Division of Bioinformatics and Data Management for Research, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, THAILAND. Tel. [+66] 2-419-7000 Ext.2685-6 : the future of healthcare PRECISION MEDICINE [email protected][email protected]Prapat Suriyaphol
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Division of Bioinformatics and Data Management for Research,Department of Research and Development, Faculty of MedicineSiriraj Hospital, Mahidol University, Bangkok, THAILAND.
How much did it cost to sequence the first human genome?
~1 billion USD
How long did it take to sequence the first human genome?
~13 years
How long for sequencing human genome using NGS?
~ 1wk – 3wks
How much for sequencing human genome using NGS?
~ 1,000 USD
MinION: A complete DNA sequencer on a USB stick
MinION: A complete DNA sequencer on a USB stick
Just a SmidgION: Oxford Nanoporeannounce iPhone-powered sequencing
The study drew on electronic health records of 16,234 patients admitted to intensive care units—including medical, surgical, and cardiac units—at Boston's Beth Israel Deaconess Medical Center from 2001 to 2007. Researchers created an algorithm that combines 27 factors into a Targeted Real-time Early Warning Score, or TREWScore, measuring the risk of septic shock.
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Evolution of the concept
Precision Medicine
• Clinicians have always practiced personalized medicine, using personal health information to make decisions on diagnosis and treatment.
• When we refer to personal health information we are including genetic, physiological, anatomical, environmental risk factors, socio economic issues, cultural and psychological aspects as well as the familial and individual health history.
The East Room, January 30, 2015
President Obama Announces the Precision Medicine Initiative
Precision Medicine: Defined and Compared
Personalized medicine:Collect and analyze extensive information and data
about patient, EHR to genome and beyond; physician
uses this information and data to make more informed
diagnosis and treatment plan
Current medical practice:Use vital signs today relative to last visit (EHR?); assess