Il parto nella donna con diabete Federico Mecacci Prenatal Medicine High Risk Pregnancy Unit Careggi Universitary Hospital Newborn’s and Women's Health Department
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Il parto nella donna con diabeteFederico Mecacci
Prenatal Medicine High Risk Pregnancy Unit
Careggi Universitary Hospital Newbornrsquos and Womens Health Department
0
1
2
3
4
5
6
7
madri obese
48
Del 20 delle madri obese dal 2008 al 2016Dati regione Toscana
57
Nascere in Toscana 2015
MATERNAL AGE DELAYED CHILDBEARING AND METASBOLIC SYNDROME
2016
Prevalence of metabolic syndrome(NCEP ATP III) in the NHANES III survey Ford ES JAMA 2002 287356
Balkau B Diabet Metabol 2002
36 of Europeans were observed at the ageof 40-55 years with metabolic syndrome
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
0
1
2
3
4
5
6
7
madri obese
48
Del 20 delle madri obese dal 2008 al 2016Dati regione Toscana
57
Nascere in Toscana 2015
MATERNAL AGE DELAYED CHILDBEARING AND METASBOLIC SYNDROME
2016
Prevalence of metabolic syndrome(NCEP ATP III) in the NHANES III survey Ford ES JAMA 2002 287356
Balkau B Diabet Metabol 2002
36 of Europeans were observed at the ageof 40-55 years with metabolic syndrome
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM 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Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631595104670616083397623100001162157485402000021634809945730000316480450374400002166128012915167451522086000011687750312570000217009854042800001171422049598999991727455587717406906794100001175392577112000031767160862830000117803959545399999179363104625000011806866137960000218201012296700003183333632138000011846571413091859806504800000118730415965100002188627668822189951177993000021912746871641925981963350000119392170550600002195245214677000011965687238480000219789223301919921574219000001200539251361000032018627605320000120318626970299999204509778874000012058332880450000220715679721620848030638700001209803815558211127324729000012124508339000000221377434307121509785224200002216421361413217744870584000012190683797550000222039188892600001221715398097000022230389072682243624164390000122568592561000003227009434781000012283329439520000222965645312300001230979962294000022323034714652336269806360000123495048980723627399897800001237597508149000022389210173224024452649100002241568035662242891544833000012442150540040000224553856317500001246862072346000022481855815172495090906880000125083259985925215610903000001253479618201000022548031273720000125612663654300002257450145714000032587736548849999826009716405626142067322700001262744182398000022640676915690000326539120073999999266714709911268038219082000012693617282530000227068523742400004272008746594999992733322557662746557649370000127597927410800003277302783278999982786262924499999927994980162100001281273310792000022825968199630000328392032913399999285243838305286567347476000012878908566470000228921436581800003290537874988999992918613841629318489333100001294508402502000022958319116730000429715542084399999298478930015299802439186000023011259483570000330244945752800004303772966698999993050964758700000130641998504100002307743494212000033090670033829999931039051255431171402172500001313037530896000023143610400670000331568454923799999317008058409318331567580000013196550767510000232097858592199998322302095092999993236256042643249491134350000232627262260600003327596131776999983289196409479999933024315011900001331566659290000023328901684610000333421367763199999335537186803336860695974000013381842051450000233950771431600003340831223486999993421547326583434782418290000134480175100000002346125260171000043474487693419999934877227851335009578768400002
Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
MATERNAL AGE DELAYED CHILDBEARING AND METASBOLIC SYNDROME
2016
Prevalence of metabolic syndrome(NCEP ATP III) in the NHANES III survey Ford ES JAMA 2002 287356
Balkau B Diabet Metabol 2002
36 of Europeans were observed at the ageof 40-55 years with metabolic syndrome
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
| 124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
| 125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
| 127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
| 128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
| 129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
| 130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
| 131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
| 132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
| 134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
| 135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
| 142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
| 143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
| 144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
| 145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
| 146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
| 148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
| 149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
| 150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
| 151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
| 152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
| 153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
| 155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
| 156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
| 157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
| 158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
| 159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
| 124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
| 125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
| 127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
| 128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
| 129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
| 130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
| 131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
| 132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
| 134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
| 135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
| 142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
| 143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
| 144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
| 145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
| 146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
| 148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
| 149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
| 150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
| 151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
| 152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
| 153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
| 155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
| 156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
| 157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
| 158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
| 159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
| 124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
| 125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
| 127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
| 128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
| 129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
| 130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
| 131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
| 132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
| 134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
| 135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
| 141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
| 142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
| 144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
| 145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
| 146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
| 148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
| 149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
| 150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
| 151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
| 152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
| 153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
| 155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
| 156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
| 157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
| 158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
| 159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||||
| GDM |
| Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
| AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
| 17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
| 120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
| 121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
| 122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
| 123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
| 127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
| 128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
| 129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
