Proteus proprietary access to breakthrough technology (march 2012)f

Proteus Venture Partners’ Network

Proprietary Access to Breakthrough Technology

March 2012

Worldwide Coverage of the Regenerative Medicine

Proteus Offices

Scientific Advisors

University Affiliations

Conference Presentations

Professional Organizations

CONFIDENTIAL 2

Scientific Advisory Board

Proteus Core Team

The Proteus Network: 7 Major Components

A deep network generates early access to breakthrough technology & innovation

Leveraging Key Opinion Leaders – US

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* Core team or scientific advisory board member from these institutions

Leveraging Key Opinion Leaders – ROW

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* Core team or scientific advisory board member from these institutions

Professional Organizations & Advocacy Groups

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* Core team or advisory board member part of these organizations

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Conference Presentations / Publications

84 speaking engagements worldwide at leading academic and professional conferences over the past 3 years (core Proteus team)

Core team and Advisors are peer reviewers in virtually all the major RM Journals:

Biomaterials, Blood, Cell + Cell Stem Cell + Cloning and Stem Cells + JAMA + Journal of Biomedical Materials + Journal of Experimental Medicine + Journal of Orthopedic Research + Journal of Tissue Engineering and Regenerative Medicine + Nature + Nature Biotechnology + Nature Medicine + Nature Reviews Drug Discover + NEJM + PLOS-Biology + PLOS-Medicine + PNAS + Regenerative Medicine + Science + Stem Cells and Development + Tissue Engineering

Core team and advisors contributed directly to the following publications:

- Books

- Reports-Advance cell & Tissue Therapies - A mission to the US, Guidance on Standards on methods and

regulation for cell-based therapeutics (British Standards Institute)-Regenerative Medicine Terminology (British Standards Institute)

Principles of Tissue Engineering

Essentials of Stem Cell Biology

Handbook of Stem Cells

Stem Cells Now The Immortal Cell Stem Cells in Drug Discovery

Stem Cells: Bench to Bedside,

Advances in Tissue Engineering

Surfaces and Interfaces for Biomaterials

CONFIDENTIAL 8CONFIDENTIAL 8

Darin Weber: FDA & Regulatory Issues(CBER)

Matt Vincent, Patent Attorney

Vern Norviel, Patent Attorney

Barry Frankel & Devyn Smith: Life Science &RM Business Consultants

Chip Lion & David Riley: Fund Counsel

Tom Keelin & Michael Reeds:Decision Analysis & Asset Valuation

James Lawford-Davies

Peter Johnson

Sofi Fexby, Pierre Maillet &John Watkins

Robert Preti, Stewart Craig, Lee Buckler

Shankar Seetharaman, CEO

John Robinson, CEO

Jon Rowley, David Smith & Kim Warren

Steve Bengston

RM RegulatoryAdvice

RM SpecificConsulting

US & EUIntellectual

Property & Legal

Cell Processingand CRO / CMO

Leverage Deep Domain Expertise of Partners

Leverage Venture Capital Relationships

CONFIDENTIAL 9

Leverage Proteus’ Proprietary Databases

Three Core Databases: RM Companies, Academic Research, IP

Appendices

Details of Proteus’ Network of Relationships and Publications

1. Academic & Research Organizations: US and ROW

2. Professional Organizations & Advocacy Groups

3. Funding and Regulatory Agencies

4. Conference Presentations and Publications

Academic & Research Organizations: US – Team Contacts

Organization Contact

Brown University Michael Lysaght

Burnham Institute for Medical Research Evan Snyder

Children’s Hospital Oakland Research Institute Bertram Lubin

Columbia University Silviu Itescu

Duke University Nelson Chao, Diane Kurtzberg, Bob Taber

Emory University Edmund Waller

Harvard University George Daley, Brock Reeves, David Scadden , Amy Wagers, Charles Vacanti

Johns Hopkins University Gary Brocker, Doug Kerr, Aristides Melissaratos, Jeff Rothstein

