Pure Science. Innovative Thinking. Unparalleled Quality 1 What is VESIsorb ® ? Naturally self-assembling colloidal delivery system that enables us to meet.

Pure Science. Innovative Thinking. Unparalleled Quality 1

What is VESIsorb®?

Naturally self-assembling colloidal delivery system that enables us to meet the growing demand for enhanced bioavailability of unique science-based formulas taking their absorption and efficacy to the next level.

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• Consistent advantage under all conditions• Absorption & bioavailability impacted by– Aging population = nutrient absorption declines

with age– Low-Fat Diet…see Omthera study Lovaza vs.

Epanova – Sickness & Stress negatively impact absorption– More standard capsules = < efficient absorption

Delivers Maximum Benefits

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Introducing VESIsorb® Ultimate Red Yeast Rice

The VESIsorb® Ultimate Red Yeast Rice

is a one-of-a kind formulation, never

before available, with the most clinically

proven, thoroughly tested, safe and

efficacious combination of ingredients

that deliver powerful benefits all in one

patent-pending formulation.

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VESIsorb® Ultimate Red Yeast Rice

• No other red yeast rice formulation contains Cholesstrinol™HP which has been clinically proven to deliver natural support for healthy total cholesterol, LDL cholesterol, triglycerides, and HDL cholesterol.

• Cholesstrinol™HP delivers multiple heart health benefits working synergistically with the organic red yeast rice and CoQsource® coenzyme Q10, one of the most absorbable and bioavailable coenzyme Q10 formulations, in the patented VESIsorb® delivery system.

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What is Cholesstrinol™?• Cholesstrinol™ is an award winning platform of proprietary heart

healthy formulas that tells a powerful brand story.• It pulls together the detailed scientific data in an easy-to-

understand package for the consumer reducing, if not eliminating, the need for laborious guesswork or research on their part.

• Branding these combinations under the name – Cholesstrinol™ – is designed to leverage their scientific basis.

• It is a widely scoped and all-encompassing platform that provides numerous targeted and customized solutions for consumers with specific cardiovascular concerns.

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Three Different and Complementary Mechanisms to Modify Cholesterol and Triglycerides

1. Polymethoxylated flavones (PMFs) decrease apoprotein B, a structural protein needed for endogenous synthesis of LDL cholesterol.

Lipids, Vol 39. no2., 2004Kurowski and Manthely., 2002

2. PMFs Tangeretin and Nobiletin decrease diacylglycerol acetyl transferase (DGAT), a liver

enzyme needed for endogenous synthesis of triglycerides.

Lipids, Vol 39. no2.,2004 3. Tocotrienols inhibit HMG CoA reductase, a liver enzyme needed for endogenous synthesis of cholesterol.

Pearce et al ., 1992; Parker et al., 1993; Qureshi et al., 1996

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ACETYL COA

HMG-CoA Reductase

GERANYL GERANIO

GERANIOL

FARNESOL

PROTEINS CoQ10

CHOLESTEROL

CHOLESTEROLSYNTHESIS

CoQ10 ↓ by statinMay lead to ↓ energy

Protein ↓ by statinMay lead to myopathy

STATIN

XTOCOTRIENOL(Targets Farnesol)Down RegulatesHMGCR

HMGCR-INCREASE RATEOF NATURALDEGRADATION

HMG-CoA REDUCTASE

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Fatty acids Triglycerides

DGAT

LDL Lipoprotein Assembly

Fatty Acids TriglyceridesX

Triglycerides Nascent apo B

MTP

X

Kurowska et al.,2004

ß-oxPPARFatty acids

PMF Mechanism

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4-week Clinical Results

-35%

-30%

-25%

-20%

-15%

-10%

-5%

0%TC LDL TG LDL / HDL

I ΙΙ ΙΙΙ I ΙΙ ΙΙΙ I ΙΙ ΙΙΙ I ΙΙ ΙΙΙ

Multiple Clinical Study Summary

% R

edu

ctio

n

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Exclusive Partnership with World Leader in Citrus Bioflavonoids and Polymethoxylated Flavones (PMFs)

• Through SourceOne’s exclusive partnership with Ingredients by Nature (IBN), the world leader in citrus extracts, we have established ourselves as the principal marketer of Citrus Bioflavonoids and PMFs with multiple products, including our award-winning Cholesstrinol Family of Heart Healthy Formulas.– Over 80 years of analytical experience and expertise.– New showcase facility and on-site state-of-the-art

laboratory.– Formulation expertise through proprietary blending

granulation and state of the art sterilization.

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Published Study Results

Alternative Therapies in Health and Medicine published the results of several studies that combined the PMF-source™ and TocoSource™, key ingredients found in Cholesstrinol™. The largest study, a 12-week double blind, placebo-controlled protocol with 120 subjects, resulted in significant improvements in total cholesterol (-30%), LDL (-27%), and triglycerides (-34%).

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SourceOne Global Partners“Delivering the best science nature has to offer.”

- Thank You