PROCELL’s Transdermal Cosmeceuticals : pII SKIN™ Oct. 23. 2014.

PROCELL’s Transdermal Cosmeceuticals : pII SKIN™

Oct. 23. 2014

Brand Competitiveness of pII-SKIN™

Innovativeness of ProCell’s platform technology

Collaboration with out-standing Global partners

ProCell’s top notchtechnology

Self supply of cosme-ceutical active ingredients

Production of highly purified materials

Efficacy and safety validated

Product safety is verified by certified clinical test institution 3

2

4

1 Worldwide IP application

and registration

Publication in peer-reviewed top scientific journals

Global Partner : co-development of cosmeceutical active ingredients and PCT application

Collaboration with global cosmetic giants and partnership with domestic - based cosmetic companies

Efficient transdermal delivery of active ingre-dients

Maximizing efficacy through

skin cell activation

Diverse application of ac-tive

ingredients to cosmetics

Top quality and safety-guaranteed active ingredients

Uniqueness and high performance of cosmeceutical active ingredients

Development of unique and high-performance active ingredients

Fusion with innova-tive biotechnology

●

ProCell’s Platform Technology : MITT

Cargo (active ingredients)

▷ Antibodies

▷ Recombinant Proteins

▷ Peptides

▷ siRNA or DNA

▷ Low MW chemicals

▷ Nanoparticles

MTD

Macromolecule Transduction Domain

Basic Technology (MITT)

MITT

Macromolecule Intracellular Transduction Technology

Skin and Skin Cell Permeable MTD

Delivery of MTD-conjugated FITC into artificial skins

Delivery of MTD-conjugated FITC into skin cells

Keratinocyte Melanocyte Fibroblast Cells

3

Skin penetrating MTDs

Functional Pep-tides

siRNAs

Growth Factors

Anti-agingAnti-wrinkle

Whitening

Skin-liftingElasticity

Moisturization

Skin nourishment Natural Materials

Pure to Skin

Premium to Skin

Precious to Skin

pII-SKIN●

pII SKIN™ The novel platform for Cosmetics ●

Paraben free Mineral oil free

ProCell’s Platform Technology - MITT for Transdermal Delivery-

1st ac-tion

MTD efficiently delivers active ingredients into stratum corneum and dermis

2nd action MTD maximizes efficacy of active ingredients by intercellular or intracel-lular delivery

MTD enhances skin permeability of cosmeceutical ingredients

MTD-EGF Effect on Dermal Fibroblast Proliferation

0 0.01 0.1 1 1050.00

100.00

150.00

200.00

Procell MTD-EGFs (ng/mL)

Cell p

rolife

rati

on

(% o

f contr

ol)

0 0.01 0.1 1 1050.00

100.00

150.00

200.00

Procell MTD-EGFs (ng/mL)

Cell p

rolife

rati

on

(% o

f contr

ol)

Human Dermal Fibroblast (NHDF)

Mouse Fibroblast (NIH3T3)

NHDF (Human) NIH3T(Mouse)

control

0.1 ng/mL

1.0 ng/mL

Skin Permeability of MTD-EGF

GF MTD-GF10.00

0.05

0.10

0.15

0.20

0.25

0.30

0.35

6h 24h

pe

rme

ati

on

ra

te

(% o

f d

on

or

pro

tein

co

nc.)

0.3%

0.01%

Skin permeability of MTD-conjugated EGF is 30

times more

than that of EGF after 24 hour treatment on artifi-

cial skin.4

EGF MTD-EGF

MTD-FGF2 Effect on Dermal Fibroblast Proliferation

control

0.8 ng/mL

3.0 ng/mL

Human Dermal Fibroblast (NHDF)

0 0.1 1 10 10050.0

75.0

100.0

125.0

150.0

Procell MTD-FGF2 (ng/mL)

Ce

ll P

rolif

era

tio

n(%

of

co

ntr

ol)

Skin Permeability of MTD-FGF2

4

Skin permeability of MTD-conjugated FGF is 2

times more

than that of FGF after 24 hour treatment on ca-

daver skin.

GF2 MTD-GF20.00

0.10

0.20

0.30

0.40

0.50

0.60

0.1630.186

1h 24h

Pe

rme

ati

on

ra

te

(% o

d d

on

or

pro

tein

co

nc

.)

