Ppt Analgetik Opioid Pptx

8/19/2019 Ppt Analgetik Opioid Pptx

1/22

ANALGESIK OPIOID

OLEH:NAMA ANGGOTA : 1. Try Saputra (08121006035) 2. Della N!"e #$eta (0812100603%) 3. T&" Ha$'ulla& (0812100603) . *arl"+a ,ella (0812100601)

-ELOMO- : 5 (L/MA)


2/22

A+ale$" p"" aala& l+a+ 'atpe+&"la+ +yer" ala"4 $e"$"+te$"$ a+$"+te$"$ ya+ $e'a"a+ $"at$"at+ya $aaatau &ap"r $aa e+a+ p"u atau r7+.

e+u+aa+ utaa p"" "+" aala&u+tu e+ata$" ra$a +yer" ya+ t"a&"la+ e+a+ a+ale$" '"a$a. e+u+aa+la"+ $e+yaa p"" "+" aala& a+t""are(lpera") a+ a+t"tu$" (terutaa e"+).e+u+aa+ 'at'at "+" &aru$ &at"&at"are+a e+epre$" pu$at per+apa$a+ a+e+"'ula+ a"$" (e9a+ua+) $erta

A+ale$" Op""

-eu+aa+ Op""


3/22

e+l+a+ Op""Me+urut ;e+"$


4/22

Analgesik Opioid Kuat

A+ale$" "+" &u$u$+ya "u+aa+ paaterap" +yer" tupul ya+ t"a terlal"$a$"e+a+ 'a" (!"$eral). Mr7+ pare+teral

'a+ya "u+aa+ u+tu e+"'at" +yer"&e'at a+ r7+ ral erupaa+ 'atterp"l"& paa peraata+ ter"+al.


5/22

Analgesik Opioid KuatMorfn a+ a+ale$" p"" la"++ya e+&a$"la+

$uatu "$ara+ ee $e+tral ya+ el"put" a+ale$"a4eur"a4 $ea$"4 epre$" +apa$4 epre$" pu$at!a$tr4 Mr7+ '"a$ e+ye'a'a+ pelepa$a+&"$ta"+e e+a+ !a$"lata$" a+ ra$a atal.

Diamorfn (&er"+4 "a$et"lr7+)-aar pu+9a ya+le'"& t"+" e+"'ula+ $ea$" ya+ le'"& uatar"paa r7+. D$"$ e9"l "ar7+ ep"ural$ea"+ 'a+ya "u+aa+ u+tu e+e+al"a++yer" &e'at.

Fentanil apat "'er"a+ $e9ara tra+$eral paapa$"e+ e+a+ +yer" r+"$ ya+ $ta'"l4 terutaa '"lap"" ral e+ye'a'a+ ual a+ u+ta& &e'at.


6/22

Analgesik Opioid KuatMetadon epu+ya" ura$" er;a pa+;a+ a+ ura+

$eat"!e "'a+"+a+ r7+. Meta+ "u+aa+$e9ara ral u+tu terap" tuata+ pe9a+u &er"+ ataur7+. aa pe9a+u4 eta+ e+9ea& pe+u+aa+'at "+tra!e+a.

Petidin epu+ya" er;a 9epat tetap" ura$"+ya ya+$"+at (3 ;a) e'uat+ya t"a 99 u+tupe+e+al"a+ +yer" ;a+a pa+;a+. et""+ 'er"+tera$"$er"u$ e+a+ MAO/ e+ye'a'a+ +!ul$" atau epre$"+apa$.

Buprenorfn erupaa+ a+"$ par$"al re$eptr =.,upre+r7+ epu+ya" er;a la'at4 tetap" erupaa+a+ale$"9 eet" $etela& pe'er"a+ $u'l"+ual.


7/22

Analgesik Opioid Lema

A+ale$" p"" lea& "u+aa+paa +yer" >r"+a+ $apa" $ea+?.A+ale$" "+" '"$a e+ye'a'a+

etera+tu+a+ a+ 9e+eru+"$ala&u+aa+. Aa+ tetap"4'upre+r7+ ura+ e+ar" u+tupe9a+u are+a t"a e'er"a+

>ee? ya+ &e'at.


