1 of 25 Name: Claude J Le Saux , PhD EDUCATION 2009 - 1989 Universite de Provence, Marseille, France BS MajorBiochemistry and Microbiology 2009 - 1990 Universite de Provence, Marseille, France MS MajorCell and Molecular Biology 2009 - 1991 Universite de Provence, Marseille, France MENG MajorMicrobiology and Biotechnology 2009 - 1992 Universite de Provence, Marseille, France PhD MajorCell and Molecular Biology PhD AdvisorDr. Pascal Sommer PRINCIPAL POSITIONS HELD 2000 - 2009 University of Hawaii, Honolulu, HI Assistant Researcher 2009 - 2015 University of Texas Health Science Center at San Antonio Assistant Professor Tenure-Track Medicine, Cardiology 2015 - present University of Texas Health Science Center at San Antonio Assistant Professor(10% FTE) Medicine, Pulmonary and Critical Care 2016 - present UCSF Associate Adjunct Professor Medicine Pulmonary and Critical Care OTHER POSITIONS HELD CONCURRENTLY - HONORS AND AWARDS 1994 Pre-doctoral Fellowship Award Association pour la Recherche sur le Cancer 1995 Pre-doctoral Fellowship Award Association pour la Recherche sur le Cancer 1996 Pre-doctoral Fellowship Award Glaxo Pharmaceutical Products
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PRINCIPAL POSITIONS HELD...2012 American Association of Immunologists 99th Annual Meeting, AAI, Boston, MA Co-author on oral presentation 2012 Fibrosis Across Organ Systems Symposium,
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Name: Claude J Le Saux , PhD
EDUCATION
2009 - 1989 Universite de
Provence, Marseille,
France
BS MajorBiochemistry and
Microbiology
2009 - 1990 Universite de
Provence, Marseille,
France
MS MajorCell and Molecular
Biology
2009 - 1991 Universite de
Provence, Marseille,
France
MENG MajorMicrobiology and
Biotechnology
2009 - 1992 Universite de
Provence, Marseille,
France
PhD MajorCell and Molecular
Biology
PhD AdvisorDr.
Pascal Sommer
PRINCIPAL POSITIONS HELD
2000 - 2009 University of Hawaii, Honolulu, HI Assistant
Researcher
2009 - 2015 University of Texas Health Science
Center at San Antonio
Assistant Professor
Tenure-Track
Medicine,
Cardiology
2015 - present University of Texas Health Science
Center at San Antonio
Assistant
Professor(10%
FTE)
Medicine,
Pulmonary and
Critical Care
2016 - present UCSF Associate Adjunct
Professor
Medicine
Pulmonary and
Critical Care
OTHER POSITIONS HELD CONCURRENTLY
-
HONORS AND AWARDS
1994 Pre-doctoral Fellowship Award Association pour la Recherche sur le
Cancer
1995 Pre-doctoral Fellowship Award Association pour la Recherche sur le
Cancer
1996 Pre-doctoral Fellowship Award Glaxo Pharmaceutical Products
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1996 Award for best promising pre-doctoral
fellow
Association de la Technolopole de
Gerland
2012 Young investigator award 17th colloquium on lung and airways
fibrosis, Modena, Italy
2014 Carol Basbaum Award American Thoracic Society Respiratory
RESEARCH AND CREATIVE ACTIVITIES SUMMARY My research activities will focus on understanding the role of senescent cells in aging and fibrotic lungs.
RESEARCH AWARDS - CURRENT
1. U01 HL134766 co-investigator 14 % effort Chapman, HA (PI)
NIH/NHLBI 09/21/2016 05/31/2023
Epithelial stem/progenitor cells as repair agents in
diffuse alveolar damage
The overall objective of this application is to develop human lung epithelial stem/progenitor
cells, either endogenous or derived from iPS cells, as an adjunctive therapy to promote
recovery from severe lung injury, i.e diffuse alveolar damage. The application involves a
multi-disciplinary investigative team and uses influenza infection in both mice and macaques
as pre-clinical models to assess efficacy of cell-based therapy in lung repair.
