PROGRAMME: M.SC. (CHEMISTRY) FACULTY OF … · FACULTY OF SCIENCE AND HUMANITIES CURRICULUM ... 4. Finar I. L., Organic Chemistry, 6th Edition, ... trans effect and its influence,

SATHYABAMA INSTITUTE OF SCIENCE AND TECHNOLOGY FACULTY OF SCIENCE AND HUMANITIES

M.Sc. (CHEMISTRY) REGULAR xii REGULATIONS 2015

PROGRAMME: M .SC . ( C H E M I S T R Y )

FACULTY OF SC I ENCE AND HUM ANI T I ES

CURRI CULUM

SEMESTER 1

Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

THEORY

1 SCY5101 Organic Synthesis and Retrosynthetic Methods 3 0 0 3 1

2 SC 02 Coordination Chemistry 3 1 0 4 2

3 SC 03 Thermodynamics 3 1 0 4 3

4 SCY5104 Quantum Chemistry and Group Theory 3 1 0 4 4

5 SCY5105 Analytical Chemistry and Spectroscopy 3 1 0 4 5

PRACTICAL

6 SCY6530 Physical chemistry Lab – I 0 0 4 2

6

7 SCY6531 Inorganic Chemistry Lab – I 0 0 4 2 7

Sl. No. COURSE CODE

SEMESTER 2

COURSE TITLE

Total Credits: 23

C

PAGE No.

L T P

THEORY

1 SCY5106 Chemistry of the Main Group Elements

3 0 0 3

8

2 SCY5107 Stereochemistry and Organic Photochemistry 3 1 0 4 9

3 SCY5108 Chemical Kinetics and Solid State Chemistry 3 1 0 4 10

4 Elective – 1 3 1 0 4

5 Elective – 2 3 1 0 4

PRACTICAL

SCY6532 Organic Chemistry Lab – I

0 0 4 2

11 6

7 SCY6533 Inorganic Chemistry Lab – II 0 0 4 2 12

INTERNSHIP

Professional Training 0 0 0 5

8 S58PT

Total Credits: 28

L - LECTURE HOURS, T – TUTORIAL HOURS, P – PRACTICAL HOURS, C – CREDITS

SATHYABAMA INSTITUTE OF SCIENCE AND TECHNOLOGY FACULTY OF SCIENCE AND HUMANITIES

M.Sc. (CHEMISTRY) REGULAR xii REGULATIONS 2015

Sl. No. COURSE CODE

THEORY

1 SCY5201

2 SCY5202

3 SCY5203

4

5

PRACTICAL

6 SCY6534

7 SCY6535

8

SEMESTER 3

COURSE TITLE

Physical Chemistry Lab – II

Organic chemistry Lab – II

Project Work (Phase – 1)

L T P C PAGE No.

3 0 0 3 13

3 1 14

3 1 0 4 15

3 1 0 4

3 1 0 4

0 0 4 2 16

0 0 4 2 17

Total Credits: 23

SEMESTER 4 Sl. No. COURSE CODE COURSE TITLE L T P C PAGE No.

1 S58PROJ Project Work (Phase – 1 & 2) 0 0 40 20

Total Credits: 20 TOTAL CREDITS FOR THE PROGRAMME: 94

LIST OF ELECTIVES (FOR SEMESTER 2)

COURSE CODE

SCY5601

SCY5

SCY5603

SCY5

SCY5605

SCY5606 SCY5607

COURSE TITLE

Surface Chemistry and Catalysis

02 Computational Chemistry

Spectroscopy: Applications in Inorganic Chemistry

04 Organometallic Chemistry

Chemistry of Natural Products

Advanced Organic Synthesis

Advanced Quantum Chemistry

L 3

3 3

3 3

3 3

T P C PAGE No.

1 0 4 18

1 0 4 19

1 0 4 20

1 0 4 21

1 0 4 22

1 0 4 23

1 0 4 24

LIST OF ELECTIVES (FOR SEMESTER 3)

Sl. No. COURSE CODE

1 SCY5608

2 SCY5609

3 SCY5

4 SCY5

5 SCY5612

6 SCY5

7 SCY5614

COURSE TITLE

Corrosion and its Prevention

Chemistry of Materials

0 Supramolecular Chemis 1 Industrial Chemistry

Physical Organic Chemistry

3 Medicinal Chemistry

Advanced Environmental Chemistry

L T P

3 1 0

3 1 0

3 1

3 1

3 1 0

3 1

3 1 0

C PAGE No.

4 25

4 26

4 27

4 28

4 29

4 30

4 31

Bio Inorganic Chemistry

Electrochemistry, Interfaces and Organized Assemblies

Organic Reaction Mechanism

Elective – 3 Elective – 4

SATHYABAMA INSTITUTE OF SCIENCE AND TECHNOLOGY FACULTYOF SCIENCEANDHUMANITIES

M.Sc. (CHEMISTRY) REGULAR 1 REGULATIONS2015

SCY51 01 ORGANICSYNTHESIS AND L T P Credits Total Marks

RET ROSYNT HETIC METHODS 3 0 0 3 100

COURSE OBJECT IVES To know the methods of synthetic strategies and applications To apply the knowledge of chemical reactions in organic synthesis To learn the various types of reactions, rearrangements and their synthetic utility

UNIT 1 ORGANICSYNTHESIS 9 Hrs. Synthetic Analysis and Planning: Retrosynthetic analysis – Synthetic equivalent – Control of stereochemistry –

Linear, convergent and divergent syntheses. Use of protecting groups in multi-step synthesis: Different protection and deprotection methods.

UNIT 2 REAGENTSIN ORGANIC CHEMISTRY 9 Hrs. Oxidation Reagents: Potassium Permanganate, HIO4, OsO4, MnO2 Alcohol to carbonyls Cr(VI) oxidants, PCC,

DCCD, 1 ,3-dithiane – Swern oxidation, Silver carbonate, Prevost and Woodward oxidation, Oxidation of allylic and benzylic C-H bonds: DDQ, SeO2.

Reducing Reagents: Catalytic hydrogenation: LAH, NaBH4, DIBAL, Electrophilic metal hydrides: BH3, AlH3. Dissolving metal reductions including Birch reduction – Wilkinsons catalysts. Functional group transformations: Use of Organo-lithium dimethyl cuprate, Lithium diisopropyl amide (LDA), RMgX, Gilman’s reagent, Trimethylsilyliodide and Tri-N-butyltinhydride, Phase transfer catalysts – Crown ethers and Merrifield resin, Baker yeast.

UNIT 3 NAMEDREACT IONS–I 9 Hrs. Wurtz Reaction – Wolf Kishner – Clemmenson reduction – Kolbe – Corey-House reaction – Reformatsky

reaction – Claisen condensation – Dieckman reaction – Aldol condensation – Knoevenagal condensation – Perkin reaction – Stobe – Friedal crafts alkylation and acylation – Cannizzaro reaction – Benzoin condensation – Vilsmeir-Haak reaction – Reimer-Tiemann reaction – Bischler-Napieralski reaction.

UNIT 4 NAMEDREACT IONS–II 9 Hrs. Wittig reaction – Robinson-Mannich reaction – Stork enamine reaction – Mannich Reaction – Sharpless

asymmetric epoxidation –, Ene reaction – Barton reaction – Hofmann-Loffler-Fretag reaction – Chichibabin reaction – Suzuki Coupling – Stille coupling – Umpoloung reaction.

UNIT 5 MOLECULAR REARRANGEMENT 9 Hrs. General mechanistic considerations: Types of rearrangement by nature of migration – Intra and Inter molecular rearrangement – Cross over experiment.

C-C Migration: Pinacol-Pinacolone, Wagner-Meerwein, Demjanov, Benzil-Benzilic acid, Favorski rearrangements.

C-N Migration: Neber, Arndt-Eistert synthesis, Beckmann, Hofman, Curtius, Schmidt rearrangements. C-O Migration: Bayer-Villiger, Shapiro reaction. Miscellaneous: Fries, Cope, Somlet hauser, Stevens, Van-Richter rearrangement.

Max. 45 Hours

T EXT / REF ERENCE BOOKS 1. March J., and Smith M., Advanced Organic Chemistry, 5th Edition, John-Wiley and Son, 2001. 2. Gould E. S., Mechanism and Structure in Organic Chemistry Holt, Rinehart and Winston Inc., 1959. 3. Gilchrist T. L., Heterocyclic Chemistry, Longman Scientific and Tech., 1985.

4. Finar I. L., Organic Chemistry, 6th Edition, Pearson Education Asia, 2004. 5. House H.O., Modern Synthetic Reactions, W.A. Benjamin Inc, 1972.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 80 Exam Duration: 3 Hrs. PART A: 6 Questions of 5 Marks each-No choice 30 Marks PART B: 2 Questions from each unit of internal choice, each carrying 10 Marks. 50 Marks

(Out of 80 Marks, maximum of 10% problems may be asked.)



SCY5102 COORDINATIONCHEMISTRY L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECT IVES To know the nature of metal-ligand bonding in coordination compounds and quantification of the bonding parameters To study about the coordination complexes, substitution in coordination complexes

UNIT 1 STRUCTURESAND ISOMERS 12 Hrs.

Coordination compounds: Ligand – Coordination number – Nomenclature of coordination compounds. Types of isomerism; Hybridization and geometries of coordination compounds. Thermodynamic stability and structural effects – Successive and overall stability constants – Irving-William series – Chelate and macrocyclic effect.

UNIT 2 THEORIES OF BONDING 12 Hrs.

Valence Band Theory – Crystal Field Theory and their limitations – d-orbital splitting in octahedral – Jahn Teller distortions: Distorted octahedral – Square planar – Square pyramidal – Trigonal bipyramidal and tetrahedral complexes. Crystal field stabilisation energy for d1 to d10 systems – Pairing energy – Low-spin and high-spin complexes and magnetic properties – Ligand Field Theory and Molecular Orbital (MO) theory of octahedral and tetrahedral complexes.

UNIT 3 ELECTRONIC SPECTRA 12 Hrs.

Absroption spectra: Charge transfer spectra – Colors, intensities and origin of spectra – Interpretation – Term Symbols and splitting of terms in free atoms – Selection rules for electronic transitions – Orgel and Tanabe-Sugano diagram – Calculation of Dq, Racah parameter (B), C, Spectrochemical and Nephelauxetic series.

UNIT 4 REACTIONS AND MECHANISMS 12 Hrs.

Substitution reactions in octahedral and square planar complexes, mechanism, trans effect and its influence, water exchange – Anation and base hydrolysis – Stereochemistry – Oxidation and reduction reactions. Inner and outer sphere electron transfer mechanisms – Conditions for high and low oxidation numbers – Template reactions.

UNIT 5 ACIDSANDBASES 12 Hrs.

Arrhenius concept – Bronsted-Lowry concept – Lux-Flood concept – Lewis concept – Usanovich concept – Theory of hard and soft acids and bases (HSAB) – Classification of acids and bases as hard and soft – Lewis-acid base reactivity approximation – Donor and acceptor numbers, E and C equation – Applications of HSAB concept – Solvation and acid-base strength – Non-aqueous solvents and acid-base strength – Levelling effect – Symbiosis – Proton sponges.

Max. 60 Hours

T EXT / REF ERENCE BOOKS

1. Huheey J. E., Keiter E. A., and Keiter R. L., Inorganic Chemistry: Principles of Structure and Reactivity, Pearson Education, 2006.

2. Atkins P. W., Overton T., Rourke J., Weller M., and Armstrong F., Shriver & Atkins: Inorganic Chemistry, 4 th Edition, Oxford University Press, 2006.

3. Cotton F. A., Wilkinson G., Murillo C. A., and Bochmann M., Advanced Inorganic Chemistry, 6 th Edition, Wiley, 1999.

4. Drago R. S., Physical Methods in Inorganic Chemistry, Affiliated East-West Press, 1971.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 Exam Duration: 3 Hrs.

PART A: 6 Questions of 5 Marks each-No choice 30 Marks

PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks. 70 Marks (Out of 80 Marks maximum of 10% problems may be asked).



