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Pre-Feasibility Report M/s. Satellite Pharmaceuticals Pvt. Ltd. Plot No.: B-40, MIDC Paithan, Taluka-Paithan, District-Aurangabad, Maharashtra

April 2017

Pre-Feasibility Reportfor M/s. Satellite Pharmaceuticals Pvt. Ltd. at MIDC Paithan, Taluka-Paitha, District- Aurangabad

Page 1 of 43

Table of Contents

1. Executive Summary .......................................................................................................... 3

2. Introduction of the Project ............................................................................................... 5

I. Identification of project and project proponent: ............................................................... 5

II. Nature of the project. .................................................................................................... 5

III. Need of the Project and its importance to the country and or region .................................. 5

IV. Demand-Supply Gap ...................................................................................................... 6

V. Imports vs. Indigenous Production .................................................................................. 7

VI. Export Possibility ........................................................................................................... 7

VII. Employment Generation (Direct & Indirect) due to the project ........................................... 7

3. Project Description .......................................................................................................... 8

I. Type of Project including interlinked and interdependent projects ...................................... 8

II. Location of Project ........................................................................................................ 8

III. Details of Alternate Site ............................................................................................... 11

IV. Size or Magnitude of operation ..................................................................................... 11

V. Project Description with process details ......................................................................... 12

VI. Raw Material Required ................................................................................................ 35

VII. List of Plant Machineries .............................................................................................. 35

VIII. Resource optimization/recycling and reuse .................................................................... 36

IX. Auxiliary Requirement ................................................................................................. 36

X. Waste Generation & Management ................................................................................ 36

XI. Schematic representations of the feasibility drawing which give information of EIA purpose.

37

4. Site Analysis .................................................................................................................. 38

I. Connectivity ............................................................................................................... 38

II. Land Form, Land Use & Land ownership ......................................................................... 38

III. Topography ................................................................................................................ 38

IV. Existing Land use pattern ............................................................................................. 38

V. Existing Infrastructure .................................................................................................. 38

VI. Soil Classification ......................................................................................................... 39

VII. Climate data from secondary sources ............................................................................ 39

5. PLANNING BRIEF ............................................................................................................ 41

I. Planning Concept ........................................................................................................ 41

II. Population Projection .................................................................................................. 41

III. Land use Planning........................................................................................................ 41


Page 2 of 43

IV. Assessment of Infrastructure Demand ........................................................................... 41

V. Amenities/Facilities ..................................................................................................... 41

6. Proposed Infrastructure ................................................................................................. 42

I. Industrial Area ............................................................................................................ 42

II. Residential Area .......................................................................................................... 42

III. Green Belt .................................................................................................................. 42

IV. Social Infrastructure .................................................................................................... 42

V. Connectivity ............................................................................................................... 42

VI. Drinking Water ............................................................................................................ 42

VII. Sewerage System ........................................................................................................ 42

VIII. Industrial Waste Management ...................................................................................... 42

IX. Solid Waste Management ............................................................................................ 42

X. Power Requirement ..................................................................................................... 43

7. Rehabilitation and Resettlement (R & R) Plan ................................................................... 43

8. Project Schedule & Cost Estimates .................................................................................. 43

I. Likely date to start of Construction & likely date of completion ........................................ 43

II. Estimated Project Cost ................................................................................................. 43

9. Analysis of Proposal ....................................................................................................... 43

I. Financial & Social Benefits ............................................................................................ 43


Page 3 of 43

1. Executive Summary

M/s. Satellite Pharmaceuticals Pvt. Ltd. existing synthetic organic chemical

manufacturing industry located at Plot No. B-40, MIDC Paithan, District-Aurangabad,

Maharashtra currently involving in chemical manufacturing Sodium Chloride,

Ammonium Chloride & Potassium Chloride which are used in cough formulation as

expectorant . Now, said industry propose for expansion with respect to

manufacturing of 15 type of intermediates chemicals which will be useful in

pharmaceutical industry. M/s. Satellite Pharmaceuticals Pvt. Ltd. having total plot area

6840 Sq.M. & total built up Area 1570.39 Sq.M. vide MIDC sanction letter no.

DB/2231/ of 2009 dated 24/12/2009. For expansion purpose no any additional

construction activity will be involved.

In existing plant, three types chemicals viz. Ammonium Chloride, Potassium Chloride

& Sodium Chloride are going to manufacturing with valid consent from Maharashtra

Pollution Control Board (MPCB) vide letter no. MPCB-16/161000823

MPCB/ROA/ABD/E-25/98/O/C-749/633/2016 dated 24/10/2016 & further

amendment vide letter no. MPCB/ROA/Amend/196/2017 dated 06/03/2017. These

products are used in preparation of formulations having expectorant action.

