Analgesics and Anti- inflammatory Agents NURS 1950 Pharmacology Nancy Pares, RN, MSN Metro Community College 1
Analgesics and Anti-inflammatory Agents
NURS 1950Pharmacology
Nancy Pares, RN, MSNMetro Community College
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What are the assessments?
What is included in a pain history?
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Obj. 3. Describe factors included in assessment of pain
Schedule I: high potential for abuse◦No accepted medical use in US
Schedule II:◦ high potential for abuse◦Opiate analgesics
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Obj. 4 Describe scheduled drugs
Schedule III: lower potential for abuse than schedule II.◦Tylenol with codeine
Schedule IV: lower potential for abuse than schedule III.◦Librium, Valium
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Schedule V: lowest potential for abuse◦Usually antidiarrheal and antitussive
◦Lomotil◦Robitussin A-C
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Bind to opiate receptors in the CNS◦This inhibits transmission of pain impulse and alters pain perception
◦Also produce euphoria
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Obj. 6. Describe actions of narcotic analgesics
Signs and symptoms of overdose◦Respirations under 12/minute◦Pin-point pupils◦Coma What drug can be used to reverse these effects?
Why does it work?
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MS 5-20 mg dose q 4 hr
10-60 min onset
Longer duration of action than Demerol
Demerol◦50-100 mg q 3-4
hr◦10-45 min onset◦Shorter duration
of action than MS
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Assessment of painAssessment of respirationsMS can be used in cancer painMeperidine (Demerol) metabolite is normeperidine: causes hallucinations
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Nursing Implications
Some narcotic analgesics are◦Hydrocodone + acetaminophen (Vicodin)
◦Fentanyl (Duragesic)◦Oxycodone + ASA (Percodan)
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A client is receiving MSContin q 12 hr-30 mg
At the next dose time, there is break through pain.
Can the client also have the MSIR dose?
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Thinking Question
Narcotics work in the CNS and affect the nociceptors (nerve endings) and the neurotransmitter pathways of pain transmission
Acetaminophen, ASA, and the NSAIDs work in the periphery and interfere with prostaglandins
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Obj. 9 compare narcotics with acetaminophen, asa and nsaids
Nonopioid drugs are also readily available (OTC) and inexpensive
Are antipyretic and ASA and some NSAIDs have antiplatelet activity
No tolerance or dependence is caused as is the case with opiates
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Double lockSign outUse non-drug interventionsAssess painGive meds before pain severeDon’t under treat pain
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Obj. 10 describe nursing interventions associated with narcotic administration
Peripherally acting Interfere with synthesis of prostaglandins◦What are prostaglandins?
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Obj.11 describe nursing implications associated with salicylates
Acetylsalicylic acid (aspirin, ASA) used over 100 years
AnalgesicAntipyreticAnti-inflammatoryAntiplatelet
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Contraindicated if: on anticoagulants
if gastric ulcerpregnancychildren with viral infectionsHypersensitive—teach client to read OTC labels
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Nursing Implications
Client must take adequate fluids If GI upset, take with food or antacid◦Options: buffered ◦ enteric coated
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What does it mean when the label says the ASA is buffered?
What does enteric coating mean?◦Can EC drugs be crushed or chewed?
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ASA can cause false + for glycosuria SE: tinnitus and vertigo with high doses Store ASA in closed, child proof container Overdose needs prompt treatment
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Acetaminophen (Tylenol)◦Nonopioid analgesic◦Antipyretic ◦Available as a liquid
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Obj. 14 Identify the uses, advantages and major disadvantages of acetamenophen
Buprenophine HCl (Buprenex) Butophanol tartrate (Stadol) Pentazocine HCl (Talwin) Ibuprofen (Motrin) Naproxin (Aleve)
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If your client is taking Percocet and also has Tylenol ordered, what precautions will you take?
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Question
Nonsteroidal anti-inflammatory agents modify inflammation response◦Inhibit prostaglandin synthesis◦Includes Aspirin as well as Motrin, Aleve, indomethacin (Indocin), oxaprozin ( Daypro), ketoralac (Toradol) Toradol only one given IM, IV
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New NSAIDs are the COX-2 inhibitors
Vioxx off the market 2004Celecoxib (Celebrex) and its cousin Bextra under review
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Advantage of COX-2 inhibitors:◦ Less GI bleeding than other NSAIDs◦ Once a day or BID dosing
Disadvantages:◦ Can’t use if allergic◦ expensive
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Gouty arthritis: ◦caused by uric acid crystals◦Deposit in joints and subq tissue◦Treat ASAP when acute attack occurs◦Treat acute attack with colchicine IV, oral
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Obj.17 Define gout and list drugs used in treatment
think it prevents migration of granulocytes to inflamed area so no lactic acid released
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Colchicine action
Adverse effects of colchicine◦N/V◦Diarrhea◦GI bleeding◦Neuritis◦Myopathy ◦Alopecia◦Bone marrow depression
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NSAIDs may be used for inflammation, pain and fever
Two other types of drugs used for gout◦Uricosurics increase excretion of uric acid
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Alternate treatments for gout
Adverse effects:◦kidney stones can develop
Examples: probenecid (Benemid) and sulfinpyrazone (Anturane)
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uricosurics
With Benemid keep urine alkaline No ASA Anturane works like Benemid but also affects clotting time◦Can cause GI bleeding, skin rash and blood dyscrasias
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Allopurinol (Zyloprim) prevents formation of uric acid◦Usually 300 mg dose 1x daily◦Can be given with colchicine or a NSAID
◦SE of allopurinol: skin rash, hepatotoxicity
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AssessmentNursing diagnoses
◦Pain◦Chronic pain◦Risk for injury◦Deficient knowledge
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Nursing Process
Goals ◦Pain to be controlled◦Chronic pain will be controlled◦Demonstrate a proactive approach to pain management
◦No injury from pain management◦Verbalize knowledge◦Implement plan
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Use pain-relieving measures Pain history Be proactive Don’t under treat Record pain relief Assess respirations Assess nausea, vomiting and decreasing BP
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Acetaminophen: no substitute for ASA
If allergic to ASA, avoid some NSAIDs
Indomethacin: ulcerogenic, aggravate epilepsy, psychiatric disorders
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