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Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in<br /> advanced melanoma (MEL) Presented By Mario Sznol at 2014 ASCO Annual Meeting
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Presented By Mario Sznol at 2014 ASCO Annual Meeting

Feb 22, 2016

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Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in
advanced melanoma (MEL) . Presented By Mario Sznol at 2014 ASCO Annual Meeting. Disclosures. - PowerPoint PPT Presentation
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Page 1: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in<br /> advanced melanoma (MEL)

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 2: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Disclosures

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 3: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Ipilimumab and Nivolumab Clinical Experience in Patients with Advanced Melanoma

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 4: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Objectives

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 5: Presented By Mario Sznol at 2014 ASCO Annual Meeting

CA209-004 Phase I Study: Dose Cohorts

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 6: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Patient Demographics

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 7: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Activity Summary: Concurrent and Sequenced Cohorts from 004

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 8: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Response in Target Lesions

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 9: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Slide 9

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 10: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Characteristics of Response

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 11: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Safety Overview

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 12: Presented By Mario Sznol at 2014 ASCO Annual Meeting

ORR by BRAF Status for Concurrent Cohorts

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 13: Presented By Mario Sznol at 2014 ASCO Annual Meeting

ORR by PD-L1 Status (5% cutoff)

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 14: Presented By Mario Sznol at 2014 ASCO Annual Meeting

ORR by Ipilimumab Exposure at Time <br />of Nivolumab Treatment

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 15: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Overall Survival for Concurrent <br />Therapy by Dose Cohort

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 16: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Survival Endpoints for Concurrent and Sequential Therapy by Dose Cohort

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 17: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Conclusions

Presented By Mario Sznol at 2014 ASCO Annual Meeting

Page 18: Presented By Mario Sznol at 2014 ASCO Annual Meeting

Acknowledgments

Presented By Mario Sznol at 2014 ASCO Annual Meeting