For proposed expansion activity involves manufacturing of 15 types of intermediates

chemicals. As per the EIA Notification 2006 & amendments thereof, for manufacturing

of Bulk Drugs & Intermediates chemicals requires Environment Clearance under the

category 5(f).

Table No. 1 : Production Details

Sr.No. Name of Chemical Quantity

EXISTING PRODUCTION DETAILS

1. Ammonium Chloride 11 MT/M

2. Sodium Chloride 11 MT/M

3. Potassium Chloride 11 MT/M


Page 4 of 43

PROPOSED PRODUCTION DETAILS

1. Benzhydrol 250 MT/Yr

2. 2-(2 bromoethyl) benzaldeyde 3 MT/Yr

3. Cinnamyl alcohol 56 MT/Yr

4. Diethyl amine salicylate 60 MT/Yr

5. Ethyl triphenyl phosphonium bromide 18 MT/Yr

6. Isosorbide 36 MT/Yr

7. Bromo methyl cyano biphenyl 17 MT/Yr

8. Isosorbide-2-acetate 20 MT/Yr

9. Tetrabutyl ammonium bromide 117 MT/Yr

10. Isatoic anhydride 58 MT/Yr

11. Tri-o-tolyl phosphine 11 MT/Yr

12. Meta chloro propiophenone 25 MT/Yr

13. 3-Chloro-4-N-morpholino 1,2,5

thiadiazole

4 MT/Yr

14. 4-methoxy propiophenone 99 MT/Yr

15. Anethole 58 MT/Yr

With reference to Environment & Social safety point of view, proposed manufacturing

activity involves manufacturing of organic chemicals which will be used as

intermediate in active bulk drug manufacturing industry. Project site is located within

Maharashtra Industrial Development Corporation (MIDC) Paithan, thus industrial

activity is permitted. Following studies are recommended Environment Impact

Assessment (EIA), Environment Management Plan (EMP), Disaster Management Plan

(DMP), Risk & Hazards study, Solid waste management, Hazardous waste storage,

disposal will be studied & followed.


Page 5 of 43

2. Introduction of the Project

I. Identification of project and project proponent:

M/s. Satellite Pharmaceuticals Pvt. Ltd. an existing synthetic organic chemical industry

located at Plot No. B-40, MIDC Paithan, District-Aurangabad, Maharashtra. Industry is

involving chemical manufacturing activity without drug manufacturing. Now, said

industry propose for expansion with respect to manufacturing of 15 type of Bulk Drugs

Intermediates which will be useful in pharmaceutical industry. They are used as an

intermediate of API belonging to antihistaminic, antidepressants , antihypertensive

and CNS stimulant.

Project proponent is Dr. Kedar Sinari, having M.Pharm and Ph. D (Tech) degree from

the prestigious ICT, Mumbai. He is the technical director of this company and has over

13 years experience working in pharma companies in India and abroad.

II. Nature of the project.

Proposed expansion activity involves manufacturing of 15 types of intermediate bulk

drugs chemicals. Manufacturing process involves series of chemical reactions from the

raw material to get final products. These final products will be useful in the bulk drug

pharmaceutical industry as a starting material to manufacture API (Active

Pharaceutical Ingredient).

III. Need of the Project and its importance to the country and or region

Now a day’s rate of human health diseases are increasing rapidly, medical treatment

with the help of drugs/medicines is a common practices in which, medicines/drugs

plays the important role in recover the health & control the diseases. Pharmaceuticals

industries required raw material in the form of synthetic chemicals, bulk drugs,

intermediates to prepare final products as a medicine. Bulk drugs interemdiates are

the active raw materials used in drug that are useful as therapeutic agents. Therefore,

proposed manufacturing of various Bulk Drugs & Intermediates has importance.

Many pharma companies enjoy success largely because their major operations are

based in Maharashtra. The government support received by the industry has been


Page 6 of 43

substantial and the presence of a pragmatic and stable state government has been

one of the main reasons the state has managed to remain a principal destination for

all pharma companies whether Indian or MNC. Maharashtra has been a hub for the

pharma industry, both in terms of manufacturing as well as supply of materials.

Aurangabad industrial belt occupies 40% of chemical producing industries for pharma

and other industries. In view of future market demand it is best opportunity to set up

a business in Aurangabad which may lead to employment generation to local youth

and economical upliftment of Paithan region.

IV. Demand-Supply Gap

The Indian pharmaceutical industry is the world's second-largest by volume and is

likely to lead the manufacturing sector of India. Several Government and private

sector projects with huge amount of investments have been initiated but could not

attend the speed of development for the need of good quality material. Over the last

decade, there has been a sizeable growth in Pharmaceutical sector both in small,

medium and large scale units. This has given rise to many small and medium scale

units to manufacture pharmaceutical intermediate. The ever growing requirements of

India, due to higher population and various diseases indicated the need for the growth

of this industry. Thus there is a gap in demand and supply. Our efforts of generating

products, by-products, downstream products and recycling - reprocessing are indeed

needed. With multinational pharmaceutical companies enhancing their presence in

India, the long-term prospects of the pharmaceutical industry seem fairly bright.

