

C

ullin

gs H

M (

Dep

artm

ent o

f Sta

tisti c

s)O

hish

i W (

Dep

artm

ent o

f Clin

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Stu

dies

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iros

him

a)H

ida

A

Miz

oue

T (

Nat

iona

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ter

for

Glo

bal H

ealth

an

d M

edic

ine)

Ara

ki Y

(K

urum

e U

nive

rsity

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kaho

shi M

(K

eiju

Hos

pita

l)

2012

Seru

m T

SH w

ithin

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refe

renc

e ra

nge

and

the

risk

of c

oron

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hear

t dis

ease

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old

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(N

orw

egia

n U

nive

rsity

of

Sci

ence

and

Tec

hnol

ogy)

Imai

zum

i M20

12



FY20

14 C

olla

bora

tive

Stud

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out E

xter

nal F

unds

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Titl

e of

Res

earc

hN

ame

of C

hief

of R

esea

rch

Gro

upIn

vest

igat

or(s

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RF

Inve

stig

ator

(s)

outs

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RE

RF

Initi

atio

n Ye

ar

Dep

artm

ent

of C

linic

al S

tudi

es,

Nag

asak

iSe

rum

TSH

leve

ls a

nd th

e ri

sk o

f str

oke ̶

Add

endu

m to

“The

ass

ocia

tion

betw

een

subc

linic

al th

yroi

d dy

sfun

ctio

n an

d ca

rdio

vasc

ular

dis

ease

and

mor

talit

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n in

divi

dual

par

ticip

ant p

oole

d an

alys

is o

f lar

ge

inte

rnat

iona

l coh

ort s

tudi

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v an

Dijk

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Era

smus

Med

ical

C

ente

r, th

e N

ethe

rlan

ds)

Imai

zum

i MC

hake

r L

(Era

smus

Med

ical

Cen

ter,

the

Net

herl

ands

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eter

s R

P (E

rasm

us M

edic

al C

ente

r, th

e N

ethe

rlan

ds)

Fran

co O

(E

rasm

us M

edic

al C

ente

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e N

ethe

rlan

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2013

Subc

linic

al th

yroi

d dy

sfun

ctio

n an

d ad

vers

e bo

ne o

utco

mes̶

Add

endu

m to

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ass

ocia

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een

subc

linic

al th

yroi

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ctio

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d ca

rdio

vasc

ular

dis

ease

and

mor

talit

y: A

n in

divi

dual

par

ticip

ant p

oole

d an

alys

is o

f lar

ge

inte

rnat

iona

l coh

ort s

tudi

es”

Blu

m M

R (

Inse

lspi

tal U

nive

rsity

H

ospi

tal,

Uni

vers

ity o

f Ber

n,

Switz

erla

nd)

Imai

zum

i Mda

Cos

ta B

(In

stitu

te o

f Soc

ial a

nd

Prev

entiv

e M

edic

ine,

Uni

vers

ity o

f Ber

n,

Switz

erla

nd)

Rod

ondi

N (

Inse

lspi

tal U

nive

rsity

Hos

pita

l, U

nive

rsity

of B

ern,

Sw

itzer

land

)

2013

The

ass

ocia

tion

betw

een

thyr

oid

stat

us a

nd th

e pr

ogre

ssio

n of

ren

al fu

nctio

n ov

er ti

me

den

Elz

en W

(Le

iden

Uni

vers

ity

Med

ical

Cen

ter,

the

Net

herl

ands

)Im

aizu

mi M

Ohi

shi W

(D

epar

tmen

t of C

linic

al S

tudi

es,

Hir

oshi

ma)

Meu

wes

e C

L (L

eide

n U

nive

rsity

Med

ical

C

ente

r, th

e N

ethe

rlan

ds)

Gus

sekl

oo J

(Le

iden

Uni

vers

ity M

edic

al

Cen

ter,

the

Net

herl

ands

)R

odon

di N

(In

sels

pita

l Uni

vers

ity H

ospi

tal,

Uni

vers

ity o

f Ber

n, S

witz

erla

nd)

