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DR.EFRIYAN IMANTIKA
BAGIAN FISIOLOGI
PSPD UNILA
ORG N REPRODUKSI W NIT
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ORGAN REPRODUKSI WANITA
OVARIUM (KEL. GONAD): OVUM (n)
1. FUNGSI GAMETOGENIK
FASE PROLIFERASI
FASE PERTUMBUHAN FASE PEMBELAHAN (MEOTIK)
FASE PEMATANGAN
SATU JENIS OVUM ADALAH 23 KROMOSOM + X
2. FUNGSI HORMONAL
ESTROGEN
PROGESTERON
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TUBA FALOPII: TRANSFER OVUMATAU SEBAGAI TEMPAT FERTILISASI
UTERUS: TEMPAT IMPLANTASIBLASTOKISTA/ PERKEMBANGANEMBRIO - FETUS
VAGINA: PROSES PENGELUARANSPERMA PADA SAAT COITUS
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Siklus ovum:
Oocyte MaturationFollicle DevelopmentThe Effect of LH on Theca Cells
The Effect of FSH on Granulosa CellsFollicular Microenvironment
Inhibin
Follicle-Regulatory ProteinProstaglandinsMelatoninSteroids, Gonadotropins, anda Prolactin
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SIKLUS HIDUP WANITA
1. Intrauterine
2. Childhood
3. Puberty4. Adulthood
5. Pre menopause
6. Peri menopause7. Post menopause
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1. Intrauterin
Tergantung TDF dan MIS
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Perkembangan seks
intrauterin:1. Jaringan embrionik indifferen
Tuberkel genital
Lipatan uretra2. Saluran reproduksi2 sistem duktus primitif
Wolfii testosteron
Mulleri MIF3. Genitalia eksterna--DHT
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2. Childhood
0 10 15300.000- menarche 300-400 ovulasi
400.000
folikelprimordial
fetus childhood pubertas menopause
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Oogenesis:
SESAAT SEBELUM OVULASI--MEIOSIS
Oogonium
Oosit
primer
Oositsekunder(23)
BadanPolar
Ovum
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3. Pubertas (Menstruasi)
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Siklus Menstruasi (28
hari/21-35 hari)1. HIPOTALAMUSGnRH (Gonadotropin releasing hormon)
2. ADENOHIPOFISE
FSH: BEKERJA PADA SEL TEKA
LH: BEKERJA PADA SEL GRANULOSA
3. OVARIUM
FASE FOLIKULER = ESTROGEN
OVULASI FASE LUTERAL = PROGES TERON
4. UTERUS
FASE PROLIFERASI FASE SEKRESI
FASE MENSTRUASI
5. VAGINA
6. KELOMPOK MAMMA
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Siklus Menstruasi Rutin:
Cyclic hormonal stimulation of endometrial
growth
Average length 28 days (21-35 days)
Divided into two phases :
Follicular phase
Lutheal phase
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Fase folikular
The first part of the menstrual cycle whichextends from day 1 to ovulation
Characteristic :
A variable length. A low basal temperature. Development of the ovarian follicles.
Increase in the number of glandular andstoma cells of the endometrium. Vascular growth of the endometrium. Secretion of osterogen from the ovary.
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Fase luteal
The second part of the menstrual cycle, whichextends from ovulation to the onset ofmenses.
Characteristic : A fairly constant duration of 12 to 16 days
(usually 12 days). A basal body temperature that is elevated
above 98oF.
Tortuosity of endometrial glands. Marked edema of the endometrial stroma. Increased secretion of progesterone by the
ovary.
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5 & 6:Pre dan perimenopause
Final menstrual bleeding
The disruption of the ovulatory mechanism
The imbalance between progesterone andestrogen
Establish a characteristic syndrome of premenopause: sweating ,hot flushes, dizzinesstingling sensation the in the extremities,headaches, sleeplessness and anxiety
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7. Postmenopause
The remaining follicles in both ovariesbecome less sensitive to gonadotropinstimulation. There is a resultant:
Increase in follicle stimulating hormone(FSH)Endometrial disease
The relative estrogen dominance at premenopausal age -- unscheduled bleeding
The estrogen's stimulations withoutprogesterone develops endometrialhyperplasia -- continuous stimulationdevelops atypical hyperplasia --endometrial carcinoma
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Fungsi Estrogen:
PROLIFERASI DAN PERTUMBUHAN JARINGAN DARI ORGAN SEX.
1. UTERUS : PEMBESARAN ENDOMETRIUM : PROLIFERASIDAN PERKEMBANGAN KELENJAR UNTUK NUTRISI DARIOVUM YANG MENGALAMI IMPLAMTASI.