L T P Credits Total Marks

SCY5103 THERMODYNAMICS 3 1 0 4 100

COURSE OBJECT IVES To understand statistical thermodynamics that leads to classical thermodynamics

To apply the concepts of statistical thermodynamics for the study of equilibrium reactions and reaction rates

UNIT 1 CLASSICALTHERMODYNAMICS-I 12 Hrs. First and Second law of thermodynamics Need – Statements – Concept of entropy – Carnot cycle - Gibbs

function – Gibbs – Helmholtz equation – Clausius-Clapeyron equation – Maxwell relations – Thermodynamic equation of state – Thermodynamics of systems of variable compositions – Partial molar quantities, partial molar volume – Chemical potential, Gibbs – Duhem equation –Third law of thermodynamics.

UNIT 2 CLASSICALTHERMODYNAMICS-II 12 Hrs. Ellingham diagram and its significance. Thermodynamics of real gases and real solutions: Fugacity: Methods

of determination. Dependence on temperature, pressure and composition. Activity and activity coefficient: Standard states – Determination of activity and activity coefficient of non-electrolytes and electrolytes. Solubility of ionic solids in water – Solubility curves – Ternary system involving water and two soluble ionic solids – Formation of double salts.

UNIT 3 STATIST ICALTHERMODYNAMICS- I 12 Hrs. `Probability theorems – Partition function and its physical significance: Phase space – Ensembles: Different

types of ensembles –, Micro canonical, canonical and grand canonical partition function – Distinguishable and indistinguishable molecules – Partition function and thermodynamic functions – Separation of partition function – Translational, rotational, vibrational and electronic partition functions. Statistical approach to thermodynamic properties: Internal energy, Entropy, Enthalpy, Helmholtz function, Gibbs function, Residual entropy, Equilibrium constant, Average energies and equipartition.

UNIT 4 STATIST ICALTHERMODYNAMICS- II 12 Hrs. Quantum Statistics Bose-Einstein statistics – Fermi-Dirac statistics – Free energy function Heat capacity of

mono and diatomic gases. Ortho- and para hydrogen and mixture of the two viz., o-H2 and p-H2 .Heat capacity of solids – Einstein and Debye models – Thermodynamic properties of solids.

UNIT 5 IRREVERSIBLETHERMODYNAMICS 12 Hrs. Near equilibrium process: General theory – Conservation of mass and energy – Entropy production in open

system by (i) heat (ii) matter and (iii) current flow. Onsager theory: Validity and verification. Application of irreversible thermodynamics to biological and non-linear systems.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Rastogi R. P., and Misra R. R., An Introduction to Chemical Thermodynamics, 6th Revised Edition, Vikas Publishing House Ltd.,

2009. 2. Atkins P. W., Physical Chemistry, Oxford University Press, 1978. 3. Glasstone S., Thermodynamics for Chemists, Affiliated East-West Press, 1974. 4. Klotz I. M., and Rosenberg R. M., Chemical Thermodynamics: Basic Theory and Methods, 18th Edition, Benjamin/Cummings

Pub. Co., 1986. 5. Rastogi R. P., and Misra R. R., Classical Thermodynamics, Vikas Publishing House Ltd.,1990. 6. Rajaram J., and Kuriakose J. C., Thermodynamics, 3rd Edition, S. Chand & Co., 1999.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 Exam Duration: 3 Hrs. PART A: 6 Questions of 5 Marks each-No choice 30 Marks

PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks 70 Marks (Out of 80 Marks, maximum of 10% problems may be asked.)



SCY51 04 QUANTUMCHEMISTRY AND GROUP L T P Credits Total Marks THEORY 3 1 0 4 100

COURSE OBJECT IVES To have a good foundation in understanding the physical and mathematical aspects of quantum mechanics

To study the fundamental principles of quantum chemistry, Schrodinger wave equation and its applications

To study the elements of group theory and the applications of group theory

UNIT 1 BASICS OF QUANTUMMECHANICS 12 Hrs. Planck's explanation about black-body radiation – de-Broglie's concept of matter waves, Compton Effect –

Heisenberg's uncertainty principle and complementarity. Operators – Linear operators, Hermitian Operators – Method of getting the following quantum mechanical operators – position, momentum, Kinetic energy, potential energy, total energy, angular momentum, raising and lowering operators and spin angular momentum.

UNIT 2 POSTULATESOF QUANTUMMECHANICS 12 Hrs. Postulates of quantum mechanics – Hermicity and proving the quantum mechanical operators are Hermitian –

Commutator algebra – Evaluation of commutators – Vanishing and non – Vanishing commutators – Eigen function and Eigen Value – Expansion theorem – Orthogonality and normalization of wave functions. Derivation of Schrodinger wave equation – Application of SWE to simple systems – Free particle moving in one dimensional box.

UNIT 3 APPLICATIONOF QUANTUMMECHANICS 12 Hrs. Characteristics of wave function – Average momentum of a particle in a box is zero-particle moving in a 3-D box

– Degeneracy – Distortion – Particle moving in ring – Rigid rotator – Spherical harmorics – Simple harmonic oscillator – Hermite polynomials – Radial wave function – Radial probability distribution – Shapes of various atomic orbitals. Need for approximation methods – Schrodinger equation for He atom and other many electron system. UNIT 4 GROUPTHEORY 12 Hrs.

Molecular symmetry elements and symmetry operations – Vector and matrix algebra – Symmetry operations and transformation matrices – Group-definition and properties of a group – Symmetry point groups – Representation of a group-reducible and irreducible representations – Great orthogonality theorem – Characters – Construction of a character tables– C2V, C3V, C2h. oh. D2h. UNIT 5 APPLICATIONOF GROUPTHEORY 12 Hrs.

Symmetry of Normal modes of vibrations, application of Group theory to normal modes of vibrations and to normal mode analysis – symmetry properties of integrals – Application for spectral selection rules of vibration spectra – Character table, hybrid orbital in non linear molecules (CH4, XeF4, BF3, SF6 and NH3). Determination of representations of vibrational modes in non-linear molecules (H2O, CH4, XeF4, BF3, SF6 and NH3) – IR and Raman active fundamentals symmetry of molecular orbitals and symmetry selection rule for electronic transitions in simple molecules like ethylene, formaldehyde and benzene. HMO calculations and delocalization energy for cyclopropenyl, butadiene and benzene systems.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Chandra A. K., Introductory Quantum Chemistry, 4th Edition, Tata Mc Graw Hill Publishing Co., 1998. 2. Prasad R. K., Quantum Chemistry, Revised 3rd Edition, New Age International Publishers, 2006. 3. Strauss H. L., Quantum Mechanics, Prentice Hall, 1972. 4. Atkins P. W., and Friedman R. S., Molecular Quantum Mechanics, 3rd Edition, Oxford University Press, 1997. 5. Eyring H., Walter J., and Kimball G. E., Quantum Chemistry, John Wiley & Sons, 1944 6. Cotton F. A., Chemical Applications of Group Theory, 3rd Edition, John Wiley & Sons, 1999. 7. Raman K. V., Group Theory and its Applications to Chemistry, Tata McGraw-Hill, 1990 8. Ramakrishnan V., and Gopinath, Group Theory in Chemistry, 2nd Edition, Vishal Publications, 1991

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 Exam Duration

PART A: 6 Questions of 5 Marks each-No choice 30 Marks PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks 70 Marks




SCY51 05 ANALYTICALCHEMISTRYAND L T P Credits Total Marks SPECTROSCOPY 3 1 0 4 100

COURSE OBJECT IVES To learn the basic analytical methods and have a sound knowledge of chemistry involved in an analysis

To know the application of spectroscopy to study the structure of molecules UNIT 1 INSTRUMENTALMETHODS IN CHEMICALANALYSIS 12 Hrs.

Introduction: Theory – Instruments – Working of Atomic Absorption Spectroscopy introduction – Principle of AAS and AES – Instrumentation – Single and double beam AAS – Detection limit and sensitivity, Interferences, applications. Working principle and application of EDX, SEM, TEM, AFM, Powder XRD, Single crystal XRD, AFM, Inductively coupled Plasma Spectroscopy: Instrumentation – Interferences. UNIT 2 THERMALMETHODS OF ANALYSIS 12 Hrs.

Introduction to thermal analysis: TG and DTG – Static thermogravimetry and dynamic thermogravimetry: Instrumentation – Thermogram – Factors affecting thermograms – Application of thermogravimetry. Reaction kinetics: Kinetics by single and multiple heating rates. Differential thermal analysis: DTA theories – DTA curves – Factors affecting DTA curves – Instrumentation – Applications of DTA – Simultaneous determination in thermal analysis. Correlation of DTA and TGA data with examples – Thermal decomposition of CaC2O4.H2O and CuSO4.5H2O. DSC: Introduction – Principle – Instrumentation and Application of DSC. UNIT 3 SEPARATION TECHNIQUES 12 HRS.

Chromatographic separation: Gas chromatography: Principle – instrumentation – Detectors: Flame ionisation detector – Photo ionisation detector and ECD – Application of GC using mass spectrometry. Liquid Chromatography: Types – Application of LC using mass spectrometry. HPLC: Principle – Instrumentation – Advantages of HPLC. Electrophoresis: Principle – Instrumentation – Capillary electrophoresis and detector, Gel electrophoresis. UNIT 4 INFRARED AND RAMANSPECTROSCOPY 12 Hrs.

Infrared Spectroscopy: The vibrating diatomic molecule – Force constant – Zero point energy – Simple harmonic vibrator – Anharmonicity – Morse potential – Overtones – Hot bands – Diatomic vibrating rotators – P,Q,R branches – Vibration of polyatomic molecules – Normal mode of vibrations. Fourier transform spectroscopy. Raman spectroscopy: Theories of Raman scattering – Vibrational Raman spectra – Mutual exclusion principle – Laser Raman spectra –Electronic spectra of diatomic and polyatomic molecules intensity of vibrational electronic spectra – Franck Condon principle – Rotational fine structure of electronic vibrational spectra – The Fortrat parabola – Dissociation and predissociation spectra UNIT 5 NMRAND ESR SPECTROSCOPY 12 Hrs.

Nuclear Magnetic Resonance Spectroscopy: Basic principles of NMR – Theory of nuclear magnetic resonance – Spin lattice relaxation – Spin-spin relaxation – Experimental techniques chemical shift – The chemical shift – The origin of shielding constant – Pattern of coupling – Origin of spin - spin coupling – The nuclear overhauser effect – 1H and 13C NMR: Principles – Instrumentation.

Electron Spin Resonance Spectroscopy: Basic principles of ESR – Experimental technique – The g-value hyperfine structure – Applications of ESR spectroscopy to the study of free radicals and fast reactions – Spin densities and Mc Connell relationship.

Max. 60 Hours T EXT / REF ERENCE BOOKS 1. Banwell C. N., Fundamentals of Molecular Spectroscopy, Tata McGraw Hill, 1983. 2. Hollas J. M., Modern Spectroscopy, 4th Edition, John Wiley & sons, 2004. 3. Chang R., Basic Principles of Spectroscopy, McGraw-Hill, 1971. 4. Barrow G. M., Introduction to Molecular Spectroscopy, McGraw-Hill, 1962. 5. Willard H. H., Merritt Jr. L. L., Dean J. A., and Settle Jr. A. F., Instrumental methods of analysis, 6th Edition, Van Nostrand,

1981. 6. Meites L., and Thomas H. C., Advanced Analytical Chemistry, McGraw-Hill, 1958. 7. Skoog D. A., West D. M., Holler f. J., and Crouch S. R., Fundamentals of Analytical Chemistry, 9th Edition, Wadsworth

Publishing Co. Inc., 2012. 8. Braun R. D., Introduction to Instrumental Analysis, McGraw-Hill, 1987.


PART A: 6 Questions of 5 Marks each-No choice 30 Marks PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks 70 Marks




SCY6530 PHYSICALCHEMISTRYLAB– I L T P Credits Total Marks 0 0 4 2 100

The list of probable experiments is mentioned below, which delineates the experiment to be performed in a semester. Any seven experiments can be selected from the list.

COURSE OBJECT IVE

To know about the practical applications of conductometry, potentiometry, pH metry, chemical kinetics and adsorption studies

I. CONDUCTOMETRICEXPERIMENTS

Determination of dissociation constant of weak acids

II POTENTIOMETRIC METHODS

Determine the strength of a given solution of ferrous ammonium sulphate by potentiometric titration with K2Cr2O7 solution.

