ProCutiGen® Bond - Active Concepts · protection from chemical damage to promote healthy hair. ProCutiGen® Bond offers protection from harsh chemical treatments to promote healthy

Code Number: 20829

INCI Name: Salvia Hispanica Seed ExtractINCI Status: ConformsREACH Status: CompliesCAS Number: 93384-40-8EINECS Number: 297-250-8

Origin: BotanicalProcessing:

GMO FreeNo EthoxylationNo IrradiationNo Sulphonation

Additives: Preservatives: NoneAntioxidants: NoneOther additives: None

Solvents Used: WaterAppearance: Clear to Slightly Hazy LiquidSoluble/ Miscible: Water SolubleEcological Information: 91.80% BiodegradabilityMicrobial Count: < 100 CFU/g, No Pathogens

Suggested Use Levels: 1.0-10.0%Suggested Applications: ProBonding, Hair Protection, Nourishing, Support

Technical Data Sheet

ProCutiGen® Bond

Version#2/04.13.2017

BACKGROUNDThe “Plex Phenomenon” has swept the global haircare industry – resulting in a myriad of products focused on bond multiplying or re-bonding. As the market is currently saturated with formulations claiming to re-bond the hair, Active Concepts has taken a proactive approach towards technology that protects the hair. Active Concepts is shifting the focus to proactively protect the hair shaft through “ProBonding”. ProCutiGen® Bond is an incredible scientific breakthrough that is slated to shake the foundations of how we consider preventative hair care – repair beyond the bond.

ProCutiGen® Bond prevents the chemical damage that breaks the protein bonds of your hair, making it porous, weakened and more prone to breakage. Rather than focusing on repairing broken bonds that occur during chemical stress, ProCutiGen® Bond consists of bivalent cationic peptides that create a de novo cuticle on the hair to prevent damage from happening in the first place.

Cuticle preservation is essential to prevent hair damage. The cuticle is the outermost layer of the hair, composed of overlapping cells that shield the cortex, while holding moisture and protecting hair from the environment. Damage to the cuticle compromises the structural integrity of the hair shaft, making hair prone to breakage. Utilizing the concept of synthetic biology, ProCutiGen® Bond is a bivalent cationic lipopeptide that self-assembles into a neo-cuticle on the hair. The formation of this biomimetic cuticle offers protection from harsh chemical treatments to promote healthy hair.

Benefits of ProCutiGen® Bond:

• Protects and Strengthens Hair

• Great for All Hair Types

• Ideal for Chemically Damaged Hair

• Perfect for Pre and Post Treatments

page 1/7

Proactive. Protection. ProBonding.Bivalent Cationic LipopeptideRepair Beyond the Bond!

. support + protect hair cuticleProBonding, chia derivedbiomimetic, neo-cuticlestrength

preventative haircare


SCIENCEDamage that occurs to hair after chemical treatment is a result of the structural integrity of the cuticle being compromised. When the structure of the hair cuticle is degraded, hair is more susceptible to breakage. Hair needs a solid foundation to prevent damage, and the building block of hair is protein. Our hair is full of protein, which is necessary to strengthen and restore the hair fiber. “Chia” is the ancient Mayan word for “strength” and chia seeds are a nutritional powerhouse composed of 23% protein, which can help restore the strength of the hair. ProCutiGen® Bond is a lipopeptide derived from chia protein, harnessing the natural strength of the seed for hair protection.

The bivalent cation of ProCutiGen® Bond is the anchor to secure the neo-cuticle, as hair is naturally anionic. The specific amino acid composition, the structural material of the anchor, allows these properties which differentiate the bio-films formed by the ProCutiGen® line. Film-forming properties are a popular claim in hair care, however this is boring and usually misleading. A film can loosely be defined as a thin layer of something, by that definition, water on the skin is a film. A bio-film is of much more interest; a polymeric chain forming a conglomeration of proteins, amino acids and polysaccharides that creates a complex, supporting, interwoven matrix on the hair cuticle. A major benefit of the bio-film is its action as a scaffolding rather than a true barrier. Able to support and protect hair, this scaffolding allows small molecules, like those in harsh chemical treatments, in via its semi-permeable facade. It is this bio-film and its semi-permeable membrane that promotes the exhibition of properties such as moisturization, pH balance, barrier protection, and additionally, protection from hair weakening after exposure to chemical processes.

BENEFITSBond repair is so last year. ProCutiGen® Bond utilizes the concept of synthetic biology to self-assemble into a biomimetic neocuticle on the hair. The formation of this biomimetic cuticle helps to retain style while offering protection from chemical damage to promote healthy hair. ProCutiGen® Bond offers protection from harsh chemical treatments to promote healthy cuticles and is an ideal ingredient for use in a wide range of hair care applications. Incorporate ProCutiGen® Bond into pre-treatment, during treatment, and post treatment applications to offer revolutionary ProBonding protection!

EFFICACY DATAAs seen in Figures 1-10, the Standard Electron Microscopy (SEM) imaging demonstrates that, untreated hair is already prone to damage from everyday stressors, showing characteristic signs of breakdown. Treating hair with ProCutiGen® Bond, makes a difference at the microscopic level. The SEM images depict how the outermost layer of the hair, the cuticle, is affected by bleach treatments as well as chemical relaxing treatments. When the untreated images are compared to both the ProCutiGen® Bond treated swatches, a significant decrease in damage of the cuticle is exhibited.