Indian agro sector demand is increasing to improve productivity and to deal with

attack of various types of pests etc. The intermediates proposed will substitute

imports.

The food industry demand for preservative is increasing as multinational companies

are shifting manufacturing base in India. But the impact of some factors on the

industry's growth remains to be seen.

The fate of industrialization depends on the proper and effective conjugation of large

and medium/small scale industries each supporting each other in their requirement

to bridge the gap between demand and supply. In order to be competitive in the global

market this synergy between large & medium/small scale industries is a prerogative.

Therefore considering the above, large companies do require the help of small units

to support them by giving them quality products at lesser price.


Page 7 of 43

V. Imports vs. Indigenous Production

Today’s Indian market going to be export intermediate chemicals for active

pharmaceutical industries.

VI. Export Possibility

Proposed industry is small scale industry so whatever products will produce it will

sell to local market only.

VII. Employment Generation (Direct & Indirect) due to the project

There will be no employment generation due to proposed industrial expansion.

Industry is being operated since 10 years and existing manpower will be efficient for

proposed product change.


Page 8 of 43

3. Project Description

I. Type of Project including interlinked and interdependent projects

M/s. Satellite Pharmaceuticals Pvt. Ltd., is proposing for expansion with respect to

manufacturing of 15 type of intermediate synthetic organic chemicals. Does not

interlink with any project.

II. Location of Project

M/s. Satellite Pharmaceuticals Pvt. Ltd. ia an existing synthetic organic industry

located at Plot No. B-40, MIDC Paithan, District-Aurangabad, Maharashtra. Location

Map of the Project site is shown in Figure No. 1. & 2 . Project site is located 36 km at

South direction from Aurangabad city & 7 km at North direction from Paithan town.

Geographical location of industry is 19°32'35.08"N, 75°23'14.30"E with elevation of

470 m from mean sea level. Project site is spread in to 6840 Sq. M area within MIDC –

Paithan. Project site marked on Paithan MIDC layout plan is shown in Figure No.3. For

expansion purpose no additional plot or construction activity will be required.


Page 9 of 43

M/s. Satellite Pharmaceuticals Pvt. Ltd.

at Plot No. B-40, MIDC Paithan, District-

Aurangabad, Maharashtra

Figure No. 1 : Location of Project Site


Page 10 of 43

Figure No. 2 : Google Imagery of Project Site

Figure No. 3 : Paithan MIDC Layout Plan

Latitude : 19°32'35.62"N

Longitude: 75°23'12.11"E

Latitude : 19°32'33.85"N


Latitude : 19°32'36.39"N


Latitude : 19°32'34.56"N



Page 11 of 43

III. Details of Alternate Site

It is the expansion of existing industry though alternate site not examined or

considered.

IV. Size or Magnitude of operation

Size & Magnitude of operation is presented below table

Table No. 2: Production Details

Sr.No. Name of Chemical Quantity

EXISTING PRODUCTION DETAILS

1. Ammonium Chloride 11 MT/M

2. Sodium Chloride 11 MT/M

3. Potassium Chloride 11 MT/M

PROPOSED PRODUCTION DETAILS

1. Benzhydrol 250 MT/Yr

2. 2-(2 bromoethyl) benzaldeyde 3 MT/Yr

3. Cinnamyl alcohol 56 MT/Yr

4. Diethyl amine salicylate 60 MT/Yr

5. Ethyl triphenyl phosphonium bromide 18 MT/Yr

6. Isosorbide 36 MT/Yr

7. Bromo methyl cyano biphenyl 17 MT/Yr

8. Isosorbide-2-acetate 20 MT/Yr

9. Tetrabutyl ammonium bromide 117 MT/Yr

10. Isatoic anhydride 58 MT/Yr

11. Tri-o-tolyl phosphine 11 MT/Yr

1. Meta chloro propiophenone 25 MT/Yr

2. 3-Chloro-4-N-morpholino 1,2,5 thiadiazole 4 MT/Yr

3. 4-methoxy propiophenone 99 MT/Yr

4. Anethole 58 MT/Yr


Page 12 of 43

V. Project Description with process details

I. BENZHYDROL

Chemical Reaction :

O

H2/Ni/NaOH

OH

C13H12OExact Mass: 184.09Mol. Wt.: 184.23


Benzophenone Benzhydrol

CH3OH,

CH3COOH

Product: Benzhydrol( CAS NO : 91-01-0)

Process description:

Step one: Benzophenone is dissolved in calculated amount of methanol at room

temperature. To this, sodium hydroxide solution is added followed by Raney nickel catalyst.

