Precision Medicine - Center for Cancer Research · Precision Medicine: Report of the Surgeon General, 2014 premature deaths Caused by Smoking and LUNG CANCER Cancer Statistics (ACS),

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Precision Medicine

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Disease classification

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Research strategy

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Information commons

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Lung cancer

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Geographical map

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Smoke exposure

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Never smokers

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Worldwide cancers

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Early stage lung cancer

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Exposome

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p53

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Chronic inflammation and infection

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Pro-inflammatory cytokines

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IL-6 and IL-8

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Genome

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Chemical agents

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TP53 mutations

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Mutational processes

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NSCLC evolution

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TP53 mutations

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Patient prognosis

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Transcriptome

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MicroRNA

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microRNA mechanisms

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Hypothesis

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Upregulated microRNA

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Increased miR-21 expression

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miR-21 expression

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Cancer biomarkers

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microRNA secretion

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4-gene classifier

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Meta-Analysis

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Mechanistic cancer bimarkers

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miR-21 and 4 coding genes

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Non-coding RNA

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Proof of Principle

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Epigenome

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DNA methylation

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Prognostic epigenetic signature

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Survival curve

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Metabolome

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Tumor metabolism

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Urinalysis

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Survival curve

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Creatine ribose

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Lung cancer risk

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Creatine riboside and NANA

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Lung cancer screening

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Spiral CT scans

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Low dose CT

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Unmet needs

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Precision medicine goals

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Coworkers and collaborators