15/24
PBPK model
PBPK modeling of pravastatin disappearance
i.v. 0.134mg/kg (observed)p.o. 0.26mg/kg (observed)
Plasma conc-time profile of pravastatin in human
Lung
Brain
Muscle
GI
QBrain
QMuscle
QLiver
PSinf
PSbile
PSeff
CLmet
Blood UrineQtotal
ka
i.v.
p.o.
Liver
inlet
Liver
Liver
Liver
Liver
inlet inlet inlet inlet
KidneyQKidney
( )
( )
( ) jH,bilemeteffhji,infbjH,jH,
jH,effhji,infji,jb,hji,
ji,
brbihb
b
CPSCLPSfCPSfdt
dCV
CPSfCPSfCCQdt
dCV
CCLCCQdt
dCV
⋅++⋅−⋅⋅=⋅
⋅⋅+⋅⋅−−=⋅
⋅−−=⋅
b
Blood
Capillary inthe liver
Hepatocytes
Extrapolated parameters based on in vitro(animal, human) and in
vivo (animal)
Graph1
52018.080.36
104018.440.72
206018.81.08
409019.161.44
6012019.521.8
9018019.762.16
120202.52
18020.362.88
20.723.24
21.083.6
21.443.96
21.84.32
22.164.66
22.525
22.885.36
23.245.72
23.66.08
23.966.44
24.326.8
24.687.16
25.047.52
25.47.88
25.768.24
26.128.6
26.488.96
26.849.32
27.29.66
27.5610
27.9210.36
28.2810.72
28.6411.08
2911.44
29.3611.8
29.7212.16
30.0812.52
30.4412.88
30.813.24
31.1613.6
31.5213.96
31.8814.32
32.2414.68
32.615.04
32.9615.4
33.3215.76
33.6816.12
34.0416.48
34.416.74
34.7617
35.1217
35.4817.36
35.8417.72
36.218.08
36.5618.44
36.9218.8
37.2819.16
37.6419.52
3819.76
38.3620
38.7220.36
39.0820.72
39.4421.08
39.7221.44
4021.8
40.3622.16
40.7222.52
41.0822.88
41.4423.24
41.823.6
42.1623.96
42.5224.32
42.8824.68
43.2425.04
43.625.4
43.9625.76
44.3226.12
44.6826.48
45.0426.84
45.427.2
45.7627.56
46.1227.92
46.4828.28
46.8428.64
47.229
47.5629.36
47.9229.72
48.2830.08
48.6430.44
4930.8
49.3631.16
49.7231.52
50.0831.88
50.4432.24
50.832.6
51.1632.96
51.5233.32
51.8833.68
52.2434.04
52.634.4
52.9634.76
53.3235.12
53.6835.48
54.0435.84
54.436.2
54.7636.56
55.1236.92
55.4837.28
55.8437.64
56.238
56.5638.36
56.9238.72
57.2839.08
57.6439.44
5839.72
58.3640
58.7240.36
59.0840.72
59.4441.08
59.7241.44
6041.8
60.3642.16
60.7242.52
61.0842.88
61.4443.24
61.843.6
62.1643.96
62.5244.32
62.8844.68
63.2445.04
63.645.4
63.9645.76
64.3246.12
64.6846.48
65.0446.84
65.447.2
65.7647.56
66.1247.92
66.4848.28
66.8448.64
67.249
67.5649.36
67.9249.72
68.2850.08
68.6450.44
6950.8
69.3651.16
69.7251.52
70.0851.88
70.4452.24
70.852.6
71.1652.96
71.5253.32
71.8853.68
72.2454.04
72.654.4
72.9654.76
73.3255.12
73.6855.48
74.0455.84
74.456.2
74.7656.56
75.1256.92
75.4857.28
75.8457.64
76.258
76.5658.36
76.9258.72
77.2859.08
77.6459.44
7859.72
78.3660
78.7260.36
79.0860.72
79.4461.08
79.861.44
80.1661.8
80.5262.16
80.8862.52
81.2462.88
81.663.24
81.9663.6
82.3263.96
82.6864.32
83.0464.68
83.465.04
83.7665.4
84.1265.76
84.4866.12
84.8466.48
85.266.84
85.5667.2
85.9267.56
86.2867.92
86.6468.28
8768.64
87.3669
87.7269.36
88.0869.72
88.4470.08
88.870.44
89.1670.8
89.5271.16
89.7671.52
9071.88
90.3672.24
90.7272.6
91.0872.96
91.4473.32
91.873.68
92.1674.04
92.5274.4
92.8874.76
93.2475.12
93.675.48
93.9675.84
94.3276.2
94.6876.56
95.0476.92
95.477.28
95.7677.64
96.1278
96.4878.36
96.8478.72
97.279.08
97.5679.44
97.9279.8
98.2880.16
98.6480.52
9980.88
99.3681.24
99.7281.6
100.0881.96
100.4482.32
100.882.68
101.1683.04
101.5283.4
101.8883.76
102.2484.12
102.684.48
102.9684.84
103.3285.2
103.6885.56
104.0485.92
104.486.28
104.7686.64
105.1287
105.4887.36
105.8487.72
106.288.08
106.5688.44
106.9288.8
107.2889.16
107.6489.52
10889.76
108.3690
108.7290.36
109.0890.72
109.4491.08
109.891.44
110.1691.8
110.5292.16
110.8892.52
111.2492.88
111.693.24
111.9693.6
112.3293.96
112.6894.32
113.0494.68
113.495.04
113.7695.4
114.1295.76
114.4896.12
114.8496.48
115.296.84
115.5697.2
115.9297.56
116.2897.92
116.6498.28
11798.64
117.3699
117.7299.36
118.0899.72
118.44100.08
118.8100.44
119.16100.8
119.52101.16
119.76101.52
120101.88
120.36102.24
120.72102.6
121.08102.96
121.44103.32
121.8103.68
122.16104.04
122.52104.4
122.88104.76
123.24105.12
123.6105.48
123.96105.84
124.32106.2
124.68106.56
125.04106.92
125.4107.28
125.76107.64
126.12108
126.48108.36
126.84108.72
127.2109.08
127.56109.44
127.92109.8
128.28110.16
