An Integrated Tool to Test Mechanical Stability of Airborne Nanoparticles Yaobo Ding 1 , Michael Riediker 1,2 1 Institut de Santé au Travail (IST), Université de Lausanne, Switzerland 2 SAFENANO, IOM Singapore, Singapore, 048622, Singapore Contact: [email protected] ; [email protected] EXPOSURE INHALATION TRANSLOCATION Motivation Are nanoparticle agglomerates in the air stable ? How big are they ? Nanopowder handling Deposition in the lung Circulation in the body Method Results Aerosolization under different air flows Treatment under different energy input Changes in size and particle generation ACKNOWLEDGEMENT: This work is supported by the EU FP7 MARINA project (grant agreement no: 263215). The participation of this conference is funded by “Fondation pour l’université de Lausanne” . The authors appreciate the support of the project and the foundation. Conclusions Stable aerosolization process Pressure drop seems to break up large agglomerates: reduction of particle size; increase of particle number Ranking of deagglomeration potential of engineered nanomaterials seems possible Test results can be useful for human exposure and risk assessment Figure 2 Particle number and size evolutions under different air flows Figure 3 Particle size distributions under different pressure conditions Figure 4 Particle sizes and generation rates under varied pressures SMPS OPC 10-42 nm primary particle sizes Figure 1 Schematic diagram of aerosolization and deagglomeration system