Regulation of cell cycle

REGULATION OF CELL CYCLE

MODERATOR: DR. S.

AGARWAL

PRESENTER: DR.

KARTHIKEYAN P

Overview

• History

• Phases

• Cyclin and cyclin dependant kinase

• Transition and check points• 3 check points

• Role of RB & p53

• Biomedical importance

Pioneers

2011

cdc mutants

Features

• Unidirectional

• All or None decisions have to be taken

• Entire chromosomal DNA is replicated only once per cycle

• Identical and equal distribution of chromosomes to daughter cells

Bakers yeast are used by scientist too !

Stage Cyclin cdk

G1 D1, D2, D3

E

4,6

2

S A 2

G2/M B, B3 1

Viruses exploit pRB

Amaurosis fugax

Product of genes activated by p53

Gene Product Description

p21 Inhibits cdks, Arrests cell at G1/S

14-3-3σ Arrests cell at G2/M

GAAD45 Growth Arrest and DNA Damage, binds to PNCA

Bax Bcl-2-associated X protein, Positive regulator of apoptosis

Apaf1 Apoptotic protease activating factor 1, scaffold protein

Maspin mammary serine protease inhibitor

miRNA34a, b/c Induce senescence & apoptosis

BaxBax Bax

Normal CellApoptosis Cancer cell

Apoptosome formation by APAF1

Spindle check point

THANK YOU !