Presentación de PowerPoint - BioBarica · Fibromyalgia Rheumatoid ... PRESENTATION OF CASES VARIOUS ESSAYS, SERIES AND CASE REPORTS RAISE THE EFFECTIVENESS OF HBOT AS A SUCCESSFUL

BIOBARICAGLOBAL NETWORK OFHYPERBARIC THERAPY

1. BIOBARICA INTRODUCTION2. MEDICAL PRESENTATION3. TECHNICAL PRESENTATION

BIOBARICA SYSTEM

WHO WE ARE

BIOBARICA IN THE WORLD We are in more than 28 countries of the world.

BIOBARICA SYSTEM

ADRESSED TO

WHERE WE WORK

BIOBARICA PROVEN THERAPEUTIC EFFICIENCY

WHY IS THIS HYPERBARIC CHAMBER UNIQUE?

BIOBARICA GLOBAL SYSTEM

BIOBARICA

CLINICAL RESEARCH

BioBarica provides all the communication segmented by audiences: operators, doctors and patients needed to reach all those who are related to the hyperbaric treatment.

We work to develop messages based on concepts tested by market research.

We promote the hyperbaric medicine that is constantly growing. New applications are constantly discovered.

BIOBARICACOMUNICATION

Our communication is based on transmitting our know how to the medical community and patients through the correct pieces of information and providing training.

GLOBAL OUTREACH

CONTRACT LIABILITY

BUSINESS ALTERNATIVES

Step 1 (1 day)

•Sign Confidentiality Agreement

•BioBarica providescomercial and medical documentation

Step 2 (3 days)

•Discuss ket termsof the contract

•Sign contractwith BioBarica

Step 3 (7 days)

•Purchasehyperbaricchamber (DEMO)

•BioBarica deliversthe chamber

Step 4 (2 days)

•Installation and training byBioBarica

•The hyperbaricmedicine unit isready to operate.

Certification(time dependson the country)

Developmentand growing

DISTRIBUTORS PROCESS AND TIMING

BIOBARICA IN NUMBERS


HYPERBARIC MEDICINE

Increasing the concentration of O2 that we breathe

Increasing the pressure of the air we breathe (environment ≥1.45 ATM) *

O2 100% HYPERBARIA

O2 dissolved in blood: HYPEROXIA reaching very poorly

irrigated tissues and producing other physiological effects

TREATMENT

HYPERBARIC OXYGENATION (HBOT)

*Undersea and Hyperbaric Medicine Society >>>1.4 ATA

DALTON'S LAW

The pressure of a mixture of

gases is equal to the sum of

partial pressures (Pp) of each of

the gases that compose it.

HENRY'S LAW

Gases dissolve in liquids

when under pressure.

PHYSIOLOGY OF OXYGENPHYSICOCHEMICAL FUNDAMENTALS

PHYSIOLOGY OF OXYGENAnalogy with a Sparkling Wather bottle

You can see no bubbles in a closed sparklingwater bottle. When you open it, bubblesappear. This is due to the physical laws statingthat gasses dilute in liquid when they are underpressure.

The same physical laws apply to our body.When O2 is breathed in a pressurized cabin, theO2 dilutes in blood plasma, which is 50% water.

PHYSIOLOGY OF OXYGEN

Normobaria (Air at sea level):

Atmospheric pressure: 760 mmHg (1 ATA)

Partial concentration of O2: 21%

Pp O2: 0.21 x 760 mmHg = 160 mmH

Hyperbaria: 1.45 ATA

Partial concentration of O2: 21%

Pp O2: 0.21 x (1.45 x760 mmHg) = 231 mmHg

FiO2: (Fraction Inspired by O2 - VN: 0.21)

VH20: 47 mmHg (internal humidity - Water)

PACO2: 40 mmHg (Alveolar Pressure CO2)

CR = 0.8 (respiratory coefficient between CO2 and O2)

Alveolar pressure of the O2

PAO2 = (760 - 47) x 0.21 - 40 / 0.8 = 100 mmHg

100% O2 to 1.45 ATA: PAO2 = (760 * 1.45 - 47) x 1 - 40 / 0.8 = 950 mmHg

INCREASING

THE PRESSURE

IN THE

ALVEOLO

INCREASES THE

DISSEMINATION

TO THE PLASMA

VH20 PACO2 CR

PHYSIOLOGY OF OXYGEN

CONTENT OF

O2 IN THE BLOOD

The hyperbaric effect on dissolved oxygen:

1. Normobaric air (21% O2 1 ATA 97% Hb): 0.3ml / dl dissolved oxygen2. Hyperbaric oxygen (100% 1.45 ATA 100% Hb): 3.0 ml / dl dissolved oxygen

Hyperoxia:

Increases 10 times the amount of dissolved oxygen (independent of Hemoglobin) O2 is immediately and completely available for cells.

