Renal Ultrastructural Pathology Renal Ultrastructural Pathology Lecture 2 Me - Mi Lecture 2 Me - Mi Bart E Wagner Bart E Wagner BSc CSc FIBMS Dip Ult Path BSc CSc FIBMS Dip Ult Path Chief Biomedical Scientist Chief Biomedical Scientist Electron Microscopy Section Electron Microscopy Section Histopathology Department Histopathology Department Northern General Hospital Northern General Hospital Sheffield Sheffield South Yorkshire South Yorkshire UK UK S5 7AU S5 7AU [email protected]Tel+44(0)114-27 14154 Tel+44(0)114-27 14154 Basic Renal EM workshop Southampton September 30 th 2011 Histopathology Department Northern General Hospital
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Renal Ultrastructural PathologyRenal Ultrastructural PathologyLecture 2 Me - MiLecture 2 Me - Mi
Bart E Wagner Bart E Wagner BSc CSc FIBMS Dip Ult PathBSc CSc FIBMS Dip Ult Path
Chief Biomedical ScientistChief Biomedical ScientistElectron Microscopy SectionElectron Microscopy SectionHistopathology DepartmentHistopathology DepartmentNorthern General HospitalNorthern General Hospital
Stage 1: Small subepithelial deposits – no spikes on silver stainStage 1: Small subepithelial deposits – no spikes on silver stain
Stage 2: New basement membrane around lateral border of Stage 2: New basement membrane around lateral border of deposits – spikes present on silver staindeposits – spikes present on silver stain
Stage 3: Occasional lysed deposit, occasional new basement Stage 3: Occasional lysed deposit, occasional new basement membrane between deposit and podocytemembrane between deposit and podocyte
Not a good correlation between level of proteinuria and extent of foot Not a good correlation between level of proteinuria and extent of foot process effacement within a single glomerulus due to variability of process effacement within a single glomerulus due to variability of degree of pathology between glomeruli.degree of pathology between glomeruli.
Proteinuria reflects mean of foot process effacement.Proteinuria reflects mean of foot process effacement.