power of science implemented in life quality Improvement of the effectiveness of radiation therapy with radiomodification by Polyplatillen and Fluoropyrimidine Yu.V.Dumansky 1 , N. G. Semikoz 1 , G.S. Efimova 2 , I.N. Grishina 3 1 Donetsk National Medical University named after M. Gorky, 2 Kharkovsky Regional Clinical Oncology Center 3 Cherkassy Regional Oncology Center
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Power of science implemented in life quality Improvement of the effectiveness of radiation therapy with radiomodification by Polyplatillen and Fluoropyrimidine.
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power of science implemented in life quality
Improvement of the effectiveness of radiation
therapy with radiomodification by Polyplatillen
and Fluoropyrimidine
Yu.V.Dumansky 1, N. G. Semikoz 1, G.S. Efimova2, I.N. Grishina3
1 Donetsk National Medical University named after M. Gorky,2 Kharkovsky Regional Clinical Oncology Center3 Cherkassy Regional Oncology Center
PolyplatillenPolyplatillen®®platinum on DNA carrierplatinum on DNA carrier
POLIPLATILLEN POLIPLATILLEN ®®
- Does not cause :
•hemotoxicity
•nephrotoxicity
•ototoxicity
•neurotoxicity
- does not hit hematopoietic stem cells from bone marrow
- does not develop resistance
- reduces the damage to the peripheral blood and organs during radiation
injuries
power of science implemented in life quality
Open randomized multicentre trial
807 patients
The main group The control group
Quantity of patients
406 401
Treatment
Polyplatillen
Tegafur
Reosorbilakt
Radiation Therapy according to the
order of Ministry of Health of
Ukraine № 554, 645, 247
Tegafur
Reosorbilakt
Radiation Therapy according to the
order of Ministry of Health of Ukraine
№ 554, 645, 247
power of science implemented in life quality
Localization of the tumor process The main group
The control group
Tumors of the maxillofacial area and neck stage III - IV with metastases on one or two sides
158 148
Tumors of the reproductive system of women stage I B - III 116 120
Tumors of the rectum stage II - III B 69 65
Breast tumors stage II B - III B with metastases in lymphatic nodes as a result of disease progression on the background of chemotherapy
Tegafur daily oralReosorbilakt intravenously weekly on the 2nd - 3rd day of exposure, 200-400mlRadiotherapy single radiation dose 2 Gray, 5 times a week