128.64110.52
129110.88
129.36111.24
129.72111.6
130.08111.96
130.44112.32
130.8112.68
131.16113.04
131.52113.4
131.88113.76
132.24114.12
132.6114.48
132.96114.84
133.32115.2
133.68115.56
134.04115.92
134.4116.28
134.76116.64
135.12117
135.48117.36
135.84117.72
136.2118.08
136.56118.44
136.92118.8
137.28119.16
137.64119.52
138119.76
138.36120
138.72120.36
139.08120.72
139.44121.08
139.8121.44
140.16121.8
140.52122.16
140.88122.52
141.24122.88
141.6123.24
141.96123.6
142.32123.96
142.68124.32
143.04124.68
143.4125.04
143.76125.4
144.12125.76
144.48126.12
144.84126.48
145.2126.84
145.56127.2
145.92127.56
146.28127.92
146.64128.28
147128.64
147.36129
147.72129.36
148.08129.72
148.44130.08
148.8130.44
149.16130.8
149.52131.16
149.88131.52
150.24131.88
150.6132.24
150.96132.6
151.32132.96
151.68133.32
152.04133.68
152.4134.04
152.76134.4
153.12134.76
153.48135.12
153.84135.48
154.2135.84
154.56136.2
154.92136.56
155.28136.92
155.64137.28
156137.64
156.36138
156.72138.36
157.08138.72
157.44139.08
157.8139.44
158.16139.8
158.52140.16
158.88140.52
159.24140.88
159.6141.24
159.96141.6
160.32141.96
160.68142.32
161.04142.68
161.4143.04
161.76143.4
162.12143.76
162.48144.12
162.84144.48
163.2144.84
163.56145.2
163.92145.56
164.28145.92
164.64146.28
165146.64
165.36147
165.72147.36
166.08147.72
166.44148.08
166.8148.44
167.16148.8
167.52149.16
167.88149.52
168.24149.88
168.6150.24
168.96150.6
169.32150.96
169.68151.32
170.04151.68
170.4152.04
170.76152.4
171.12152.76
171.48153.12
171.84153.48
172.2153.84
172.56154.2
172.92154.56
173.28154.92
173.64155.28
174155.64
174.36156
174.72156.36
175.08156.72
175.44157.08
175.8157.44
176.16157.8
176.52158.16
176.88158.52
177.24158.88
177.6159.24
177.96159.6
178.32159.96
178.68160.32
179.04160.68
179.4161.04
179.7161.4
180161.76
180162.12
162.48
162.84
163.2
163.56
163.92
164.28
164.64
165
165.36
165.72
166.08
166.44
166.8
167.16
167.52
167.88
168.24
168.6
168.96
169.32
169.68
170.04
170.4
170.76
171.12
171.48
171.84
172.2
172.56
172.92
173.28
173.64
174
174.36
174.72
175.08
175.44
175.8
176.16
176.52
176.88
177.24
177.6
177.96
178.32
178.68
179.04
179.4
179.7
180
180
iv
po
Time (min)
Plasma concentration(μM)
0.9406494961
0.0111982083
0.00316269
1.298
0.4591265398
0.0447928331
0.00476181
1.252
0.2575587906
0.0515117581
0.00633922
1.21
0.1119820829
0.0403135498
0.00789059
1.171
0.0671892497
0.0302351624
0.00941402
1.134
0.0358342665
0.0201567749
0.0104134
1.098
0.0223964166
0.0113995
1.064
0.0100783875
0.0128528
1.032
0.0142748
1.001
0.0156647
0.971
0.0170224
0.943
0.0183476
0.916
0.0196403
0.891
0.0209006
0.868
0.0221286
0.844
0.0233247
0.821
0.0244892
0.799
0.0256224
0.778
0.026725
0.758
0.0277972
0.738
0.0288398
0.72
0.0298533
0.701
0.0308382
0.684
0.0317952
0.667
0.0327248
0.651
0.0336277
0.636
0.0345045
0.622
0.0353558
0.608
0.0361822
0.594
0.0369844
0.58
0.037763
0.567
0.0385185
0.555
0.0392515
0.542
0.0399627
0.53
0.0406525
0.519
0.0413216
0.508
0.0419704
0.497
0.0425996
0.486
0.0432096
0.476
0.043801
0.466
0.0443742
0.457
0.0449296
0.448
0.0454679
0.439
0.0459894
0.43
0.0464946
0.421
0.0469838
0.413
0.0474576
0.407
0.0479163
0.401
0.0483603
0.401
0.0487899
0.393
0.0492056
0.386
0.0496078
0.379
0.0499967
0.371
0.0503727
0.364
0.0507361
0.357
0.0510872
0.351
0.0514264
0.346
0.0517539
0.342
0.0520701
0.336
0.0523752
0.33
0.0526695
0.324
0.052891
0.318
0.0531064
0.312
0.0533742
0.307
0.0536321
0.301
0.0538803
0.296
0.0541192
0.291
0.0543488
0.285
0.0545694
0.28
0.0547812
0.276
0.0549845
0.271
0.0551794
0.266
0.0553661
0.261
0.0555448
0.257
0.0557158
0.253
0.0558791
0.248
0.056035
0.244
0.0561836
0.24
0.0563251
0.236
0.0564597
0.232
0.0565874
0.228
0.0567086
0.224
0.0568233
0.221
0.0569316
0.217
0.0570338
0.213
0.0571299
0.21
0.0572201
0.206
0.0573046
0.203
0.0573833
0.2
0.0574566
0.196
0.0575245
0.193
0.057587
0.19
0.0576445
0.187
0.0576968
0.184
0.0577443
0.181
0.0577869
0.178
0.0578248
0.175
0.0578581
0.173
0.0578869
0.17
0.0579113
0.167
0.0579314
0.165