Massachusetts Institute of Technology (MIT) Myron Spector, Lita Nelsen, Ioanis Yannas, Robert Langer, Fiona Murray

McGowan Institute – UPMC Alan Russell, Eric Lagasse

MD Anderson Cancer Center Krishna Komanduri, Jeff Molldrem

Memorial Sloan Kettering Cancer Center Malcolm Moore

Stanford University Amato Giaccia, Geoffrey Gurtner, Michael Longaker, Irving Weissman

U of Texas: Texas Heart Institute Paul Simmons, Emerson Perin, James Willerson

UC San Francisco Arnold Kriegstein, Yerem Yeghiazarian, Emmanuel Passague

University of Florida-Gainesville Dennis Steindler

University of Michigan Steve Feinberg, Wayne Harvey, Sean Morrison

University of Pennsylvania George Cotsarelis,

University of Washington Shelly Heimfeld, Don Thomas, Reiner Storb, Phil Greenberg

University of Wisconsin-Madison Jamie Thompson, Gabriela Cezar, Lynn Allen-Hoffmann

Wake Forest University Anthony Atala

Academic & Research Organizations: ROW – Team Contacts

Organization Contact Organization Contact

A*Star (Singapore) Alan Colman University College of London (UK) Chris Mason

Babraham Institute (UK) Wolf Reik University of Cambridge (UK) Roger Pederson, Azim Surani

Imperial College London (UK) Julia Polak University of Edinburgh (UK) Ian Wilmut

King's College London (UK) Stephen Minger University of Oxford (UK) Paul Fairchild

Monash University (Australia) Richard Boyd University of Southampton (UK) Richard Oreffo

The University of Nottingham (UK) Kevin Shakesheff University of Toronto (Canada) Gordon Keller, Vince Tropepe

The University of Sheffield (UK) Peter Andrews Weizmann Institute of Science (Israel) Yair Reissner, Yoav Soen, Tzvi Lapidot

Professional Organizations & Advocacy Groups

Organization Team Involvement

International Society of Stem Cell Research (ISSCR) Advisory Board, Finance Committee, Industry Committee, Global Forum (Organizer)

International Society for Cellular Therapy (ISCT) Commercialization Committee

Tissue Engineering & Regenerative Medicine Society International (TERMIS) Past President

Juvenile Diabetes Research Foundation Working Relationship (Alan Lewis, Dick Ensel, Robert Goldstein, Julia Greenstein, Peter Lomedico, Charlie Queenan)

Harvard Stem Cell Institute Executive Director

Stem Cell Network (Canada) Advisor

UK National Stem Cell Network (UKNSCN) Founder, Steering Committee

East of England Stem Cell Network (UK) Founder

London Regenerative Medicine Network (LRMN) (UK) Founder/CEO/Trustee

Centre of Excellence for Life Sciences – Newcastle (UK) Advisor

Ministry of Defence, Defence Society and Technology Laboratory (UK) Advisor

UK Department of Health – UK Stem Cell Initiative Consult/Contributor

Funding and Regulatory Agencies

Agency Contacts

USA

FDA - CBER Donald Fink, Celia Witten, Steven Bauer

California Institute for Regenerative Medicine Alan Trounson, Robert Klein

National Institutes of Health Ron McKay, Jefferey Barker

UK

MHRA (UK) Jeremy Tinkler, Chris Bravery

British Standards Institute (BSi) Mike Low, Regenerative Medicine Standards Committee (PAS 83/84)

LGC (formerly Laboratory of the Government Chemist) Julian Braybrook, Neil Harris

National Physical Laboratory (NPL) Kamal Hossain, Mark Bailey, Markys Cain, Peter Tomlins

UK Stem Cell Bank (Nat. Instit. for Biological Stds + Control [NIBSC]) Glyn Stacey, Charles Hunt, Lyn Healy

Conference Presentations

Conference Year(s) Team Involvement

American Society of Bone Marrow Transplantation (ASBMT) 2005-2008 Member, Speaker