0.5%

0.25%

FGF2 MTD-FGF2

MTD-FGF2 Effect on Dermal Fibroblast Proliferation

control 1 ng/mL 3.0 ng/mL

Human Dermal Fibroblast (NHDF)

0 0.1 1 10 10050.0

75.0

100.0

125.0

150.0

Procell MTD-FGF2 (ng/mL)

Ce

ll P

rolif

era

tio

n(%

of

co

ntr

ol)

Cell proliferation was stimulated in human

dermal fibroblast after 72 hrs treatment of

MTD-FGFs.

Cell migration by MTD-FGF2

control 5 ng/mL

MTD-FGF2 treatment greatly enhanced the

migration of HUVEC cell compared to control.

control MTD-FGF250

75

100

125

150

Nu

mb

er

of

Mig

rati

ng

Ce

lls/F

ield

s(%

of

co

ntr

ol)

MTD-VEGF Effect on HUVEC Cell Proliferation and Migration

control 5 ng/mL 25 ng/mL

Increased cell proliferation of HUVEC cells was

observed after 72 hrs treatment of MTD-VEGF.

Cell migration by MTD-VEGFcontrol 25 ng/mL

MTD-VEGF treatment greatly enhanced the

migration of HUVEC cell compared to control.

HUVEC cell

control 3 ng 6 ng 12 ng 25 ng80

100

120

140

160

Pcocell MTD-VEGF (ng/mL)

Cell P

rolife

rati

on

(% o

f co

ntr

ol)

0 3 6 12 25

control MTD-VEGF50

75

100

125

150

175

Nu

mb

er o

f M

igra

tin

g

Cel

ls/F

ield

s(%

of

con

tro

l)

Skin Permeability & Collagen synthesis

Efficacy of acetylpentapeptide-MTD

Acetyl pentapeptide (AP)

IntoSkinCell-AP®0

5

10

15

20

0.5

14.2

Hu

man

Cad

aver

Ski

n F

lux

rat

e (%

)

MTD-AP

Cadaver skin permeability of acetylpentapeptide-MTD

In vitro collagen synthesis efficacy of acetylpentapeptide-MTD

control AP MTD-AP90.0

95.0

100.0

105.0

110.0

115.0

120.0

Collag

en

syn

thesis

(%

of

con

trol)

Conc. : 10 ppmCell-line : NHDF

pII SKIN™ Solutions

Products functions Characteristics

Regenerative Anti-wrinkle

CreamAnti-wrinkle

Advanced skin permeability of growth factors and peptides effective for skin elasticity : MEGF. MFGF, MVEGF, P2Skin-AP, P2Skin-AH

Exceptional efficacy of anti-wrinkle and skin elastic-ity, compared to any other brand’s products

Bright Whitening Serum

Whitening

New concept whitening ingredient by the collabora-tion with Institut Curie

IP co-application and registration in International Cosmetic Ingredient Dictionary(ICID)

New concept whitening serum strengthened with anti-wrinkle and skin elasticity

Multi-factors Double Action

High-perfor-mance

- skin regenera-tion - anti-aging - anti-wrinkle - whitening

Development of high-performance ampule contain-ing highly purified and concentrated ingredients

Outstanding efficacy of anti-wrinkle and elasticity via customized ampule application

Strengthened skin regeneration and elasticity with the simultaneous use of anti-wrinkle cream

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Skin penetrating MTDs

Functional Peptides

Functional proteins Hormones

Growth Factors

Skin penetration Intracellular delivery

Anti-aging/wrinkle Hair regrowth

Anti-oxidation Slimming

Anti-wrinkle Whitening

Moisturization Skin nourishment

Natural Materials

The main ingredients of pII-SKIN™ so-lutions

●

ProCell patented MTDs M085, M1067, M2173A etc.

EGF, FGF-2, KFG, VEGF, IGF-1, SCF, PDGD etc.

SOD, Irisin, FGF21 etc.

Acetyl & Amidated Di, Tri, Penta-peptides

Plant extracts Natural origin proteins

PROCELL Anti-wrinkle Cream

Application

MainIngredients

Characteristics

Anti-wrinkle, skin cell regeneration, and anti-aging

• MTD-applied skin permeable human growth factors

- MTD-EGF, MTD-FGF, MTD-VEGF, and other growth factors

• MTD-applied skin permeable cell regenerative peptides

- MTD-conjugated peptides

• Nonapeptide-29 Pentapeptide-4 and Nonapeptide-29 Hexapeptide-8: ProCell’s patented peptides highly effective for collagen synthe-sis and skin lifting.