0.0579473
0.162
0.057959
0.16
0.0579668
0.157
0.0579706
0.155
0.0579705
0.152
0.0579667
0.15
0.0579592
0.148
0.0579481
0.145
0.0579335
0.143
0.0579155
0.141
0.0578941
0.139
0.0578694
0.137
0.0578415
0.135
0.0578105
0.133
0.0577764
0.131
0.0577394
0.129
0.0577085
0.127
0.0576759
0.126
0.0576315
0.124
0.0575843
0.122
0.0575344
0.12
0.0574819
0.118
0.0574269
0.116
0.0573693
0.115
0.0573093
0.113
0.0572469
0.111
0.0571821
0.11
0.057115
0.108
0.0570458
0.107
0.0569743
0.105
0.0569007
0.104
0.0568251
0.102
0.0567474
0.101
0.0566678
0.099103
0.0565862
0.0976855
0.0565028
0.096292
0.0564175
0.0949223
0.0563304
0.0935764
0.0562416
0.092253
0.0561511
0.0909529
0.0560589
0.0896744
0.0559651
0.0884182
0.0558697
0.087183
0.0557728
0.0859689
0.0556744
0.0847755
0.0555746
0.0836023
0.0554733
0.0824488
0.0553706
0.0813149
0.0552666
0.0802001
0.0551613
0.0791043
0.0550547
0.0780267
0.0549468
0.0769675
0.0548378
0.0759257
0.0547276
0.074902
0.0546162
0.073895
0.0545037
0.072905
0.0543902
0.0719316
0.0542755
0.0709741
0.0541599
0.0700332
0.0540433
0.0691074
0.0539257
0.0681976
0.0538072
0.0673025
0.0536878
0.0664224
0.0535675
0.0655567
0.0534463
0.0647056
0.0533244
0.0638684
0.0532016
0.0630452
0.053078
0.0624143
0.0529537
0.0617913
0.0528287
0.0610024
0.052703
0.0602262
0.0525765
0.059463
0.0524495
0.0587119
0.0523218
0.0579737
0.0521934
0.0572472
0.0520645
0.0565325
0.051935
0.0558298
0.051805
0.055138
0.0516744
0.0544581
0.0515433
0.053789
0.0514118
0.0531308
0.0512797
0.0524832
0.0511472
0.0518461
0.0510142
0.0512192
0.0508809
0.0506024
0.0507471
0.0499957
0.050613
0.0493984
0.0504785
0.0488114
0.0503436
0.0482331
0.0502084
0.0476647
0.0500729
0.0471049
0.0499371
0.0465544
0.049801
0.0460123
0.0496646
0.0454792
0.0495279
0.0449542
0.049391
0.044438
0.0492539
0.0439296
0.0491166
0.0434295
0.048979
0.0429372
0.0488413
0.0424523
0.0487494
0.0419757
0.0486574
0.0415061
0.0485193
0.0410442
0.048381
0.0405892
0.0482426
0.0401417
0.048104
0.0397009
0.0479654
0.0392671
0.0478267
0.0388401
0.0476878
0.0384194
0.0475489
0.0380057
0.0474099
0.0375979
0.0472708
0.037197
0.0471318
0.0368017
0.0469926
0.0364129
0.0468534
0.0360299
0.0467142
0.0356527
0.046575
0.0352815
0.0464358
0.0349155
0.0462966
0.0345557
0.0461575
0.0342008
0.0460183
0.0338518
0.0458792
0.0335078
0.0457401
0.033169
0.045601
0.0328354
0.0454621
0.0325065
0.0453232
0.0321831
0.0451843
0.031864
0.0450455
0.0315502
0.0449069
0.0312407
0.0447683
0.0309359
0.0446298
0.0306358
0.0444914
0.0303397
0.0443532
0.0300485
0.044215
0.0297611
0.044077
0.0294785
0.0439391
0.0291995
0.0438014
0.0289251
0.0436638
0.0286543
0.0435263
0.0283875
0.043389
0.0281248
0.0432519
0.0278653
0.0431149
0.0276105
0.0429781
0.0273589
0.0428415
0.0271109
0.0427051
0.0268664
0.0425688
0.0266254
0.0424328
0.0263881
0.0422969
0.0261535
0.0421612
0.0259232
0.0420258
0.0256955
0.0418905
0.0254714
0.0417555
0.0253236
0.0416206
0.0251773
0.041486
0.0249602
0.0413517
0.0247463
0.0412175
0.0245352
0.0410836
0.0243273
0.0409499
0.0241221
0.0408165
0.0239195
0.0406833
0.0237202
0.0405503
0.0235233
0.0404176
0.0233292
0.0402852
0.0231378
0.0401529
0.0229487
0.040021
0.0227627
0.0398893
0.0225786
0.0397579
0.0223977
0.0396268
0.0222187
0.0394959
0.0220423
0.0393653
0.0218683
0.039235
0.0216965
0.0391049
0.0215269
0.0389751
0.0213596
0.0388456
0.0211946
0.0387164
0.0210314
0.0385875
0.020871
0.0384589
0.0207121
0.0383305
0.0205558
0.0382025
0.0204011
0.0380747
0.0202486
0.0379473
0.0200978
0.0378201
0.0199493
0.0376932
0.0198025
0.0375667
0.0196576
0.0374825
0.0195146
0.0373984
0.0193731
0.0372726
0.0192338
0.037147
0.0190959
0.0370218
0.01896
0.0368968
0.0188256
0.0367722
0.018693
0.0366479
0.0185617
0.0365239
0.0184326
0.0364003
0.0183046
0.0362769
0.0181784
0.0361539
0.0180537
0.0360311
0.0179303
0.0359087
0.0178087
0.0357867
0.0176882
0.0356649
0.0175695
0.0355434
0.0174519
0.0354223
0.017336
0.0353015
0.017221
0.0351811
0.017108
0.0350609
0.0169959
0.0349411
0.0168851
0.0348216