2013

Ass

ocia

tion

of c

hron

ic k

idne

y di

seas

e an

d al

bum

inur

ia w

ith c

ardi

o vas

cula

r di

seas

e am

ong

A-b

omb

surv

ivor

s

Sera

N (

Nag

asak

i Uni

vers

ity)

Hid

a A

Har

uta

DIm

aizu

mi M

Taka

hasi

I (

Dep

artm

ent o

f Clin

ical

St

udie

s, H

iros

him

a)Ya

mad

a M

(D

epar

tmen

t of C

linic

al

Stud

ies,

Hir

oshi

ma)

Tats

ukaw

a Y

(D

epar

tmen

t of C

linic

al

Stud

ies,

Hir

oshi

ma)

Nak

ashi

ma

E (

Dep

artm

ent o

f Sta

tistic

s)O

hish

i W (

Dep

artm

ent o

f Clin

ical

Stu

dies

, H

iros

him

a)

Aka

hosh

i M (

Kei

ju H

ospi

tal)

Kaw

akam

i A (

Nag

asak

i Uni

vers

ity)

2014

The

rel

atio

n be

twee

n lo

w th

yroi

d fu

nctio

n an

d an

emia

, and

the

impa

ct o

f bot

h co

nditi

ons

on

adve

rse

outc

omes

: Add

endu

m to

RP

A10

-08

(The

ass

ocia

tion

betw

een

subc

linic

al th

yroi

d dy

sfun

ctio

n an

d ca

rdio

vasc

ular

dis

ease

and

m

orta

lity:

an

indi

vidu

al p

artic

ipan

t poo

led

anal

ysis

of l

arge

inte

rnat

iona

l coh

ort s

tudi

es)

den

Elz

en W

(Le

iden

Uni

vers

ity

Med

ical

Cen

ter,

the

Net

herl

ands

)Im

aizu

mi M

2014



FY20

14 C

olla

bora

tive

Stud

ies

(With

out E

xter

nal F

unds

)

Titl

e of

Res

earc

hN

ame

of C

hief

of R

esea

rch

Gro

upIn

vest

igat

or(s

) at

RE

RF

Inve

stig

ator

(s)

outs

ide

RE

RF

Initi

atio

n Ye

ar

Dep

artm

ent

of C

linic

al S

tudi

es,

Nag

asak

iT

he a

ssoc

iatio

n be

twee

n ra

diat

ion

and

atri

al

fibri

llatio

n am

ong

atom

ic-b

omb

surv

ivor

sH

arut

a D

Land

es R

D (

Dep

artm

ent o

f Sta

tistic

s)H

ida

AIm

aizu

mi M

Ichi

mar

u S

Taka

hash

i I (

Dep

artm

ent o

f Clin

ical

St

udie

s, H

iros

him

a)O

hish

i W (

Dep

artm

ent o

f Clin

ical

Stu

dies

, H

iros

him

a)

Sera

N (

Nag

asak

i Uni

vers

ity)

Aka

hosh

i M (

Kei

ju H

ospi

tal)

Mae

mur

a K

(N

agas

aki U

nive

rsity

)

2014

Dep

artm

ent

of G

enet

ics

Mol

ecul

ar a

ltera

tions

in e

arly

-ons

et b

reas

t and

ov

aria

n ca

ncer

s am

ong

atom

ic-b

omb

surv

ivor

sM

abuc

hi K

(U

.S. N

atio

nal C

ance

r In

stitu

te)

Land

CE

(U

.S. N

atio

nal C

ance

r In

stitu

te)

Hir

ai Y

2001

Mut

atio

n de

tect

ion

in r

at o

ocyt

esK

amig

uchi

Y (

Asa

hika

wa

Med

ical

C

olle

ge)

Asa

kaw

a J

2003

ESR

mea

sure

men

ts o

f too

th s

ampl

es fr

om

Nag

asak

i sur

vivo

rsM

ine

M (

Nag

asak

i Uni

vers

ity)

Hir

ai Y

Nak

amur

a N

(C

onsu

ltant

of t

he

Dep

artm

ent)