Then hydrogen gas is purged in to the reactor and solution is stirred till reaction is over.

Step Two: The catalyst is filtered through Nutche filter and then methanol is removed by

distillation.

Step two: Calculated amount of water and acetic acid is added and organic layer so

obtained is concentrated is unloaded in trays for natural cooling for solidification. The

solidified product is then milled to obtain Benzhydrol .


Page 13 of 43

Process Flow Chart with Batchwise Raw Material Requirement:

II. 2-(2-Bromoethyl)- Benzaldeyde

Chemical Reaction :

OH

H3PO4, HCl,CH3COOH

CHO

Br

O

(HCHO)n

isochroman

2(2'-bromoethyl)benzaldehyde


Product: 2- (2- bromoethyl) benzaldehyde (CAS no:22901-09-3)

Phenethyl alcohol


Dichloromethane

C9H9BrOExact Mass: 211.98Mol. Wt.: 213.07

Br2


Page 14 of 43


Step one: Phenethyl alcohol is dissolved in calculated amount of dichloromethane

at room temperature. To this, 85% phosphoric acid, paraformaldehyde, acetic

acid and hydrochloric acid is added and solution is stirred till reaction is over.

Calculated amount of Dichloromethane and water is added, layer separation is

done. Organic dichloromethane layer is separated and washed with sodium

bicarbonate solution. Organic dichloromethane layer is dried over sodium

sulphate and used as such in the next step for bromination.

Step two: To the organic dichloromethane layer, calculated amount of bromine

dissolved in dichloromethane is added and stirred. Then after reaction is over,

dichloromethane is removed by atmospheric distillation. The liquid obtained after

distillation is crude 2-(2-bromoethyl) bromobenzaldehyde.

Step three: The crude product is added to aqueous sodium metabisulfite solution

containing isopropyl alcohol. Dichloromethane is then added and the solid

obtained is centrifuged to obtain powder of metabisulfite adduct of the final

product.

Step four: The metabisulfite adduct is dissolved in calculated amount of water

and sodium carbonate is added to it. The organic product obtained is extracted in

dichloromethane and the dichloromethane layer is washed with water, dried and

concentrated to obtain 2- 2-bromoethyl benzaldehyde as yellow liquid.


Page 15 of 43

Process Flow Chart with Batchwise Raw Material Requirement:


Page 16 of 43


Page 17 of 43

III. Cinnamyl alcohol

Chemical Reaction :

CHO


NaBH4

BH4NaExact Mass: 38.03Mol. Wt.: 37.83

CH30H

CH2OH


Cinnamic aldehyde Cinnamyl alcohol

Process Description:

➢ Cinnamic aldehyde is dissolved in calculated amount of methanol at room

temperature. To this, sodium borohydride dissolved in sodium hydroxide solution

is added slowly.

➢ The reaction is maintained till all Cinnamic aldehyde is consumed.

➢ Methanol is removed by distillation and water is added to the reaction mixture

➢ Acetic acid is then added to neutralize the reaction.

➢ Lower aqueous layer is removed which goes to MEE ETP .

➢ Organic upper layer is taken up for vacuum distillation to obtain pure Cinnamyl

alcohol.


Page 18 of 43

Process Flow Chart with Batchwise Raw Material Requirement

IV. Diethyl Amine Salicylate

Chemical Reaction :

OH

COOH

C7H6O3

Exact Mass: 138.03Mol. Wt.: 138.12

OH

COOH

HN

C11H17NO3


Salicylic acid Diethyl amine salicylate

HN

Toluene

C4H11NExact Mass: 73.09Mol. Wt.: 73.14


➢ Calculated amount of toluene is taken to which calculated amount of salicylic

acid is added.


Page 19 of 43

➢ Then the reaction mass is cooled and calculated amount of diethyl amine is

added slowly.

➢ The reaction mass is stirred till reaction is over.

➢ Then the desired product precipitates out.

➢ The product obtained is centrifuged and dried.


V. Ethyl Triphenyl Phosphonium Bromide

Chemical Reaction :

P

C18H15PExact Mass: 262.09Mol. Wt.: 262.29

C2H5BrExact Mass: 107.96Mol. Wt.: 108.97

Toluene

P

Br

C20H20BrPExact Mass: 370.05Mol. Wt.: 371.25

Triphenyl phosphineEthyl triphenyl phosphonium bromide


Page 20 of 43


➢ Calculated amount of triphenyl phosphine is dissolved in toluene and ethyl

bromide is added and reaction is stirred till the reaction is over.

➢ The reaction mass is centrifuged to obtain triphenyl phosphonium bromide

powder which is washed with toluene.

➢ The Mother liquor obtained after centrifuge is distilled to recover toluene which

is again used in the next batch.