0.0167758
0.0347024
0.0166673
0.0345836
0.0165608
0.0344651
0.0164547
0.0343469
0.0163506
0.0342291
0.0162471
0.0341116
0.0161452
0.0339944
0.0160441
0.0338775
0.0159441
0.033761
0.0158455
0.0336448
0.0157474
0.0335289
0.0156513
0.0334134
0.0155558
0.0332982
0.0154612
0.0331834
0.0153679
0.0330688
0.0152754
0.0329546
0.015184
0.0328408
0.0150936
0.0327272
0.0150041
0.032614
0.0149155
0.0325012
0.0148279
0.0323887
0.0147413
0.0322765
0.0146555
0.0321646
0.0145706
0.0320531
0.0144866
0.0319419
0.0144035
0.031831
0.0143213
0.0317205
0.0142398
0.0316103
0.0141592
0.0315005
0.0141058
0.0313909
0.0140531
0.0312818
0.0139743
0.0311729
0.0138964
0.0310644
0.0138192
0.0309562
0.0137429
0.0308484
0.0136672
0.0307408
0.0135924
0.0306336
0.0135181
0.0305268
0.0134447
0.0304203
0.013372
0.0303141
0.0132998
0.0302082
0.0132286
0.0301027
0.0131578
0.0299975
0.0130879
0.0298926
0.0130183
0.0297881
0.0129499
0.0296838
0.0128817
0.02958
0.0128144
0.0294764
0.0127476
0.0293732
0.0126812
0.0292703
0.0126158
0.0291677
0.0125507
0.0290655
0.0124862
0.0289636
0.0124225
0.028862
0.0123589
0.0287607
0.0122965
0.0286598
0.0122341
0.0285592
0.0121728
0.0284589
0.0121115
0.0283589
0.0120512
0.0282593
0.011991
0.02816
0.0119316
0.0280609
0.0118724
0.0279623
0.0118141
0.0278639
0.0117561
0.0277659
0.0116986
0.0276682
0.0116416
0.0275708
0.0115847
0.0274737
0.0115289
0.0273769
0.0114731
0.0272805
0.0114181
0.0271844
0.0113633
0.0270886
0.011309
0.0269931
0.0112552
0.0268979
0.0112015
0.026803
0.0111488
0.0267085
0.011096
0.0266142
0.0110441
0.0265203
0.0109922
0.0264267
0.0109409
0.0263334
0.01089
0.0262404
0.0108392
0.0261477
0.0107893
0.0260554
0.0107392
0.0259633
0.0106901
0.0258715
0.0106409
0.0257801
0.0105922
0.0256889
0.010544
0.0255981
0.0104957
0.0255076
0.0104485
0.0254173
0.0104009
0.0253274
0.0103543
0.0252378
0.0103075
0.0251485
0.0102615
0.0250594
0.0102155
0.0249707
0.0101698
0.0248823
0.0101247
0.0247942
0.0100795
0.0247063
0.0100352
0.0246188
0.00999077
0.0245316
0.00994688
0.0244446
0.00990304
0.024358
0.00985979
0.0242716
0.00981655
0.0241856
0.00977388
0.0240998
0.00973117
0.0240144
0.00968915
0.0239292
0.00964712
0.0238443
0.00960527
0.0237597
0.00956408
0.0236754
0.00952282
0.0235914
0.00948214
0.0235076
0.0094413
0.0234242
0.00940125
0.023341
0.00936103
0.0232582
0.00932139
0.0231756
0.00928169
0.0230932
0.00924253
0.0230112
0.00920329
0.0229295
0.00916469
0.022848
0.00912605
0.0227668
0.00908757
0.0226859
0.00904967
0.0226053
0.00901161
0.0225249
0.00897423
0.0224449
0.00893666
0.0223651
0.0088997
0.0222856
0.00886252
0.0222063
0.00882607
0.0221273
0.0087894
0.0220486
0.00875331
0.0219702
0.00871715
0.0218921
0.00868133
0.0218142
0.00864575
0.0217365
0.00861018
0.0216592
0.00857511
0.0215821
0.00853994
0.0215053
0.00850529
0.0214288
0.00847057
0.0213525
0.00843621
0.0212765
0.00840203
0.0212007
0.00836772
0.0211252
0.00833418
0.02105
0.0083004
0.0209751
0.00826707
0.0209128
0.00823356
0.0208507
0.00820053
0.0208507
0.00816782
0.00813499
0.00810253
0.00806991
0.00803797
0.00800583
0.00797413
0.00794228
0.00791096
0.00787953
0.00784833
0.00781742
0.00778628
0.0077559
0.0077251
0.00769503
0.00766471
0.00763469
0.00760485
0.00757497
0.00754551
0.00751593
0.00748676
0.00745741
0.00742862
0.00739969
0.00737105
0.00734246
0.00731371
0.00728574
0.00725744
0.00722956
0.00720151
0.00717395
0.00714625
0.00711874
0.00709149
0.00706398
0.0070372
0.00700996
0.00698343
0.00695661
0.0069301
0.00690369
0.00687706
0.00685116
0.00682493
0.00679911
0.00677309
0.00675176
0.00673045
0.00673045
報告値
Time(hr)ivpo
9.9mg19.2mg/73.8kguM表示 ヒョウジ
0.1340.260ivpo
Dose0.1340.26mg/kg0.30011198210.5823068309umol/kg
50.4250.9406494961
100.205100.4591265398
200.1150.005200.25755879060.0111982083
400.050.02400.11198208290.0447928331
600.030.023600.06718924970.0515117581
900.0160.018900.03583426650.0403135498
1200.010.01351200.02239641660.0302351624
1800.00450.0091800.01007838750.0201567749
MOMENT parameters by PKUT Ver17
iv
i.v.