| 130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
| 131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
| 132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
| 19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
| 134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
| 135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
| 136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
| 137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
| 138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
| 139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
| 20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
| 141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
| 142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
| 143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
| 144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
| 145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
| 146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
| 21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
| 148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
| 149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
| 150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
| 151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
| 152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
| 153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
| 22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
| 155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
| 156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
| 157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
| 158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
| 159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
| 160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
| 23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
| 162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
| 163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
| 164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
| 165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
| 166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
| 167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
| 24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
| 169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
| 170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
| 171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
| 172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
| 173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
| 174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
| 25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
| 176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
| 177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
| 178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
| 179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
| 180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
| 181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
| 26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
| 183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
| 184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
| 185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
| 186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
| 187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
| 188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
| 27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
| 190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
| 191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
| 192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
| 193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
| 194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
| 195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
| 28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
| 197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
| 198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
| 199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
| 200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
| 201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
| 202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
| 29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
| 204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
| 205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
| 206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
| 207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
| 208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
| 209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
| 30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
| 211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
| 212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
| 213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
| 214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
| 215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
| 216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
| 31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
| 218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
| 219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
| 220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
| 221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
| 222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
| 223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
| 32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
| 225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
| 226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
| 227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
| 228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
| 229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
| 230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
| 33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
| 232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
| 233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
| 234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
| 235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
| 236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
| 237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
| 34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
| 239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
| 240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
| 241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
| 242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
| 243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
| 244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
| 35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
| 246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
| 247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
| 248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
| 249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
| 250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
| 251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
| 36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
| 253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
| 254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
| 255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
| 256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
| 257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
| 258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
| 37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
| 260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
| 261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
| 262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
| 263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
| PDM1 | ||||||||||||||||||||||||||||||||||||
| PDM 2 | ||||||||||||||||||||||||||||||||||||
| GDM |
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
- Diapositiva numero 1
- Diapositiva numero 2
- Diapositiva numero 3
- Diapositiva numero 4
- Diapositiva numero 5
- Diapositiva numero 6
- Diapositiva numero 7
- Birth weight distribution in diabetic pregnancies
- Diapositiva numero 9
- Diapositiva numero 10
- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
- Diapositiva numero 12
- Diapositiva numero 13
- Diapositiva numero 14
- Diapositiva numero 15
- Diapositiva numero 16
- Diapositiva numero 17
- Diapositiva numero 18
- Diapositiva numero 19
- Differences in placental pathology according to diabetes types
- Diapositiva numero 21
- Pathophysiology of fetal compromise in diabetic pregnancy
- Diapositiva numero 23
- Diapositiva numero 24
- Diapositiva numero 25
- Diapositiva numero 26
- Diapositiva numero 27
- Diapositiva numero 28
- Diapositiva numero 29
- Diapositiva numero 30
- Diapositiva numero 31
- Diapositiva numero 32
- Diapositiva numero 33
- Diapositiva numero 34
- Diapositiva numero 35
- Diapositiva numero 36
- GDM and the Use of Betamethasone
- Diapositiva numero 38
- Diapositiva numero 39
- Diapositiva numero 40
- Pathophysiology of fetal compromise in diabetic pregnancy
-
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