Product Note www.appliedbiosystems.com Analyst ® QS 1.1 Software New Robust Software with Improved Functionality for QSTAR ® Systems The QSTAR ® XL system provides the highest in performance in an orthogonal quadrupole time-of-flight (QqTOF) mass spectrometry system by combining electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) sources on a single platform to achieve a greater depth of coverage in proteomic applications. New Analyst QS 1.1 software extends the range of applications available on the QSTAR ® system by improving software support for many workflows such as rapid protein identification, LC MALDI and biomarker quantitation workflows using both ICAT and iTRAQ TM reagent labeling. Analyst QS 1.1 software includes all previous improvements and feature updates provided by Analyst QS 1.0 (SP1 through SP8) and offers compatibility with all previous Analyst QS releases. Many new features have been incorporated including added support for devices and hardware to enable flexibility in workflow design. Software Enhancements: New improved peak finder enables improved mass accuracy and charge state recognition allowing more efficient peak detection during IDA (information dependent acquisition) and therefore enhanced performance during automated acquisition. Improved software stability enables longer batch runs providing a greater level of automation and unattended acquisition. Increased Sensitivity by reducing the number of MS/MS transmissions taking advantage of the higher RF levels on the QSTAR XL system. Support for flexible MALDI workflows using oMALDI Server 4.0 and Xpert 2.0 software enabling LC-MALDI as well as ICAT ® and iTRAQ™ reagent-based quantitative experiments for biomarker discovery and validation. Support for new enhanced proteomic biosoftware such as Pro ID Software 1.1 (protein identification), Pro ICAT Software 1.1 (identification and quantitation when using ICAT ® reagents), Pro QUANT Software 1.1 (identification and quantitation when using iTRAQ™ reagents), Pro BLAST Software 1.1 (identification using protein sequence similarity searching) and Pro Automate 1.1 (automates data acquisition and processing). Key Features of Analyst QS 1.1 Software • Software Support o Greater stability for multi-day batch runs o Improved peak finding algorithm for enhanced MS/MS precursor selection o Enables oMALDI™ Xpert 2.0 software to support flexible workflows such as LC-MALDI and quantitation using ICAT and iTRAQ TM reagent labeling • Hardware Support o High repetition laser for MALDI for faster acquisition o Heated NanoSpray ® Source interface for increased nano electrospray stability o Tissue imaging application for small molecules • LC System Integration Support o Agilent’s 1100 Nano LC System and diode array detector o CTC HTS PAL Autosampler o User defined mode functionality for LC Packings nano LC System