TREATMENT

HYPERBARIC OXYGENATIONEssential effect of Hyperbaric Oxygenation

Oxygenate the tissues

The average density of capillaries varies in tissues (~ 600 / mm3)• 2500-3000 / mm3 (brain, kidneys, liver, myocardium);• 300-400 / mm3 (skeletal muscles);• <100 / mm3 (bones, adipose tissue, connective tissue)

Average separation of ~ 40μm between adjacent capillaries

Distance capillary cells in living tissues: ~ 1-3 cells

Source: Robert A. Freitas Jr., Nanomedicine, Volume I: Basic Capabilities, Landes Bioscience, Georgetown, TX, 1999

Describes radial gradients of PO2 in a tissue cylinder

of radius R. The model considers the O2 consumption,

the solubility, the diffusion coefficient of O2 and the

non-linear fall of PO2 from the arterial to the venous

end of the capillary.

It allows calculating the PO2 at any point r, where c is

the radius of the capillary and r is the distance from

the center of the capillary inside the tissue cylinder.

The penetration of O2 into tissues is a function of PO2

BLOOD END

VENOUS END

a.radial

L

L

DISSEMINATION OF O2:

KROGH MODEL

DISSEMINATION OF O2:

KROGH MODELO2 Penetration to tissues:

Pressure in hyperbaric chamber = 1.45 ATA

generates PO2arterial = 950mmHg

Minimum effective PO2, tissue = 20mmHg

Penetration radius ~ 75μm (diameter ~ 150 μm)

Under these conditions, the penetration of O2 into

all tissue cells is guaranteed

950mmHg

PHYSIOLOGICAL EFFECTS

O2 gradient between the alveolus and pulmonary capillary

O2 diffusion and availability in tissues

Blood pressure of O2 and amount of dissolved O2:

HYPEROXIA (independent of hemoglobin)

AEROBIC METABOLISM

Through HBOT, O2 is administered as an active ingredient, seeking to maximize the oxygenation of

tissues to fulfill cellular and metabolic functions.

Molecular oxygen (O2) is an essential element for the cell: its main "mechanism of action" is to

participate as fuel in the energy supply of the cell.

O2

Energy production

ATP

FREE RADICALSFree radicals (RL) are chemical species with

an unpaired electron in their outer orbit. The

RL seek to match that electron, so they are

highly reactive. Oxygen is also present in the

form of RL (EROs) used by our body for

multiple functions:

• Inflammatory and immunological

response (against viruses and / or

bacteria)

• Proliferation and cell division

• Apoptosis

EROs

OXIDATIVE STRESSANTIOXIDANT DEFENSE

BALANCE OF THE OXIDIZING SYSTEM - ANTIOXIDANT

DISBALANCE: DISEASE

(H₂O₂ -0₂ -OH NO NOO-)

antioxidant

Free radical

electron

MECHANISM OF ACTION - HOBT

HYPEROXIA

EROs production

Improves the antioxidant system

Objective: to guarantee the arrival of O2 to tissues to fulfill

biochemical, metabolic and physiological functions

InglésInglésInglés

HYPERBARIC OXYGEN

GENERATES A STRONG HYPEROXIA

BENEFICIAL PHYSIOLOGICAL EFFECTS

HYPEROXIA - PHYSIOLOGICAL EFFECTS

VASOCONSTRICTION

ANGIOGENESIS

OSTEOGÉNESIS

CELLULAR IMMUNITY

PERIPHERAL AXONAL

REGENERATION

COLLAGEN SYNTHESIS

OXIDATIVE STRESS AND INFLAMMATORY RESPONSE

NEURAL FUNCTION

PROLIFERATION AND STIMULATION

OF MOTHER CELLS

GRAFTS AND FLANGES

OXYGEN DOSEThe therapeutic effect of hyperoxia is

determined by the dose of oxygen.