Perform mouse pre-clinical models and determine whether senescent mesenchymal cells
contribute to the severity of the lung injury.
2. 1R01 HL142265 co-investigator 35 % effort Chapman, HA (PI)
NHI/NHLBI 02/01/2019 01/31/2024
LOXL-2 dependent blockade of TGF Beta1
signaling and lung fibrosis
This proposal aims to translate the recent discovery of a lysyl-oxidase-like-2 (LOXL2)-
dependent pathway for fibroblast-specific inhibition of TGFb1 signaling into a clinical
therapeutic to attenuate pulmonary fibrosis. The specific aims are intended to further define
the LOXL2-dependent inhibition pathway and execute a proof of principle pilot study in
patients scheduled for lung biopsies to determine if combined LOXL2 and TGFb1 inhibition
can be achieved in vivo.
Development of biomarkers that will use in the clinical trial
RESEARCH AWARDS - SUBMITTED
1. Grant Number PI 35 % effort Jourdan Le
Saux, C (PI)
Scleroderma Research Foundation Start Date Start Date
Dynamic expression of senescence-associated
eicosanoids contributes to fibrotic phenotypes in
scleroderma
$ 199,735
direct/yr 1
$ 199,735 total
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The major goals of this project are identify the dynamic change in senescence-induced
eicosanoid production in SSc and normal human skin and lung fibroblasts and its relevance
to fibrosis in the skin and the lungs.
I will be directly responsible for overseeing every phase of this project, will develop methods
as necessary to address the project aims, and analyze the data. She will also be responsible
for the dissemination of the results in the scientific community (journal articles, seminars, or
posters).
RESEARCH AWARDS - PAST
1. G12RR-03601 Co-investigator Your Effort %50 %
effort
PI NameTam, E (PI)
Granting Agency NIH-NCRR Start Date 09.2001 Start Date 09.2001
Grant TitleResearch Centers in minority
institutions program
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct
Costs$650,000 total
Grant Description NIH Research Center for Minorities Institution-Activity 3 pilot Project
Your contribution to the grant to study the Molecular Pathogensis of Airway Remodeling in
Asthma. Our project aimed to determine what are the genetic variations that could explain
the high prevalence of asthma among Asian and Pacific Islanders. We hypothesized that the
variants should be found in genes encoding inflammatory factors and consequently
enhanced airway remodeling.
2. NIH-NCRR 20 RR-1 Junior investigator Your Effort %50 %
effort
PI NameSmith, Dean
(PI)
NIH-NCRR Start Date04/2005 Start Date04/2005
Grant Title Hawaii State Biomedical
Research Infrastructure Network
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct Costs
total
Grant Description The goal of this grant was to increase the biomedical research capacity of
Hawaii.
Your contribution to the grant Junior investigator in charge of a project on pulmonary
fibrosis.
3. PF-7291 PI Your Effort % 10 %
effort
PI NameLe Saux, C
(PI)
Granting Agency Pfizer Inc. Start Date09/2014 Start Date09/2014
Grant Title Test of Janus Kinase inhibitor in
mouse lung bleomycin model
$ Yr 1 Direct
Costs$80,000
direct/yr 1
$ Total Direct Costs
total
Grant Description contract to test the anti-fibrotic properties of a Janus Kinase inhibitor
compound in mouse lung bleomycin model.
Your contribution to the grant: conduct the studies and prepare report
4. Grant Number PI Your Effort %10 %
effort
PI NameLe Saux,C
(PI)
Granting Agency Janey Briscoe
Distinguished Chair
Start Date09/2013 Start Date09/2013
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Grant TitlePreventive Effect of Tacrolimus on
Restenosis after Coronary Stenting
$ Yr 1 Direct
Costs$10,000
direct/yr 1
$ Total Direct Costs
total
Grant Description This award provided the funding necessary for the supplies to test the
hypothesis that inhaled tacrolimus could limit restenosis after coronary stenting.
Your contribution to the grant conduct the studies and prepare report
5. 10GRNT4020024 PI 10 % effort Le Saux, C (PI)
American Heart Association 07/2010 03/2013
Caveolin-1 prevents the development and
progression of cardiac remodeling.