Dose0.134mg/kg
TimeConc
minμg/mL
50.42
100.205
200.115
400.05
600.03
900.016
1200.01
1800.0045
AUCMRTCLVdssVdzAUCLMRTLCLLVdssLVdzLextraAICCzket1/2
μg・min/mLminmL/min/kgL/kgL/kgμg・min/mLminmL/min/kgL/kgL/kgμg/mL1/minmin
8.177532.63527973116.38642616940.53477560187.913904318434.245305876916.93222391980.5798491873
8.515630742241.470296685515.73576920560.65256701751.18238829368.252035060743.296569244216.23841864640.70306781731.22015745552-infinite0.00450.013308461652.0831934753
8.496099724940.843321442915.77194293120.64417853491.12799595568.232504043442.653851646116.2769431140.69427431681.16411313963-19.64992392110.00445474710.01398226949.5732973258
8.451817375139.510689079715.85457825860.62642531211.02213077668.188221693541.28811055516.36496971080.67567867871.05503526664-15.18201130650.00425501940.015511301144.686591748
8.415204666638.467845385815.92355804860.6125449690.94139084598.151608985140.219528030816.43847248390.66114760480.9718322675-13.5121176630.00402075720.016914927740.9784301118
8.36068490936.995378453416.0273950590.59293954580.82754531638.097089227438.710920381316.54915689280.64063309490.85448553716-6.97290296640.00354781410.019367392635.7893906462
8.322108639836.000292154516.1016883820.57966548590.74533081718.058512958337.691496931716.62837805110.62674846030.76971074757-2.46119955690.003124040.021603411532.0850796657
8.287861617235.147868651916.16822362490.56827860030.66813522658.024265935736.818289418716.69934684040.61484138510.690083347683.88837382570.0026706440.024199028928.6435949441
extrapolation to time zero
leadAICC0t1/2ΔAUCΔAUMCΔAUCLΔAUMCLAUCMRTCLVdssVdzAUCLMRTLCLLVdssLVdzL
2-infinite0.86048780494.83201304592.151219512202.02069390081.51682488810.647319237132.591202005712.58532753790.41017095210.94566358710.272728961534.927586782613.04424564320.45560402170.9801467692
3-8.8471969580.56076035348.42458775031.401900883401.38497226510.544587436
4-7.71474484310.429815243112.2805476511.074538107801.07444363390.0406608435
5-6.18239377790.364281442615.4204893150.910703606600.9074004267-0.2404577777
6-3.44896418180.303395560419.2630809380.758488900900.742715943-0.5257113738
7-0.73562709410.260643854922.89367915230.651609637200.6200505112-0.7441344557
83.88837382570.208126240428.64359494410.520315601100.4588361696-1.040090423
MOMENT parameters by PKUT Ver17
po
p.o.
Dose0.26mg/kg
MAT128.1157718408min
TimeConcKa0.0078054402min^-1
minμg/mL
200.005
400.02
600.023
900.018
1200.0135
1800.009
AUCMRTCLVdssVdzAUCLMRTLCLLVdssLVdzLextraAICCzket1/2BACmaxTmax
μg・min/mLminmL/min/kgL/kgL/kgμg・min/mLminmL/min/kgL/kgL/kgμg/mL1/minmin%μg/mLmin
2.492589.3079237713104.31293881649.31597198822.477109000290.74929093104.96106549299.52514226870.02360
3.8243038697172.424229013567.98622935311.722473179710.06048037083.8089128699173.697470688168.260947121611.856753861810.10113261392-infinite0.0090.0067577518102.5706774811
3.6675601735160.706973846570.891815731211.39280917669.36880373863.6521691736161.985481524371.190568574211.53183853059.40828582443-18.55247750620.00889143930.007566794891.6038026339
3.6156919587157.056347745771.908780662411.29373046179.16106120873.6003009589158.337668278672.216184972111.43454234059.20022401564-23.5403598530.00881637640.007849394288.3058186946
3.9230837771178.428888545666.274394015911.825266463310.18663710763.9076927773179.693595009766.535425075711.955989727310.22675861635-15.66259244370.00930739670.0065060131106.5394696602
64.91965402314853.06217047374.004950487119.436273703419.477125017364.90426302334854.24682862674.005900196519.445628324719.481743703563.06123604310.01283647670.00020562333370.956603518
報告値
iv
po
time(min)
concentration(nmol/mL)
simulation
iv
po
time(min)
concentration(μg/mL)
Sheet3
Values at t =0.0 minutesPSinf45.5PSinf45.5PSinf55.9PSinf55.9
PSeffh2.23PSeffh2.23PSeffh9.57PSeffh9.57
CLbile9.35po 0.5823umol/kgi.v. 0.3umol/kgpo 0.5823umol/kgi.v.