Cyclic voltammetry of redox reaction

III TITRATIONSUSINGPH METER

Determination of first, second and third dissociation constants of phosphoric acid

Determination of dissociation constants of acetic acid

IV KINETIC EXPERIMENTS Study the Saponification of ethyl acetate by sodium hydroxide and determine the order of the reaction / by fluorescence method

V ADSORPTIONEXPERIMENTS

Verify the Freundlich and Langmuir adsorption isotherms for adsorption of acetic acid/oxalic acid on activated charcoal

T EXT / REF ERENCE BOOKS 1. Garland, Nibler and Shoemaker, Experiments in Physical Chemistry, 7th Edition, McGraw-Hill, 2003.

2. Jahagirdan D. V., Experiments in Chemistry, Himalaya Publishers House, 2003.



SCY6531 INORGANIC CHEMISTRY LAB– I L T P Credits Total Marks 0 0 4 2 100


COURSE OBJECT IVES

To improve the skill in quantitative estimation of metal ions

To identify the methodology to quantitatively separate and estimate mixture of metal ions x To identify the methodology to estimate a metal ion in the presence of another metal ion

I ONE COMPONENT GRAVIMETRIC ESTIMAT IONS Estimation of Zn2+ by AAS/ICP

Estimation of Ba2+

II ANALYSIS OF TWOCOMPONENT MIXTURES: Separation of Ni2+ and Cu2+ in a mixture and estimation of Ni2+ and Cu2+ by column chromatography

Separation of Ag+ and Ca2+ in a mixture and estimation of Ag+ (gravimetric) and Ca2+ (volumetric) – TLC

Separation of Al3+ and Fe3+ in a mixture and estimation of Al3+ (gravimetric) and Fe3+ (volumetric)

III ANALYSIS OF THREECOMPONENT MIXTURES: Separation of (Fe2+ and Ni2+) from Zinc (Zn2+) in the given mixture and estimation of Fe2+, Ni2+ and Zn2+

Determination of melting point (Melting point apparatus)


1. Jeffery G. H., Bassett J., Mendham J., and Denney R. C.,, Vogel’s Textbook of Quantitative Chemical Analysis, 6th Edition, Pearsons Education, 2004.

2. Kolthoff I. M., and Sandell E. B., Text Book of Qualitative Inorganic Analysis, 3rd Edition, The Macmillan Company; 1956.



SCY5106 CHEMISTRY OF THE MAIN GROUP L T P Credits Total Marks

ELEMENTS 3 0 0 3 100

COURSE OBJECT IVES To know the different kinds of compounds of the main group elements

To know the structure and bonding in inorganic chains, rings, and cages

To synthesize important classes of nonmetal compounds

UNIT 1 CHEMISTRY OF BORANES 9 Hrs.

Structure and bonding in polyhedral boranes and carboranes – Styx notation – Wade’s rule – Electron count in polyhedral boranes – Synthesis of polyhedral boranes – Isolobal analogy – Boron halides – Phosphine-boranes – Boron heterocycles – Borazine.

UNIT 2 CHEMISTRY OF SI, S, P COMPOUNDS 9 Hrs.

Silanes, silicon halides, silicates, silicones, silanols – Silenes, germenes and stannenes – Phosphorous halides, acids and oxyacids of phosphorous, phosphazenes – Sulphur halides, oxo acids of sulpur – Structural features and reactivity of reactivity of S-N heterocycles.

UNIT 3 ORGAMETALLICREAGENTS AND MACROCYCLES 9 Hrs. Synthesis and reactivity of organo-lithium, beryllium and magnesium compounds – Calixarines, cryptands and crown ethers in complexation chemistry.

UNIT 4 ORGANYLS 9 Hrs. Preparation and reactivity of aluminium organyls – Carbalumination, hydroalumination – Chemistry of Ga(I) and In(I) – Reduction of Al, Ga and In organyls – Germanium, tin and lead organyls.

UNIT 5 PROPERTIES OF F-BLOCKELEMENTS 9 Hrs. Lanthanides and Actinides – Contraction, coordination, optical spectra and magnetic properties.

Max. 45 Hours


1. Shriver D. F., Atkins P. W., and Langford C. H., Inorganic Chemistry, Oxford University Press, 1990.

2. Huheey J. E., Keiter E. A., and Keiter R. l., Inorganic Chemistry: Principles of Structure and Reactivity, Pearson Education, 2004.

3. Carey F. A., Wilkinson G., Murillo C. A., and Bochmann M., Advanced Inorganic Chemistry, Wiley Interscience, 2003.

4. Housecroft C. E., and Sharpe A. G., Inorganic Chemistry, Prentice Hall, 2005.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 Exam Duration: 3 Hrs. PART A: 6 Questions of 5 Marks each-No choice 30 Marks

PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks 70 Marks (Out of 80 Marks, maximum of 10% problems may be asked.)



SCY51 07 STEREOCHEMISTRY AND ORGANIC L T P Credits Total Marks PHOTOCHEMISTRY 3 1 0 4 100

COURSE OBJECT IVES To suggest synthetic route for simple organic compounds with stereochemistry To make the students understand and appreciate the concept of stereochemistry and reaction mechanism To know the nature of addition in pericyclic reactions To understand the chemical and photochemical organic reactions UNIT 1 STEREOCHEMISTRY-I 12 Hrs.

Elements of symmetry – Chirality – Representation of organic molecules (Fischer, Sawhorse, Newman and Zig-Zag) and their interconversion. Molecules with more than one chiral centre: Erythro and threo isomers – Enantiotropic and diastereotopic atoms – Groups and faces – Stereospecific synthesis. Optical activity in the absence of chiral carbon – biphenyls, allenes and spiranes. Racemic modifications – Racemisation – Thermal, anion, cation, reversible formation. Resolution of racemic modifications – Epimerisation, mutarotation and asymmetric transformations. Criteria for optical purity. D and L Notation, Cahn- Ingold-Prelog rules – R and S-notations. Absolute and relative configuration. UNIT 2 STEREOCHEMISTRY-II 12 Hrs.

Stereochemistry of the compounds containing nitrogen, sulphur, and phosphorus. Conformational analysis: In acyclic systems – Simple 1,2 disubstituted ethane derivatives. (Sawhorse and Newmann projections), in cyclic systems (cyclobutane, cyclopentane, cyclohexane and cycloheptane) – Disubstituted cyclohexanes, Cis and trans decalins. Topicity of ligands and faces – Nomenclature and prostereoisomerism, sereogenecity, chirogenicity, pseudoasymmetry and prochiral centre. Stereospecific and stereoselective reaction. Asymmetric synthesis – Cram’s rule and its modification – Prelog’s rule. UNIT 3 PERICYCLICREACT IONS 12 Hrs.

Characteristics – Types of pericyclic reactions – electrocyclic, cycloaddition – cycloreversion and sigmatropic reactions – Eamples – 4n and 4n+2 electron type – Stereospecificity. Theories involved in understanding pericyclic reactions. Frontier Molecular Orbital Theory concept – Woodward Hoffmann selection rules for electrocyclic, cycloaddition – Cycloreversion and sigmatropic reactions based on FMO approach. Diels Alder and Retro Diels Alder reaction. Conservation of MOT concept – Framing of Woodward-Hoffmann selection rules for electrocyclic, cycloaddition and cycloreversions based on conservation of MO approach. UNIT 4 ORGANICPHOTOCHEMISTRY-I 12 Hrs.

Organic photochemistry: Molecular orbitals, carbonyl chromophore-triplet states – Frank-Condon principle – Jablonski diagram inter-system crossing. Energy transfer: Energies properties and reaction singlet and triplet states of and transitions.

Photochemical reaction: Photoreduction – Mechanism – Influence of temperature, solvent, nature of hydrogen donars – Structure of substrates on the course of photo reduction. UNIT 5 ORGANICPHOTOCHEMISTRY-II 12 Hrs.

Norrish cleavage type-I: Mechanism – Acyclic cyclicdiones – Influence of sensitizer – Photo Fries rearrangement – Norrish type II cleavage: Mechanism and stereochemistry – Type II reactions of esters: 1:2 diketones, photo Decarboxylation. Photochemistry of unsaturated ketones – Olef in photochemistry (Cis-Trans isomerism) – Cyclic olef ins – Photochemistry of conjugated dienes: Electrocyclisations – Influence of triplet energy of sensitizer – Sensitized and unsensitized electrocyclisations. Electrocyclisations of dienes in crossed sense. Photochemistry of arenes and benzene derivatives. Cycloaddition of benzene to olef ins and dienes.

Max. 60 Hours T EXT / REF ERENCE BOOKS 1. Eliel E. L., Stereochemistry of Carbon Compounds, Tata-McGraw Hill, 2000. 2. Kalsi P. S., Stereochemistry, 3rd Edition, New Age International Publishers, 1995. 3. March J., and Smith M., Advanced Organic Chemistry, 5th Edition, John-Wiley and Sons, 2001. 4. Carey F. A., and Sundberg R. J., Advanced Organic Chemistry Part-A and B, 4th edn, Kluwer

Academic/Plenum Publishers, 2000. 5. Gill G. B., and Wills M. R., Pericyclic Reactions, Chapman Hall, 1974.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 PART A: 6 Questions of 5 Marks each-No choice PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks. (Out of 80

Marks, maximum of 10% problems may be asked.)

ExamDuration: 3 Hrs. 30 Marks 50 Marks



SCY51 08 CHEMICALKINETICS AND SOLID STATE L T P Credits Total Marks CHEMISTRY 3 1 0 4 100

COURSE OBJECT IVES To elucidate the use of chemical kinetics in understanding reaction mechanisms To introduce and give an insight into the fascinating area of solid state chemistry and material science

UNIT 1 ADVANCED CHEMICALKINETICS 12 Hrs. Thermodynamic formulation of activated complex theory, Lindemann – Hinshelwood mechanism of

unimolecular react ions. London- Eyring-Polanyi method of calculation of energy of activation. Application of activated complex theory of reaction rates. Temperature dependence of pre-exponential factor. Thermodynamic aspects of reaction rates. Unimolecular reactions and its validity.

UNIT 2 KINETICS OF FAST REACT IONS 12 Hrs. Fast reactions techniques – Chemical relaxation methods, temperature and pressure jump methods, ultrasonic

absorption technique, reactions in flow system, continuous and stopped flow, Shock tube methods – Chemical kinetics in crossed molecular beams – Flash photolysis – Spin resonance technique in the study of reaction kinetics. UNIT 3 REACTION DYNAMICS 12 Hrs.

Molecular beams: Principle of crossed-molecular beams. Molecular encounters and principal parameters: e .g. Impact parameter, Collision cross-section – Reaction cross-section and relation between reaction cross-section and reaction rate (single velocity). Dependence of collisional cross-section on translational energy. Probing the transition state – Dynamics of barrier less chemical kinetics in solution – Dynamics of unimolecular reactions.

Ion-ion reaction – Ion-dipole reaction and enzyme kinetics (effect of pH and temperature). Lineweaner-Burk plot for the analysis of enzymolysis. Reactions between polar molecules – Kinetic salt – Salt effect.

UNIT 4 CRYSTALSTRUCTURE 12 Hrs. Crystalline and amorphous solids: Crystal systems – Space goups – point groups – Methods of characterizing and

classifying crystal structure – Powder x-ray diffraction – Electron and neutron diffraction – Types of close packing: hcp and ccp, packing efficiency, radius ratios – Polyhedral description of solids – Structure types: NaCl, ZnS, Na2O, CdCl2, wurtzite, nickel arsenide, CsCl, CdI2, Rutile and Cs2O, Perovskite ABO3, K2NiF4, Spinels. UNIT 5 PREPARATIVE METHODS OF SOLIDS 12 Hrs.