$ 70,000 direct/yr 1 $ 140,000 total
The goal of this study is to determine how caveolin-1 regulates remodeling of the left
ventricle (LV) following myocardial infarction (MI), focusing on macrophage activation
mechanisms.
Conduct the studies and prepare report
6. 42588 PI 10 % effort Le Saux, C (PI)
HCF Fund-Leahi Fund to Treat and Prevent
Pulmonary Diseases
01/2010 01/2012
Caveolin-1 is a key mediator for the
development and progression of lung fibrosis
$ Yr 1 Direct Costs
$60,000 direct/yr 1
$ Total Direct Costs
$120,000 total
Grant Description The aim of this grant was to determine the role of caveolin-1 in the
regulation of TGF-beta signaling pathway, the main pathway that promotes pulmonary
fibrosis.
Your contribution to the grant conduct the studies and prepare report
7. 20080485 PI 10 % effort Le Saux, C (PI)
Hawaii Community Foundation 09/2008 09/20010
Caveolin-1 in the regulation of TGF-beta
signaling in myocardial remodeling
$ 50,000 direct/yr 1 $ 100,000 total
Grant Description The aim of this grant was to determine the role of caveolin-1 in the
regulation of TGF-beta signaling pathway
Conduct Research
8. 20011744 PI 10 % effort Le Saux, C (PI)
Hawaii Community Foundation
Involvement of IL-4 in airway remodeling:
activation of the lung fibroblasts
The aim of this proposal was to identify the cell and molecular mechanism that was
triggered by IL-4 in airway fibroblasts
Your contribution to the grant conduct the studies and prepare report
9. Grant Number NIH R21-
12167181
PI 40% % effort Le Saux, C (PI)
Granting Agency NIH 06/01/2016 05/31/2018
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Grant TitleCharacterization of the Various
Senescent Cells in the Aging Lungs
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct Costs
total
Grant Description This work proposes to determine whether senescence cells contribute to
the age-associated structural changes. We will determine whether the presence of
senescence cells is necessary to provoke the age-associated structural changes.
Furthermore, we will characterize the secretome of three main cell types (endothelial and
alveolar epithelial cells, and fibroblasts) and determine their relative contribution to the
structural changes.
Your contribution to the grant is to be directly responsible for overseeing every phase of this
project, develop methods as necessary to address the project aims, and analyze the data. I
will also be responsible for the dissemination of the results in the scientific community
(journal articles, seminars, or posters).
10. Grant Number AHA
15GRNT25710065
PI 10% % effort Le Saux, C (PI)
Granting Agency American Heart Association 07/2015 Start Date 07/2015
Grant TitleCellular senescence due to
invasive pneumococcal disease leads to
cardiac interstitial fibrosis
$ Yr 1 Direct Costs
$63,500 direct/yr 1
$ Total Direct
Costs$127,000 total
Grant Description This project explores how S. pneumoniae induced cellular senescence in
cardiomyocytes resulting in the release of senescence-associated secreted proteins that
recruit immune cells and elicit a profibrotic response and permanent cardiac alterations that
negatively impact cardiac function.
Your contribution to the grant is to directly be responsible for overseeing every phase of this
project and to develop methods as necessary to address the project aims. I will have final
authority on all aspects of the project.
11. Grant ISSEXEN0012 PI 25% % effort Le Saux, C (PI)
Granting Agency AstraZeneca 6/2016 6/2017
Grant TitleGradient of inflammation in
Adipocytes near Coronary Vessel Wall
Associated with Atherosclerotic Plaque
$ Yr 1 Direct Costs
direct/yr 1
$ Total Direct Costs
$390,848.00 total
Grant Description This project is designed to determine the possible role of the perivascular
fat in atherogenesis in particular the activation of macrophage and inflammatory markers.
Your contribution to the grant is to directly be responsible for overseeing every phase of this
project and to have final authority on all aspects of the project.
12. 7501313/7504366 co-OI 0 % effort Tien (PI)
UCSF-Academic Senate Shared Instrument
Awards
02/01/2017 07/31/2018
Integrated Lung Physiology Platform for
Murine Models
$ 35000 direct/yr 1
To provide an integrated lung physiology platform to improve the quality and reproducibility
of our studies in various lung pathology models.