0.3umol/kg
CLmet0ts1ts1ts1ts1
CLrenal11.30001.3640001.363
Cp-0.3600.361.2980.3600.361.287
Fa0.470.7200.721.2520.7200.721.225
Kpbr0.0331.0801.081.211.0801.081.171
Kplu0.671.4401.441.1711.4401.441.121
Kpmu0.21.801.81.1341.801.81.075
Kpr0.12.1602.161.0982.1602.161.033
PSeffh2.239.572.5202.521.0642.5202.520.994
PSinf45.555.92.8802.881.0322.8802.880.959
Qbr103.2403.241.0013.2403.240.926
Qh20.73.603.60.9713.603.60.896
Qmu10.73.9603.960.9433.9603.960.868
Qr15.74.3204.320.9164.3204.320.842
Qtot74.94.6604.660.8914.6804.680.817
Rb0.565050.8685.0405.040.794
Va3935.3605.360.8445.405.40.773
Vbr20.75.7205.720.8215.7605.760.753
Vh17.46.0806.080.7996.1206.120.734
Vhe6.76.4406.440.7786.4806.480.716
Vlu16.76.806.80.7586.8406.840.699
Vmu4297.1607.160.7387.207.20.683
Vr4.437.5207.520.727.5607.560.668
ex1.bolus300.17.8807.880.7017.9207.920.653
ex1.infusion08.2408.240.6848.2808.280.639
ex3.bolus08.608.60.6678.6408.640.626
ex3.infusion08.9608.960.6519090.613
fB0.8399.3209.320.6369.3609.360.601
fTh0.519.6609.660.6229.7209.720.589
flux(0,7)0100100.60810.08010.080.578
flux(0,15)010.36010.360.59410.44010.440.567
flux(0,16)010.72010.720.5810.8010.80.556
flux(0,17)011.08011.080.56711.16011.160.546
flux(0,19)011.44011.440.55511.52011.520.536
flux(1,3)011.8011.80.54211.88011.880.527
flux(2,1)11.98872812.16012.160.5312.24012.240.518
flux(3,2)012.52012.520.51912.6012.60.509
flux(3,4)012.88012.880.50812.96012.960.5
flux(3,5)013.24013.240.49713.32013.320.492
flux(3,18)013.6013.60.48613.68013.680.483
flux(4,1)7.63613213.96013.960.47614.04014.040.475
flux(5,1)8.17066214.32014.320.46614.4014.40.467
flux(6,1)15.80679414.68014.680.45714.76014.760.46
flux(6,7)015.04015.040.44815.12015.120.452
flux(6,8)015.4015.40.43915.48015.480.445
flux(7,6)015.76015.760.4315.84015.840.438
flux(8,7)016.12016.120.42116.2016.20.431
flux(8,15)016.48016.480.41316.56016.560.424
flux(8,16)0.00E+0016.74016.740.40716.78016.780.42
flux(8,17)0.00E+00170170.401170170.416
flux(8,19)0.00E+00170170.401170170.416
flux(9,8)0.00E+0017.362.58E-0417.360.39317.362.15E-0417.360.41
flux(11,6)0.00E+0017.721.57E-0317.720.38617.721.27E-0317.720.404
flux(11,15)0.00E+0018.083.16E-0318.080.37918.082.62E-0318.080.397
flux(12,1)8.63E+0018.444.76E-0318.440.37118.444.07E-0318.440.391
flux(13,11)0.00E+0018.86.34E-0318.80.36418.85.59E-0318.80.386
flux(13,16)0.00E+0019.167.89E-0319.160.35719.167.16E-0319.160.38
flux(14,13)0.00E+0019.529.41E-0319.520.35119.528.76E-0319.520.374
flux(14,17)0.00E+0019.761.04E-0219.760.34619.769.85E-0319.760.37
flux(15,11)0.00E+00201.14E-02200.342201.09E-02200.367
flux(16,13)0.00E+0020.361.29E-0220.360.33620.361.26E-0220.360.361
flux(17,14)0.00E+0020.721.43E-0220.720.3320.721.42E-0220.720.356
flux(18,14)0.00E+0021.081.57E-0221.080.32421.081.59E-0221.080.351
flux(18,19)0.00E+0021.441.70E-0221.440.31821.441.75E-0221.440.346
flux(19,18)0.00E+0021.81.83E-0221.80.31221.81.91E-0221.80.341
k(0,7)0.00E+0022.161.96E-0222.160.30722.162.07E-0222.160.336
k(0,15)0.00E+0022.522.09E-0222.520.30122.522.23E-0222.520.331
k(0,16)0.00E+0022.882.21E-0222.880.29622.882.39E-0222.880.326
k(0,17)0.00E+0023.242.33E-0223.240.29123.242.54E-0223.240.322
k(0,19)0.00E+0023.62.45E-0223.60.28523.62.69E-0223.60.317
k(1,3)6.69E+0023.962.56E-0223.960.2823.962.84E-0223.960.312
k(2,1)3.99E-0224.322.67E-0224.320.27624.322.98E-0224.320.308
k(3,2)3.54E+0124.682.78E-0224.680.27124.683.13E-0224.680.304
k(3,4)1.46E+0125.042.88E-0225.040.26625.043.26E-0225.040.299
k(3,5)1.25E-0125.42.99E-0225.40.26125.43.40E-0225.40.295
k(3,18)1.54E+0125.763.08E-0225.760.25725.763.53E-0225.760.291
k(4,1)2.54E-0226.123.18E-0226.120.25326.123.66E-0226.120.287
k(5,1)2.72E-0226.483.27E-0226.480.24826.483.79E-0226.480.283
k(6,1)5.27E-0226.843.36E-0226.840.24426.843.91E-0226.840.279
k(6,7)6.54E-0227.23.45E-0227.20.2427.24.03E-0227.20.275
k(6,8)8.50E-0327.563.54E-0227.560.23627.564.15E-0227.560.272
k(7,6)6.67E+0027.923.62E-0227.920.23227.924.26E-0227.920.268
k(8,7)2.74E-0128.283.70E-0228.280.22828.284.37E-0228.280.264
k(8,15)2.74E-0128.643.78E-0228.640.22428.644.48E-0228.640.261
k(8,16)2.74E-01293.85E-02290.221294.59E-02290.257
k(8,17)2.74E-0129.363.93E-0229.360.21729.364.69E-0229.360.254