The dose of oxygen depends on 5 variables:

• % of O2

• Pressure of the camera

• Duration of the session

• Session frequency

• Total number of sessions

5 weekly sessions

4 weekly sessions

3 weekly sessions

2 weekly sessions

1 weekly session

INDICATION OF THE TREATMENTSessions

Generally, a minimum of 10-20 sessions are indicated, according to the pathology of each patient.

Duration of the session

The average time used is 60 minutes. In acute patients, sessions of 90 minutes up to 2 times a day

are performed.

Session cycle

Number of sessions to be done indicating: total number, daily amount, weekly periodicity (1 to 6)

and duration of the session.

Intercycle period

Rest indicated between cycles.

HBOT: INDICATIONS

MEDICAL CLINIC

• Fibromyalgia

• Chronic fatigue

• Migraines and headaches

• Tinnitus

• Geriatrics

• Apneas of sleep

• Crohn's disease

Adjuvant treatment that reduces inflammation and edema, relieves pain, improves tissue perfusion, energy efficiency and quality of life.

Inglés

• Trauma

• Pre and post-surgical

• Progressive bacterial gangrene

• Acute traumatic ischemia

• Ligament injuries

• Osteomyelitis

Adjuvant treatment accelerates recovery and healing, reduces inflammation and edema, relieves pain, reduces the risk of infection and amputation and improves quality of life.

HBOT: INDICATIONS

TRAUMATOLOGY

Adjuvant treatment prepares athletes during training, improves energy efficiency, shortens recovery, prevents fatigue and improves injury rehabilitation.

• Training

• Muscle and tendon injuries

• Post-exercise recovery

• Chronic Fatigue Syndrome

HBOT: INDICATIONS

SPORT MEDICINE

• ACV

• Parkinson's disease

• Multiple sclerosis

• Alzheimer disease

Adjuvant treatment reduces edema, redistributes blood flow and improves cerebral oxygenation, reduces spasticity and tremors, improves cognitive function, neuroprotection and quality of life.

PEDIATRIC PATIENT:

• Autism

• TGD

• Cerebral palsy

• Detoxification

HBOT: INDICATIONS

NEUROLOGY

• Wounds

• Ulcers - Diabetic foot

• Venous ulcers

• Post-surgical injuries

• Burns

• Grafts and implants

The treatment of hyperbaric oxygenation accelerates healing, favors angiogenesis, reduces

inflammation and edema, stimulates collagen synthesis, triggers the immune response and

improves perfusion.

HBOT: INDICATIONS

WOUNDS

Fibromyalgia

Rheumatoid arthritis

Osteoarthritis

Bone edema

Bone necrosis

Osteomyelitis

Adjuvant treatment to accelerate recovery, relieve pain, reduce inflammation and edema, reduce the risk of infection and improve quality of life.

HBOT: INDICATIONS

REUMATOLOGY

• Tumors

• Radio-necrosis and radiotherapy

Adjuvant treatment to improve sensitivity to radio and chemotherapy, control tumor growth, relieve

pain, prevent and recover radio-necrosis and improve quality of life

HBOT: INDICATIONS

ONCOLOGY

EVIDENCE ANDPRESENTATION OF CASES

VARIOUS ESSAYS, SERIES AND CASE REPORTS

RAISE THE EFFECTIVENESS OF HBOT AS A

SUCCESSFUL TREATMENT FOR DIFFERENT

DISEASES.

Hyperbaric Oxygen Induces Late Neuroplasticity

in Post Stroke Patients - Randomized,

Prospective Trial

Shai Efrati1,2,3*, Gregori Fishlev1, Yair Bechor1,

Olga Volkov3,4, Jacob Bergan1, Kostantin

Kliakhandler5,

Izhak Kamiager3,6, Nachum Gal1, Mony

Friedman1, Eshel Ben-Jacob2,5,7, Haim Golan3,4

Hyperbaric Oxygen Induces Late Neuroplasticity in PostStroke Patients -Randomized, Prospective Trial

A normal and healthy adult brain

should be seen primarily yellow in

the SPECT scanner. Green

indicates lower blood flow and

oxygen. Blue and violet represent

a significant reduction of blood

flow in the brain.

Patient: Man.

Age: 60 years.

Diagnosis: Ischemic ulcer - rheumatoid arthritis

Number of sessions: 40

Patient: Man.

Age: 60 years.

