Introduc)on • Obesity rates have dramatically increased in the last 20 years and are set to double by 2050. • The prevalence of obesity in women of childbearing age increased from 12% in 1993 to 20% in 2010. • The prevalence of obesity in the first trimester has more than doubled in the last 20 years. As it stands, 2 % of women are morbidly obese at booking. • Well-established associations exist between obesity and pregnancy complications, namely: o Hypertensive disorders o Gestational diabetes o Fetal anomalies o Fetal growth abnormalities o Venous thrombo-embolism o Stillbirth o IOL and augmentation of labour o Caesarean section and instrumental deliveries o Preterm labour Objective to analyse the effects of morbid obesity (class III; BMI≥40) on pregnancy outcomes in a tertiary unit teaching hospital and to compare our outcomes to women with a normal BMI and to current literature Materials and methods • All cases of women with a BMI greater than or equal to 40kg/m 2 who booked at our unit (a London tertiary teaching hospital) between 01/01/10 and 31/11/15 were included (n 512). • 2000 randomised cases of women with normal BMI (20-25) over the same time period were obtained. • The groups were matched for parity, pervious caesarean section and age. 449 morbidly obese women were compared with 1359 normal BMI women. • The outcome data collected were: • maternal and fetal complications • gestation at deliver • mode of delivery • onset of labour • blood loss at delivery • actual birth weight References o Health & Social Care information Centre (HSCIC) statistics on Obesity, Physical Activity and Diet England 2015). 2016. o Morgan K, Rahman M, Macey S, Atkinson M, Hill R, Khanom A et al. Obesity in pregnancy: a retrospective prevalence-based study on health service utilisation and costs on the NHS. BMJ Open. 2014;4(2):e003983- e003983. o Cedergren M. Maternal Morbid Obesity and the Risk of Adverse Pregnancy Outcome. Obstetrical & Gynecological Survey. 2004;59(7):489-491. o Sebire N, Jolly M, Harris J, Wadsworth J, Joffe M, Beard R et al. Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London. Int J Obes Relat Metab Disord. 2001;25(8):1175-1182. o Usha Kiran T, Hemmadi S, Bethel J, Evans J. Outcome of pregnancy in a woman with an increased body mass index. BJOG: An International Journal of Obstetrics and Gynaecology. 2005;112(6):768-772. :112. Conclusion o Some of the well accepted risks associated with morbid obesity are supported in this analysis of our obese population o However, macrosomia, shoulder dystocia, IUGR, VTE and stillbirth are no more likely to occur in our obese women o The reason behind these encouraging results may be explained by the dedicated specialist clinic care that we are able to offer Discussion It is possible that some risks associated with morbid obesity in pregnancy are unavoidable for example fetal anomalies, Hypertensive disorders, and to a lesser extent, GDM may also fall into this category The reduced rates of some of the complications may be explained by morbidly obese women being seen in a consultant lead dedicated specialist clinic, where management includes: • Strict information on reduced fetal movements and growth scans routinely at 36/40 thus potentially reducing the stillbirth rate in this group • Early and on-going strict management of VTE prophylaxis with LMWH antenatally and 6 weeks postpartum • Educating women on healthy eating choices, may benefit their long-term health and the future health of their offspring • Detailed intrapartum plans including active management of the third stage and the early recognition of risk factors possibly reducing our rates of MOH • Use of Cervical-ripening balloon/ Propess IOL for women who opt for VBAC and STAN monitoring in labour possibly leading to reduced interventions such as emergency caesarean section This specialist clinic is the ideal opportunity to engage patients prior to future pregnancies and minimise pregnancy complications. We also provide information to our women on weight loss diet/ bariatric surgery and organise postpartum referrals to our bariatric surgical team if women wishes to be informed further. Also we believe pre- pregnancy public health education is essential to improve pregnancy outcomes and the health of the offspring Pregnancy outcomes of women with morbid obesity at a tertiary teaching hospital: A case-control study Kelly Hepburne Scott 1 , Berrin Tezcan 1 1 - St George’s University Hospitals NHS Foundation Trust, Department of Obstetrics, Blackshaw Road, Tooting, London, SW17 0QT Demographics Antenatal complications of higher incidence in women with BMIs ≥ 40: o PET and PIH requiring treatment 8 x more common o GDM 12 x more common o Fetal anomalies 3 x more common Antenatal complications not of higher incidence in women with BMIs ≥ 40: o Macrosomia o IUGR o Venous Thromboembolism o Stillbirth Labour and Delivery complications of higher incidence in women with BMI ≥ 40: o Induction of labour 2.6 x more common o Reduced rate of spontaneous labour 41% o Emergency caesarean section 1.5 times common o Haemorrhage greater than 1000mls 1.6 times more common Results 0 2 4 6 8 10 12 14 % BMI >40 % BMI <40 0 10 20 30 40 50 60 70 80 BMI >40 BMI 20-25 Labour and delivery complications not of higher incidence in women with BMIs ≥40: o Normal vaginal delivery rate o Elective caesarean section rate o Instrumental deliveries o If instrumental deliveries did occur they were more likely to be forceps o Preterm delivery < 37/50 and <34/40 o MOH greater than 2000mls. o Shoulder dystocia Vaginal Birth A<er Caesarean Sec)on o No differences in successful VBAC, 68.96%. o No differences in attempted VBAC, 46.7% 0 10 20 30 40 50 60 70 80 Attempted VBAC Successful VBAC Total Overall VBAC success BMI >40 BMI 20-25