American Society of Hematology (ASH) 2005-2008 Member, Speaker

BIO International Convention 2007, 2008 Speaker

bioprocessUK Conference 2006 Speaker

Bioproduction 2006 2006 Keynote speaker

Cambridge University Technology and Enterprise Club (CUTEC) Technology Ventures Conference 2007 Panel Member

Commercial Translation for Regenerative Medicine 2007 Organizer, Keynote Speaker, Scientific Advisory Board + Meeting Chair

Commercialisation of Tissue Engineering & Regenerative Medicine Conference 2005 Conference Chairman, Scientific Advisory Panel

Commercialization of Tissue Engineering and Cell Therapy 2006, 2007 Event Chair and adviser

Congress of International Drug Discovery Science and Technology (IDDST) 2007 Scientific Advisory Board

ESACT-UK Annual Meeting 2006 Session Chairman and organiser

EU Marie Curie Conference 2007 Organising Committee

European Stem Cell & Regenerative Medicine Congress 2006, 2007, 2008

Originator, Organizer, Keynote Speaker, Scientific Advisory Board + Chairman

EuroSciCon 2005 Speaker

Genesis Conference 2005 Session Chairman, Advisory Panel

International Stem Cell Conference 2007 Speaker

Conference Presentations

Conference Year(s) Team Involvement

ISCT Annual Meeting 2007, 2008 Speaker

ISSCR Annual Meeting 2007 Speaker

Kellogg Business of Healthcare Conference 2008 Speaker

Medical Device Technology European Conference 2005 Guest speaker

National Stem Cell Conference (UK) 2005 Speaker

Netherlands Science & Technology Conference 2006 Speaker

Phacilitate Cell & Gene Therapy Forum 2008 Speaker

Stem Cells & Regenerative Medicine Conference 2006, 2007 Speaker

Stem Cells & Regenerative Medicine Congress 2005, 2006, 2007 Speaker

STEPS: Stem Cell Therapy as an Emerging Paradigm in Stroke 2007 Keynote

Strategies for Engineered Negligible Senescence (SENS) 2007 Session Chair

The International Conference on Advanced Laser Technologies 2003 Speaker

The Stem Cell Congress 2007, 2008 Speaker

Tissue Engineering & Regenerative Medicine Society International (TERMIS) 2007 Speaker

World Congress on Regenerative Medicine 2007 Organizer, Keynote Speaker, Advisory Board, Session Chair

World Stem Cell Summit 2007 Speaker

Conference Presentations

Workshops/Symposia Year(s) Team Involvement

Advanced Medical Technologies Enterprise Florida (eFlorida) Mission to UK 2006 Session Chair

Anatomical Society of Great Britain & Ireland Summer Meeting 2007 Speaker

BA Festival of Science 2006 Speaker

BBSRC “The Cell Supply Chain Workshop” 2005 Conference co-organizer and Session Chairman

BIA Roundtable 2007 Speaker

BioIndustry Association (BIA) Regulatory Affairs Committee (RAAC) 2006 Session Chair

bioLogic USA 2005 Speaker

Bionanotechnology and Tissue Engineering Meeting 2003 Speaker

BIOS (Research Centre for the study of Bioscience, Biomedicine, Biotechnology and Society) Public Debate 2007 Speaker

Brainy Brave New World public meeting 2007 Panel Member

British Standards Institute/Department of Trade and Industry Workshop 2005 Co-organizer and Chairman

British-Russian Workshop in association with the European Commission on Stem Cells 2007 Advisor, Speaker

Cheltenham Science Festival 2007 Panel Member

Cross Council Stem Cell Programme Grant-holder’s Workshop 2006 SpeakerDTI funded Global Watch Mission, “Advanced Cell & Tissue Therapies - a mission to the US” 2006 Speaker