Diagnosis: Ischemic ulcer - rheumatoid arthritis


Patient: Man.

Age: 27 years.

Diagnosis: Arteriovenous fistula


Patient: Man.

Age: 27 years.

Diagnosis: Arteriovenous fistula


Patient: Man.

Age: 60 years.

Diagnosis: Post-heart surgery


Patient: Man.

Age: 60 years.

Diagnosis: lower limb, Necrosis, circulatory failure.


Patient: Male.

Age: 5 years

Diagnosis: Arteriovenous malformation


Patient: Man

Age: 70 years.

Diagnosis: Diabetic ulcer


Patient: Woman

Age: 90 years.

Diagnosis: Gluteal scapula


Patient: Woman

Age: 60 years.

Diagnosis: Pyoderma gangrenosum


Patient: Woman

Age: 11 years

Diagnosis: Trauma


Patient: Woman

Age: 70 years.

Diagnosis: Lip melanoma


Patient: Man.

Age: 90 years.

Diagnosis: Venous insufficiency


Patient: Man.

Age: 90 years.

Diagnosis: Venous insufficiency


Patient: Baby.

Age: 3 days.

Diagnosis: Penicillin reaction


Patient: Baby.

Age: 3 Weks.

Diagnosis: Fasciitis Necrotizing.


AbsolutePneumothorax not treatedBulla Pulmonar

RelativeTympanic perforationCancer treatment (Bleomycin, Cisplatin, Doxorubicin, Disulfiram)Pacemaker

Special caresMild hypoglycemic and Hypertensive.Congestion or catarrhClaustrophobiaPathology of VAS and COPD

CONTRAINDICATIONS

HYPERBARIC TREATMENT WITHREVITALAIR 430 CHAMBERS

Verification protocol in healthy patients:

It concludes:

Treatment at 1.45 ATA does not modify the biochemical parameters of acute phase

inflammation and oxidative stress in healthy volunteers.

Significant increase in antioxidant enzyme suggests the effect of hyperoxia in healthy

The biochemical parameters at 10 and 20 sessions are kept within the values of reference.

The treatment is safe and well tolerated, without adverse effects

CONCLUSION

The strong HYPEROXIA increases the volume of dissolvedoxygen in the blood plasma. This increase in O2 diffusionreaches less irrigated tissues.

Hyperoxia produces a broad chain of PHYSIOLOGICAL BENEFITS in the body.

HYPERBARIC TREATMENT: The patient breathes high doses of O2 in a hyperbaric environment.

SYSTEMIC PERFORMANCE IN PATHOLOGIES.


INSTALLATION AND OPERATION OF THE HYPERBARIC CHAMBER

Hermetic Cabin: It is pressurized in a stable manner (Treatment Pressure), where the patient remains during the session.

Compressors Cabinet: It enters filtered air into the cabin to reach the treatment pressure by venting in a safe manner.

Oxygen external source:It may be by hub or tank, it supplies high-concentration of O2 to the patient.

COMPONENTS

HYPERBARIC CHAMBER

COMPONENTS

➔ Components:Cabin pressurizationCompressor cabinetSupport tableBioBarica Support systems

➔ Optional:

Removable Stretcher for patients with low mobility.

O2 Concentrator.

Monitoring System via Web

Extended warranty.

Please read the User Manual carefully. It will tell you step by stephow to operate and maintain this high-technology medical product.

HYPERBARIC CHAMBER

INSTALLMENT

HYPERBARIC CHAMBER

BioBarica recommends 3 brands:

Airsep, Intensity 10 model - High Flow 10 liters per minute.

NidekMedical - Novo 10 - High Flow 10 liters per minute.

Hikoneb® OxyBreath 10L - High Flow 10 liters per minute.

OXYGEN CONCENTRATOR

Oxygen mask with reservoir bag isrecommended for maximumtherapeutic efficiency.

➢ We recommend using the mask closed

and exhaust valves clogged.

➢ This mask delivers 100% O2 available.

➢ The more O2 inspire the most effective

treatment will be patient.

➢ Some children do not like to use the

mask and you have to place them

mustache but this reduces to 50% O2

concentration.

OXYGEN MASKS

If the mask for local use matches the characteristics sent to the equipment or is similar, you can validate it use with BioBarica.

Hyperbaric Chamber MaintenanceThe maintenance is performed by the equipment operator with the instructions mentioned in theBioBarica Global System. The online system alerts the operator of all the necessary maintenancefor the equipment to operate properly.

