CSCI2951-N: Advanced Algorithms in Computational Biol http ://www.cs.brown.edu/courses/ csci2951-n/ Prof. Sorin Istrail Published Genome-Wide Associations through 2011 1,617 published GWA at p≤5X10 -8 for 249 traits Autism marker Multiple Sclerosis Marker The GWAS Human Genome
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Published Genome-Wide Associations through 2011 1,617 published GWA at p≤5X10 -8 for 249 traits
CSCI2951-N: Advanced Algorithms in Computational Biology http ://www.cs.brown.edu/courses/ csci2951-n/ Prof. Sorin Istrail. Published Genome-Wide Associations through 2011 1,617 published GWA at p≤5X10 -8 for 249 traits. The GWAS Human Genome. Autism marker Multiple Sclerosis Marker. - PowerPoint PPT Presentation
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CSCI2951-N: Advanced Algorithms in Computational Biology http://www.cs.brown.edu/courses/csci2951-n/
Prof. Sorin Istrail
Published Genome-Wide Associations through 20111,617 published GWA at p≤5X10-8 for 249 traits
Published Genome-Wide Associations through 20111,617 published GWA at p≤5X10-8 for 249 traits
Genetic Heterogeneity
The Common Disease Common Variant (CDCV) hypothesis is dead. Long live the Common Disease Many Rare Variants hypothesis!
The CDCV ‘s classical drawing metaphor as “Needles in the Haystack,” with few needles with a common look in a large haystack, needs to be replaced now with a van Gogh-like drawing, with many needles each differently looking and private to areas in the large haystack.
Vincent
CSCI2951-N: Advanced Algorithms in Computational Biology http://www.cs.brown.edu/courses/csci2951-n/
• Markov Chain Monte Carlo Algorithms Biological Problem: Population Substructure
• Knapsack Algorithms and Statistical Hypothesis Testing, The Neyman-Pearson Lemma, Multiple Testing Biological Problem: Statistical Associations in GWAS
Algorithms
• Voting Theory Algorithms, von Neumann-Morgenstern Utility Theory & The Social Network of Protein Folds
Biological Problem: The Protein Folding Problem - Individual Preferences of Amino Acids and the Thermodynamic "Social Choice" Hypothesis - The Protein Folding Energy Function Inference Problem