FOR PROFESSIONAL USE ONLY *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE. The Role of Probiotics Not All Probiotics are the Same • A range of factors including diet, viruses, bacteria and antibiotics can lead to disturbances in the normal intestinal microbiota, a key factor in digestive and immune issues. • Probiotics can help restore the balance by promoting colonization to support better digestion and immune health. • Different strains of probiotics do different things, one must be careful to select the appropriate strain for the intended purpose. • Lactobacillus rhamnosus GG (LGG ® ) is the most clinically proven effective probiotic strain. † • Lactobacillus rhamnosus GG (LGG ® ) has over 200 human clinical trials behind it, making it the most studied probiotic available. †† Only Culturelle ® has 100% Lactobacillus rhamnosus GG (LGG ® ) ** You can trust Culturelle ® , the expert in probiotics, to help keep your patients’ digestive and immune systems healthy. * † Based on the studies of a range of benefits throughout the lifespan †† Based on the number of Lactobacillus GG clinical studies, as of May 2017. ** Among leading brands Culturelle ® is a trademark of DSM. LGG® and LGG logo® are trademarks of Chr. Hansen A/S. Recommend the Proven Probiotic for Digestive and Immune Health. †*
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FOR PROFESSIONAL USE ONLY *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
The Role of Probiotics
Not All Probiotics are the Same
• A range of factors including diet, viruses, bacteria and antibiotics can lead to disturbances in the normal intestinal microbiota, a key factor in digestive and immune issues. • Probiotics can help restore the balance by promoting colonization to support better digestion and immune health.
• Different strains of probiotics do different things, one must be careful to select the appropriate strain for the intended purpose.
• Lactobacillus rhamnosus GG (LGG®) is the most clinically proven effective probiotic strain.†
• Lactobacillus rhamnosus GG (LGG®) has over 200 human clinical trials behind it, making it the most studied probiotic available.††
Only Culturelle® has 100% Lactobacillus rhamnosus GG (LGG®)**
You can trust Culturelle®, the expert in probiotics, to help keep your patients’ digestive and immune systems healthy.*
† Based on the studies of a range of benefits throughout the lifespan†† Based on the number of Lactobacillus GG clinical studies, as of May 2017.** Among leading brands Culturelle® is a trademark of DSM. LGG® and LGG logo® are trademarks of Chr. Hansen A/S.
Recommend the Proven Probiotic for Digestive and Immune Health.†*
Clinical Evidence
FOR PROFESSIONAL USE ONLY
Lactobacillus rhamnosus GG (LGG®)Helps Reduce the Incidence of Diarrhea During Triple Antibiotic Therapy
Lactobacillus rhamnosus GG (LGG®) improves antibiotic treatment tolerability by reducing several side effects associated with triple antibiotic regimens, including diarrhea.
Digestive40
30
20
10
0
Part
icip
ants
wit
h D
iarr
hea
(%)
1. Armuzzi, et al 2001 N=60
Duration=2 Weeks
2. Armuzzi, et al 2001 N=120
Duration=4 Weeks
3. Cremonini, et al 2002 N=85
Duration=4 Weeks
● LGG® ● PLACEBO
Lactobacillus rhamnosus GG (LGG®) Has Been Shown to Modulate Nonspecific Immune Responses Differently in Milk Tolerant and Milk-Hypersensitive Adults.
The expression of phagocytic receptors on neutrophils and monocytes was compared prior to and after a milk challenge. While milk significantly increased the expression of certain phagocytic receptors in milk-hypersensitive individuals, the addition of Lactobacillus rhamnosus GG (LGG®) attenuated this increase and ultimately the inflammatory response. Lactobacillus rhamnosus GG (LGG®) had the opposite effect in healthy participants where the phagocytic receptor expression was up-regulated.
N=17 Dose: 0.26 Billion CFU/d Duration: 1 week Age: 22-50 years old
Without LGG®
Control Subjects Milk-Hypersensitive Subjects
Without LGG®With LGG® With LGG®
40
20
0
-20Without LGG®
Milk-Hypersensitive Subjects
With LGG® Without LGG® With LGG®
80
60
40
20
0
-20
CR1 CR3 FcγRI FcγRII FcγRIII IgαR
Expr
essi
on in
Mon
ocyt
esC
hang
e fr
om B
asel
ine
(%)
Expr
essi
on in
Neu
trop
hils
Cha
nge
from
Bas
elin
e (%
)
Immune Modulation
Lactobacillus rhamnosus GG (LGG®) Improves Influenza Vaccine Response in Adults
Lactobacillus rhamnosus GG (LGG®) behaves as an adjuvant to improve influenza vaccine immunogenicity. Lactobacillus rhamnosus GG (LGG®) increased seroprotection for H3N2.