➢ The residue obtained after distillation is reused in the next batch.



Page 21 of 43

VI. Isosorbide

Chemical Reaction:

HO

OH

OH

OH

OH

OH

C6H14O6


sorbitol

SO3H

C7H8O3SExact Mass: 172.02

Mol. Wt.: 172.2

O

OH

O

H

HHO

C6H10O4


isosorbide


➢ Calculated amount of 70% sorbitol is taken to which para toluene sulfonic acid is

added.

➢ The reaction mass is heated to remove water from the reaction.

➢ Then the reaction mass is cooled and then sodium bicarbonate solution is added

for neutralization.

➢ Then water is removed from the reaction mass by heating under vacuum.

➢ Then isosorbide is obtained by distillation under vacuum



Page 22 of 43

VII. Isosorbide-2-acetate

Chemical Reaction:

O

OH

O

H

HHO

C6H10O4


isosorbide

(CH3CO)2O

C4H6O3


O

OH

O

H

HH3COCO

C8H12O5


isosorbide -2- acetate


➢ Calculated amount of isosorbide is taken to which sodium acetate is added.

➢ Then calculated amount of acetic anhydride is added

➢ The reaction mass heated and then acetic acid formed in the reaction is distilled

out

➢ Then distillation is continued under vacuum and isosorbide -2- acetate is distilled

under vacuum at 200 to 220 degree.



Page 23 of 43

VIII. Bromo Methyl Cyano Biphenyl

Chemical Reaction:

CN

C14H14


Br2

MDC, H2O2

AIBNCN

Br

C14H10BrNExact Mass: 271Mol. Wt.: 272.14

2-cyano-4-methyl biphenyl 4-bromo methyl cyano biphenyl

Process Flow Chart with Raw Material Requirement


Page 24 of 43

IX. Tetrabutyl Ammonium Bromide

Chemical Reaction:

N

C12H27NExact Mass: 185.21Mol. Wt.: 185.35

Br

C4H9BrExact Mass: 135.99

Mol. Wt.: 137.02

N

Br

C16H36BrNExact Mass: 321.2Mol. Wt.: 322.37

Tr-n-butyl amine tetra butyl ammonium bromide


➢ Calculated amount of acetonitrile is taken to which calculated amount of tri-n-

butyl amine is added.

➢ Then calculated amount of n-butyl bromide is added slowly.

➢ The reaction mass is heated till reaction is over.

➢ Then calculated amount of ethyl acetate is added and then acetonitrile and other

volatiles are distilled out.

➢ The reaction mass is cooled and product obtained is centrifuged and dried to

obtain tetra n-butyl ammonium bromide.



Page 25 of 43

X. Isatoic Anhydride

Chemical Reaction:

NH

O

O

C8H5NO2


NaOH/ Cl2

NH

O

O

O

C8H5NO3


PhthalimideIsatoic anhydride


➢ Calculated amount of ice and sodium hydroxide solution is taken.

➢ Chlorine gas is purged till reaction is over.

➢ The solution obtained is sodium hypochlorite solution. This solution is used for

next step

➢ In next step, calculated amount of phthalimide is taken to which water is added.

➢ To the reaction mass, sodium hydroxide solution is added.

➢ Then the reaction mass is cooled and then sodium hypochlorite solution prepared

above is added.

➢ Then after reaction is over, hydrochloric acid is added to neutralize the reaction.

➢ The solid obtained is centrifuged and dried to obtain isatoic anhydride.


Page 26 of 43


XI. Tri-O-Tolyl Phosphine

Chemical Reaction:

Cl

C7H7ClExact Mass: 126.02

Mol. Wt.: 126.58

Mg/THF

PCl3

Cl3PExact Mass: 135.88Mol. Wt.: 137.33

P

C21H21PExact Mass: 304.14Mol. Wt.: 304.37

O-chloro toluene

Tri-ortho tolyl phosphine


➢ Calculated amount of magnesium and dry tetrahydofuran is taken is taken to which

small amount of o-chloro toluene is added for initiation.

➢ Then remaining amount of o-chloro toluene is added slowly.

➢ Then phosphorous trichloride in toluene is added to the reaction mass.

➢ Stirring is continued till reaction is over.

➢ Then the reaction mass is quenched in water containing hydrochloric acid.


Page 27 of 43

➢ The product obtained is centrifuged to obtain crude tri-o-tolyl phosphine.

➢ The product is then recrystallized using calculated amount of isopropyl alcohol.

➢ The product obtained is centrifuged and dried to obtain final pure tri-o-tolyl

phosphine.