8/22

Analgesik Opioid LemaKodein (et"lr7+) "a'$r+$" 'a" $e9ara

ral4 teta" epu+ya" a7+"ta$ ya+ $a+atre+a& ter&aap re$eptr p"". -e"+ ;ua"u+aa+ $e'aa" 'at a+t"tu$" a+ a+t""are.

Dekstropropoksi!en epu+ya" "ra"ra$ete+a& pte+$" e"+4 tetap" epu+ya"a$" ya+ $erupa paa $"$ au"a+ale$".-'"+a$" e+a+ para$etal 'er'a&aya

paa !er$"$ are+a e$trpp$"e+e+ye'a'a+ epre$" +apa$4 $ee+tarapara$etal 'er$"at &epatt$".


9/22

Farmakodinamik "eseptor Opioid dan Mekanisme Ker#a Opioid

Op"" 'er"+tera$" $e9ara $tere$pe$"7 e+a+prte"+ re$eptrpaa e'ra+ $el$el terte+tu ala

S4 paa u;u+ $ara per"er a+ paa $el$el $alura+9er+a. ,a+ya pept"a ya+ e'er"a+ ee "r"p

r7+ ya+ ";upa" ala ta a+ ala ;ar"+a+la"+. ept"apept"a "+" "+aa+ p"pept"+.

#e$eptr Op"" :#e$eptr $ %mu&' ya+ ter+yata 'erpera+a+ ala ee

ee a+ale$"4 per+apa$a+4 a+ etera+tu+a+ 7$".#e$eptr ( %kappa&' ya+ u+"+ epera+tara"

eeee a+ale$" $p"+al4 "$"$4 a+ $ea$".#e$eptr %sigma&' ya+ 'erpera+a+ ala eeee

&alu$"+e+" a+ pera+$a+a+ ;a+tu+


10/22

Farmakodinamik Distri)usi "eseptor dan Fungsin*aBatang otak : re$eptr p"" epe+aru&" per+apa$a+4 'atu4

ual4 a+ u+ta&4 eel"&ara tea+a+ ara&4 "aeter pup"l4a+ e++trl $ere$" la'u+.

Talamus medialis: aera& "+" ee+aru&" +yer" ya+ alaya+ t"a terlal"$a$" a+ e+aru&" e$".

Medula spinalis: re$eptr " ala $u'$ta+$"a elat"+$aterl"'at ala pe+er"aa+ a+ "+tera$" &a$"l pe'e+tua+$e+$r" ya+ ee+aru&" pe+ura+a+ $t"ulu$ aere+ ra$a+yer".

Hipotalamus: re$eptr " tepat "+" ee+aru&" $ere$"

+eure+r"+Sistem limbik : ala $"$te "+" terapat +$e+tra$" re$eptr

p"" ya+ ter'e$ar4 ya"tu " a"ala.

Perifer : p"" ;ua ter"at " $era'ut $ara per"er a+u;u+ter"+al+ya.


11/22

Farmakodinamik

E!ek opioid *ang digunakan se+araklinis

Mr7+ a+ e'a+yaa+ a+"$ la"+ ya+

"u+aa+ $e9ara l"+"$ e'er"a+ee+ya elalu" re$eptr p"". O'at "+"e+pe+aru&" $y$te 7$"l"$ $e9aralua$. O'at "+" e+ye'a'a+ analgesia'

mempengarui mood' perilaku puas'dan mengu)a !ungsi perna!asan'kardio,askular' gastrointertinal' danneuroendokrin.


