RANK induces epithelial-mesenchymal transition and ... · 1 RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis
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1
RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial
cells and promotes tumorigenesis and metastasis
Marta Palafox1, Irene Ferrer1, Pasquale Pellegrini1, Sergi Vila1, Sara Hernandez-Ortega1, Ander
Urruticoechea2, Fina Climent3, Maria Teresa Soler3, Purificación Muñoz1, Francesc Viñals4, Mark
Tometsko5, Dan Branstetter6, William C. Dougall5 and Eva González-Suárez1,*
1Cancer Epigenetics and Biology Program, 2Catalan Institute of Oncology, 3University Hospital of
Bellvitge, 4University of Barcelona, Bellvitge Biomedical Research Institute, (1-4) IDIBELL.
Barcelona, Spain; 5Department of Hematology/Oncology Research; 6Department of Pathology, (5-6)
Amgen Inc, Seattle, WA, USA
*corresponding author: Eva González Suárez.
Cancer Epigenetics and Biology Program, PEBC, Bellvitge Institute for Biomedical Research,
IDIBELL. Av.Gran Via de L'Hospitalet, 199 – 203. 08908 L'Hospitalet de Llobregat. Barcelona.
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on April 10, 2012; DOI: 10.1158/0008-5472.CAN-12-0044