PROCELL Regenerative Anti-wrinkle Cream contains ProCell’s platform technology-applied human growth fac-tors such asEGF, FGF, and VEGF designed for efficient transdermal delivery and high-performance peptides for anti-wrin-kle, and efficient delivery of these active ingredients into skin fibroblast cells helps skin regeneration and lifting.

Anti-wrinkle cream developed using innovative human growth factors including EGF, FGF, VEGF effective for anti-wrinkle and cell regeneration

ProCell Regenerative Anti-wrinkle Cream

ProCell Regenerative Anti-wrinkle Cream

- Boosting the proliferation of dermal fibroblast cells – anti-wrinkle effect

- Enhanced skin elasticity through increasedcollagen synthesis- Reduction in transepidermal water loss(TEWL)

* Skin irritation and cytotoxicity test completed

• EGF(Epidermal Growth Factor): interacts with skin cell receptorsand boosts proliferation of dermal fibroblast cells, and has function of skin regeneration, anti-aging, and anti-wrinkle

• FGF(Fibroblast Growth Factors) and VEGF(Vascular Endothelial Growth Factor) induce proliferation and differentiation of dermal fibroblast cells, and endotherial cells in blood vessel.Both factors enhance the synthesis of collagen and elastin, fi-

nallyelevating skin elasticity.

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PROCELL Skin Regenerative Ampule

Application

MainIngredients

Characteris-tics

• Anti-wrinkle, collagen synthesis, and improved skin

elasticity• Whitening and moisturization

• Ampule

- Concentration of growth factors, based on their optimized

combination ratio, and exceptional skin elasticity and

regeneration

- Anti-wrinkle and lifting effects on sagging skins

- Whitening via anti-oxidants and whitening ingredients

• Regenerative Anti-wrinkle Cream

- Improved skin elasticity and regeneration, after application

of Ampule on deeply lined and sagging skins

- Skin protection by reduction of Transepidermal Water Loss

- Improved skin elasticity through collagen synthesis

• MTD-applied skin permeable human growth factors

- MTD-EGF, MTD-FGF2, MTD-VEGF

• MTD-applied skin permeable cell regenerative peptides

- MTD-Acetylpentapeptide, MTD-Acetylhexapeptide

• Niacinamide, Adenosine, Tranexamic acid

pII SKIN Multi-factors Double Action contains highly purified and concentrated skin-perme-ablehuman growth factors effective for anti-aging andanti-wrinkle. Also, pII SKIN Multi-factors Dou-ble Action helps skin regeneration via prompt and efficient delivery of human growth fac-tors into skin

pII SKIN Multi-factors Double Action

pII SKIN Multi-factors Double Action

- Boosting skin elasticity and regeneration- Anti-wrinkle and lifting effects on sagging skins- Whitening via anti-oxidants and whitening ingredients

* Skin irritation and cytotoxicity test completed

pII SKIN Multi-factors Double Action System is developed by the aid of ProCell’s innovative platform technology designedfor efficient transdermal delivery of bioactive ingredients, and pII SKIN’s unique and optimized combination ratio of skinpermeable growth factors helps effective skin regeneration and lifting.

PROCELL Whitening Serum

Application

MainIngredients

Characteristics

Whitening, Anti-oxidant, and moisturizing

• Co-development material with Institut Curie, France

- MTD-Kif13A

• Inhibitory effect of melanin translocation

• Melanogenesis inhibition

• Reduction in melanin pigmentation through the

deoxidation and removal of produced melanin

• Boosting collagen synthesis

• Strengthened moisturizing effect

• Skin anti-aging effect using Omega ingredient rich in

vegetable oil and lycopene

Main ingredient of PROCELL WHITENING SERUM Was developed by the application of ProCell’sInnovative platform technology to Curie’s newConcept whitening ingredient.

ProCell Bright Whitening SerumProCell Whitening Cream Serum Fresh

Whitening serum was developed by the application of ProCell’s innovation platform technology to Institut Curie’s new concept whitening ingredient. Its main functions are inhibition of melanin translocation and melanogenesis, and consequent reduction in melanin pigmentation

PROCELL whitening Serum

- Inhibitory effect of melanin translocation

- Melanogenesis inhibition

- Reduction in melanin pigmentationthrough the deoxidation and inhibi-

tionof melanin synthesis- Boosting collagen synthesis

Skin irritation and cytotoxicity test com-pleted

Vol.: 30 mL

• MTD-applied skin permeable human growth factors

- MTD-EGF, MTD-FGF, MTD-VEGF

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Thank you for your atten-tion !