Provide support to investigators who would like to use the Flexivent (Scireq) equipment
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PEER REVIEWED PUBLICATIONS
1. Baulard A, Jourdan C, Mercenier A, Locht C. Rapid mycobacterial plasmid analysis by electroduction between Mycobacterium spp. and Escherichia coli. Nucleic Acids Research. 1992; 20(15):4105. PMID: 1508702
2. Jourdan Le Saux C, Gleyzal C, Garnier JM, Peraldi M, Sommer P, Grimaud JA. Lysyl oxidase cDNA of myofibroblast from mouse fibrotic liver. Biochemical and Biophysical Research Communications. 1994; 199(2):587-92. PMID: 7510957
3. Jourdan Le Saux C, Gleyzal C, Raccurt M, Sommer P. Functional analysis of the lysyl oxidase promoter in myofibroblast-like clones of 3T6 fibroblast. Journal of Cellular Biochemistry. 1997; 64(2):328-41. PMID: 9027591
4. Jourdan Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. Genomics. 1998; 51(2):305-7. PMID: 9722957
5. Jourdan Le Saux C, Tronecker H, Bogic L, Bryant-Greenwood GD, Boyd CD, Csiszar K. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. The Journal of Biological Chemistry. 1999; 274(18):12939-44. PMID:10212285
6. Reynaud C, Gleyzal C, Jourdan Le Saux C, Sommer P. Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells. Cellular and Molecular Biology. 1999; 45(8):1237-47. PMID: 10643973
7. Jourdan Le Saux C, Le Saux O, Gleyzal C, Sommer P, Csiszar K. The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus. Matrix Biology. 2000; 19(2):179-83. PMID: 10842102
8. Hein S, Yamamoto SY, Okazaki K, Jourdan Le Saux C, Csiszar K, Bryant-Greenwood GD. Lysyl oxidases: expression in the fetal membranes and placenta. Placenta. 2001; 22(1):49-57. PMID: 11162352
9. Jourdan Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. Genomics. 2001; 74(2):211-8. PMID: 11386757
10. Lozanoff S, Johnston J, Ma W, Jourdan Le Saux C. Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. The journal of Histochemistry and Cytochemistry. 2001; 49(9):1081-97. PMID: 11511678
11. Chan DS, Callahan CW, Beckham S, Kishaba G, Yamamoto K, Malone FJ, Boychuk R, Tam E, Jourdan Le Saux C, Underwood G, Vogt TM, Takafuji E. Report of the first annual Hawaii Asthma Research Consortium. Hawaii Medical Journal. 2002; 61(9):194-8. PMID: 12422384
12. Jourdan Le Saux C, Bollt O, Orozco C, Concepcion J, Yamaga K, Yamamoto F, Haymer D, Tam EK. A base substitution in the interleukin-10 (IL-10) promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels. Cellular and Molecular Biology. 2003; 49(7):1109-15. PMID: 14682393
13. Tam EK, Jourdan LeSaux C, Stauder S, Bollt O, Reber B, Yamamoto F, Haymer D. Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy
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and asthma in an admixed population in Hawaii. Cellular and Molecular Biology. 2003; 49(8):1345-9. PMID: 14984008
14. Hayashi K, Cao T, Passmore H, Jourdan Le Saux C, Fogelgren B, Khan S, Hornstra I, Kim Y, Hayashi M, Csiszar K. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. The Journal of Investigative Dermatology. 2004; 123(5):864-71. PMID: 15482472
15. Harrigan RC, Easa D, Jourdan Le Saux C, Millar L, Kagihara LE, Shomaker TS, Greer MH, Beck JD, Offenbacher S. Oral health disparities and periodontal disease in Asian and Pacific Island populations. Ethnicity & Disease. 2005; 15(4 Suppl 5):S5-39-46 PMID: 16315381
16. Hoffmann PR, Jourdan Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ. A role for dietary selenium and selenoproteins in allergic airway inflammation. Journal of Immunology. 2007; 179(5):3258-67. PMID: 17709542
17. Hoffmann PR, Gurary A, Hoffmann FW, Jourdan Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ. A new approach for analyzing cellular infiltration during allergic airway inflammation. Journal of Immunological Methods. 2007; 328(1-2):21-33. PMID: 17825315
18. Jourdan Le Saux C, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. The Journal of Biological Chemistry. 2008; 283(9):5760-8. PMID: 18056268
