Total Synthesis and Evaluation of [ψ[CH 2 NH]Tpg 4 ] Vancomycin Aglycon: Reengineering Vancomycin for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding Brendan M. Crowley and Dale L. Boger J. Am. Chem. Soc. 2006, 128, 2885-2892 Contribution from the Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037 Presented by, Michael Elbaum
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Total Synthesis and Evaluation of [ψ[CH2NH]Tpg4] Vancomycin Aglycon: Reengineering Vancomycin for Dual D-
Ala-D-Ala and D-Ala-D-Lac Binding
Brendan M. Crowley and Dale L. BogerJ. Am. Chem. Soc. 2006, 128, 2885-2892
Contribution from the Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey
Pines Road, La Jolla, California 92037
Presented by,Michael Elbaum
Dale L. Boger• B.S. University of Kansas, 1975• Ph.D. Harvard University, 1980• Assistant / Associate Professor of
Medicinal Chemistry, University of Kansas 1979-1985
• Associate Professor / Professor of Chemistry, Purdue University, 1985-1991
• Professor, The Scripps Research Institute, 1991-Present
• Member, The Skaggs Institute for Chemical Biology, 1996-present
• Editor-in-Chief, Bioorganic and Medicinal Chemistry Letter, 1990-present