PROGRAM - Campus Alberta Neuroscience

2016 INTERNATIONAL CONFERENCE

Promoting Healthy Brain Aging and Preventing DementiaRESEARCH AND TRANSLATION

May 24-27, 2016 | The Fairmont Banff SpringsBanff, Alberta, Canada

CONFERENCE

PROGRAM

Dementia is a global, national, and local issue. In Canada approximately 15% of people 65 and older are living with dementia, and the combined direct and indirect costs are a staggering $33 billion per year. The solutions to the problems presented by dementia will also be found globally, nationally, and locally. The Alberta Healthy Brain Aging and Dementia (HBAD) community – led by a committee of dementia researchers from the Universities of Alberta, Calgary, and Lethbridge – is a research team that brings together Alberta researchers and clinicians along the entire spectrum of dementia research, from basic to translational sciences. Brought together and facilitated by Campus Alberta Neuroscience, the HBAD team aims to transform the dementia research and translation landscape by understanding and enhancing healthy brain aging while delaying or preventing dementia.

The overarching goal of HBAD is to accelerate diagnostic advancements, improve cognitive health and reduce the overall burden of dementia. To this end, HBAD is reaching out to the national and international research community in aging and dementia to form collaborative partnerships as part of the global battle against dementia.

The Alberta HBAD community is proud to host the world’s dementia experts in the majestic Canadian Rockies. We sincerely hope you find this conference to be a unqiue and valuable learning experience. We look forward to the opportunity to connect with the international community to determine how we can all work together to improve outcomes for those with dementia.

On behalf of the Conference Organizing Committee and Campus Alberta Neuroscience, welcome to the international conference on Promoting Healthy Brain Aging and Preventing Dementia: Research and Translation.

SCIENTIFIC PROGRAMCOMMITTEE

Roger DixonUniversity of Alberta

Jayna Holroyd-Leduc University of Calgary

Marc PoulinUniversity of Calgary

Eric SmithUniversity of Calgary

Robert Sutherland University of Lethbridge

David Westaway University of Alberta

TUESDAY, MAY 24, 2016All sessions are in Van Horne Ballroom AB unless otherwise noted

4:00pm Registration Open Van Horne Ballroom Foyer

5:00 – 6:00pm Welcome Reception

6:00 – 6:15pm Conference Opening

VIP Greetings

6:15 – 7:30pm Keynote AddressPotential for Brain Health Promotion and Dementia Prevention

Martin Prince, King’s College London

7:30pm Dinner on own / Free Evening in Banff

CONFERENCE SCHEDULE

7:30 – 8:25am Breakfast

8:25 – 11:30am Session #1: Brain and Cognitive Resilience in Aging: Trajectories, Biomarkers, Risk and Protection S E S S I O N C O - C H A I R S : Roger A. Dixon, University of Alberta, and Richard Camicioli, University of Alberta In a recent statement, the US National Institutes of Health noted that the long-term etiology of Alzheimer’s disease is more complex, dynamic, and interactive than previously understood. In this session the invited speakers will address timely issues such as: (1) identifying the multiple trajectories and full range of classifiable outcomes of brain and cognitive aging, (2) examining multi-modal biomarkers (ranging from leading signals of neuropathology or resilience to pivotal risk and protective factors) that independently or interactively modify these trajectories, and (3) developing early risk reduction, protection enhancing, and precision strategies for promoting healthier brain aging, delaying impairment, and preventing dementia.

8:30am Modifiers of Trajectories and Outcomes in Brain and Cognitive Aging Roger A. Dixon, University of Alberta and the Canadian Consortium on Neurodegeneration in Aging

9:00am Population Health Approaches to Cognitive Health Promotion and Dementia Risk Reduction Kaarin Anstey, Australian National University

9:30am Strategies for Promotion of Cognitive Resilience Kristine Yaffe, University of California San Francisco

10:00am Refreshment Break

WEDNESDAY, MAY 25, 2016All sessions are in Van Horne Ballroom AB unless otherwise noted

WEDNESDAY, MAY 25, 2016 (continued)All sessions are in Van Horne Ballroom AB unless otherwise noted

10:30am The SuperAging Study: Identifying Neurobiologicand Psychosocial Features Associated with UnusuallyHigh Memory Performance Over Age 80 Emily J. Rogalski, Northwestern University