Subj
ects
wit
h H
3N2
Tite
r (%
) 100
80
60
40
20
0
● LGG® ● PLACEBO
PLACEBO
LGG®
N=39 Dose: 2 x10 9 CFU Duration: 28 DAYS
Age: 18-49 years old
Davidson, et al. Eur. J. Nutr. 2011; 65(4):501-507
Pelto, L., et al. Clinical and Experimental Allergy. 1998,28(1474-9)
1. Armuzzi, et al. Aliment Pharmacol Ther. 2001;15(2):163-1692. Armuzzi, et al. Digestion. 2001;63(1):1-73. Cremonini, et al. Am J Gastroenterol. 2002;97(11):2744-2749
FOR PROFESSIONAL USE ONLY
The LGG® Advantage
Kekkonen, et al. World J Gastroenterol 2008; 14(13):2029-36.
Evidence Suggests Lactobacillus rhamnosus GG (LGG®) May Help Reduce Inflammatory Markers
Lactobacillus rhamnosus GG (LGG®) has been shown to lower certain inflammatory markers in healthy adults including serum CRP, highlighting its potential for reducing inflammation.
Inflammation
N=62 Dose: 16 Billion CFU Duration: 3 weeks Age: 23-26 years old
● LGG® ● PLACEBO
0.3
0.2
0.1
0
-0.1
-0.2
-0.3
-0.4
-0.5hsC
RP A
UC
0-21
Min
us B
asel
ine
(mg/
L)
Probiotic Strain
Origin
Guaranteed Dose (CFU)
Clinically Shown Benefits for:
Antibiotic Associated Diarrhea
Acute Gastroenteritis
Traveler’s Diarrhea
VRE Elimination
Irritable Bowel Syndrome
Immune Benefits
Published Scientific Studies
Published Clinical Studies
Human
10 Billion
1000+
200+
Lactobacillus rhamnosus GG (LGG®)
Dairy
10 Million
30+
5
Bifidobacterium infantis 35624 (Bifantis®)
Lactobacillus rhamnosus GG (LGG®) is the probiotic
in Culturelle®.
Bifidobacterium infantis 35624 (Bifantis®) is the
probiotic in Align®.
Works naturally with your body to keep your digestive system in balance*
Helps with occasional digestive upset, including diarrhea, gas and bloating*
Helps your digestive system work better*
Directions /DosageFor 12 years of age and older: For daily use, take one (1) capsule per day. For optimal results, continued daily use is suggested. If experiencing occasional digestive upset, take two (2) tablets daily [take one (1) in the morning and one (1) at night] until discomfort subsides. When traveling, take two (2) capsules daily [one (1) in the morning and one (1) at night] throughout the trip. For best results start two to three days prior to travel.
Works naturally with your body to keep your digestive system in balance*
Helps with occasional digestive upset, including diarrhea, gas and bloating*
Helps your digestive system work better*
Directions /DosageFor 12 years of age and older: For daily use, chew one (1) tablet per day. For optimal results, continued daily use is suggested. If experiencing occasional digestive upset, chew two (2) tablets daily [one (1) in the morning and one (1) at night] until discomfort subsides. When traveling, chew two (2) tablets daily [one (1) in the morning and one (1) at night] throughout the trip. For best results start two to three days prior to travel.
Culturelle® Pro-Well® Health and Wellness Helps Optimize Your Immunity*
Culturelle® Pro-Well® 3 in 1 Complete Supports your heart, digestive and immune health in one complete capsule*
Culturelle® Pro-Well® Immune + Energy A specially formulated blend of a probiotic and energy- inducing B-vitamins ̂that support your immune health and help keep you energized.*
Culturelle® Digestive Health Daily Probiotic
Culturelle® Digestive Health Daily Probiotic Chewables
Digestive & Immune Products containing Lactobacillus rhamnosus GG (LGG®)
Recommend These Other Great Products!
To find out more information about Culturelle,® including how to sign up for the professional sampling program, visit: www.culturelle.com.
Culturelle® and Pro-Well® are trademarks of DSM. LGG® is a trademark of Chr. Hansen A/S. Bifantis® and Align® are trademarks of the Proctor & Gamble Company.
^B-vitamins support energy through metabolic function.
CDQP4730
FOR PROFESSIONAL USE ONLY *THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
Serving Size: One (1) Tablet Amount Per Serving % Daily Value**
Calories 5Total Carbohydrate 1g <1%** Total Sugars 0g † Incl. 0g Added Sugars 0%** Xylitol <1g †Lactobacillus 10 billion CFUs † rhamnosus GG (LGG®) Inulin (chicory root extract) 200mg †** Based on a 2,000 calorie diet. †Daily Value not established.Other Ingredients: xylitol (corn or wheat), microcrystalline cellulose, glyceryl behenate, magnesium stearate, natural & artificial flavor, sucrose‡, maltodextrin, citric acid, and malic acid.
Serving Size: One (1) Capsule Amount Per Serving % Daily Value**
Calories 0Total Carbohydrate 0g 0%**
Total Sugars 0g † Incl. 0g Added Sugars 0%Lactobacillus 10 billion CFUs † rhamnosus GG (LGG®) Inulin (chicory root extract) 200 mg †** Percent Daily Values are based on a 2,000 calorie diet. †Daily Value not established.Other Ingredients: hydroxypropyl methylcellulose, sucrose‡ maltodextrin, sodium ascorbate, vegetable magnesium stearate, silicone dioxide, and titanium dioxide (color).
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