UW APL & CIE Invention to Start Up Jack Gallagher Pierre Mourad
UWAPL & CIE
Invention to Start Up
Jack GallagherPierre Mourad
Agenda
• How We Got Started
• University Resources
• Intellectual Property
• Building a Team
• Business Plan
• Funding Sources
• Research Process & Evolution
• Research Concept Findings
• Questions
How We Got Started
• Random meeting with Allez PhysiOnix
• Started research at UW in August 2003 (WTC Grants)
• Negotiated exclusive license to UW technology (Tech
Transfer)
• First patent published in 2005 (Tech Transfer)
• Funding from founders, private investors (Angels &
Venture Capital), WTC research grants, NIH Phase 1 and
2 SBIR grants
University Resources
• Applied Physics Laboratory
• Department of Neurological Surgery
• Schools of Dentistry and of Public Health
• Office of Technology Transfer
• Washington Technology Center (WTC)
• Washington Research Foundation (WRF Capital)
Intellectual Property
• Get a good patent attorney
• Extensive review of 500 patents before started
• Patent filed November 2003 (published May 05)
• Additional patents filed in 2006
Building a Team
• Start with Technical Types
• Build & prove out technology
• Need 1 Business / Marketing Type
• Build vision of future, negotiations, legal
work, fund raising • Start part time; eventually convert to full time
Business Plan
• How big is the market
• What is your reason for being i.e. competitive advantage
• What is your anticipated market share
• Projected pricing
• Estimated spending by year
• Planned exit (Sale, IPO)
• Capital requirements by year
• Fund raising strategy
Funding Sources
• Need a strategy
• Founders
• Washington Technology Center (WTC)
• National Institutes of Health (NIH)
• Angels
• Venture Capital
Research Process
Evolution of Research
2004-2006
Optimize Parameters:
what is the optimal
technology design?
2006-2007
External Testing: independent
confirmation of safety &
effectiveness
Internal Testing:
what are the primary benefits?
2005-2006
Concept Testing:
does the concept deliver a benefit?
2003-2004
University of Washington
WTC Grants
Univ. of Wash.
& Ultreo
NIH SBIR Phase I Grant
Ultreo, Inc.
NIH SBIR Phase II
Grant
Ultreo, Inc. & Universities
NIH SBIR Phase II
Grant
pierre’s turn
some details of the research
• What is old, and how and what old does
• What is new, and how and what new does
• More of what new does
• Summary statement of some partnering lessons I’ve
learned
manual brushes
• manual brushes move several times per second and clean
only at the point of bristle contact
power brushes
• power brushes move their bristles several hundred times per
second and clean primarily at the point of bristle contact, in a
manner vastly more efficient than manual brushes.
power brushes
• However, even the best power brushes still leave behind significant
amounts of plaque in your mouth, much of it in areas where the bristles
don’t contact.
www.studentbmj.com/issues/00/10/education/369.php
• Therefore, the world needs an even better toothbrush.
here it is.
what is special about the Ultreo
• we’ve added optimally configured and delivered ultrasound to
a power toothbrush foundation.
what is special about the Ultreo
• the Ultreo’s bristles scrub on time scales similar to that of
other power toothbrushes - hundreds of times a second.
Thanks to the ultrasound-activated bubbles, the Ultreo also removes plaque bacteria where the ultrasound and dental slurry intersect, including where the bristles may not reach.
a sense of gentleness
some of our earliest prototypes
we’ve come a long way• a testimony to the initial vision, the initially applied resources and alacrity of
SAP/APL/Neurosurgery/Pediatric Dentistry/Periodontology/Public Health,
and the subsequent and considerable effort and expertise utilized at Ultreo,
along with continuing efforts of UW.
vs
• so, does it work?
ultrasound from a stationary brush rapidly removes a ‘line’ of plaque bacteria.
• Artificial teeth with bacteria dyed pink before (left) and after (right) application
of ultrasound without bristle contact. Discrete bacteria colonies along a band
stretching from lower left to upper right were removed by the ultrasound
activated bubbles, in a shape corresponding to the shape of ultrasound
emitted from the face of the stationary brush head.
plaque bacteria removal via combined sonic & ultrasound processes
• Artificial teeth with bacteria dyed pink before (left) and after (right)
treatment with a sonically vibrating brush head that emitted ultrasound
in the presence of sonically produced bubbles, 2-3 mm from the
artificial teeth. Discrete bacteria colonies were reduced or removed
across the entire tooth surface after only 5 seconds of application of
the prototype.
sonic & ultrasound versus sonic only
• Artificial teeth with bacteria dyed pink before (above) and after (below)
treatment with (AA’) a sonically vibrating brush head that emitted
ultrasound in the presence of sonically produced bubbles or (BB’) a popular
power toothbrush, each acting 2-3 mm from the artificial teeth. Bacteria
were removed across the entire tooth surface after only 5 seconds of
application of the prototype.
• So, does it work?
yes!
partnership lessons
• assuming sufficient technical skills, it is the character of the
people with whom you work that matters the most.
• start your research with the clinical problem in mind.
• be open to new perspectives and to new knowledge.
• appreciate the opportunities afforded by serendipity and be
willing to act, quickly!, in response to those opportunities.
• surround yourself with (interdisciplinary) people who sufficiently
interact and are open to the fruits of those interactions.
• make sure your environment facilitates and nurtures those
interactions.
Questions?