Renal physiology Renal physiology
Renal physiologyRenal physiology
Urine Formation =Urine Formation =
Filtration Filtration 1 1 – Reabsorption– Reabsorption 2 2 + Secretion + Secretion 3 3
Determinants of GFRDeterminants of GFR
GFR= KGFR= Kf f x net filtration pressurex net filtration pressure
Net Filtration PressureNet Filtration Pressure3.3. Hydrostatic pressure inside the glomerular Hydrostatic pressure inside the glomerular
capillaries + 60capillaries + 604.4. Hydrostatic pressure in bowmans capsule -18Hydrostatic pressure in bowmans capsule -185.5. Colloid osmotic pressure of glomerular Colloid osmotic pressure of glomerular
capillary - 32capillary - 326.6. Colloid osmotic pressure of bowmans Colloid osmotic pressure of bowmans
capsule+ 0capsule+ 0
Control of GFControl of GF
Sympathetic activation GFRSympathetic activation GFRHormonal & autocoid controlHormonal & autocoid control NorepinephrineNorepinephrine EpinephrineEpinephrine EndothelinEndothelin AngiotensinAngiotensin Nitric oxideNitric oxide prostaglandinsprostaglandins
Autoregulation of GFAutoregulation of GF
Myogenic autoregulationMyogenic autoregulation Tubuloglomerular feedbackTubuloglomerular feedback