12/22

Farmakodinamik Ter&aap $u$u+a+ $ara pu$at

Se'aa" a+alet"4 'at "+" 'eer;a paat&alau$ a+ $u'$ta+$" elat"+$a eulla$p"+al"$4 " $ap"+ "tu4 +art" ;ua

epu+ya" ee $ea$". Ter&aap re$p"ra$"

Me+"'ula+ epre$" pu$at +aa$terutaa paa 'ay" a+ ra+ tua. Nau+

ee "+" apat "pul"&a+ e+a+ +alr7+ atau+al$+.

Ter&aap 'r+u$4 pet""+ e+ye'a'a+"lata$" 'r+u$4 $ea+aa+ r7+

e+ye'a'a+ +$tr"$" a"'at pe+aru&ele a$a+ &"$ta"+.


13/22

Farmakodinamik Ter&aap $"rula$" T"a e+"'ula+ epre$" $y$te $"rula$"4 $e&"+a9uup aa+ "'er"a+ paa $eua pa$"e+ e9ual" 'ay" a+ra+ tua.

aa e&a"la+4 p" apat eleat" 'a"rer

pla$e+ta $e&"+a '"$a e+"'ula+ epre$" +aa$ paa'ay" 'aru la&"r.

Ter&aap $y$te la"+

Mera+$a+ pu$at u+ta&4 e+"'ula+ $pa$e$p"+ter a+u+ epeu $e&"+a e+"'ula+ l"

a'e+. Mr7+ era+$a+ pelepa$a &"$ta"+e$e&"+a '"$a e+"'ula+ ra$a atal $eluru& tu'u& atau"+"al paa aera& &"u+4 $ea+a+ pet""+4pelepa$a+ &"$ta"++ya 'er$"at l9al "tepat $u+t"a+.


14/22

FarmakokinetikA)sorpsi - er"!at r7+ ("$: r7+4 &er"4

e"+) "$erap e+a+ 'a" " $alura+ 9er+a.Nau+ 'a+ya "a+tara


15/22

FarmakokinetikMeta'l"$e

Se'a"a+ 'e$ar p""p"" "+!er$" e+;a" eta'l"teta'l"t plar4 $e&"+a ua& " e$re$" le& "+;al $e+yaa ya+ epu+ya" uu$a+ &"r$"l 'e'a$ $epert"

r7+a+ le!ra+l e+a+ ua& " +yua$" e+a+ a$a

lur+at. $e+yaa$e+yaa 'e+tu e$ter ($epert" : eper""+ a+ &er"+)

le'"& 9epat "&"rl"$"$ le& e$tera$e ya+ uu terapat la ;ar"+a+.

Her"+ ("a$et"lr7+) "&"rl"$"$ e+;a" +a$et"lr7+ a+a&"r+ya ;a" r7+ ya+ eu"a+ "+yua$" e+a+ a$a

lur+at.Op"" ;ua e+ala" N"et"la$" le& &at"4 tetap" "+" &a+ya$e'a"a+ e9"l $a;a. Auula$" eta'l"t eper""+4+raper""+ apat "teua+ paa pa$"e+pa$"e+ ya+e+er"a 'at ala $"$ ya++9uup t"+"4 eta'l"tapat e+"'ula+ e;a+ terutaa paa a+a.


16/22

FarmakokinetikE$re$"

Meta'l"t plar p"" "e$re$"terutaa elalu" "+;al. Se'a"a+ e9"lp"" "e$re$" ala 'e+tu t"a

'eru'a&. O'at ter$e'ut "el""+a$" elalu"7ltra$" lerulu$4 0B e$re$" ttalter;a" paa &ar" pertaa. Ter;a" $"rula$"e+ter&epat" r7+ a+ luur+"a+ya4

ya+ e+ye'a'a+ aa+ya $e;ula& e9"lr7+ ala e$e$ a+ ala ur"+ $elaa'e'erapa &ar" $etela& $"$ tera&"r.-+yua$" luur+" ;ua "e$re$" e

ala epeu4 tetap" $"rula$"


17/22

ECE- SAM/NG O/O/D

Gel"$a&4 eetar4 a+ &"perat"

Depre$" per+apa$a+

Mual a+ u+ta&

H"pte+$"