Solid state reaction – Chemical precursor method – Co-Precipitation – Sol-gel – Metathesis – Self-propagating high temperature synthesis – Ion exchange reactions – Intercalation / deintercalation reactions – Hydrothermal and template synthesis – Methods of Single Crystal Growth: Czochralski method.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Laidler K. J., Chemical Kinetics, 3rd Edition, Harper International Edition, 1987. 2. Laidler K. J., Theories of Chemical Reaction Rates, McGraw-Hill, 1969. 3. Frost A. A., and Pearson R. G., Kinetics and Mechanism, John Wiley and Sons, 1990. 4. Julian R.H. Ross, Heterogeneous Catalysis: Fundamentals and Applications, Wiley-VCH, 2007. 5. Glasstone S., Laidler K. J., and Eyring H., Theory of Rate Processes, McGraw Hill, 1941. 6. Kalidas C., Chemical Kinetic Methods, New Age International,1996. 7. Bradley J. N., Fast Reactions, Clarendon Press – Oxford, 1975. 8. Wilkinson F., Chemical Kinetics and Reaction Mechanism, Van Nostrand Reinhold Co., 2000. 9. West R., Solid State Chemistry and its Applications, John Wiley & Sons, 1984. 10. Smart L., and Moore E., Solid State Chemistry - An Introduction, Chapman & Hall, 1992. 11. Keer H. V., Principles of the Solid State, Wiley Eastern Limited, 1993. 12. Chakrabarty D. K., Solid State Chemistry, New Age Publishers, 1996.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 PART A: 6 Questions of 5 Marks each-No choice PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks.


Exam Duration: 3 Hrs. 30 Marks 70 Marks



SCY6532 ORGANICCHEMISTRY LAB– I L T P Credits Total Marks 0 0 4 2 100


COURSE OBJECT IVES

To enable the student to develop analytical skill in organic qualitative analysis and to develop preparative skills in organic preparations involving two or three stages.

Systematic identification of compounds containing one or more functional groups.

Systematic identification of mixtures containing two compounds:

Separation and identification simple binary mixtures having acidic, basic and neutral components / by chromatography. Preparation of their derivatives.

TEXT / REF ERENCE BOOKS

1. Gurtu J. N., and Kapoor R., Advanced Experimental Chemistry (Organic), S. Chand and Co., 1987.

2. Vogel’s Textbook of Practical organic chemistry, ELBS/Longman, 1984.



SCY6533 INORGANIC CHEMISTRY LAB– II L T P Credits Total Marks

0 0 4 2 100


COURSE OBJECT IVES

To enable the learners to apply the principle in the semi-micro analysis of an inorganic salt mixture and to prepare the inorganic complexes

To study the principle of distribution of common and rare metal ions in different groups

To improve the skill in synthesis of inorganic compounds Semi-micro qualitative analysis of mixtures containing two common and two rare cations / by AAS

The following are the rare cations to be included:

W, Ti, Se, Ce, Th, Zr, V, U, Li, Mo, Be. Complexometric titrations (EDTA): Estimation of Ca, Mg, Zn

Separation of metals by RO.

Magnetic measurements – Guoy balance

Preparation of the following:

Potassium tris (oxalate) aluminate (III) trihydrate

Tris (thiourea) copper (I) chloride

Potassium tris (oxalato) chromate (III) trihydrate

Sodium bi (thiophosphato) cuprate (I)

Tris (thiourea) copper (I) sulphate Sodium hexanitrocobaltate (III) Chloropentammine cobalt (III) chloride

Bis (acetylacetanato) copper (II) Hexanrinennickel (II) chloride

Bis (thiocyanato) pyridine manganese (II)

Separation of zinc and magnesium by anion exchange method.

T EXT / REF ERENCE BOOKS 1. Jeffery G. H., Bassett J., Mendham J., and Denney R. c., Vogel’s Textbook of Quantitative chemical analysis, 6 th Edition,

Pearsons Education, 2004.

2. Kolthoff I. M., and Sandell E. B., Text Book of Qualitative Inorganic Analysis, 3rd edition, The Macmillan Company; 1956.



L T P Credits Total Marks SCY5201 BIOINORGANIC CHEMISTRY

3 0 0 3 100

COURSE OBJECT IVES To understand the use of inorganic compounds in biological chemistry

To understand the role of organo metallic complexes in enzyme catalysis

UNIT 1 METALIONS INBIOLOGICALSYSTEMS 9 Hrs. Brief survey of metal ions in biological systems – Effect of metal ion concentration and its physiological effects –

Basic principles in the biological selection of elements – Metal storage transport and biomineralisation: Ferritin, transferrin and siderophores – ion transport in membranes – Membrane potential – Na, K balance – Trace metals – Micronutrients.

UNIT 2 TRANSITIONELEMENTSIN BIOLOGY 9 Hrs. Their occurrence and function – Active-site structure and function of metalloproteins and metalloenzymes with

various transition metal ions and ligand systems – O2 binding properties of heme (haemoglobin, myoglobin, hemerythrene and hemocyanine) and non-heme proteins hemocynin & hemerythrin), their coordination geometry and electronic structure – Co-operativity effect – Hill coefficient and Bohr Effect – Characterization of O2 bound species by Raman and infrared spectroscopic methods – Representative synthetic models of heme and non-heme systems.

UNIT 3 METALLOENZYMES 9 Hrs. Zinc enzymes – Carboxy peptidase and carbonic anhydrase – Catalase – Peroxidase. Copper enzymes – Superoxide dismutase – Molybdenum oxatransferase enzymes – Xanthine oxidase

UNIT 4 ELECTRONTRANSFERPROTEINS 9 Hrs. Their active site structure and functions of ferredoxin – Rubridoxin and cytochromes, and their comparisons.

Vitamin B1 2 and cytochrome P4 5 0 and their mechanisms of action – Photosynthesis: Structural aspects of Chlorophyll – Photosystem I and Photosystem II – Nitrogen fixation-nitrogenas – Hydrogenases.

UNIT 5 METALS INMEDICINE 9 Hrs. Therapeutic applications of cis-platin – Natural and man-made radio isotopes and their application (e.g., Tc & I2 ) and MRI agents. Toxicity of metals - Cd, Hg and Cr toxic effects with specific examples.

Max. 45 Hours


1. Housecroft C. E., and Sharpe A. G., Inorganic Chemistry, Prentice Hall, 2005.

2. Lippard S. J., and Berg J. M.,, Principles of Bioinorganic Chemistry, Univ. Science Books, 1994.

3. Kaim W., and Schwederski B., Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life (An introduction and Guide), John Wiley & Sons, 1994.

4. Shriver D. F., Atkins P. W., and Langford C. H., Inorganic Chemistry, Oxford Univ. Press, 1990.

5. Huheey J. E., Keiter E. A., and Keiter R. L., Inorganic Chemistry, Principles of Structure and Reactivity, Pearson Education, 2004.

6. Carey F. A., Wilkinson G., Murillo C. A., and Bochmann M.,, Advanced Inorganic Chemistry, Wiley Interscience, 2003.

END SEMESTEREXAMQUEST IONPAPERPATTERN

Max. Marks: 100 PART A: 6 Questions of 5 Marks each-No choice PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks.





SCY5202 ELECTROCHEMISTRY, INTERFACES AND L T P Credits Total Marks

ORGANIZED ASSEMBLIES 3 1 0 4 100

COURSE OBJECT IVES To study the structure of electrical double layer, electrochemical kinetics, and over potential

To enable the learners to understand the importance and significance of electrochemistry To understanding of basic nomenclature, concepts and tools of colloid and interface science

UNIT 1 ELECT RODICS 12 Hrs. Debye-Hückel theory of ion- ion interaction and activity coefficient – Applicability and limitations of

Debye-Hückel limiting law, its modification for finite -sized ions – Effect of ion-solvent interaction on activity coefficient. Physical significance of activity coefficients – Mean activity coefficient of an electrolyte. Debye-Huckel-Onsager (D-HO) theory of electrolytic conductance – Debye - Falkenhagen effect – Wein effect. D-H-O equation - its applicability and limitations, Pair-wise association of ions (Bjerrum treatment) – Modification of D-H-O theory to account for ion-pair formation – Metal/Electrolyte interface.

UNIT 2 ELECTROKINETICS 12 Hrs. The electrical double layer and zeta potential – Perrin, Gouy-Chapmen and Stern models – Polarisable and

non-polarisable interfaces – Electrokinetic phenomena – Dynamic electrochemistry – Electrode processes and non-equilibrium electrode potential – Over potential – Butler volmer equation – Tafel equation – Current-potential curves – Hydrogen over voltage.. UNIT 3 ELECTROANALYTICALTECHNIQUES 12 Hrs.

Brief introduction and applications of various electrochemical methods: Principle of electrochemical methods such as polarography – Half wave potentials – Applications of polorography chrono amperometry – Cyclic voltammetry – Chrono potentiometry – Coulometry – AC-impedance – Spectro electrochemistry and hydrodynamic methods. Ion selective electrodes: Electrical Properties of membrane – Glass electrode with special reference to H+ ,Na+ , K+ ions – Operation of solid membrane electrode –,Operation of liquid membrane electrode – Coated type ion electrode – Applications of ion selective electrode indetermination of some toxic metals and some anions (F– , Cl– , Br–, I– and NO3– ). UNIT 4 SURFACE INTERFACES 12 Hrs.

Surface and Interfaces: Types of interfaces – Liquid surfaces: Microscopic picture of interfaces – Curved interfaces – Young-Laplace and Kelvin equations – Capillary condensation – Surface tension – Measuring surface tension. Solid-Liquid interfaces: Contact angle and wetting, Gibbs adsorption isotherm. Solid surfaces: External and internal surfaces – Bulk and surface structure of FCC, BCC, and HCP metals – Notation of surface structures – Relaxation and reconstruction of surfaces – Homogeneous and heterogeneous surfaces. Solid-gas interfaces: Types of adsorption – Adsorption isotherms – Langmuir, Tempkin and BET. Determination of surface area of adsorbents – Temperature dependence of adsorption isotherms.

UNIT 5 DISPERSED SYSTEMS 12 Hrs. surfactants in solution – Critical micellation concentration (CMC) – Temperature dependence – Influence of chain

of emulsions – Phase behavior of micro-emulsions. Colloids, Vesicles, lipid bilayer membrane: Structure and length and salt concentration – Srfactant parameter. Emulsion: Macro- and Micro-emulsions – Aging and stabilization Dispersed systems: Types of dispersions – Spontaneous self organization. Surfactants: Structure of

properties – Monolayers – Liquid crystals – Foams and aerosols. Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Glasstone S., “Electro chemistry”, Affiliated East-West Press, Pvt., Ltd., New Delhi, 1974. 2. Bockris J. O. M., and Reddy A. K. N., Modern Electrochemistry 1: Ionics, 2nd Edition, Springer, 1998. 3. Bockris J. O. M., and Reddy A. K. N., Modern Electrochemistry 2B: Electrodics in Chemistry, Engineering, Biology and

Environmental Science, 2nd Edition, Springer, 2001. 4. Bockris J. O. M., Reddy A. K. N., and Gamboa –Aldeco M. E., Modern Electrochemistry 2A: Fundamentals of Electrodics, 2nd

Edition, Springer, 2001. 5. Moroi Y. Micelles: Theoretical and Applied Aspects, Plenum, 1992. 6. Paul C. Hiemenz, Rajagopalan R., Principles of Colloid and Surface Chemistry, 3rd Edition, Marcel Dekker, 1986. 7. Schmickler W., and Henderson D., Progress in Surface Science, 22, 323 (1986).

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100 PART A: 6 Questions of 5 Marks each-No choice PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks





SCY5203 ORGANICREACTION MECHANISM L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECT IVES To understand the mechanism of nucleophilic and electrophilic substitution reactions To appreciate the concept of substitution, addition and elimination reactions and their reaction mechanism

UNIT 1 NAT UREOF BONDINGIN ORGANIC MOLECULES 12 Hrs. Nature of Bonding in Organic Molecules, Delocalized chemical bonding – Conjugation, cross-conjugation, hyper

conjugation and hydrogen bonding. Aromaticity. Benzenoid and nonbenzenoid compounds. Huckel and Craig rules. Application of Huckel’s rule for annulenes, heteroannulenes, fullerenes, Ferrocene, cyclopropenium cation, cyclopentadienyl anion, cycloheptadienyl cation, Homo-and antiaromaticity, Ψ-aromaticity Energy levels of pi molecular orbitals, PMO approach,

UNIT 2 REACTION MECHANISM– REACT IVEINTERMEDIATES 12 Hrs. Types of reactions and mechanism. Generation, structure, stability and reactivity of carbocations, non classical

carbonium ion, carbanions and free radicals. Structure of carbenes, nitrenes and benzynes. Neighbouring group participation. Energy profile diagrams – Intermediate versus transition state – Effect of structure on reactivity – Field effects (inductive, electromeric effects), mesomerism, resonance, steric effects. Methods of determining mechanisms – Labelling and kinetic isotope effects – Hammonds postulate (definition only) – The Hammett equation and linear free energy relationship, substituent and reaction constants, Taft Equation.