k(8,19)2.74E-0129.724.00E-0229.720.21329.724.79E-0229.720.25
k(9,8)9.59E-0330.084.07E-0230.080.2130.084.89E-0230.080.247
k(11,6)1.54E+0130.444.13E-0230.440.20630.444.98E-0230.440.243
k(11,15)6.54E-0230.84.20E-0230.80.20330.85.07E-0230.80.24
k(12,1)2.88E-0231.164.26E-0231.160.231.165.16E-0231.160.237
k(13,11)1.54E+0131.524.32E-0231.520.19631.525.25E-0231.520.234
k(13,16)6.54E-0231.884.38E-0231.880.19331.885.34E-0231.880.231
k(14,13)1.54E+0132.244.44E-0232.240.1932.245.42E-0232.240.228
k(14,17)6.54E-0232.64.49E-0232.60.18732.65.50E-0232.60.225
k(15,11)6.67E+0032.964.55E-0232.960.18432.965.58E-0232.960.222
k(16,13)6.67E+0033.324.60E-0233.320.18133.325.66E-0233.320.219
k(17,14)6.67E+0033.684.65E-0233.680.17833.685.73E-0233.680.216
k(18,14)1.54E+0134.044.70E-0234.040.17534.045.81E-0234.040.213
k(18,19)6.54E-0234.44.75E-0234.40.17334.45.88E-0234.40.21
k(19,18)6.67E+0034.764.79E-0234.760.1734.765.95E-0234.760.208
ka8.50E-0335.124.84E-0235.120.16735.126.01E-0235.120.205
q13.00E+0235.484.88E-0235.480.16535.486.08E-0235.480.202
q20.00E+0035.844.92E-0235.840.16235.846.14E-0235.840.2
q30.00E+0036.24.96E-0236.20.1636.26.20E-0236.20.197
q40.00E+0036.565.00E-0236.560.15736.566.27E-0236.560.194
q50.00E+0036.925.04E-0236.920.15536.926.32E-0236.920.192
q60.00E+0037.285.07E-0237.280.15237.286.38E-0237.280.189
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126.123.53E-02126.121.28E-02126.125.11E-02126.122.00E-02
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126.843.51E-02126.841.27E-02126.845.07E-02126.841.97E-02
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132.963.31E-02132.961.16E-02132.964.79E-02132.961.80E-02
133.323.30E-02133.321.16E-02133.324.77E-02133.321.79E-02
133.683.28E-02133.681.15E-02133.684.76E-02133.681.78E-02
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134.43.26E-02134.41.14E-02134.44.73E-02134.41.76E-02
134.763.25E-02134.761.14E-02134.764.71E-02134.761.75E-02
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135.483.23E-02135.481.13E-02135.484.68E-02135.481.73E-02
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136.23.21E-02136.21.11E-02136.24.65E-02136.21.72E-02
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1383.15E-021381.09E-021384.57E-021381.67E-02
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141.243.05E-02141.241.04E-02141.244.43E-02141.241.60E-02
141.63.04E-02141.61.04E-02141.64.41E-02141.61.59E-02
141.963.03E-02141.961.04E-02141.964.40E-02141.961.58E-02
142.323.02E-02142.321.03E-02142.324.38E-02142.321.57E-02
142.683.01E-02142.681.03E-02142.684.37E-02142.681.57E-02
143.043.00E-02143.041.02E-02143.044.35E-02143.041.56E-02
143.42.99E-02143.41.02E-02143.44.33E-02143.41.55E-02
143.762.98E-02143.761.01E-02143.764.32E-02143.761.54E-02
144.122.97E-02144.121.01E-02144.124.30E-02144.121.54E-02
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144.842.95E-02144.849.99E-03144.844.27E-02144.841.52E-02
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145.562.93E-02145.569.90E-03145.564.24E-02145.561.51E-02
145.922.92E-02145.929.86E-03145.924.23E-02145.921.50E-02
146.282.91E-02146.289.82E-03146.284.22E-02146.281.49E-02
146.642.90E-02146.649.77E-03146.644.20E-02146.641.49E-02
1472.89E-021479.73E-031474.19E-021471.48E-02
147.362.88E-02147.369.69E-03147.364.17E-02147.361.47E-02
147.722.87E-02147.729.65E-03147.724.16E-02147.721.46E-02
148.082.86E-02148.089.61E-03148.084.14E-02148.081.46E-02
148.442.85E-02148.449.56E-03148.444.13E-02148.441.45E-02
148.82.84E-02148.89.52E-03148.84.11E-02148.81.44E-02
149.162.83E-02149.169.48E-03149.164.10E-02149.161.44E-02
149.522.82E-02149.529.44E-03149.524.08E-02149.521.43E-02
149.882.81E-02149.889.40E-03149.884.07E-02149.881.42E-02
150.242.80E-02150.249.36E-03150.244.06E-02150.241.42E-02
150.62.79E-02150.69.32E-03150.64.04E-02150.61.41E-02
150.962.78E-02150.969.28E-03150.964.03E-02150.961.40E-02
151.322.77E-02151.329.24E-03151.324.01E-02151.321.40E-02
151.682.76E-02151.689.20E-03151.684.00E-02151.681.39E-02
152.042.75E-02152.049.16E-03152.043.98E-02152.041.38E-02
152.42.74E-02152.49.13E-03152.43.97E-02152.41.38E-02
152.762.73E-02152.769.09E-03152.763.96E-02152.761.37E-02
153.122.72E-02153.129.05E-03153.123.94E-02153.121.36E-02
