HYPERPLASTIC COLONIC POLYPS HEALTHY COLON Wallace et al. Miami classification for pCLE. Endoscopy, 2011 ADENOMATOUS COLONIC POLYPS ADENOCARCINOMA © Mauna Kea Technologies , February 2013 Optical Biopsy in the lower GI tract Crypt lumen Epithelial cells Blood vessels Goblet cells Regular crypts Star-shaped luminal crypt openings Regular crypts and epithelium surrounding the lesion Tortuous glands appearing doubled Normal goblet cells distribution Tubular and villous structures Thickening of epithelial lining Dark cells Distorted or elongated crypts Complete disorganization and loss of structures in the tissue