-+$t"pa$"

#ete+$" ur"+

rur"tu$-etera+tu+a+ O'at


18/22

E!ek Samping KususMorfn

-e;a+ +al"$+ re!er$"'le4 paa $"$ t"+" r"""ta$ 'at

Me'e'a$a+ &"$ta"+e ar" ;ar"+a+ !a$"lata$"4'r+$pa$e paa pe+er"ta a$a4 ra+$a+a+ atal4pe+eluara+ er"+at

Petidin

Ee $pa$e+ ya+ re+a& paa $"$ t"+" apate+ye'a'a+ e;a+

Nal$+ ya+ re!er$"'le $epert" r7+ e'e'a$a+

&"$ta"+e ar" ;ar"+a+ ee $ap"+ le'"& r"+a+ ar"r7+

.ramadol

Le'"& r"+a+ ar"paa r7+4 $"rula$" +etral4 $e""t &"+a$aa $eal" t"a aa epre$" per+apa$a+


19/22

E!ek Samping Kusus .ilidin

T"a epu+ya" ee a+t"tu$"4 epre$" per+apa$a+ $epert"pet""+4 etera+tu+a+ a+ aa e;ala tlera+$" '"+a$"e+a+ +al$+ u+tu e+"+ar" pe+yala&u+aa+.

Buprenorfn

-are+a "ata+ paa re$eptr uat a+ laa4 epre$"per+apa$a+ t"a apat "a+ta+"$ le& +al$+ (a+alept"9per+apa$a+ $apra4 pra) $epert" &al+ya paa r7+

Mula" ar" $"$ terte+tu4 $euatu pe+"+ata+ $"$e+a"'ata+ pe+uru+a+ ee a+ale$"+ya (p+e+a+ta+"$t"9)

Penta/osin

D"r"$4 p$""et"

-e+a"a+ aar atela"+ pla$a4 e+a"a+ tea+a+ ara&4

reue+$" ;a+tu+4 tea+a+ pe+"$"a+ ;a+tu+ paa a&"r"a$tle tea+a+ arter" ul+al


20/22

Antagonis OpioidNalokson

Nal$+ erupaa+ a+ta+"$ pet"t" ya+u+"4 a+ 'at p"l"&a+ ala terap" era9u+a+p"". re$"p"ta$" $"+r putu$ 'at 'erat paa

"+"!"u ya+ epu+ya" tlera+$" p"".e+el"t"a+ l"+"$ e+u+;ua+ eu+"+a+a+aat +al$+ $"$ t"+" paa $y $ept".

Le,alor!an

Le!alra+ epu+ya" $"at a+"$a+ta+"$4ee a+ta+"$ le'"& uat ar" ee a+"$. Eea+ta+"$ "&a$"la+ le& er;a+yaya+ apate+e$erp"" la"+ ar" re$eptr+ya.


21/22

Adiksi' Ketergantungan O)at Serta.oleransi Pada Morfn Dan Opioid

Dala a"$" terapat 2 e+e+a :Aa+ya te+e+$" u+tu e+"+ata+ $"$ (are+a

aa+ya tlera+$")

Aa+ya etera+tu+a+

Terapat 3 t"pe tlera+$" aral"4 ya"tu :

Tlera+$" "$p$"$"+alperu'a&a+ ara"+et"e+ye'a'a+ 'at le'"& $e""t 'eraa " tepat er;a.Mea+"$e utaa "ala& "t"+ata++ya eta'l"$e'at

Tlera+$" ara"+a"peru'a&a+ 'erupa pe+ye$ua"a+e+a+ ;ar"+a+ taret e+a+ "turu+a++ya re$p+ter&aap +$e+tra$" 'at ya+ "'er"a+.

Tlera+$" per"laupe+ye$ua"a+ ter&aap ee 'at ya+e+u'a& t"+a& lau.


22/22

TE#/MA -AS/H

CA#MAS/ FNS#/ 2012 -ELOMO- 5

Ppt Analgetik Opioid Pptx

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