UNIT 3 ELECT ROPHILICANDNUCLEOPHILIC ALIPHATIC SUBSTITUTION REACTIONS 12 Hrs. Aliphatic Nucleophilic substitution: Types of nucleophiles – attacking nucleophile, ambident nucleophiles, hard and

soft Nucleophiles. SN1, SN2 and SNi mechanisms. Neighbouring group participation, anchimeric assistance. Nucleophilic substitution at allylic, aliphatic trigonal and vinylic carbon. Nucleophilicity and solvent effects, Competition between nucleophilicity and basicity, leaving group effects, steric substituent effects on substitution.

Aliphatic Electrophilic substitution: Mechanisms - SE2 and SEi, SE1, Substitution by double bond shifts. Effect of substrates, leaving group and solvent polarity on the reactivity.

UNIT 4 ELECT ROPHILICANDNUCLEOPHILIC AROMATIC SUBSTITUTION REACTIONS 12 Hrs. Aromatic Electrophilic Substitution: The arenium ion mechanism, orientation and reactivity, Ortho/para ratio,

ipso attack, orientation in naphthalene ring systems. Diazonium coupling, Vilsmeir reaction, Gattermann-Koch reaction. Aromatic Nucleophilic Substitution: Mechanisms: SNAr, SN1 and Benzyne mechanisms. - Reactivity, Effect of

structure, leaving group and attacking nucleophile. Typical reactions: O and S-nucleophiles, Bucherer reaction and Rosenmund reduction, Von Richter, Sommelet-Hauser and Smiles rearrangements.

UNIT 5 ADDITIONANDELIMINATION REACTIONS 12 Hrs. Addition to C-C Multiple Bond: Mechanism of addition of HX (X=Halo, OH) to alkenes and alkynes.

Regioselective and Chemoselective reactions, Hydroboration, Diel- Alder reaction, 1,3 dipolar addition, Nucleophilic addition to alkenes. Michael Reaction.

Addition to Carbon-Hetero Atoms Multiple Bonds –Nucleophilic addition of carbonyl compounds. Addition - Elimination Reactions of Ketones and Aldehydes, Reactivity of carbonyl compounds towards Addition. Aldol condensation and related reactions.

Elimination Reactions: The El, E1cB and E2 mechanism, Syn elimination, Orientation Effects in Elimination. Reactions, Saytzeff and Hoffman rules, Stereochemistry and Eclipsing Effects in E2 Elimination. Dehydration of Alcohols, Pyrolytic eliminations, Chugaev reaction

Max. 60 Hours T EXT / REF ERENCE BOOKS

1. March J., and Smith M., Advanced Organic Chemistry, 5th Edition, John-Wiley and Sons, 2001. 2. Carey F. A., and Sundberg R.J.,, Advanced Organic Chemistry Part-A and B, 4th Edition, Kluwer Academic/Plenum

Publishers, 2007. 3. Morrison R., and Boyd R., Organic Chemistry, 2nd Edition, Allyn & Bacon, 1967. 4. Bansal R. K., Organic Reaction Mechanism, New Age International Pvt. Ltd. Publishers, 2010. 5. Pine S. H., Organic Chemistry, 5th Edition, McGraw Hill International Edition, 1987.

END SEMESTEREXAMQUEST IONPAPERPATTERN Max. Marks: 100

PART A: 6 Questions of 5 Marks each-No choice PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks





SCY6534 PHYSICALCHEMISTRYLAB- ll L T P Credits Total Marks 0 0 4 2 100


COURSE OBJECT IVES

To know about the practical applications of UV-Visible spectrophotometer

To understand the construction of phase diagrams

To gain practical knowledge in the synthesis of nanomaterials

To learn the use of Ostwald’s viscometer for viscosity determination

I DISTRIBUTION EXPERIMENTS

Determine distribution coefficient of ammonia between chloroform and water Determine the equilibrium constant of the reactionbetween Iodine and potassium iodide by partition method / UV-Visible spectrophotometer

Solvatochromism of a dye based on absorption

II PHASE DIAGRAM

To study the phase diagram for m-toluidine and glycerine system Construction of phase diagram for a simple binary system: naphthalene – phenanathrene and benzophenonediphenyl amine

Construction of the phase diagram of the threecomponent of partially immiscible liquid system (DMSOwaterbenzene; acetone –chloroform-water;chloroform-acetic acid-water)

III VISCOSITYEXPERIMENTS Determine the viscosity of methyl acetate and ethyl acetate using Ostwald viscometer

Study the variation of viscosity with concentration for a glycerol solution using Ostwald viscometer and thereafter determine the concentration of unknown solutionof glycerolDetermination of molar mass of a polymer

IV NANOPARTICLESSYNTHESIS

Nanoparticles synthesis and separation by centrifugation


1. Garland, Nibler and Shoemaker, Experiments in Physical Chemistry, 7th Edition, McGraw-Hill, 2003.

2. Jahagirdan D. V., Experiments in Chemistry, Himalaya publishers House, 2003.



SCY6535 ORGANICCHEMISTRY LAB– II L T P Credits Total Marks 0 0 4 2 100

The list of probable experiments is mentioned below, which delineates the experiment to be performed in a semester. Any seven experiments can be selected from the list..

COURSE OBJECT IVES

To enable to students to understand the mechanism involved in conditions of the reactions involving the preparations

To enable the student to develop analytical skill in organic quantitative analysis

To appreciate and apply the techniques involved in the estimation of substances.

To familiarize the interpretation of spectra provided.

PREPARATIONOF ORGANIC COMPOUNDS INVOLVINGTWOSTAGES.

Nitration

Halogenation

Diazotization

Rearrangement Oxidation

ESTIMATION OF SIMPLE ORGANIC COMPOUNDS (FLUORESCENCE TITRATION METHOD MAY ALSO BE INCLUDED)

Phenol and aniline

Ketones (ethyl methyl ketone) Sugars (Glucose)

Ascorbic acid (Vitamin C tablets)

Amino groups (aniline)

Nitro groups (aromatic nitro compounds) Amino acids (glycine)

IDENTIFICATION OF ORGANICCOMPOUNDSBY THEANALYSISOF SPECTRALDATA x

UV, IR, PMR, CMR and MS

THINLAYERCHROMATOGRAPHY (DEMONSTRATIONONLY)

Separation and identification of the organic compounds and determination of Rf values


1. Gurtu J. N., and Kapoor R., Advanced Experimental Chemistry (Organic), S. Chand and Co., 1987.

2. Vogel’s Textbook of Practical organic chemistry, ELBS/Longman, England, 1984.



SCY5601 SURFACE CHEMISTRY AND L T P Credits Total Marks CATALYSIS 3 1 0 4 100

COURSE OBJECT IVES To get themselves exposed to kinetic mechanism and familiar with the concepts of catalysis x To study enzyme catalysis and kinetics of complex reactions

UNIT 1 ADSORPTION ISOTHERMS 12 Hrs. Introduction – adsorption of gases on solids – physisorption and chemisorptions – adsorption isotherms –

Freundlich – Gibbs adsorption equation, Langmuir adsorption isotherm and its kinetic derivation for non- dissociative and dissociative adsorption, BET adsorption isotherm, its kinetic derivation and applications.

UNIT 2 COLLOIDS 12 Hrs. Definition of colloid, classification of colloids Sols, Lyophilic and lyophobic sols, properties of sols-– kinetic,

optical and electrical: stability of colloids, protective action Hardy-Schulze law, gold number, coagulation. Sols of surface active reagents, surface tension and surfactants, critical micelle concentration. Liquids in solids (gels): classification, preparation and properties, inhibition, general application of colloids

UNIT 3 MACROMOLECULES 12 Hrs.

Macromolecu les: Mechanism of polymerization, molecular weight of a polymer (Number and mass average) viscosity average molecular weight,numerical problems. Degree of polymerization and molecular weight, methods of determining molecular weights (Osmometry, viscometry, light scattering, diffusion and ultracentrifugation)

UNIT 4 HETEROGENEOUSCATALYSIS AND HOMOGENEOUSCATALYSIS 12 Hrs. Heterogeneous catalysis, surface heterogeneity, surface catalyzed unimolecular and bimolecular reactions,

temporary and permanent catalytic poisons, activation energy for surface reactions. General introduction to Homogeneous catalysis: Homogeneous catalytic hydrogenation, Zeigler-Natta polymerization of olefins - catalytic reactions involving carbon monoxide such as hydrocarbonylation of olefins (oxo reaction) - Comparison of homogeneous and heterogeneous catalysis

UNIT 5 GENERALCATALYTIC MECHANISM 12 Hrs. General catalytic mechanisms. Equilibrium and steady state treatments - Mechanisms of reactions on Surfaces (Langmuir, Rideal and Langmuir-Hinshelwood mechanisms) - Comparisons

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Chorkendorff I., and Niemantsverdriet J., Concepts of Modern Catalysis and Kinetics, Wiley-VCH, 2007.

2. Laidler K. J., Chemical Kinetics, 3rd Edition, Harper International Edition, 1987. 3. Atkins P. W., Physical Chemistry, Oxford University Press, 1978.

4. Adamson A. W., Physical Chemistry of Surfaces, 5th Edition, John Wiley & Sons, 1990.





SCY5602 COMPUTATI ONAL L T P Credits Total Marks

CHEMISTRY 3 1 0 4 100

COURSE OBJECT IVES

To understand the basic concepts of computational chemistry

To enable the students to understand the use of computer applications in chemistry x To familiarize the density functional theory and molecular dynamics

UNIT 1 INTRODUCTION TOCOMPUTATIONALCHEMISTRY 12 Hrs.

Basic concepts on computational chemistry-Potential energy surface: stationary point, transition state or saddle point, local and global minima-Modeling of polysaccharides and polypeptides- molecular visualization and graphics.

UNIT 2 MOLECULAR MECHANICS 12 Hrs. Force fields-bond stretching, angle bending, torsional terms, intermolecular interactions: non-bonded

interactions- electrostatic interactions- origin and modeling of dispersion forces & hydrogen bonds, strengths, weaknesses- Applications of various types of force-fields. Application of QM method in organic, inorganic and systems including bio molecules.

UNIT 3 DENSITYFUNCTIONALTHEORYAND MONTECARLOSIMULATIONS 12 Hrs.

Introduction to Density functional theory and Monte Carlo Simulations-Comparison of molecular mechanics, ab

initio, semi-empirical and DFT methods-Important features of commonly used force fields like MM3, MMFF, AMBER and CHARMM.

UNIT 4 MOLECULAR DYNAMICS 12 Hrs. Molecular Dynamics-Introduction and applications- Classical Molecular Dynamics- constrained dynamics,

Newtonian equations of motions- Periodic boundary conditions- Dynamical properties of complex systems. MD at constant temperature and pressure, solvent effects.

UNIT 5 CHEMINFORMATICS 12 Hrs.

Introduction to Chemical databases- CHEM DB- PUBCHEM- CAS- Cambridge structural Database-Various chemical notations- Database searching of chemical compounds- Solid phase Synthesis of Peptides- Combinatorial chemistry- Combinatorial library- Chemical data management.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Lewars E., Computational Chemistry, Springer, 2003.

2. Balagurusamy E., Numerical Methods, Tata McGraw-Hill Publishing Company Limited, 2002.

3. Leach A. R., Molecular Modeling: Principles and Applications, 2n d Edition, Pearson Prentice Hall, 2001.





FACULTYOF SCIENCEANDHUMANITIES

SCY5603

SPECTROSCOPY: APPLICATIONS IN INORGANIC

L T P Credits Total Marks


COURSE OBJECT IVES To enable the students in-depth study of spectral applications to the structural elucidation of inorganic compounds

To learn the applications of spectroscopy for the study and structural elucidation of molecules

To apply the principles of mass, UV-Visible, IR, NMR, ESR, NQR spectroscopy through simple problems

UNIT 1 MAGNET IC RESONANCE SPECTROSCOPY-I 12 Hrs. NMR phenomenon, spin ½ nuclei, (1H, 1 3C, 3 1P and 19F) - 1H NMR, Zeeman splitting, effect of magnetic field

strength on sensitivity and resolution - Chemical shift d, inductive and anisotropic effects on d, chemical structure correlations of d - Chemical and magnetic equivalence of spins, spin-spin coupling - structural correlation to coupling constant J, first order patterns.