2. VAGINA : SEL KUBOID STRATIFIED (KUAT THDPTRAUMA/INFEKSI, PEMBESARAN
3. TUBA FALOPII : PEMBESARAN KELENJAR, CILIA
4. PEMBESARAN GENETALIA EKSTERNA : DEPOSISI LEMAK :MONS PUBIS, LABIA MAYORA, LABIA MINORA.
5. KELENJAR SUSU : JARINGAN STROMA, SISTEM DUKTUS,
DEPOSISI LEMAK, AREOLA.6. TULANG : AKTIVITAS OSTEBLAST, MATRIX TULANG, DEPOSISI
GARAM TULANG, PENUTUPAN EPIFISE.
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7. DEPOSISI PROTEIN
8. DEPOSISI LEMAK : LEMAK--- SUBKUTAN, KEL. MAMMA,PANTAT DAN PAHA -- FIGURE WANITA
9. RAMBUT TUBUH : ESTROGEN TAK BERPENGARUH
10. KULIT : HALUS LEMBUT , VASKULARISASI HANGAT
11. AIR DAN ELETROLIT SEPERTI ALDOSTERON : RETENSI
NATRIUM DAN AIR
12. BEHAVIOUR : LEBIH EMOSIONAL
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Fungsi Progesteron:
1. UTERUS :
- FASE SEKRESI DARI ENDOMETRIUM PERSIAPAN
IMPLANTASI
- RELAKSASI MIOMETRIUM
2. TUBA FALOPII : SEKRESI MUKUS UNTUK NUTRISI OVUM YANG DI
BUAHI SEBELUM IMPLAMTASI
3. KEL. MAMMA : PERKEMBANGAN LOBULUS, ALVEOLI DAN
SEKRETORISPERSIAPAN EFEK PROLAKTIN
4. AIR DAN ELEKTROLIT : RETENSI NATRIUM, AIR DAN CHLORIDA
5. PROTEIN : KATABOLIK SEPERTI GLUKOKORTIKOID
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ORGAN REPRODUKSI PRIA
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PERJALANAN SPERMA
TESTIS (TUBULUS SEMINIFERUS)
EPIDIDIMIS
DUKTUS DEFERENS (VASDEFERENS) VESICA SEMINALIS
DUKTUS EJAKULATORIUS
URETRADIBANTU OLEH:-KEL.PROSTAT
-KEL. BULBOURETRA
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Spermatogenesis:
Spermatogonium
Spermatogonia
Spermatositprimer(4)
Spermatositsekunder (16)
spermatid
spermatozoa
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Siklus hidup pria:
1. Intrauterin: Proses Maskulinisasi
2. Lahir: Sekresi testosteron terhenti
3. Pubertas
Sel leydig pertama kali aktif kembali
Sekresi testosteron terus menerus
- feedback sekresi GnRH o/ hipofisis
anterior4. Menopause PriaEfisiensi testis --
Degeneratif
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Sexual Respon:
Kaplan three stage : desire,excitement, orgasm
Master and Johnson four phase model : Excitement phase : penisflaccid, semi
erect, fully erect penis, tetstes elevate,scrotum thicken, sex flush
Plateu phase : cowperssecretion,tetstes elevate further and rotate
Orgasm : emission phase, expulsion
phase, rectal sphincter contact Resolution phase ; loss of erection,
testes descend, scroum thins
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Spermache: Beginning of
ejaculationPituitary-Testicular axis of SpermatogenicRegulation
Structure and Function of Leydig Cells---
Testosterone Transport andMetabolism(mol. Prekursor kol.) Pituitary-Leydig Cell Axis: Hormonal
Control
Pituitary-Seminiferous Tubule Axis Sertoli Cells FSH & Testosterone Inhibin: Produced by sertoli cells
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Kontrol fungsi testis:
- feedback
Inhibin Testosteron
Spermatogenesis
Hipotalamus
GnRH
Hipofisisanterior
FSH LH
Sel sertoli Sel leydig
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Histology of Spermatogenesis
Spermatocytogenesis
Meiosis Spermiogenesis
Sperm Maturation in the Epididymis
Sperm Capacitation and Acrosome Reaction
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ORGAN SEKS PRIMER(TESTIS)
TESTOSTERON SPERMATOZOA
ORGAN SEKSSEKUNDER
KARAKTERISTIK SEKSSEKUNDER
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KONGENITAL
Klinefelterssyndrome (47.XXYand variants)
Cryptocrcidism
Congenital anorchia (vanisningtestis synarome)
Noonansssyndrome
Motonic muscular dystrophy
Sickle cell disease
ACQUIRED
Orchtis (mumps, pyogenic,traumatic)
Malignacy (germ cell,leukemia, lmphoma)
Torsion
Varicocele
Spinal cord injury
Systemic illness (liver disease,renal filure)
Drug
X-irradiatin
Aging
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TERIM K SIH