POPULOMICS AND PERSONALIZED MEDICINE Bradford W. Hesse, PhD Chief, NCI Health Comm. and Informatics Research Friday, March 14, 14
Jan 26, 2015
POPULOMICS AND PERSONALIZED MEDICINE
Bradford W. Hesse, PhDChief, NCI Health Comm. and Informatics Research
Friday, March 14, 14
Wired Magazine, July 2010
• Invested $50 million in Parkinson’s research
• Started public blog on LRRK2
• Is leveraging the power of “big data” to accelerate the science
• Helped found, with wife Anne Wojcicki, 23andMe
Friday, March 14, 14
Data-Intensive Research Paradigm to Speed Discovery?
Traditional Model
• Hypothesis
• Studies
• Data aggregation
• Analysis
• Writing
• Submission
• Acceptance (NEJM)
• Publication
Time Elapsed: 6 years
Friday, March 14, 14
Data-Intensive Research Paradigm to Speed Discovery?
Genetics Initiative
• Tool construction
• Recruitment
• Analysis
• Presentation
Time Elapsed: 8 months
Friday, March 14, 14
A Fourth Paradigm in Science?
Friday, March 14, 14
A New Era in Health?:,
DPE,.LJIERLTH
mAP OF DISIUPTILsE IWWDIIRTIORJ
The Institute for the Future’s Health Horizons Program hasdeveloped a new paradigm for disruptive innovation inthe global health economy—we call it “Open Health.” Thisparadigm leverages the concepts and successes of openinnovation and open-source software, and applies themto the world of health. Open Health strategies will redefinethe research and development process and will require aradically new way of thinking about innovation systems, theinstitutional culture of firms, partnerships, and collaborations,and the very meaning of health itself. The implications ofOpen Health are relevant to all stakeholders in the globalhealth economy, be they beauty, food, consumer electronics,biopharma, health care, or medical technology companies.As it diffuses across industries, Open Health will inspire newapproaches to meeting significant global health problems,and it will provide a framework for generating and sustainingnew business models of tomorrow.
We have identified ten core principles that serve as afoundation for implementing Open Health strategies. This mappresents these principles in the context of emerging trendsand innovation leaders. It describes the external forces that aredriving Open Health and emphasizes the networks and culture,the ethos and skills, the business models and strategies, andthe tools and platforms that will shape innovation systems inthe global health economy over the next decade.
The Open Health Map of Disruptive Innovation (SR-1117A)is your guide to putting Open Health into practice. Use it,along with its companion piece, the Open Health Toolkit: AFramework for Innovation (SR-1117B), to build the capacity toinnovate to solve health’s pressing problems.
A Fourth Paradigm in Science?
Friday, March 14, 14
A Fourth Paradigm in Science?Molecules to Populations
Genomics
Nanotechnology
ProteomicsPopulomics
Forman MR, Greene SM, Avis NE, et al. Bioinformatics: Tools to accelerate population science and disease control research. Am J Prev Med. Jun 2010;38(6):646-651.
Friday, March 14, 14
Platforms for participation
Harnessing collective intelligence
Data as the new “Intel Inside”
End of the software release cycle
Lightweight programming models
Software above the level of the single device
Rich user experience
From Web 2.0 to Health 2.0
*Source: http://oreilly.com/web2/archive/what-is-web-20.html
Facets of Web 2.0*
Friday, March 14, 14
Platforms for participation
Harnessing collective intelligence
Data as the new “Intel Inside”
End of the software release cycle
Lightweight programming models
Software above the level of the single device
Rich user experience
From Web 2.0 to Health 2.0
*Source: http://oreilly.com/web2/archive/what-is-web-20.html
Facets of Web 2.0*Facets of Web 2.0*Platforms for participation
Harnessing collective intelligence
Data as the new “Intel Inside”
End of the software release cycle
Lightweight programming models
Software above the level of the single device
Rich user experience
Friday, March 14, 14
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101.
Friday, March 14, 14
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101.
Friday, March 14, 14
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101.
Friday, March 14, 14
Hesse B, W. , Sproull L, Kiesler SB, Walsh JP. Returns to science: computer networks in oceanography. Commun. ACM. 1993;36(8):90-101.
• Data Liquidity
Friday, March 14, 14
Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health 2.0. IEEE Computer, 43(12), 45-52.
• Platforms for Participation• Harnessing Collective Intelligence
Friday, March 14, 14
Hesse, B. W., Hansen, D., Finholt, T., Munson, S., Kellogg, W., & Thomas, J. C. (2010). Social Participation in Health 2.0. IEEE Computer, 43(12), 45-52.
• Platforms for Participation• Harnessing Collective Intelligence
Friday, March 14, 14
• Software above single device
Hesse BW. Enhancing Consumer Involvement in Health Care. In: Parker JC, Thornson E, eds. Health Communication in the New Media Landscape. New York, NY: Springer Publishing Company; 2008:119-149.
Friday, March 14, 14
Hesse BW. Time to reboot: resetting health care to support tobacco dependency treatment services. Am J Prev Med. Dec 2010;39(6 Suppl 1):S85-87.
ClearPractice, Inc. • Rich User Experience
Friday, March 14, 14
The Learning Healthcare System
Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181.
Friday, March 14, 14
The Learning Healthcare System
Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181.
Friday, March 14, 14
The Learning Healthcare System
Hesse BW, Woods SS, Ahern DK. Nudging Best Practice: The HITECH Act and Behavioral Medicine. Translational Behavioral Medicine. 2011;1(1):175-181.
Friday, March 14, 14
Hesse BW. Public Health Informatics. In: Gibbons MC, editor. eHealth Solutions for Healthcare Disparities. New York, NY: Springer; 2007. p. 109-129.
Data-informed Personalized Medicine
Friday, March 14, 14
Stay Tuned!
Friday, March 14, 14