153.482.71E-02153.489.01E-03153.483.93E-02153.481.36E-02
153.842.70E-02153.848.97E-03153.843.91E-02153.841.35E-02
154.22.69E-02154.28.94E-03154.23.90E-02154.21.35E-02
154.562.68E-02154.568.90E-03154.563.89E-02154.561.34E-02
154.922.67E-02154.928.86E-03154.923.87E-02154.921.33E-02
155.282.66E-02155.288.83E-03155.283.86E-02155.281.33E-02
155.642.65E-02155.648.79E-03155.643.85E-02155.641.32E-02
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157.442.61E-02157.448.61E-03157.443.78E-02157.441.29E-02
157.82.60E-02157.88.58E-03157.83.76E-02157.81.29E-02
158.162.59E-02158.168.54E-03158.163.75E-02158.161.28E-02
158.522.58E-02158.528.51E-03158.523.74E-02158.521.28E-02
158.882.57E-02158.888.47E-03158.883.72E-02158.881.27E-02
159.242.56E-02159.248.44E-03159.243.71E-02159.241.26E-02
159.62.55E-02159.68.40E-03159.63.70E-02159.61.26E-02
159.962.54E-02159.968.37E-03159.963.69E-02159.961.25E-02
160.322.53E-02160.328.33E-03160.323.67E-02160.321.25E-02
160.682.52E-02160.688.30E-03160.683.66E-02160.681.24E-02
161.042.51E-02161.048.27E-03161.043.65E-02161.041.24E-02
161.42.51E-02161.48.23E-03161.43.63E-02161.41.23E-02
161.762.50E-02161.768.20E-03161.763.62E-02161.761.23E-02
162.122.49E-02162.128.17E-03162.123.61E-02162.121.22E-02
162.482.48E-02162.488.13E-03162.483.59E-02162.481.21E-02
162.842.47E-02162.848.10E-03162.843.58E-02162.841.21E-02
163.22.46E-02163.28.07E-03163.23.57E-02163.21.20E-02
163.562.45E-02163.568.04E-03163.563.56E-02163.561.20E-02
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164.282.44E-02164.287.97E-03164.283.53E-02164.281.19E-02
164.642.43E-02164.647.94E-03164.643.52E-02164.641.18E-02
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165.722.40E-02165.727.85E-03165.723.48E-02165.721.17E-02
166.082.39E-02166.087.82E-03166.083.47E-02166.081.16E-02
166.442.38E-02166.447.79E-03166.443.46E-02166.441.16E-02
166.82.38E-02166.87.76E-03166.83.44E-02166.81.15E-02
167.162.37E-02167.167.73E-03167.163.43E-02167.161.15E-02
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167.882.35E-02167.887.66E-03167.883.41E-02167.881.14E-02
168.242.34E-02168.247.63E-03168.243.39E-02168.241.13E-02
168.62.33E-02168.67.60E-03168.63.38E-02168.61.13E-02
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170.042.30E-02170.047.49E-03170.043.33E-02170.041.11E-02
170.42.29E-02170.47.46E-03170.43.32E-02170.41.11E-02
170.762.28E-02170.767.43E-03170.763.31E-02170.761.10E-02
171.122.28E-02171.127.40E-03171.123.30E-02171.121.10E-02
171.482.27E-02171.487.37E-03171.483.29E-02171.481.09E-02
171.842.26E-02171.847.34E-03171.843.27E-02171.841.09E-02
172.22.25E-02172.27.31E-03172.23.26E-02172.21.08E-02
172.562.24E-02172.567.29E-03172.563.25E-02172.561.08E-02
172.922.24E-02172.927.26E-03172.923.24E-02172.921.07E-02
173.282.23E-02173.287.23E-03173.283.23E-02173.281.07E-02
173.642.22E-02173.647.20E-03173.643.22E-02173.641.06E-02
1742.21E-021747.17E-031743.20E-021741.06E-02
174.362.20E-02174.367.15E-03174.363.19E-02174.361.06E-02
174.722.20E-02174.727.12E-03174.723.18E-02174.721.05E-02
175.082.19E-02175.087.09E-03175.083.17E-02175.081.05E-02
175.442.18E-02175.447.06E-03175.443.16E-02175.441.04E-02
175.82.17E-02175.87.04E-03175.83.15E-02175.81.04E-02
176.162.17E-02176.167.01E-03176.163.14E-02176.161.03E-02
176.522.16E-02176.526.98E-03176.523.12E-02176.521.03E-02
176.882.15E-02176.886.96E-03176.883.11E-02176.881.03E-02
177.242.14E-02177.246.93E-03177.243.10E-02177.241.02E-02
177.62.14E-02177.66.90E-03177.63.09E-02177.61.02E-02
177.962.13E-02177.966.88E-03177.963.08E-02177.961.01E-02
178.322.12E-02178.326.85E-03178.323.07E-02178.321.01E-02
178.682.11E-02178.686.82E-03178.683.06E-02178.681.00E-02
179.042.11E-02179.046.80E-03179.043.05E-02179.041.00E-02
179.42.10E-02179.46.77E-03179.43.04E-02179.49.96E-03
179.72.09E-02179.76.75E-03179.73.03E-02179.79.93E-03
1802.09E-021806.73E-031803.02E-021809.89E-03
1802.09E-021806.73E-031803.02E-021809.89E-03
Sheet3
520
1040
2060
4090
60120
90180
120
180
iv
po
Time (min)
Plasma concentration(μM)
0.9406494961
0.0111982083
0.4591265398
0.0447928331
0.2575587906
0.0515117581
0.1119820829
0.0403135498
0.0671892497
0.0302351624
0.0358342665
0.0201567749
0.0223964166
0.0100783875