RADIAL GLIAL CELLS: key organisers in CNS development Denis S. Barry*, Janelle M.P. Pakan † and Kieran W. McDermott † *Department of Anatomy, Trinity College Dublin, Dublin, Ireland. † Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. *Corresponding author Denis Barry Department of Anatomy Trinity College Dublin Dublin Ireland Email: [email protected]Phone: + 353 1 8961793
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RADIAL GLIAL CELLS: key organisers in CNS development
Denis S. Barry*, Janelle M.P. Pakan† and Kieran W. McDermott†
*Department of Anatomy, Trinity College Dublin, Dublin, Ireland.
†Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
*Corresponding author
Denis BarryDepartment of Anatomy Trinity College DublinDublinIreland
(INL and ONL), inner and outer plexiform layer (IPL and OPL).
Figure 2. Radial glial cell structure and function in the developing CNS. A) Progenitor cell
potential of neuroepithelial cells and radial glia during development. Neuroepithelial cells
proliferate and generate neuroblasts and immature neurons. They then differentiate into radial
glia which proliferate and elongate. Radial glia in the cortex contribute to neurogenesis
directly or via immediate neuronal precursor cells (nIPC). Cortical and spinal cord radial glia
contribute to gliogenesis by producing astrocytes (light blue) and possibly oligodendrocytes.
Some radial glia may also differentiate into ependymal cells which line the ventricles of the
adult CNS. B) Radial glia proliferate at the apical surface of the VZ and serve as scaffolds for
newly formed neurons to migrate through the SVZ and into the developing CP. This process
may also facilitate the migration of radial glial cell derived astrocytes. C) BLBP-expressing
radial glial processes form structural boundaries in the spinal cord, delineating the putative
dorsal columns cord (inset). D) A 3-dimensional cross-section view of the embryonic spinal
cord (see red inset schematic) showing BLBP-expressing radial glia forming distinct
corridors (arrows) in the white matter, through which axons may grow. Scale bars = 50 µm.
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