XII. Meta Chloro Propiophenone

Chemical Reaction:

O


AlCl3Exact Mass: 131.89Mol. Wt.: 133.34

Cl2Exact Mass: 69.94Mol. Wt.: 70.91

O

Cl

C9H9ClOExact Mass: 168.03Mol. Wt.: 168.62

Propiophenone 3-chloro propiophenone



Page 28 of 43

➢ Calculated amount of propiophenone is taken to which calculated amount of

Ethylene dichloride is added.

➢ The reaction mass is chilled and calculated amount of aluminium chloride is

added to it.

➢ Then chlorine gas is purged into the reaction mass under chilled conditions.

➢ After reaction is over, the reaction mass is quenched in cold water containing

HCl.

➢ The organic layer is removed and washed with sodium bicarbonate solution for

neutralization.

➢ Then ethylene dichloride is recovered by distillation to obtain crude 3-chloro

propiophenone which is vacuum distilled to obtain pure 3-chloro

propiophenone.



Page 29 of 43

XIII. 3-Chloro,4-N-Morpholino, 1,2,5 Thiadiazole

Chemical Reaction:

H2N

NH2.2HCl

Ethylene diamine dihydrochloride

N

NS

Cl

Cl

O NH

N

NS

Cl

N O

3,4-dichloro-1,2,5-thiadiazole

3-chloro-4-(N-morpholino)- 1,2,5-thiadiazole

C2H10Cl2N2


Cl2S2Exact Mass: 133.88

Mol. Wt.: 135.04

Cl2Exact Mass: 69.94

Mol. Wt.: 70.91

C2Cl2N2SExact Mass: 153.92

Mol. Wt.: 155.01

C4H9NOExact Mass: 87.07

Mol. Wt.: 87.12

C6H8ClN3OSExact Mass: 205.01

Mol. Wt.: 205.67


Step one:

➢ Ethylene diamine dihydrochloride is dissolved in Dimethyl formamide.

➢ The solution is stirred and sulfur monochloride is added.

➢ Then solution is cooled and chlorine gas is purged in the reaction mixture till the

reaction is over.

➢ Then water is added and stirred.

➢ Organic layer is taken up for vacuum distillation.

➢ 3,4-dichloro thiadiazole which gets distilled is obtained as yellow liquid .

Step two:

➢ 3,4 dichloro thiadiazole obtained in first step is dissolved in calculated amount of

morpholine.


Page 30 of 43

➢ The reaction is heated for 2 hours till reaction is complete.

➢ Then the reaction mass is cooled and Hydrochloric acid is added .

➢ After addition , solid precipitates which is filtered and dried to obtain 3- chloro-4-N-

morpholino 1,2,5- thiadiazole.



Page 31 of 43


Page 32 of 43

XIV. 4-Methoxy Propiophenone

Chemical Reaction:

OCH3

C7H8OExact Mass: 108.06

Mol. Wt.: 108.14

(CH3CH2CO)2O

C6H10O3


OCH3

O

C10H12O2

Exact Mass: 164.08Mol. Wt.: 164.2Anisole

4-methoxy propiophenone


➢ Calculated amount of anisole and propionic anhydride is taken.

➢ Then calculated amount of zeolite catalyst is added slowly.

➢ Then reaction is refluxed till reaction is over

➢ The excess anisole and propionic acid formed is distilled and anisole is reused in

next batch.

➢ Then 4-methoxy propiophenone is distilled under vacuum.


Page 33 of 43


XV. Anethole

Chemical Reaction:

OCH3

O

C10H12O2


4-methoxy propiophenone

Ni/ H2

or NaBH4

OCH3

HO

C10H14O2


KHSO4

HKO4SExact Mass: 135.92Mol. Wt.: 136.17

OCH3

C10H12OExact Mass: 148.09

Mol. Wt.: 148.2

Anethole


Page 34 of 43


➢ Calculated amount of 4-mehoxy propiophenone is taken in methanol.

➢ Then the reaction mass is hydrogenated using hydrogen and raney nickel as catalyst

or using sodium borohydride

➢ After reaction is over, the catalyst is filtered and solvent is removed to obtain the

reduced product.

➢ This reduced product is treated with potassium hydrogen sulfate and mineral oil.

➢ The reaction is refluxed and distilled to obtain anethole as clear liquid.



Page 35 of 43

VI. Raw Material Required

Batchwise raw material requirement is detailed out in process flow chart presented in

Section 3 of V.