UNIT 2 MAGNET IC RESONANCE SPECTROSCOPY-II 12 Hrs.

Second order effects, examples of AB, AX and ABX systems - Simplification of second order spectrum - Selective decoupling, use of chemical shift reagents for stereochemical assignments - Study of dynamic processes by VT NMR - Multinuclear NMR of B, Al, Si, F and P nuclei - Structure and dynamics of representative inorganic molecules - Deriving activation and thermodynamic parameters - Application of NMR to magnetism and magnetic susceptibility measurements of paramagnetic metal complexes.

UNIT 3 EPR AND ELECT RONIC SPECTROSCOPY 12 Hrs.

Electron paramagnetic resonance (EPR) spectroscopy of inorganic compounds with unpaired electrons - Determination of electronic structure - Zeeman splitting, g-values, hyperfine and super hyperfine coupling constants - Practical considerations of measurements, and instrumentation - Electronic spectroscopy basic principle - Electronic transitions in inorganic, organometallic molecules and application to structure elucidation.

UNIT 4 INFRARED AND RAMAN SPECTROSCOPY 12 Hrs.

Application to simple inorganic molecules - Predicting number of active modes of vibrations - Analysis of representative spectra of metal complexes with various functional groups at the coordination sites - Application of isotopic substitution.

UNIT 5 MOSSBAUER SPECTROSCOPY 12 Hrs.

Mossbauer effect - Recoilless emission and absorption - Hyperfine interaction, chemical isomer shift, magnetic hyperfine and quadrupole interaction and interpretation of spectra - Applications to iron and tin compounds - Introduction to NQR, principle, quadrupole moment and electrical field - Nuclear quadrupole resonance, nuclear quadrupole coupling in atoms and molecules, identification of ionic character and hybridization - Applications.

Max. 60 Hours T EXT / REF ERENCE BOOKS

1. Abragam A., and Bleaney B., Electron Paramagnetic Resonance of Transition Metal ions, Oxford University Press, 1970.

2. Drago R. S., Physical Methods for Chemists, Saunders College Publishers, 1992.

3. Banwell C. N., and McCash E. M., Fundamentals of Molecular Spectroscopy, 4th Edition, McGraw-Hill, 1994.

4. Gunther H., NMR Spectroscopy, 2nd Edition, John Wiley and Sons, 1995.



PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks. 70 Marks (Out of 80 Marks, maximum of 10% problems may be asked.)


SCY5604 ORGANOMETALLIC L T P Credits Total Marks


COURSE OBJECT IVES

To have an insight into study of coordination compounds and their reactions

To understand the role of organo metallic complexes in catalysis process

To know the application potential of organometallic compounds in catalysis

To interpret given IR spectra of metal carbonyls

UNIT 1 ORGANOMETALLIC COMPOUNDS 12 Hrs.

EAN Rule - Valence electron count (1 6/18 electron rules) - Structure and bonding in mono and polynuclear metal carbonyls - Substituted metal carbonyls and related compounds - Synthesis and reactivity of metal carbonyls; dinitrogen and dioxygen as ligands in organometallic compounds.

UNIT 2 SYNTHESIS OF ORGANOMETALLIC COMPOUNDS 12 Hrs. Types of M-C bonds; synthesis and reactivity of metal alkyls, carbenes, alkenes, alkynes, and arene complexes - Metallocenes and bent metallocenes - Isolobal analogy.

UNIT 3 REACTIONS OF ORGANOMETALLICCOMPLEXES 12 Hrs. Ligand dissociation and substitution - Oxidative addition - Reductive elimination - Nucleophilic displacement – Insertion - Alkyl migration - 1,2 insertion - Hydride elimination - Abstraction.

UNIT 4 ORGANOMETALLIC CATALYSTS 12 Hrs.

Catalytic Deuteration - Homogeneous catalysis – Hydroformylation - Monsanto acetic acid process - Hydrogenation by Wilkinson’s catalyst - Wacker (Smidt) process - Olefin metathesis - Heterogeneous catalysts – Zieglar Natta polymerization - Water gas reaction.

UNIT 5 SPECTRALANALYSIS ANDCHARACTERIZATION 12 Hrs. Infrared spectra of metal carbonyls - NMR – 1H, 1 3C - characterization with examples.

Max. 60 Hours


1. Mehrotra R. C., and Singh A., Organometallic Chemistry: A Unified Approach, New Age International, 2006.

2. Gupta B. D., and Anil J. Elias, Basic Organometallic Chemistry:Concepts, Syntheses and Applications of Transition metals, CRC Press, 2010.


Max. Marks: 100 Exam Duration: 3 Hrs. PART A: 6 Questions of 5 Marks each-No choice 30 Marks

PART B: 2 Questions from each unit of internal choice, each carrying 14 Marks. 70 Marks ( Out of 80 Marks, maximum of 10% problems may be asked.)


SCY5605 CHEMISTRY OF NATURAL L T P Credits Total Marks

PRODUCTS 3 1 0 4 100

COURSE OBJECT IVES To know modern synthetic methods and synthetic strategies of natural products To enable the student to understand and appreciate the importance of heterocyclic compounds To understand the techniques involved in the extraction and methods of determination of structure of alkaloids and terpenes To understand and appreciate the steroid chemistry and its importance in the living systems

UNIT 1 ALKALOIDS 12 Hrs.

Definition - Nomenclature and physiological action– Occurrence – Isolation - General methods of structure determination elucidation, degradation, classification based on nitrogen heterocyclic ring, role of alkaloids of in plants. General methods used for structural determination of alkaloids. Structural elucidation, stereochemistry and total synthesis of i) Atropine ii) Quinine iii) Morphine.

UNIT 2 TERPENOIDS - CAROTENOIDS 12 Hrs. Classification – Nomenclature – Occurrence – Isolation - General methods of structure determination - Isoprene

rule. Structure determination, stereochemistry, synthesis of the following representative molecules: Citral, Geraniol, α-Terpeneol, Santonin, Abietic acid and β-Carotene.

UNIT 3 STEROIDS 12 Hrs.

Occurrence, nomenclature, basic skeleton, Diel’s hydrocarbon and stereochemistry. Isolation, structure determination and synthesis of cholesterol, bile acids, androsterone, testosterone, estrone, progesterone, aldosterone.

UNIT 4 CARBOHYDRATES 12 Hrs. Occurrence and classification of carbohydrates. Mutarotation and Epimerisation. Structural elucidation of

sucrose. Structural features and stereochemistry of sucrose, lactose, cellobiose and maltose. Structural features and biological importance of starch, cellulose and chitin.

UNIT 5 CHEMISTRY OF HETEROCYCLIC COMPOUNDS 12 Hrs. Synthesis, reactivity, aromatic character and importance of the following heterocycles: furan, thiophene, pyrrole, pyridine, quinolone, isoquinoline – Skraup synthesis – Fischer-Indole synthesis.

Max. 60 Hours T

EXT / REF ERENCE BOOKS

1..Agarwal O. P., Chemistry of Organic Natural Products, Vol. 1, Goel Publishing House, 1997.

2. Agarwal O. P., Chemistry of Organic Natural Products, Vol. 2, Goel Publishing House, 1997.

3. Finar L., Organic Chemistry, Vol.2, 5t h Edition, Pearson Education Asia, 1975

4. Pelletier, Chemistry of alkaloids, Van Nostrand Reinhold Co, 2000 5. Jain J. L., Jain S., and Jain N., Fundamentals of Biochemistry, S. Chand, 2007






SCY5606 ADVANCEDORGANIC L T P Credits Total Marks

SYNTHESIS 3 1 0 4 100

COURSE OBJECT IVES To apply the knowledge of chemical reactions in organic synthesis To enable the students to understand better concepts of organic analysis and the applications of organic chemistry towards chemical, industrial and biological systems

UNIT 1 DISCONNECT ION APPROACH ORRET ROSYNTHETICANALYSIS 12 Hrs. An introduction to synthons and synthetic equivalents - Disconnection approach - Functional group inter-

conversions - The importance of the order of events in organic synthesis: one group C -X and two group C-X disconnections - Chemoselectivity, reversal of polarity, cyclisation reactions, amone synthesis.

UNIT 2 PROTECTINGGROUPS Principle of protection of alcohols, amines, carbonyl and carboxyl groups.

12 Hrs.

UNIT 3 ONE GROUP/TWOGROUP C-CDISCONNECT IONS 12 Hrs. Alcohols and carbonyl compounds – Regioselectivity - Alkene synthesis - Use of acetylenes and aliphatic nitro

compounds in organic synthesis. Diels-Alder reaction, 1 ,3-difunctionalised compounds, α,β-unsaturated carbonyl compounds, control in carbonyl condensations, 1 ,5-difunctionalized compounds. Michael addition and Robinson annealation.

UNIT 4 SYNTHESIS OF RINGCOMPOUNDS 12 Hrs. Saturated heterocycles, synthesis of 3-,4-, 5- and 6-membered rings, aromatic heterocycles in organic synthesis.

UNIT 5 SYNTHESIS OF SOME COMPLEX ORGANIC MOLECULES 12 Hrs. Application of the above in the synthesis of the following compounds: Camphor, Longifoline, Cortisone, Reserpine, vitamin D, Juvabione

Max. 60 Hours


1. Smith M. B., Organic synthesis, McGraw Hill International Edition 1994.

2. House H. O., Modern Synthetic reactions, W.A. Benjamin Inc, 1972.

3. Ireland R. E., Organic synthesis, Prentice Hall India, Goel Publishing House, 1990.

4. Carruthers W, Modern methods of organic synthesis, Cambridge University Press, 1993.

5. Norman R.O.C., Organic synthesis, Chapman Hall, 1980.

6. March J., and Smith M., Advanced Organic Chemistry, 5th Edition, John -Wiley and Sons, 2001.

7. Carey F. A., and Sundberg R. J., Advanced Organic Chemistry: Part-A and PART B, 4th Edition, Kluwer Academic/Plenum Publishers, 2000.


Max. Marks: 100 Exam Duration: 3 Hrs.





SCY5607 ADVANCEDQUANTUM L T P Credits Total Marks CHEMISTRY 3 1 0 4 100

COURSE OBJECT IVES To become familiar with the required mathematics for solving quantum mechanical problems To understand and appreciate the quantum mechanical approach to the atomic and molecular electronic structure

UNIT 1 APPROXIMATION METHODS– I 12 Hrs. Many-body problem - Need for approximation methods: Independent particle model - Variation method including

theorem with proof – Illustration with x(a-x) as trial function for a particle in 1 D- box, using e-ar for H atom, Variation treatment for ground state of He atom

Perturbation method: Time-dependent perturbation method (non-degenerate case only) - First order correction to energy minimization – Qualitative treatment to Hellmann-Feynmann theorem.

UNIT 2 APPROXIMATION METHODS– II 12 Hrs. Hartree-Self-Consistent Field Method - Spin orbitals for many electron case - Symmetric and anti-symmetric

wave functions - Pauli exclusion principle - Hund’s rule - Slater determinan - Quantum mechanical treatment of HFSCF method - Briillouin condition and Koopmann’s theorem - Non-orthogonal basis and Roothan’s concept of basis function - Slater type orbitals - Gaussian type orbitals

Schrodinger equation for molecules - Born-Oppenheimer approximation - Singlet and triplet state functions of H2 (spin orbitals) - Electron correlation.

UNIT 3 MOLECULAR ORBITALTHEORY– I 12 Hrs. Molecular orbital for H2 + ion - MO theory for H2 molecule - MO for Li2, N2, O2, F2 - Hetero-diatomic molecule LiH, CO, NO, HF– Bond order - Correlation diagram - Spectroscopic symbols.

UNIT 4 MOLECULAR ORBITALTHEORY–II 12 Hrs. Hybridisation – Quantum mechanicsl treatment of sp, sp2, sp3 hybridisation- Semi-emperical MO treatment of

planar conjugated molecules, Huckel MO theory of ethane, allyl system, butadiene, benzene, calculation of charge distribution.