2005

ES

cell

targ

etin

gSu

emor

i H (

Kyo

to U

nive

rsity

)N

oda

A20

07

Est

ablis

hmen

t of a

rec

ombi

nant

mou

se m

odel

fo

r as

sess

men

t of g

enet

ic e

ffec

ts o

f rad

iatio

n at

lo

w d

oses

Mita

ni H

(T

he U

nive

rsity

of T

okyo

G

radu

ate

Scho

ol)

Nod

a A

2009

Est

imat

ion

of g

enet

ic e

ffec

ts o

f rad

iatio

n in

mal

e ge

rm c

ells

of m

ice:

Stu

dy fo

r as

sess

men

t of

high

-den

sity

mic

roar

ray

CG

H p

latfo

rm

Shim

ada

Y (

Nat

iona

l Ins

titut

e of

R

adio

logi

cal S

cien

ces)

Asa

kaw

a J

2009

Eva

luat

ion

of th

e no

nmel

anom

a sk

in c

ance

r ri

sk

amon

g he

tero

zygo

tes

bear

ing

a fo

unde

r m

utat

ion

alle

le u

niqu

e to

a J

apan

ese

popu

latio

n at

xer

oder

ma

pigm

ento

sum

gro

up A

(X

PA)

gene

Mab

uchi

K (

U.S

. Nat

iona

l Can

cer

Inst

itute

) K

raem

er K

H (

U.S

. Nat

iona

l C

ance

r In

stitu

te)

Hir

ai Y

Nak

amur

a N

(C

onsu

ltant

of t

he

Dep

artm

ent)

2009

Bio

logi

cal d

osim

etry

in th

e re

side

nts

of N

amie

-to

wn

in F

ukus

him

a pr

efec

ture

Yosh

ida

M (

Hir

osak

i Uni

vers

ity)

Kod

ama

YH

amas

aki K

2013



FY20

14 C

olla

bora

tive

Stud

ies

(With

out E

xter

nal F

unds

)

Titl

e of

Res

earc

hN

ame

of C

hief

of R

esea

rch

Gro

upIn

vest

igat

or(s

) at

RE

RF

Inve

stig

ator

(s)

outs

ide

RE

RF

Initi

atio

n Ye

ar

Dep

artm

ent

of G

enet

ics

Est

imat

ion

of g

enet

ic r

isk

of r

adia

tion

on m

atur

e oo

cyte

s of

mic

e by

usi

ng n

ext g

ener

atio

n se

quen

cer

Shim

ada

Y (

Nat

iona

l Ins

titut

e of

R

adio

logi

cal S

cien

ces)

Sato

h Y

2013

Est

imat

ion

of g

enet

ic r

isk

of r

adia

tion

on m

atur

e oo

cyte

s of

mic

e by

usi

ng n

ext g

ener

atio

n se

quen

cer

Sese

J (

Nat

iona

l Ins

titut

e of

A

dvan

ced

Indu

stri

al S

cien

ce a

nd

Tech

nolo

gy)

Sato

h Y

2013

Dep

artm

ent

of R

adio

biol

ogy/

Mol

ecul

ar

Epi

dem

iolo

gySt

udy

on g

ene

alte

ratio

ns a

nd e

xpre

ssio

n in

sp

orad

ic lu

ng c

arci

noge

nesi

sSu

eoka

E (

Saga

Uni

vers

ity)

Ara

gane

N (

Saga

Uni

vers

ity)

Nak

achi

K (

RE

RF

Con

sulta

nt)

Hay

ashi

TYo

shid

a K

Imai

K (

Con

sulta

nt o

f the

Dep

artm

ent)

2002

Surv

ey o

n fr

eque

ncie

s of

SN

Ps o

f var

ious

gen

es

in a

Jap

anes

e po

pula

ti on

Yosh

ida

T (

Nat

iona

l Can

cer

RERF · 2017. 9. 12. · Collaborative and Institutional Oral Presentations Annual Report 2014–2015page 94 Senior Scientist Kodama K. How large are the radiation doses and risks

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