11:00am Abstract Presentation: Testing the Reserve Hypothesiswith Multi-state Markov Models in the Nun Study:Are Higher Levels of Reserve Associated with ShorterSurvival after Diagnosis of Dementia? (36) Suzanne L. Tyas, University of Waterloo

11:15am Abstract Presentation: Investigating Age-Related Changes in Functional Connectivity of the Human Brain with Age (68) Peter Seres, University of Alberta

11:30am – 1:25pm Lunch Van Horne Foyer

Poster Viewing Van Horne C

1:25 – 2:15pm Invited Lecture 13 Things You Will Be Able to Do with the CCNA Howard Chertkow, McGill University and the Canadian Consortium on Neurodegeneration in Aging (CCNA)

2:15 – 2:30pm Nutrition Break


2:30 – 5:30pm Session #2: Vascular Contributions to Cognitive Impairment and Dementia S E S S I O N C H A I R : Eric Smith, University of Calgary and the Canadian Consortium on Neurodegeneration in Aging Vascular dementia is the second most common cause of dementia, and potentially the most preventable and treatable. In this session invited speakers will discuss the neuropathology of vascular cognitive impairment, neuroimaging markers of cerebrovascular pathology and blood vessel function, cerebral amyloid angiopathy and its association with cognitive impairment, and paradigms for diagnosis and treatment of early stage patients with vascular mild cognitive impairment to prevent progression to dementia.

2:30pm Pathologic Insights on the Relationship between Cerebrovascular Disease, Alzheimer’s Disease and Dementia Julie Schneider, Rush University

3:00pm Innovative Neuroimaging Markers of VCI Richard Frayne, University of Calgary

3:30pm Missing Links: Cerebral Amyloid Angiopathy and Cognitive Impairment Steven Greenberg, Massachusetts General Hospital

4:00pm Refreshment Break

4:30pm Vascular Mild Cognitive Impairment as a Target Population for Prevention of Dementia Eric Smith, University of Calgary and the Canadian Consortium on Neurodegeneration in Aging


5:00pm Abstract Presentation: Structural and Functional Changes in Cerebral Amyloid Angiopathy (60) Randall B. Stafford, University of Calgary

5:15pm Abstract Presentation: Silent Lesions need to be Listened to: Lacunes and White Matter Hyperintesities Attenuate Post-Stroke Outcome (38) Angela Auriat, University of British Columbia

5:30 – 6:30pm Poster Viewing Van Horne C

6:30pm – Free Evening

THURSDAY, MAY 26, 2016 All sessions are in Van Horne Ballroom AB unless otherwise noted


8:25 – 11:30am Session #3: Risk Factors and Novel Diagnostics S E S S I O N C H A I R : Jack Jhamandas, University of Alberta Finding incisive risk factors and diagnostics for Alzheimer’s disease presents a striking challenge; this situation is compounded in a practical way by disease heterogeneity and by contrasting views as to which elements might comprise the pivotal events in pathogenesis. In this session the invited speakers will discuss the clinical presentation of dementia (including cohorts of rapid-onset disease), novel chemical markers of neuronal damage and protein misfolding, novel therapeutic approaches, perturbations in unexpected neuroanatomical pathways that may presage the advent of MCI or AD and new insights that may emerge from the application of prion biology principles.

8:30am Emerging Prion Paradigm of Alzheimer Disease Diversity: Implications for Diagnostic and Therapeutic Strategies Jiri Safar, Case Western Reserve University

9:00am Alpha2 Macroglobulin and Preclinical Alzheimer’s Disease: A Marker of Neuronal Injury through the RCAN1 Pathway Madhav Thambisetty, National Institutes of Health

9:30am Using Fluorescence Spectroscopy for Detection of Alzheimer’s Peter Stys, University of Calgary and the Canadian Consortium on Neurodegeneration in Aging


10:30am The Amylin Receptor: A Target for Novel Therapeutics in Alzheimer’s Disease Jack Jhamandas, University of Alberta

11:00am Abstract Presentation: Measures of Central Presbycusis in People with Mild Cognitive Impairment and Dementia: Preliminary Outcomes of a Collaboration between Geriatric Medicine and Audiology in SW Alberta (27) Penny Gosselin, Alberta Health Services

11:15am Abstract Presentation: An Expanding Role for Prion Protein in Alzheimer Disease (33) W. Ted Allison, University of Alberta

THURSDAY, MAY 26, 2016 (continued)All sessions are in Van Horne Ballroom AB unless otherwise noted