UNIT 5 APPLICATIONTOSIMPLE CHEMICALSYSTEMS 12 Hrs. Importance in chemical bonding – Construction of hybrid orbitals of BF3, CH4, PCl5 as example, Transformation

of atomic orbitals, Symmetry Adapted Linear Combination (SALC) of orbitals with respect to C2v, C2h, C3, C3v, D3h point groups, MO diagram for H2O, NH3.

Max. 60 Hours T EXT / REF ERENCE BOOKS 1. Levine I. N., Quantum Chemistry, 6th Edition, Pearson Education Inc., 2009. 2. Atkins. P. W and Friedman R. S., Molecular Quantum Mechanics, 4th Edition, Oxford University Press, 2005. 3. McQuarrie D. A., Quantum Chemistry, University Science Books, 2008. 4. Lowe J. P and Peterson K., Quantum Chemistry, 3rd Edition, Academic Press, 2006. 5. Anatharaman R., Fundamentals of Quantum Chemistry, Macmillan India, 2001. 6. Prasad R. K., Quantum Chemistry, 3rd Edition, New Age International, 2006. 7. Engel T., Quantum Chemistry and Spectroscopy, Pearson Education, 2006. 8. Metiu H., Physical Chemistry:Quantum Mechanics, Taylor & Francis, 2006. 9. Pauling L and. Wilson E. B, Introduction to Quantum Mechanics, McGraw-Hill, 1935. 10. Pathania M. S., Quantum Chemistry and Spectroscopy (Problems & Solutions), Vishal Publications, 1984. 11. Cotton F. A., Chemical Applications of Group Theory, 3rd Edition, Wiley Eastern, 1990. 12. Hall L. H., Group Theory and Symmetry in Chemistry, McGraw Hill, 1969. 13. Ramakrishnan V and Gopinathan M. S., Group Theory in Chemistry, Vishal Publications, 1992.







SCY5608 CORROSIONAND ITS L T P Credits Total Marks PREVENT ION 3 1 0 4 100

COURSE OBJECT IVES To learn the basic electrochemical aspects to understand corrosion science and its controlling methods

To understand the importance of structural metals and its alloys, to prevent the corrosion and save their life

UNIT 1 CORROSIONPRINCIPLES 12 Hrs. Introduction – Corrosion rate expressions – Electrochemical aspects – Anode and Cathode reactions – Type of electrochemical corrosion – EMF and Galvanic series

UNIT 2 MODERN THEORY 12 Hrs.

Introduction – Applications of thermodynamics to corrosion – Electro kinetics – Polarization – Activation polarization – Concentration polarization – Over voltage – Exchange current density – Corrosion rate measurements – Tafel extrapolation.

UNIT 3 DIFFERENT FORMS OF CORROSION 12 Hrs. Uniform Corrosion – Galvanic corrosion – Selective leaching – Dezincification – Graphitisation – Stress corrosion cracking – Microbiologically induced corrosion – Passivity – Pitting, crevice, sensitizaiton.

UNIT 4 CORROSIONPREVENT ION 12 Hrs. Material selection – Inhibitors – Cathodic and anodic protection stray current effects – coatings – metallic coatings – Organic and polymer coatings – Phosphating

UNIT 5 CORROSIONTEST ING 12 Hrs. NACE test methods – OCP – Time measurements – Cyclic polarization – Tafel plot for aluminum alloys – Linear

polarisaiton – Potentiostatic steady state experiments – Small – Amplitude Cyclic Voltammetry (SACV) – AC impedance methods – Slow strain rate test.

Max. 60 Hours


1. Fontana M. G., Corrosion Engineering, 3rd Edition, Tata McGraw-Hill, 2008.

2. Uhlig H. H., The corrosion Hand Book, 3rd Edition, John Wiley & Sons. Inc., 2011.

3. Raj Narayan, An Introduction to Metallic Corrosion and its Prevention, Oxford and IBH Pub. Co., 1983.

4. Trabanelli G., and Carassiti, Advances in Corrosion Science and Technology: Vol.1, Plenum Press, 1970.

5. Putilova, Balezin, and Barannik, Metallic Corrosion Inhibitors, Pergamon Press, 1960.

6. Bard A. J., and Faulkner L. R., Electrochemical Methods: Fundamentals and Applications, 2nd Edition, John Wiley & Sons, 2000.

7. Mac Donald D. D., Transient Techniques in Electrochemistry, Plenum Press, 1977.







SCY5609 CHEMISTRY OF MATERIALS L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECT IVES To become familiar with the fundamentals of nanoscience and technology To know the various synthetic methods and characterization of 0D, 1 D, 2D and 3D nanomaterials To expose the students for the various applications of nanomaterials

UNIT 1 INTRODUCTION TONANOMATERIALS 12 Hrs. 0D, 1 D, 2D structures – Size Effects – Fraction of Surface Atoms – specific Surface Energy and Surface Stress

– Effect on the Lattice Parameter – Phonon Density of States – the General Methods available for the Synthesis of Nanostrutures – precipitative – reactive – hydrothermal/solvothermal methods – suitability of such methods for scaling – potential Uses.

UNIT 2 SYNTHESIS OF NANOMATERIALS Bulk synthesis-sol gel processing – Mechanical alloying and mechanical milling – Inert gas condensation techniques –

Chemical approaches – Biomimetic Approaches – Electrochemical Approaches – Physical approaches.

UNIT 3 CHARACTERIZATION OF NANOMATERIALS 12 Hrs. X-Ray Diffraction – Thermal analysis methods – Qualitative and Quantitative Analysis – Spectroscopic Techniques – Nanoindentation.

UNIT 4 IMAGINGTECHNIQUES 12 Hrs. Optical microscopy – Scanning electron microscopy – Transmission electron microscopy – Atomic force microscopy – Scanning tunneling microscopy.

UNIT 5 APPLICATIONS 12 Hrs. Molecular Electronics and Nanoelectronics – Nanobots- Biological Applications – Quantum Devices –

Nanomechanics – Carbon Nanotube – Photonics- Nano structures as single electron transistor –principle and design, pharmaceutical applications, semiconductor nanodevices,

Max. Hours:60

T EXT / REF ERENCE BOOKS 1. Goldstein D. E., Newbury D.C. Joy and Lym C.E., Scanning Electron Microscopy and X-ray Microanalysis, Springer

Publications, 2003. 2. Flegler S.L., Heckman J.W and Klomparens K.L., Scanning and Transmission Electron Microscopy: A Introduction, WH

Freeman & Co, 1993. 3. Goodhew P.J., Humphreys J and Beanland R., Electron Microscopy and Analysis, 3rd Edition, Taylor & Francis, London, 2001. 4. Haynes R., Woodruff D. P and Talchar T. A., Optical Microscopy of Materials, Cambridge University Press, 1986. 5. Cullity B. D., Elements of X-ray Diffraction, 4th Edition, Addison Wiley, 1978. 6. Loretto M. H., Electron Beam Analysis of Materials, Chapman and Hall, 1984. 7. Rose R. M., Shepard L. A and Wulff J., The Structure and Properties of Materials, Wiley Eastern Ltd, 1968. 8. Mott B. W., Micro-Indentation Hardness Testing, Butterworths, London, 1956.

9. Gaponenko S. P., Optical Properties of semiconductor nanocrystals, Cambridge University Press, 1980. 10. Gaddand W., Brenner D., Lysherski S and Infrate G.J., (Eds.), Handbook of NanoScience, Engg. and Technology, CRC Press,

2002. 11. Barriham K and Vvedensky D. D., Low dimensional semiconductor structures: fundamental and device applications,

Cambridge University Press, 2001. 12. Cao G., Nanostructures & Nanomaterials: Synthesis, Properties &Applications, Imperial College Press, 2004. 13. George J., Preparation of Thin Films, Marcel Dekker, Inc., New York, 1992






SCY561 0 SUPRAMOLECULAR L T P Credits Total Marks CHEMISTRY 3 1 0 4 100

COURSE OBJECT IVES To understand the importance of coordination compounds in the emerging field of supramolecular chemistry

To understand the chemistry behind self assembly and molecular devices

UNIT 1 SUPRAMOLECULAR INTERACTIONS 12 Hrs. Definition - Nature of binding interactions in supramolecular structures - ion-ion, ion-dipole, dipole-dipole, H - bonding, cation-pi, anion-pi, pi-pi, and van der Waals interactions.

UNIT 2 SYNTHESIS AND STRUCTURE 12 Hrs.

Synthesis and structure of crown ethers, lariat ethers, podands, cryptands, spherands, calixarenes, cyclodextrins, cyclophanes, cryptophanes, carcerands and hemicarcerands - Host-Guest interactions, pre-organization and complimentarity, lock and key Analogy - Binding of cationic, anionic, ion pair and neutral guest molecules.

UNIT 3 CRYSTALENGINEERING Crystal engineering - Role of H-bonding and other weak interactions.

12 Hrs.

UNIT 4 SELF ASSEMBLY 12 Hrs. Design, synthesis and properties of the molecules - Self assembling by H-bonding, metal-ligand interactions

and other weak interactions - Metallomacrocycles, catenanes, rotaxanes, helicates and knots.

UNIT 5 MOLECULAR DEVICES 12 Hrs. Molecular electronic devices: Molecular wires, molecular rectifiers, molecular switches, molecular logic -

Relevance of supramolecular chemistry to mimic biological systems - Cyclodextrins as enzyme mimics, ion channel mimics, supramolecular catalysis etc. - Examples of recent developments in supramolecular chemistry from current literature.

Max. 60 Hours


1. Lehn J. M., Supramolecular Chemistry-Concepts and Perspectives, Wiley-VCH, 1995.

2. Beer P. D., Gale P. A and Smith D. K., Supramolecular Chemistry, Oxford University Press, 1999.

3. Steed J. W and Atwood J. L., Supramolecular Chemistry, Wiley, 2000.







SCY5611 INDUSTRIAL CHEMISTRY L T P Credits Total Marks

3 1 0 4 100

COURSE OBJECT IVES To understand the principles of chemistry in laboratory level and plant level To understand the manufacturing methods of various inorganic and organic chemicals and their risk analysis

UNIT 1 PRINCIPLESOF CHEMICALTECHNOLOGY 12 Hrs. Introduction: Basic principles – importance – classification – designing and modeling of chemical plants. Basic

requirements of industrial reactors – choice and selectivity of reactor – basic principles of homogeneous and heterogeneous processes and reactors with examples.

UNIT 2 INDUSTRIALASPECTSOF PHYSICALCHEMISTRY 12 Hrs. Flow diagram for material balance - Simple material balance for chemical engineering operations such as

distillation or absorption etc. Energy Balance: Heat capacity of pure gases and gaseous mixtures at constant pressures, sensible heat changes in fluids.

UNIT 3 UNIT OPERATIONS IN CHEMICALINDUSTRY 12 Hrs. Distillation: Introduction, batch and continuous distillation, separation of azeotropes, plate columns and packed

columns. Absorption: Introduction, equipments, packed columns, spray columns, bubble columns, mechanically agitated contactors. Evaporation: Introduction, equipments, short tube evaporator, forced circulation evaporators, falling film evaporators, wiped (agitated) film evaporators. Filtration: Introduction, equipments, plate and frame filter press, Nutch filter, rotary drum filter, sparkler filter, candle filter, Bag filter. Drying: Introduction, free moisture, bound moisture, drying curve, equipments - tray dryer, rotary dryer, flash dryer, fluid bed dryer, drum dryer, spray dryer.

UNIT 4 UNIT PROCESSES IN ORGANIC CHEMICALS MANUFACTURE 12 Hrs. Nitration: Introduction, nitrating agents, mechanism and nitration of paraffin hydrocarbons. Halogenation:

Introduction, reagents for halogenations, halogenations of aromatics. Sulphonation: Introduction, sulphonating agents, sulphonation of benzene. Oxidation: Introduction, types of oxidation reactions, oxidizing agents, commercial manufacture of benzoic acid. Hydrogenation: Introduction, catalysts for hydrogenation reactions, hydrogenation of vegetable oil. Alkylation: Introduction, types of alkylation, manufacture of phenyl ethyl alcohol. Esterification: Introduction, esterification by organic acids, by addition of unsaturated compounds, commercial manufacture of ethyl acetate.

