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Renal Manifestations of Tuberous Sclerosis Complex
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Renal Manifestations of Tuberous Sclerosis Complex

Dec 31, 2015

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gloria-mcintosh

Renal Manifestations of Tuberous Sclerosis Complex. Program Goal. What Is TSC?. “Végétations Vasculaires” (1835). “Sclérose Tubéreuse des Circonvolutions Cérébrales ” (1880). Manifestations of TSC. TSC Clinical Diagnostic Criteria NIH Consensus Conference, Annapolis, Maryland, 1998. - PowerPoint PPT Presentation
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Page 1: Renal Manifestations of Tuberous Sclerosis Complex

Renal Manifestations of Tuberous Sclerosis Complex

Page 2: Renal Manifestations of Tuberous Sclerosis Complex

Program Goal

Page 3: Renal Manifestations of Tuberous Sclerosis Complex
Page 4: Renal Manifestations of Tuberous Sclerosis Complex

What Is TSC?

Page 5: Renal Manifestations of Tuberous Sclerosis Complex

“Végétations Vasculaires” (1835)

Page 6: Renal Manifestations of Tuberous Sclerosis Complex

“Sclérose Tubéreuse des Circonvolutions Cérébrales” (1880)

Page 7: Renal Manifestations of Tuberous Sclerosis Complex

Manifestations of TSC

Page 8: Renal Manifestations of Tuberous Sclerosis Complex

TSC Clinical Diagnostic CriteriaNIH Consensus Conference, Annapolis, Maryland, 1998

Page 9: Renal Manifestations of Tuberous Sclerosis Complex

TSC Clinical Diagnostic Criteria (cont)

Page 10: Renal Manifestations of Tuberous Sclerosis Complex

Genetics of TSC

Page 11: Renal Manifestations of Tuberous Sclerosis Complex
Page 12: Renal Manifestations of Tuberous Sclerosis Complex
Page 13: Renal Manifestations of Tuberous Sclerosis Complex

Pathobiology of TSC

Page 14: Renal Manifestations of Tuberous Sclerosis Complex

Clinical Manifestations of TSC

Page 15: Renal Manifestations of Tuberous Sclerosis Complex

Onset of TSC Symptoms With Age

Page 16: Renal Manifestations of Tuberous Sclerosis Complex

Angiomyolipomas and Development

Page 17: Renal Manifestations of Tuberous Sclerosis Complex

Cell-of-Origin Hypothesis

Page 18: Renal Manifestations of Tuberous Sclerosis Complex

PEComas: Angiomyolipomas

Page 19: Renal Manifestations of Tuberous Sclerosis Complex

TSC Proteins and Cell Growth

Page 20: Renal Manifestations of Tuberous Sclerosis Complex

TSC Renal Cystic Disease

Page 21: Renal Manifestations of Tuberous Sclerosis Complex

Other Solid Renal Lesions

Page 22: Renal Manifestations of Tuberous Sclerosis Complex

Common Presentation of TSC

Page 23: Renal Manifestations of Tuberous Sclerosis Complex

Diagnosis of TSC

Page 24: Renal Manifestations of Tuberous Sclerosis Complex

Angiomyolipomas: Ultrasound Images

Page 25: Renal Manifestations of Tuberous Sclerosis Complex

Angiomyolipomas: CT Scan

Page 26: Renal Manifestations of Tuberous Sclerosis Complex

Angiomyolipomas: MRI

Page 27: Renal Manifestations of Tuberous Sclerosis Complex

Role of Biopsy

Page 28: Renal Manifestations of Tuberous Sclerosis Complex

TSC Prognosis

Page 29: Renal Manifestations of Tuberous Sclerosis Complex

TSC Prognosis (cont)

Page 30: Renal Manifestations of Tuberous Sclerosis Complex

Management of TSC

Page 31: Renal Manifestations of Tuberous Sclerosis Complex

Angiomyolipoma Treatment: Sirolimus

Page 32: Renal Manifestations of Tuberous Sclerosis Complex

Changes in Volume of Angiomyolipomasa

Page 33: Renal Manifestations of Tuberous Sclerosis Complex
Page 34: Renal Manifestations of Tuberous Sclerosis Complex

Everolimus

Page 35: Renal Manifestations of Tuberous Sclerosis Complex