VII. List of Plant Machineries

Details of plant equipment’s are presented in Table No. 3

Table No. 3: Details of plant equipment’s

PARTICULAR POWER PARTICULAR POWER

Lab Instruments 7.5 HP Air Compressor 2 HP

Lab Vacuum Pump 1 HP Scrubber No. 1 2 HP

Reactor No.1 5 HP Scrubber No. 2 2 HP

Reactor No. 2 5 HP Scrubber No. 3 2 HP

Reactor No. 3 5 HP Scrubber No. 4 2 HP

Reactor No. 4 5 HP High vacuum distillation Unit 5 HP

Reactor No. 5 5 HP Glass flask No. 1 0.5 HP




Centrifuge No. 1 7.5 HP Glass flask No. 5 0.5 HP

Centrifuge No. 2 7.5 HP Glass flask No. 6 0.5 HP

Centrifuge No. 3 7.5 HP Air Handling Unit (AHU) 5 HP

Centrifuge No. 4 7.5 HP ETP 23.45 HP

Centrifuge No. 5 7.5 HP Lighting Load 2.6 HP

Dryer No. 1 5 HP FAN 1.25 HP

Dryer No. 2 5 HP AC 2 HP

Nutch filter 2 HP

Sparkler filter No. 1 1 HP

Sparkler filter No. 2 1 HP

Pressure filter No. 3 1 HP

Pressure filter No. 4 1 HP

Multimill No. 1 3 HP

Multimill No. 2 3 HP

Boiler No. 1 5 HP

Boiler No. 2 5 HP

Chilling Plant 40 HP

Cooling Tower 15 HP

Vacuum Pump Watering No. 1 5 HP

Vacuum Pump Watering No. 2 5 HP

Water Pump 3 HP

High Vacuum Pump 5 HP

Softener Pump 1 HP

Filter Pump No. 1 2 HP



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Vacuum Pump Oil ring 5 HP

VIII. Resource optimization/recycling and reuse

Proposed expansion is related to change in products only. Existing resource such as

infrastructure, equipment’s and manpower will be used in proposed expansion.

Industry is in practice to recycle & reuse waste water for gardening. The same practice

will be adopted in proposed expansion also.

IX. Auxiliary Requirement

Details of auxiliary requirement & it source are presented below

Table No. 4: Details of Auxiliary

Sr.No. Auxiliary Requirement Source

1. Water 12 CMD MIDC

2. Power 95 kVA MSEDCL

3. DG Set 50 kW Solar Energy

4. Cooling Tower

5. Boiler

X. Waste Generation & Management

Construction Phase: There is no construction in proposed expansion hence no solid

waste generation.

Operation Phase: Domestic waste would be generated in the form of dry waste 9

kg/day & 3 kg/day of wet waste. It will be collected at designated place and

disposed-off through authorized vendor.

Commercial Waste : Wooden box, raw chemical plastic drum etc. would be disposed

off through authorized vendor.

Industrial Waste: Hazardous waste will be sent to CHWTSDF facility and non-

hazardous waste will be recycled through authorized vendor.


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XI. Schematic representations of the feasibility drawing which give information of EIA

purpose.


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4. Site Analysis

I. Connectivity

The project site is in MIDC-Paithan, well connected through road, railway, and airport.

Nearest highway is SH-30 i.e. Aurangabad to Paithan which is about 0.7km from the

project site. Nearest Railway station & Airport is in Aurangabad which is at 36km

(Aerial) from project site.

II. Land Form, Land Use & Land ownership

Project site is spread in to 6840 Sq.M. area. Industry is located in notified industrial

MIDC area. Land use is for industrial activity only and land ownership is of MIDC and

taken on lease in the name of M/s. Satellite Pharmaceuticals Pvt. Ltd.

III. Topography

M/s. Satellite Pharmaceuticals Pvt. Ltd. is already established unit and located in MIDC

area. Topography of developed site is flat. For expansion purpose, no any additional

land or construction activity required.

IV. Existing Land use pattern

Land is already developed for industrial purpose. Total plot area of M/s. Satellite

Pharmaceuticals Pvt. Ltd is 6840 Sq.M. Site is located in well-developed Paithan MIDC

area. Surrounding area is already developed for industrial purpose.

V. Existing Infrastructure

Project site is having existing MIDC’s infrastructure such as road, water supply,

electricity etc., other societal infrastructure around proximity of project site is

presented in Table No. 5.


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Table No. 5.: Societal infrastructure

Particular Name Distance from

project site

(Km)

Direction

from project

site

Airport Aurangabad 36 N

Railway Station Aurangabad 36 N

Highway Aurangabad-Paithan (SH-

30)

0.7 W

Industrial area Paithan MIDC 0.0 within

Fire Station Paithan MIDC Fire station 0.9 SW

Waluj MIDC Fire station 35 NW

Hospital Bhujbal Hospital 0.8 W

Dhanwantari Hospital 0.9 SW

Police station Paithan Police Station 8.0 S

Tourist Places Paithan 6.0 S

Settlement Mudhalwadi 1.3 SE

VI. Soil Classification

The most important soils of the district are the black clay soils on plains interspersed

with occasional stretches of shallow soils on ridges. In the north, the soils are shallow

and poor and in the south they are deep and fertile and particularly so in the Godavari

valley. They are all derived from Deccan trap. The soils can be classified as light,

medium and heavy according to the depth, texture and location.