UNIT 5 INDUSTRIALPOLLUTION 12 Hrs. Pollutants and their statutory limits, pollution evaluation methods. Air pollution – various pollutants, Water

pollution – organic/inorganic pollutants, Noise pollution, Pesticide pollution, Radiation pollution and Green House Effect.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Mukhlyonov I., (ed.), Chemical Technology, Vol.1, 3rd Edition, Mir publication, Moscow, 1979. 2. De A. K., Environmental Chemistry, 11th Edition, Wiley Eastern Ltd., Meerut 1989.

3. Sharma B. K., Industrial chemistry, Goel publishing house, 2011. 4. Norris Shreve R and Brink J. A., Jr. Chemical Process Industries. 4th Edition, McGraw Hill, Tokyo, 1977. 5. Chakrabarty B. N., Industrial Chemistry, Oxford & IBH Publishing Co., New Delhi, 1981.

6. Singh P. P., Joseph T. M and Dhavale R. G., College Industrial Chemistry, 4th Edition, Himalaya Publishing House, Bombay, 1983.







SCY561 2 PHYSICAL ORGANIC L T P Credits Total Marks


COURSE OBJECT IVES To know the application of spectroscopy to study the structure of molecules To interpret given spectra to elucidate the structures of molecules To apply the principles of mass, UV-Visible, IR, NMR spectroscopy through simple problems

UNIT 1 UV-VIS SPECTROSCOPY 12 Hrs. Various electronic transitions (1 85-800 nm) - Beer-Lambert law - Effect of solvent on electronic transitions,

ultraviolet bands for carbonyl compounds, unsaturated carbonyl compounds, dienes, conjugated polyenes. Fieser-Woodward rules for conjugated dienes and carbonyl compounds, ultraviolet spectra of aromatic and heterocyclic compounds. Steric effect in biphenyls. Optical Rotation, Optical Rotatory Dispersion, Cotton effect, Circular Dichroismand Octant rule

UNIT 2 IRSPECTROSCOPY 12 Hrs. Principles of IR spectra - Characteristic vibrational frequencies of alkanes, alkenes, alkynes, aromatic

compounds, alcohols, ethers, phenols and amines. Detailed study of vibrational frequencies of carbonyl compounds (ketones, aldehydes, esters, amides, acids, anhydrides, lactones, lactams and conjugated carbonyl compounds). Effect of hydrogen bonding and solvent effect on vibrational frequencies.

UNIT 3 1H NMRAND 13CSPECTROSCOPY 12 Hrs. General introduction and definition - Chemical shift, spin-spin interaction, shielding mechanism, mechanism of

measurement, chemical shift values and correlation for protons bonded to carbon complex spin-spin interaction between two, three, four and five nuclei (first order spectra), spin system-Pople notation, virtual coupling. Hindered rotation, Karplus curve - variation of coupling constant with dihedral angle. Fourier transform technique. Further tools for simplification (chemical and instrumental) and elucidation of structures by NMR.

Carbon-13 NMR Spectroscopy – General considerations, chemical shift - coupling constants. nuclear overhauser effect (NOE).

UNIT 4 MASSSPECTROMETRY 12 Hrs. Principle of Mass spectra - Representation of Mass spectrum, Molecular ion – types of ions in mass spectra.

Effect of isotopes on mass spectra – Determination of molecular formula – McLafferty rearrangement- ortho effect-Meta stable ions – Doubly charged ion – Nitrogen rule – General fragmentation modes –Mass spectra of hydrocarbons – Alkanes, cycloalkanes, alkene, alkynes, aromatic hydrocarbons, alcohols and thiophenols.

UNIT 5 STRUCTURALELUCIDATION OF ORGANIC MOLECULES BY UV, IR, MASSANDNMR 12 Hrs. Problems pertaining to known and unknown organic compounds by using UV, IR, Mass and NMR spectroscopy.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Banwell C. N and McCash E. M., Fundamentals of Molecular Spectroscopy, 4th Edition, Tata McGraw Hill, New Delhi, 2000.

2. Silverstein R. M and Webster F. X., Spectroscopic Identification of Organic Compounds, 6th Edition, John Wiley & Sons, New York, 2003.

3. Levine I. N., Molecular Spectroscopy, John Wiley & Sons, New York, 1974.

4. Williams D. H and Fleming I., Spectroscopic Methods in Organic Chemistry, 4th Edition, Tata McGraw-Hill Publishing Company, New Delhi, 1988.

5. Kemp W., Applications of Spectroscopy, English Language Book Society, 1987.






SCY5613 MEDICINALCHEMISTRY L T P Credits Total Marks 3 1 0 4 100

COURSE OBJECT IVES To identify complexes suitable for application in medicinal chemistry To understand the basic concepts behind in the drug design and their activity

UNIT 1 PHARMACOLOGY 12 Hrs. Interdisciplinary nature of medicinal chemistry – Pharmacology, Molecular Pharmacology, Microbiology,

Biochemistry, Physiology, Medicine and Pharmacy. Classification of Drugs – Central Nervous system acting drugs-(General and Local anaesthetics, Sedatives and Hypnotics, Anticonvulsants, Narcotic and Non-narcotic analgesics, Anti-Parkinsonian agents, Anti-depressants, Tranquilizers, Psychomimetics), Pharmacodynamic agents (Antiarrythmics, Anti-anginals, Vasodialators, Anti-hypertensives, Diuretics, Antihistamines), Chemotherapeutic Agents (Antibiotics, Antivirals, Antifungals), Drugs for metabolic and endocrine disorders (Anti-thyroid drugs, Antidiabatic drugs, biosynthetic insulin) (Definitions with examples).

UNIT 2 PHARMACOKINETICSANDPHARMACODYNAMICS 12 Hrs. Pharmacokinetics: Introduction to drug absorption, disposition, elimination using pharmacokinetics - Important

pharmacokinetic parameters in defining drug disposition and in therapeutics. Mention of uses of pharmacokinetics in drug development process. Pharmacodynamics: Introduction, elementary treatment of enzyme stimulation, enzyme inhibition, suphonamides, membrane active drugs, drug metabolism, xenobiotics, biotransformation, significance of drug metabolism in medicinal chemistry.

UNIT 3 DRUGS OF IMPORTANCE 12 Hrs. Anti-neoplastic drugs: Introduction, cancer chemotherapy, role of alkylating agents and antimetabolites in

treatment of cancer. Mechlorethamine, cyclophosphamides, mustards and mercaptopurine. Recent development in cancer chemotherapy. Anticonvulsant drugs: Hydantoin, Barbiturates, Valium (Diazepan). Analgesics, antipyretic and anti inflammatory agents – Narcotic analgesic: Morphine, Codine – structure activity relationship of morphine – Synthetic analgesic – Pethadine, Benzomorphan non-narcotic analgesics – Nalorphine, Aspirin, Antibiotics: Classification based on the spectrum of biological action of antibiotics and the chemical structure. Penicillin, Streptomycine – structure, properties, structure activity relationship. Diabetes and hypoglycemic drugs – Chemical structure of insulin.

UNIT 4 DRUGDESIGN 12 Hrs. Development of new drugs - Procedures followed in drug design - Concepts of lead compound and lead

modification - Concepts of prodrugs and soft drugs - Structure-activity relationship (SAR) - Factors affecting bioactivity, resonance, inductive effect, isosterism, bio-isosterism, spatial considerations. Quantitative structure activity relationship. History and development of QSAR. Concepts of drug receptors. Elementary treatment of drug-receptor interactions.

UNIT 5 THEORIES OF DRUGACTIVITYANDQUANTITATIVE ANALYSIS 12 Hrs. Occupancy theory - Rater theory - Induced fit theory - Activation-aggregration theory. Principles of quantitative

analysis of the following drugs in formulation i) Aspirin ii) Benzylpenicillin iii) Ascorbic acid iv) Chloramphenicol v) Folic acid.

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Taylor J. B., and Kenewell P. D., Introductory Medicinal Chemistry, Halsted Press, 1985. 2. Lea and Febige, Principles of medicinal chemistry, 3rd Edition, Varghese Company, Bombay, 1989. 3. Patrick G. L., An introduction to medicinal chemistry, Oxford University Press, 1995. 4. Korolkoras and Burckhalter, Essentials of medicinal chemistry, Wiley, 1976. 5. Beckett and Stenlak, Practical pharmaceutical chemistry, Athlone Press of the University of London, 1988.





SCY5614 ADVANCED L T P Credits Total Marks

ENVIRONMENTAL CHEMISTRY 3 1 0 4 100

COURSE OBJECT IVES To learn about pollutions, types and control measures of various pollution To understand the chemistry of pollutants and their toxic effects To learn chemical toxicology

UNIT 1 ATMOSPHERICCHEMISTRY 12 Hrs. Atmosphere-compositions-regions of the atmosphere - concentrations and conversions. Types of atmospheric

reactions: Photo chemical reactions. Stratospheric ozone layer: Chapman reactions, Null cycles. Catalytic reactions for ozone destruction: HOx, NOx and ClOx species. Arctic and Antarctic ozone hole. Smog: Photochemical smog - Chemical reactions. Acid rain: Chemical reactions for nitric and sulphuric acid production. Global climate - Solar energy and surface temperature - Greenhouse gases: CO2, N2O, aerosols, O3, CFC.

UNIT 2 WATERCHEMISTRY 12 Hrs. Water chemistry: Water quality parameters - Environmental significance and determination; Fate of chemicals in

aquatic environment, volatilization, partitioning, hydrolysis, photochemical transformation, oxidation and reduction -, Eh-pH diagrams, Chemical speciation - Toxicity of metal ions such as arsenic, chromium, fluoride ions.

UNIT 3 SOILCHEMISTRY 12 Hrs. Soil formation-Physical weathering, chemical weathering, soil organic matter, Soil properties-Physical

properties-particle size, texture, porosity, structure, permeability. Chemical properties - pH, cation exchange capacity, exchangeable sodium, sodium absorption ratio (SAR). Soil profiles. Acidification-geochemical reactions and biological reactions. Salinity treatment.

UNIT 4 POLLUTION CONTROL 12 Hrs. Air pollution control: Electrostatic precipitator - Wet and dry scrubbers, filters, gravity and cyclone separator -

Adsorption, absorption and condensation of gaseous effluent. Water and wastewater treatment: Coagulation, flocculation, softening, disinfection, demineralization and defluoridation process. UNIT 5 ENVIRONMENTALSAFETY, RISKMANAGEMENT 12 Hrs.

Toxicity of chemicals and its dose effect relationships - Chemical hazards in air, water & soil and remedial measures - Monitoring and control of chemical hazards - Characteristics and hazards of radioactive materials. Risk assessment techniques for accidental release of toxic and inflammable materials - Occupational health hazards: Silicosis, asbestosis, bronchitis, heart disease, nasal cancer, Industrial chemical hazards and safety measures - Biochemical effects of toxic heavy metals, pesticides, carcinogens, mutagens and teratogens. Food adulteration, contaminations and related hazards. Handling and transport of hazardous materials, environmental safety, risk management and emergency preparedness

Max. 60 Hours

T EXT / REF ERENCE BOOKS 1. Sawyer,C. N., MacCarty, P. L. and Parkin, G. F., Chemistry for Environmental Engineering and Science, 3rd Edition, Tata

McGraw – Hill, 2003. 2. Gary W. V and Stephen J. D., Environmental Chemistry – A Global perspective, 3rd Edition, Oxford University press, 2011. 3. Stanley E. M., Environmental Chemistry, 9th Edition, CRC press, 2009. 4. Sharma B. K., Environmental Chemistry, Goel Publishing house, 1996. 5. Baird C and Cann M., Environmental Chemistry, 5th Edition, W.H. Freemam and Company, 2012. 6. Peirce J., Weiner R and Vesilind P. A., Environmental Pollution control, 4th Edition, Butterworth Heinemann Publishings, 1997. 7. Dara S. S., A text book on Environmental Chemistry and Pollution control, 1st Edition, S.S. Chand company Pvt. Ltd, 2014


( Out of 80 Marks, maximum of 10% problems may be asked.)

PROGRAMME: M.SC. (CHEMISTRY) FACULTY OF … · FACULTY OF SCIENCE AND HUMANITIES CURRICULUM ... 4. Finar I. L., Organic Chemistry, 6th Edition, ... trans effect and its influence,

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