Technical SupportBioBarica offers an extended warranty of up to 4 years (optional), in which case any problemthat may arise can be solved with the replacement of the chamber with a new one which will be sent immediately.

WarrantyThe chamber includes a one year warranty, except the closure system of the chamber which a lifetime warranty. An optional, extended warranty of up to 4 years can be purchased.

TECHNICAL FEATURES

What are the differences with the hard-shelled chambers?

Hard-shelled chambers use with high pressure levels that require high maintenance costs and

specialized operators. They also have more safety requirements and the treatment is much

more aggressive and stressful for the patient.

What advantages do these chambers have compare to lower pressure?

In the market there are low-pressure chambers that operate on 1.3 ATM, which are offered at a

lower price range. The Revitalair 430 is a certified medical device that operates at 1.4 ATM,

which is the minimum pressure necessary for hyperbaric treatment.

Chamber Operation

The device can operate all day. Brief resting periods of only five minutes per hour is sufficient,

and it is the same time between patients.

Rev

ital

air

43

0 • 1.4 ATA*

• 120Kg

• 95% of pathologies

Hig

h p

ress

ure • 3 ATA

• +1000 kg

• 100% of pathologies

Low

pre

ssu

re • 1.3ATA

• 45-60Kg

• - 30% of pathologies

*According to the UHMS of the United States the definition of hyperbaric treatment is from 1.4 ATA

Installation: Revitalair 430® cameras are assembled in little time and do not require much space. The minimum measures are 1,70m x 2,80m.

Maintenance: These cameras are easy to maintain and clean by the user.

Portable: simple to assemble in any place.

High-pressure chambers need special space, of greater size and complexity.

They also require regular hydraulic testing for maintenance and specialized technicians.

These high pressure chambers weigh approximately 1000kg and are dangerous to operate.

Revitalair 430High pressure

chamber The Revitalair 430 hyperbaric chambers are

easy to opérate by the user withoutassistance.

Security: It has increased air flowof air and 4 security valves.

In these chambers, patients enter with any type of clothing.

También se puede ingresar con libros y electrónica (celular, Tablet, etc.).

High pressure hyperbaric chambers require a specialized technician to operate.

Due to their operation in high pressure, they require greater safety measures.

Patients must enter the chamber with cotton

clothing.

Entering with electronic devices is completely forbidden.

Revitalair 430 Hyperbaric Chamber

Low pressurechamber

Patented door locking system (lifetime warranty).

Removable stretcher. Ease of entry for people with reduced mobility.

Children can enter the chamber

accompanied by an adult.

Zipper system, less durability and does not achieve complete sealing.

These chambers are located on the ground, making it difficult for people with reduced mobility to enter. They does not have a stretcher.

Due to space, only one person per session is allowed.

BIOBARICA CENTER

Infrastructure

Air-conditioning & Signage

Procedures for attention & Cleaning

BioBarica Global System - Hipermed

OPERATIONAL GUIDELINE OF A BIOBARICA CENTER

IMPORTANTHow many patients can be treated per month?

Consider:An patient needs 14 sessions average.

It provides service 10 hours a day in 22 days a month.Availability per month: 220 hours of treatment.

220 Hs. / 1 hour 14 sessions = 15.7 patients per month.

10 minutes time between sessions (plus scheduling problems ) = 20% of the time.

Patients that can be attend per month =

14 patients

BIOBARICA GLOBAL SYSTEMHipermed

Tickets

Trainings

Blog

Maintenance

BIOBARICA GIVES YOU A COMPLETE MEDICAL, TECHNICAL AND COMMERTIAL

TRAINNING SUPPORT

OUR HYPERBARIC CHAMBERS ARE DESIGNED WITH HIGH QUALITY

AND CUTTING EDGE TECHNOLOGY.

ALL THE INFORMATION ABOUT THE INSTALLATION AND OPERATION

OF A HYPERBARIC TREATMENT CENTER IS PROVIDED BY BIOBARICA

THANK YOU FOR TRUSTING

Presentación de PowerPoint - BioBarica · Fibromyalgia Rheumatoid ... PRESENTATION OF CASES VARIOUS ESSAYS, SERIES AND CASE REPORTS RAISE THE EFFECTIVENESS OF HBOT AS A SUCCESSFUL

Documents