Professor David Ames BA, MD, FRCPsych, FRANZCP University of Melbourne Professor of Ageing and Health Director National Ageing Research Institute Co-leader Australian Imaging Biomarkers and Lifestyle (AIBL) flagship study of ageing [email protected]Three year follow up results from the Australian Imaging Biomarkers and Lifestyle (AIBL) study of Ageing
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Professor David Ames BA, MD, FRCPsych, FRANZCP University of Melbourne Professor of Ageing and Health Director National Ageing Research Institute Co-leader.
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Professor David Ames BA, MD, FRCPsych, FRANZCP
University of Melbourne Professor of Ageing and HealthDirector National Ageing Research Institute
Co-leader Australian Imaging Biomarkers and Lifestyle (AIBL) flagship study of ageing
Three year follow up results from the Australian Imaging Biomarkers and Lifestyle
(AIBL) study of Ageing
PERTHMELBOURNE
Sites.
MajorSponsor
Australian Imaging Biomarkers and Lifestyle study of ageing
Launched in November 2006, largest study of its kind in Australia
Initial cohort of 1112 participants (minimum age 60 years)– 211 Patients with Alzheimer’s disease (AD), 133 with Mild Cognitive
Impairment (MCI) and 768 healthy volunteers – cohort assessed in multiple modalities and undergoing follow-up every 18 months
2 site study – 40% Perth and 60% Melbourne
What is the AIBL study?
Assessments
• BP, HR, weight, height, abdominal girth• 80 ml blood• 2 hours neuropsychological testing• HADS and GDS• Medication list• Diet and lifestyle questionnaires• PiB PET scan and MRI for ¼• Diagnostic panel evaluation• DA file review• Repeat every 18 months
ProgressAIBL 1 – initial phase of the study 2006-2010• Recruit cohort of 1000+ people (1112 by August
2008)• Conduct thorough assessment at baseline• Repeat assessment at 18-monthsAIBL-2 refunded by SIEF 2011-2014• Repeat assessments at 36 months• Repeat assessments at 54 months• Recruit 200+ replenishment/expansion• Image most of cohort• LPs for 100+• ROCS study• AIBL active study
• Higher CDR and CDR box score plus baseline prescription of a CheI predicted faster decline (OR 3.4 univariate)
• 672 HC and 64 MCI completed a subjective memory questionnaire at 18 month follow up.
• MMSE, CVLT, RCFT, BNT, GDS, HADS, group membership and APOE ε4 status were used to determine predictors of SMC scores.
• Group membership explained 20% of variance. Adding affective measures explained 27%. Only group membership and HADS were significant individual predictors.
• In HCs SMCs reflect mood rather than objectively measured cognitive performance.
• R. Buckley, M. Saling, K. Ellis, N. Lautenschlager, P Marruff, R. Martins, C Masters, C. Rowe, G. Savage, C. Szoeke, D. Ames and the AIBL group
Predictors of subjective memory complaints in AIBL
Study is conducted between Perth (40%) and Melbourne (60%)
• CSIRO P-Health*• University of Melbourne*• Neurosciences Australia Ltd (NSA)*• Edith Cowan University (ECU)*• Mental Health Research Institute (MHRI)*• National Ageing Research Institute (NARI)• Austin Health • University of WA (UWA)• CogState Ltd.• Charles Gairdner Hospital radiology and nuclear medicine• Alzheimer’s Australia• Macquarie University
*denotes signatories to the AIBL study contract
AIBL collaborators
• CSIRO (AUS)• National Health and Medical Research Council
(NHMRC) (AUS) • Alzheimer’s Association (USA)• Alzheimer’s Drug Discovery Foundation (USA)• An Anonymous Foundation (USA)• Pfizer• GE Healthcare• Astra Zeneca• Science and Industry Endowment Fund
Financial Supporters
* AIBL management committeeProf. David Ames Prof Ashley BushProf. Richard Head
Dr. Kathryn Ellis Prof. Ralph Martins Prof. Colin Masters Dr. Andrew Milner Prof. Christopher Rowe Dr. Cassandra Szoeke Dr. Lance MacauleyDr. Tim O’Meara
* The AIBL study team comprises 80+ scientists (see www.aibl.csiro.au) and 1112 Australian research volunteers
The AIBL management team
The AIBL Study Team The AIBL Study Team www.aibl.csiro.auwww.aibl.csiro.au