VII. Climate data from secondary sources

Aurangabad has a semiarid climate. Annual mean temperatures in Aurangabad range

from 17 to 33 °C, with the most comfortable time to visit in the winter – October to

February. The highest maximum temperature ever recorded was 46 °C (114 °F) on 25

May 1905. The lowest recorded temperature was 2 °C (36 °F) on 2 February 1911. In

the cold season, the district is sometimes affected by cold waves in association with

the eastward passage of western disturbances across north India, when the minimum

temperature may drop down to about 2 °C to 4 °C (35.6 °F to 39.2 °F).


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Most of the rainfall occurs in the monsoon season from June to September.

Thunderstorms occur between November to April. Average annual rainfall is 710 mm.

The city is often cloudy during the monsoon season and the cloud cover may remain

together for days. The daily maximum temperature in the city often drops to around

22 °C due to the cloud cover and heavy rains.


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5. PLANNING BRIEF

I. Planning Concept

In proposed expansion there will be no construction works involved. Industry is in

operation with chemicals without bulk drug manufacturing. Existing industrial

infrastructures are adequate for proposed expansion. Hence there is no planning in

detailed will be required.

II. Population Projection

Site is located at developed Paithan MIDC area. There is no manpower requirement

in proposed expansion.

III. Land use Planning

Land is already developed for industrial purpose.

IV. Assessment of Infrastructure Demand

Project site is in MIDC area, all infrastructure provided by the MIDC, hence additional

infrastructure demand will be negligible.

V. Amenities/Facilities

In proposed expansion addition 5CMD of effluent treatment plant will be required

followed by Multi Effect Evaporator to achieve Zero Liquid Discharge (ZLD) Scheme.

Plot Area : 6840 .00 Sq.M.

Built-Up Area : 1570.39 Sq.M

Open Area : 2770.00 Sq.M.

Green Belt Area : 2000.00 Sq.M


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6. Proposed Infrastructure

I. Industrial Area

Project site is in Paithan MIDC area, no additional land or plot will be required for the

expansion purpose.

II. Residential Area

No residential area is involved.

III. Green Belt

Industry is already developed 2000.00 Sq.M. of area as a green belt.

IV. Social Infrastructure

No any additional infrastructure proposed as project is in MIDC

V. Connectivity

As a existing industry situated in Paithan MIDC, Industry is well connected through

highway & internal roads. No new road is proposed.

VI. Drinking Water

Domestic water demand is 2 CMD and there is no additional requirement in proposed

requirement. Source of water is MIDC.

VII. Sewerage System

Existing industry has sewerage system for collection of domestic sewage. That sewage

is treated in septic tank followed by soak pit.

VIII. Industrial Waste Management

Industrial waste segregated as hazardous & non-hazardous. Hazardous waste will be

sent to CHWTSDF and non-hazardous waste will be disposed off through authorized

vendor.

IX. Solid Waste Management

Domestic waste categorized as dry & wet waste. Quantified dry waste 9 kg/day & 3

kg/day of wet waste are being collected at designated place and disposed-off

through authorized vendor.


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X. Power Requirement

Existing power requirement is 95 kVA and connected load is 187 kVA. Source of power

is MIDC/MSEDCL. Client has proposed to install 50 kW solar panel as an alternate

green energy source in proposed expansion.

7. Rehabilitation and Resettlement (R & R) Plan

As a project site is located in Paithan MIDC area there is no applicability of R & R. for

the said project.

8. Project Schedule & Cost Estimates

I. Likely date to start of Construction & likely date of completion

M/s. Satellite Pharmaceuticals Pvt. Ltd, is already existing industry in Paithan MIDC.

For proposed expansion industry does not required any construction activity.

Manufacturing of proposed synthetic organic chemicals process will start after getting

Environment Clearance from Authorities & Consent to Operate from MPCB.

II. Estimated Project Cost

Estimated cost of the project for expansion purpose is ₹. 100 Lakhs . Total cost of the

project after expansion would be ₹. 470 Lakhs (Existing & Proposed).

9. Analysis of Proposal

I. Financial & Social Benefits

M/s. Satellite Pharmaceuticals proposed expansion with respect to manufacturing of

synthetic organic chemicals as Intermediates for bulk drug , which will be used as a

raw material for preparation of various medicines for curing different diseases in social

community & help to maintain healthy life. Thus the project having social benefits in

term of production of raw material for medicines.

In financial point of view, proposed synthetic organic chemicals can be exported to

various countries it will help full to generate revenue & various taxes.

Pre-Feasibility Report - Welcome to Environmentenvironmentclearance.nic.in/writereaddata/FormB/TOR/PFR/...Pre-Feasibility Report M/s. Satellite Pharmaceuticals Pvt. Ltd. Plot No.:

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