Economic and Social Research Council (ESRC) Stem Cell Programme 2007 Speaker

IChemE - Biochemical Engineering Subject Group 2006 Speaker

London Biotechnology Network Workshops 2006 Event Chairman and adviser

London Technology Network Workshops 2007 Session Chair

McGowan Institute Retreat 2007 Speaker

Conference Presentations

Workshops/Symposia Year(s) Team Involvement

Mid-Atlantic Bio, Stem Cell Track 2007 Speaker

Presentation to National Physical Laboratories and LGC (Laboratory of the Government Chemist) 2004 Speaker

Regenerative Medicine Workshop - UK-Medicon Valley Bioscience Collaboration 2007 Session Chair

Rolduc International Polymer Meeting (European Polymer Federation) 2003 Keynote speaker

Royal Institution of Great Britain, Friday Evening Discourse 2007 Speaker

Silicon Valley Chapter of the National Association of Corporate Directors 2008 Moderator & Speaker

Stem Cell Manchester 2007 Speaker + panel member

Stem Cell Roundtable, Science and Innovation 2007 Speaker

Stem Cells for Tissue Engineering and Regenerative Medicine to Policy 2006 Speaker

Stem Cells in Orthopaedics Meeting 2005 Speaker

Symposium in Stem Cell Repair and Regeneration 2006, 2007 Session Chair + Co-organizer

The 2007 Hunterian Lecture 2007 Speaker

The Stem Cell Partnering Series 2008 Speaker

The Stem Cell Summit 2007 Speaker

The Wolfson Centre for Age-Related Diseases and the King’s College London Stem Cell Consortium 2005 Speaker

Tissue Engineering And Regenerative Medicine Workshop 2004 Speaker

Tissue Engineering Meeting, DTI Texas-UK Collaborative Bioscience Initiative 2005 Presenter

UCL Lunch Hour Lecture 2007 Speaker

UK Focus for Biomedical Engineering Committee (hosted by the Royal Academy of Engineering) 2007 Speaker

University of Sydney/UCL Frontiers of Knowledge Symposium 2007 Speaker

Publications

Publication Team and Advisors Involvement

Regenerative Medicine (Journal) Founder, Editor

Tissue Engineering (Journal) Editorial Board

Principles of Tissue Engineering, 2nd Edition (Lanza, et al.) Contributing Editor

Essentials of Stem Cell Biology (Lanza, et al.) Contributing Editor

Handbook of Stem Cells, Volumes 1 & 2 (Lanza, et al.) Contributing Editor

Stem Cells Now (C.T. Scott) Author

The Immortal Cell (M.D. West) Author

The Proteus Effect (A. Parsons) Contributor

Stem Cells: Bench to Bedside (Bongso & Lee) Contributing Author

Advanced cell & tissue therapies - A mission to the US (DTI Global Watch Mission Report) (C. Mason, et al.) Editor, Co-Author

PAS 83 - Guidance on standards, standardised methods and regulation for cell-based therapeutics, from basic research to clinical application (British Standards Institute) Co-Author

Advances in Tissue Engineering (J. Polak, ed.) Contributing Author

Surfaces and Interfaces for Biomaterials (P. Vadgama, ed.) Contributing Author

Stem Cells in Drug Discovery: Applications as Tools and Targets (C. Mason, et al.) Co-Author

PAS 84 - Regenerative Medicine Terminology (British Standards Institute) Co-Author

Various Peer Reviewed Publications Including Cell, Science, PLoS and others

Publications

Scientific Journals – Peer Review Participation (Team and Advisors):

Biomaterials Nature Biotechnology

Blood Nature Medicine

Cell Nature Reviews Drug Discovery

Cell Stem Cell New England Journal of Medicine

Cloning and Stem Cells PLOS-Biology

JAMA PLOS-Medicine

Journal of Biomedical Materials PNAS

Journal of Experimental Medicine Regenerative Medicine

Journal of Orthopedic Research Science

Journal of Tissue Engineering and Regenerative Medicine Stem Cells and Development

Nature Tissue Engineering