Figures 1-5 are the SEM images showing the effect of ProCutiGen® Bond on hair treated with bleach. Figures 6-8 are the SEM images showing the effect of ProCutiGen® Bond on hair treated with a chemical relaxer. These images clearly depict the ability of ProCutiGen® Bond to protect hair from harsh chemical treatments.

ProCutiGen® Bond

page 2/7Version#2/04.13.2017


ProCutiGen® Bond

page 3/7

Figure 2. Bleached Hair, 30V. Figure 3. Bleached Hair, 30V + 2.0% ProCutiGen® Bond

Figure 4. Bleached Hair, 40V. Figure 5. Bleached Hair, 40V + 2.0% ProCutiGen® Bond.

Figure 1. Untreated Virgin Hair.

Version#2/04.13.2017


ProCutiGen® Bond

page 4/7

Figure 7. Relaxed Hair. Figure 8. Relaxed Hair + 2.0% ProCutiGen® Bond

Figure 6. Untreated Virgin Hair.

A half head study was conducted to determine the comparison of a control shampoo vs. 2.0% ProCutiGen® Bond in the control shampoo. Additionally, a comparison between the control conditioner and 2.0% ProCutiGen® Bond in the control conditioner were reported. Each volunteer’s hair was photographed prior to the treatment and again after the shampoo and conditioner had been applied and the hair was styled. The images of the half head study were used in conjunction with a sensory assessment subjectively rating the parameters - cleansing, smoothing, dry and wet combability, anti-frizz, overall feel, shine and hydration. This assessment was conducted both before and after treatment. Based on the results in Figures 9 through 17, ProCutiGen® Bond is capable of enhancing smoothing, wet and dry combability, anti-frizz, overall feel, shine and hydration when used in a conditioner.

Active Concepts S.r.l. Milano ITALY

www.activeconcepts.it Tel +39 02 90360719

[email protected]

Half Head Treated with Control Shampoo and Conditioner

Figure 9. Full head Baseline, Untreated Hair. Figure 10. Half Head Treated.

Half-Head Treated with 2.0% ProCutiGen®

Bond in a Base Shampoo & Conditioner

Version#2/04.13.2017


ProCutiGen® Bond

page 5/7










Half-Head Treated with 2.0% ProCutiGen® Bond

in a Base Shampoo & Conditioner


Version#2/04.13.2017


ProCutiGen® Bond

page 6/7

Hirox 3D Microscopic Examination is a test method for microscopic examination of hair samples. Damage of the hair fiber can be seen within these images in which the damaged areas of the fiber fluoresce. The more fluorescence a fiber exhibits, the more damaged. HIROX images were quantified via histograms to offer a number value to the fluorescence of the hair.

Within the bleached images below, significantly less damage can be viewed on both the Untreated Virgin swatch and ProCutiGen® Bond treated swatches. Whereas the bleached only swatches, both 30V and 40V fluoresce brightly signifying the extent of damage. The ProCutiGen® Bond treated fibers are more comparable to the untreated virgin fiber, showcasing ProCutiGen® Bond’s ability to protect the hair fiber from the harsh chemical process and reducing overall damage to the fiber.

Within the relaxed images below significant less damage can be viewed on both the Untreated Virgin and the Relaxed Hair + ProCutiGen® Bond. Whereas the Relaxed Hair swatch is significantly more damaged i.e fluoresces greater. The ProCutiGen® Bond treated fiber is more comparable to the untreated fiber, showcasing its ability to protect the hair fiber from the harsh chemical process.

ProCutiGen® Bond consists of bivalent cationic peptides that create a de novo cuticle on the hair to prevent damage from happening in the first place. Significant results have been demonstrated by ProCutiGen® Bond’s proactive approach to chemical damage.

Swatch HIROX Image Histogram Quantification

Untreated Virgin Hair

Relaxed Hair

Relaxed Hair + ProCutiGen®

Bond

Figure 18. HIROX Results for Relaxed Hair.

Version#2/04.13.2017


ProCutiGen® Bond

Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, however, cannot assume any liability or risk involved in the use of its chemical products since the conditions of use are beyond our control. Statements concerning the possible use of our products are not intended as recommendations to use our products in the infringement of any patent. We make no warranty of any kind, expressed or implied, other than that the material conforms to the applicable standard specification. Freedom from patent infringement is not implied. All information is for investigative purposes only.

page 7/7

Active Concepts LLC, AsiaKaohsiung, Taiwan

www.activeconceptsllc.comTel + 886 73599900

[email protected]

Active Concepts, LLCLincolnton, NC. USA

www. activeconceptsllc.comOffice: +1 (704) 276 7100

[email protected]

Active Concepts S.r.l. Milano ITALY

www.activeconcepts.it Tel +39 02 90360719

[email protected]

Swatch HIROX Image Histogram Quantification

Untreated Virgin Hair

Bleached Hair, 30V

Bleached Hair, 30V +

ProCutiGen® Bond

Bleached Hair, 40V

Bleached Hair, 40V +

ProCutiGen® Bond

Figure 19. HIROX Results for Bleached Hair.

ProCutiGen® Bond - Active Concepts · protection from chemical damage to promote healthy hair. ProCutiGen® Bond offers protection from harsh chemical treatments to promote healthy

Documents