Pubmed vs. Full-Text Query Performance in Systematic Reviews : Application to Non- inferiority Clinical Trials André Nguyen Van Nhieu 1, 2 , Katet Moez 1 , Michel Nougairede 2 , Xavier Duval 4 , Michaël Schwarzinger 1 1 ATIP-AVENIR Inserm “Modélisation, Aide à la Décision, et Coût-Efficacité en Maladie Infectieuses”, U738, Université Denis Diderot, Paris, France; 2 Département de Médecine Générale, Université Denis Diderot, Paris, France 3 Inserm U738, Université Denis Diderot, Paris, France; 4 Inserm CIC 007, AP-HP, Hôpital Universitaire Bichat, Paris, France 1
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Pubmed vs. Full-Text Query Performance in Systematic Reviews : Application to Non-inferiority Clinical Trials André Nguyen Van Nhieu 1, 2, Katet Moez 1,
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Pubmed vs. Full-Text Query Performance in Systematic Reviews : Application to Non-inferiority Clinical Trials
André Nguyen Van Nhieu1, 2, Katet Moez1, Michel Nougairede 2, Xavier Duval4, Michaël Schwarzinger1 1 ATIP-AVENIR Inserm “Modélisation, Aide à la Décision, et Coût-Efficacité en Maladie Infectieuses”, U738, Université Denis Diderot, Paris, France; 2 Département de Médecine Générale, Université Denis Diderot, Paris, France3 Inserm U738, Université Denis Diderot, Paris, France; 4 Inserm CIC 007, AP-HP, Hôpital Universitaire Bichat, Paris, France
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I declare no conflicts of interest
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Introduction (1)
Systematic review = extensive research of appropriate publications in the literature
Usually performed through Pubmed using key-words
Methodology appropriate when keywords in title/abstract and MeSH
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Introduction (2)
Comparison of Pubmed VS FULL-TEXT
Application: Non-inferiority trials in infectious diseases1
According to Piaggio CONSORT statement JAMA 2006: improving quality of reporting Non-inferiority trials
Hypothesis : Pubmed as sensitive as FULL-TEXT
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Objective
To compare the performance of 2 query strategies to identify non-inferiority trials with mortality as a primary outcome in infectious diseases: Pubmed Full-text using the search engine of each
journal
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Methods (1)
Original articles published in 2001-2012 In :
Generalist journals : N Engl J Med, Lancet, JAMA, Ann Intern Med, BMJ, Arch Intern Med
inferior* OR not inferior OR is inferior OR was inferior) AND (surviv* OR alive OR mortality OR death* OR fatal*)] + indexation (randomized controlled trial, Kaplan-Meier method, survival, mortality, death)
FULL-TEXT method with the same keywords adapted according to each search engine
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Methods (3)
Methods (4)
Definitions : True positive (TP): Non-inferiority trial (NIT) with
mortality as primary outcome found by one or the other query strategy
False positive (FP): Original article but it is not a NIT or a NIT with primary outcome ≠ mortality
False negative (FN): NIT fount by one query search but not the other
Positive predictive value (PPV): probability to find a TP among all Positive of a query strategy
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Results (1)
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Flowchart
Articles excluded (n=101):- 88 articles with survival as a secondary outcome- 13 articles with per protocol analysis
256 articles in infectious diseases identified in PUBMED
and FULL-TEXT : 81 in common and 175 more with
FULL-TEXT
Articles excluded (n= 28):- 28 NIT with outcome different from mortality