19. Le Saux O, Teeters K, Miyasato S, Choi J, Nakamatsu G, Richardson JA, Starcher B, Davis EC, Tam EK, Jourdan Le Saux C. The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008; 295(6):L1007-17. PMID: 18849439
20. Jourdan Le Saux C, Zhang J, Lindsey ML. Extracellular matrix roles during cardiac repair. Life sciences. 2010; 87(13-14):391-400. PMID: 20670633
21. Miyasato S, Loeffler J, Shohet R, Zhang J, Lindsey M, Jourdan Le Saux C. Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling. Matrix Biology. 2011; 30(5-6):318-29. PMID: 21641995
22. Shivshankar P, Boyd A, Jourdan Le Saux C, I-Tien Yeh, Orihuela C. Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011; 10(5):798-806. PMID:21615674
23. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Jourdan Le Saux C. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. American Journal of Respiratory Cell and Molecular Biology. 2012; 47(1):28-36. PMID: 22362388
24. Ramirez TA, Jourdan Le Saux C, Joy A, Zhang J, Dai Q, Mifflin S, Lindsey ML. Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertension Research. 2012; 35(8):811-8. PMID: 22495609
25. Jourdan Le Saux C, Davy P, Brampton C, Ahuja S S, Fauce S, Shivshankar P, Nyugen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. A novel telomerase activator suppresses lung damage in a murine model ofidiopathic pulmonary fibrosis. PloS one. 2013; 8(3):e58423. PMID: 23516479
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26. Gabehart, KE, Royce, S, Maselli Caceres D, Miyasato, S, Davis, E, Tang, M, Jourdan Le Saux C. Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. Respiratory Research. 2013; 14:110. PMID: 24138138
28. Hung JY, Horn D, Woodruff K, Prihoda T, Jourdan Le Saux C, Peters J, Tio F, Abboud-Werner SL. Colony-stimulating factor 1 potentiates lung cancer bone metastasis. Laboratory Investigation. 2014; 94(4):371-81. PMID: 24468794
29. Royce, S and Jourdan Le Saux C. Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases. Expert Review of Respiratory Medicine. 2014; 8(3):339-47. PMID: 24742020
30. Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, Jourdan Le Saux C, Tuomanen EI, Orihuela CJ. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS pathogens. 2014; 10(9):e1004383. PMID: 25232870
31. Shivshankar P, Payan H, Calhoun C, William R, Jahgidair J, Levine S, Peters J, Jourdan Le Saux C. Inhaled Tacrolimus Modulates Fibrosis Development without Promoting Inflammation in Bleomycin-Injured Mouse Lungs. Journal of Drug Delivery Science and Technology. 2014 September.
32. Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Jourdan Le Saux C. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2014; 76:84-93. PMID: 25128086
33. Sanders YY, Cui Z, Jourdan Le Saux C, Horowitz JC, Rangarajan S, Kurundkar A, Antony VB, Thannickal JV. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PloS one. 2015; 10(2):e0116995. PMID: 25658089
34. Calhoun C, Shivshankar P, Sloane LB, Orihuela CJ, White E, Richardson A, Jourdan Le Saux C. Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. The Journals of Gerontology. Series A, Biological sciences and medical sciences. 2015; PMID: 25568097
35. Sanon VP, Sawaki D, Mjaatvedt CH, Jourdan Le Saux C. Myocardial tissue caveolae. Comprehensive Physiology. 2015; 5(2):871-86. PMID: 25880516
36. Pinkerton KE, Harbaugh M, Han MK, Jourdan Le Saux C, Van Winkle LS, Martin Ii WJ, Kosgei RJ, Carter EJ, Sitkin N, Smiley-Jewell SM, George M. Women and Lung Disease: Gender Differences and Global Health Disparities. American Journal of Respiratory and Critical Care Medicine. 2015; PMID: 25945507
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37. Halaney DL, Zahedivash A, Phipps JE, Wang T, Dwelle J, Jourdan Saux C, Asmis R, Milner TE, Feldman MD. Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt. 2015 PMID: 26538329.