11:30am – 1:25pm CCNA Luncheon Meeting Open to All

1:25 – 4:30pm Session #4: Exercise and Cognitive Interventions for Healthy Brain Aging and Prevention of Dementia S E S S I O N C H A I R : Marc Poulin, University of Calgary and the Canadian Consortium on Neurodegeneration in Aging With a global dementia epidemic on our doorsteps, this symposium will address the important and emerging role of lifestyle interventions such physical activity, exercise and cognitive activity for brain health with aging and the potential impact of these interventions for the prevention and/or delay of Alzheimer disease and related dementias. The speakers in this session will discuss some of the latest findings in the field, including clinical and translational physiology studies, and the application of recent developments (i.e., neuroimaging, biomarkers, modeling in human and animal research), which are helping to advance our knowledge of the role of physical activity and cognitive interventions for healthy brain aging and for the prevention of dementia. The session will conclude with a panel discussion on the role of exercise and cognitive activity in delaying and/or preventing Alzheimer disease and dementia.

1:30pm Contributions of Cognitive and Physical Activity to Cognitive Function in Aging Gail Eskes, Dalhousie University

2:00pm Practice Effects Detection in Repeated Cognitive Assessments: Conceptual Perspectives and Methodological Considerations Tolulope Sajobi, University of Calgary


2:30pm Refreshment Break

3:00pm Novel Approaches to Understand the Protective Effects of Physical Activity on the Aging Brain Claire Sexton, University of Oxford

3:30pm Investigating the Mechanisms by Which Cardiorespiratory Fitness Enhances Brain Health in Older Adults Michelle Voss, University of Iowa

4:00pm Panel Discussion and Q&A

4:30 – 6:30pm Free Time

6:30 – 9:30pm Offsite Dinner Mountview BBQ Bus transportation will be provided: buses will leave the Banff Springs at 6:15pm and 6:45pm, with return trips every 30 minutes starting at 9:00pm.

Healthy brains for better lives

hbi.ucalgary.ca

FRIDAY, MAY 27, 2016 All sessions are in Van Horne Ballroom AB unless otherwise noted


8:25 – 11:30am Session #5: Applied Research in Dementia S E S S I O N C O - C H A I R S : Jayna Holroyd-Leduc, University of Calgary, and Sharon Straus, University of Toronto With the aging world population, the prevalence of dementia is expected to increase. Dementia has a significant impact on individuals and caregivers across the world. This session will focus on applied research targeted on the translation of evidence into practice. In this session, invited speakers will present an array of implementation research initiatives that cross the disease continuum.

8:30am Challenges in Knowledge Translation Sharon Straus, University of Toronto

8:50am Applied Research in Dementia Care in Long Term Care Dallas Seitz, Queen’s University and the Canadian Consortium on Neurodegeneration in Aging

9:20am Applied Research In Residential Care – Is Transformative Change Possible? Greta Cummings, University of Alberta


10:20am Advanced Dementia: Clinical Course, Complications, and Decision-Making Susan Mitchell, Harvard University

10:50am Integrating Dementia-friendly Design and Assistive Technologies to Support Persons with Dementia David Hogan, University of Calgary and the Canadian Consortium on Neurodegeneration in Aging

FRIDAY, MAY 27, 2016 (continued) All sessions are in Van Horne Ballroom AB unless otherwise noted

11:15am Abstract Presentation: Guideline Recommendations for Depression and Anxiety in those with Dementia or Parkinson’s Disease: A Systematic Review (81) Zahra Goodarzi, University of Calgary and Alberta Health Services



1:25 – 2:15pm Keynote Address Changing Views of the Contribution of the Hippocampus to Memory and to Other Cognitive Functions Morris Moscovitch, University of Toronto

2:15 – 3:30pm Closing Panel: Promoting Healthy Brain Aging and Preventing Dementia: Big Ideas and Future Directions P A N E L D I S C U S S I O N : Panel Chair: Robert Sutherland, University of LethbridgeMorris Moscovitch, University of TorontoDavid Hogan, University of CalgaryMichele Mulder, Alzheimer Society of Alberta and the Northwest Territories

Peter Stys, University of CalgaryKaarin Anstey, Australian National University

3:30pm Conference Closing

NOTES

For more details and speaker biographies, visit

can-healthybrains.com

THANK YOU TO OUR 2016 INTERNATIONAL CONFERENCE SPONSORS

Signature Partner

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PROGRAM - Campus Alberta Neuroscience

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