Preliminary Work and Proposed Continuation: Imaging of Speech Anatomy and Behavior

Preliminary Work and Proposed Preliminary Work and Proposed Continuation: Imaging of Speech Continuation: Imaging of Speech

Anatomy and BehaviorAnatomy and BehaviorMark Hasegawa-Johnson, ECE Department

Thomas Conturo, Washington UniversityXuming He, Illinois

David Kuehn, IllinoisZhi-Pei Liang, Illinois

Jeff Marsh, Children's Hospital St. LouisLynn Marty-Grames, Children's Hospital

Jerry Moon, IowaVictor Schepkin, Illinois

Reiner Wilhelms-Tricarico, MIT

OutlineOutline

History: Normative Data

Future: Clinical Data

Difficult Imaging Problems and Possible Solutions

Normative Data: Speech PostureNormative Data: Speech PostureHasegawa-Johnson et al., Hasegawa-Johnson et al., http://www.ifp.uiuc.edu/speech/mrihttp://www.ifp.uiuc.edu/speech/mri

Purpose: Normative data for articulatory therapy, speech synthesis, speech science.

3mm Multislice, 750ms/image, 25 seconds breath hold.

Normative Tagged Cine-MRINormative Tagged Cine-MRIStone et al., 2001Stone et al., 2001

Purpose: Direct observation of biomechanical quantities.

Limitation: 32 repetitions per image sequence.

Diffusion Tensor MRI, Bovine TongueDiffusion Tensor MRI, Bovine TongueWedeen et al., 2001Wedeen et al., 2001

Purpose: Muscle segmentation, structure.

Limitation: Long acquisition => animal specimens.

Clinical Objective: Surgical PlanningClinical Objective: Surgical PlanningKacker, 2000Kacker, 2000

Beckwith-Wiedemann Syndrome

Normal intelligence, personality.

At least 9 published resection methods; no quantitative comparison of results.

Finite Element Modeling of SurgeryFinite Element Modeling of Surgery

Objective of Proposed Preliminary Study:

Simulate effects of two common surgeries.

Limitation: detailed knowledge of structure & biomechanical properties.

Clinical Data: Surgical, Cadaver Clinical Data: Surgical, Cadaver SamplesSamples

Microscopic imaging of surgically excised tissue,

Diffusion tensor imaging of muscle structure (goal: first DTI of human tongue).

Target Resolution: fascicle thickness = 0.1mm.

Clinical Data: Pre-operative and Clinical Data: Pre-operative and Post-operative MRIPost-operative MRI

Objective: Surgical PlanningObjective: Post-surgical follow-up, correlation of

anatomical and behavioral variablesLimitation: Muscle-Muscle Segmentation

Clinical: Kinematic DiagnosisClinical: Kinematic Diagnosis

Objective: Identify correlations between anatomy, behavior.

Limitation: Speed.

Difficult Imaging ProblemsDifficult Imaging ProblemsSegmentation: Transverse and longitudinal

muscle indistinguishable w/o diffusion weighting.

Diffusion Weighting: Ambiguous in presence of blood flow.

Speed: Sedated: 20 minutes.

Breath hold: 5 seconds.

Dynamic: 10-50 ms.

Possible Solution: SegmentationPossible Solution: Segmentation

Bayesian image segmentation -- combine: Prior knowledge (other segmented volumes)

Ambiguous anatomical image

Ambiguous diffusion tensor image

User-supplied "hints"

Possible Solutions: SpeedPossible Solutions: SpeedImage-recognition based image

reconstruction RIGR (Liang 1992): Morph a prior image to

match partial k-space data.

Prior information about tongue shape, e.g. from factor analysis of normative tongue shapes (Hasegawa-Johnson & Zheng, 1999):

ConclusionsConclusionsSpeech Science Research Issues

Muscle fiber organization

Strain dynamics of soft tissue

Clinical Applications Surgical planning

Diagnosis of biomechanical defects

Difficult Imaging Problems Segmentation of inter-muscle boundaries

High-speed dynamic imaging