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Renal physiology Renal physiology
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Renal physiology by Dr.Riffat

Jul 03, 2015

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Page 1: Renal physiology by Dr.Riffat

Renal physiologyRenal physiology

Page 2: Renal physiology by Dr.Riffat
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Urine Formation =Urine Formation =

Filtration Filtration 1 1 – Reabsorption– Reabsorption 2 2 + Secretion + Secretion 3 3

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Determinants of GFRDeterminants of GFR

GFR= KGFR= Kf f x net filtration pressurex net filtration pressure

Net Filtration PressureNet Filtration Pressure3.3. Hydrostatic pressure inside the glomerular Hydrostatic pressure inside the glomerular

capillaries + 60capillaries + 604.4. Hydrostatic pressure in bowmans capsule -18Hydrostatic pressure in bowmans capsule -185.5. Colloid osmotic pressure of glomerular Colloid osmotic pressure of glomerular

capillary - 32capillary - 326.6. Colloid osmotic pressure of bowmans Colloid osmotic pressure of bowmans

capsule+ 0capsule+ 0

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Control of GFControl of GF

Sympathetic activation GFRSympathetic activation GFRHormonal & autocoid controlHormonal & autocoid control NorepinephrineNorepinephrine EpinephrineEpinephrine EndothelinEndothelin AngiotensinAngiotensin Nitric oxideNitric oxide prostaglandinsprostaglandins

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Autoregulation of GFAutoregulation of GF

Myogenic autoregulationMyogenic autoregulation Tubuloglomerular feedbackTubuloglomerular feedback

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