38. Wan F, Letavernier E, Jourdan Le Saux C, Houssaini A, Abid S, Czibik G, Sawaki D, Marcos E, Dubois-Rande JL, Baud L, Adnot S, Derumeaux G, Gellen B. Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation Am J Physiol Heart Circ Physiol. 2015. PMID: 26453333
39. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127(10):3675-3688. doi: 10.1172/JCI94624. Epub 2017 Sep 5. PMID:/> 28872461
40. Jourdan Le Saux C, Chapman HA. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. American Journal of Respiratory Cell and Molecular Biology. 2018; 59(2): 137 doi.org/10.1165/rcmb.2018-0083ED
41. Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, Jourdan Le Saux C, Passos JP, Antoniou A, Rustin MHA, Campisi J, Akbar AN. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nature Communications. 2019; 10:2387. 10.1038/s41467-019-10335-5
42. Ying Wei, M.D., Julia Jackson, B.S., Genevieve Montas, B.S., Darren Leong, B.S., Jeffrey A. Golden, M.D., Binh N. Trinh, M.D., Ph.D., Elena Foster, M.S., Justin M. Oldham, M.D., Angela L. Linderholm, Ph.D., Paul J. Wolters, M.D., Xiaopeng Li, M.D., Julia Klesney-Tait, M.D., Ph.D., Prerna Kotak, M.S., Martin Decaris, Ph.D., Scott Turner, Ph.D., Jin Woo Song, M.D., Ph.D., Claude Jourdan Le Saux, Ph.D., Kirk Jones, M.D., and Harold A. Chapman, M.D. Reversal of TGFb1-driven Profibrotic State in Pulmonary Fibrosis Patients. Submitted
43. Christopher D. Wiley, Alexis N. Brumwell, Sonnet S. Davis, Julia R. Jackson, Alexis Valdovinos, Cheresa Calhoun, Fatouma Alimirah, Carlos A. Castellanos, Richard Rui, Ying Wei, Harold A. Chapman, Arvind Ramanathan, Judith Campisi, and Claude Jourdan Le Saux. Secretion of Leukotrienes by Senescent Lung Fibroblasts promotes Pulmonary Fibrosis. J Clin Invest In-sight. In Revision
44. Fan H, Rosson G, Wolf M, Sadtler K, Elisseeff J, Pardoll D, Houssean F, Wu X, Narain E, Chung L, Lebid A, Mageau A, Jourdan Le Saux C, Tam A, Vanderzee I, Čiháková D, Maestas D, Zhang X, Andorko, J.Interleukin-17 and senescence regulate the foreign body. Science Translational Medicine. In Revision
BOOKS AND CHAPTERS
1. Shivshankar P, Jourdan Le Saux C. Molecular Aspects of Aging. Rojas M, Meiners S, Jourdan Le Saux C, editors. Hoboken, New Jersey: John Wiley et sons Inc.; 2014. Chapter 5, The cellular senescence program; p.8.
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2. Keyt H, Levine S, Jourdan Le Saux C. The Aging Lung: Mechanism and Clinical Sequeia. Lee P, Bucala R, editors. Washington DC: World Scientific Press; 2015. Chap 7, Environmental and Genetic Factors - Race Ethnicity and Gender
3. Molecular aspects of aging. Rojas M, Meiners S, Jourdan Le Saux C, editors. Hoboken, New Jersey: John Wiley et sons Inc.; 2014. 207p.
SIGNIFICANT PUBLICATIONS
1. I am interested in the mechanisms by which aging and injury trigger cellular senescence in
the lungs leading to the remodeling of the pulmonary tissue. I have built over the course of
the last 20 years my expertise on remodeling/fibrosis and in the last 5 years on cellular
senescence. This publication is one of the first ones to demonstrate not only the presence
of senescent cells in aged lungs but their causal role of the age-associated remodeling