Polyoxin D Zinc Salt - University of California, Daviswrir4.ucdavis.edu/events/2017_SLR_Meeting... · Powdery mildew Botrytis Gummy stem blight ... (KAK-2016-Blueberry-WA-Conv) 0

Polyoxin D Zinc Salt IR-4 / BPIA Western Region Biopesticides Conference

April 26, 2017, Ft. Collins, CO

1

Kaken Pharmaceutical Co., Ltd. Agrochemicals & Animal Health Products Group

Presented by Cynthia Smith, Conn & Smith, Inc.

Polyoxin D Zinc Salt Kaken Pharmaceutical Co., Ltd.

2

Exclusive world-wide: TGAI producer TGAI registrant EP formulator

Japanese company Fermentation technology expertise

Polyoxin D Zinc Salt Biochemical

3

• Naturally occurring (Polyoxin D) • Nontoxic mode of action

Polyoxin D Zinc Salt US Formulations, Markets

4

Oso 5%SC (Certis; food use) Organic use pending

PH-D WDG (Arysta; food use) Conventional use only

Affirm WDG (Nufarm; T&O)

Polyoxin D Zinc Salt Targeted Crops

Grapes, berries Cucurbits Fruiting vegetables Tree fruit Tree nuts

5

Polyoxin D Zinc Salt Targeted Pests

Monilinia Powdery mildew Botrytis Gummy stem blight Southern blight Apple summer diseases

6

Polyoxin D Zinc Salt Best Practices

Apply preventatively for best efficacy Can be applied after pathogen is present Typical 5%SC application rates 6.5 to 13 fl oz/A 0.36 to 0.72 oz ai/A

Resistance management tool Risk reduction tool IMP tool

7

Polyoxin D Zinc Salt Mammalian Toxicology

No endpoint for risk assessment No acute to chronic effects Not mutagenic, teratogenic Not oncogenic, neurotoxic No reproductive toxicity No endocrine effects Low absorption; high excretion

8

Polyoxin D Zinc Salt Environmental Toxicology

Practically nontoxic to: Honeybee, ladybugs, and more Birds, Algae Earthworms, Beneficial soil fungi

Moderately toxic to: Fish, Daphnia

9

Polyoxin D Zinc Salt Rapid Environmental Degradation

DT50 (Days)

Degradation Route

0.4 Photolysis, natural water, sterile 2.3 Photolysis, pH 7 15.9 Aerobic soil 32.5 Hydrolysis, pH 7

10

Polyoxin D Zinc Salt Environmental Risk

Risk = Exposure x Hazard Low exposure Low AI application rate Rapid environmental degradation

Low risk Including for fish and Daphnia

11

Polyoxin D Zinc Salt Non-Toxic Mode of Action

Does not kill the fungus Competitive enzyme inhibitor Interferes with fungal chitin synthesis Sensitive fungus after treatment: Changed morphology Stop growing Not pathogenic

12

Polyoxin D Zinc Salt Mode of Action

13

Treated Untreated

Polyoxin D Zinc Salt Resistance Management Tool

Unique mode of action in N. America FRAC 19 No resistance observed in over 40

years of commercial use in Asia

14

Polyoxin D Zinc Salt Crop Residue

Risk Reduction Tool

0-day PHI (all crops) US EPA tolerance exemption All crops, pre- and post-harvest 40 CFR §180.1285

15

Polyoxin D Zinc Salt International MRL “Exemptions”

Canada Mexico New Zealand Taiwan Korea (pending; summer 2017) EU (pending)

16

Polyoxin D Zinc Salt MRL Trade Barrier: Japan

Toxicology data submitted Not yet reviewed

MRL “exemption” harmonization recently requested

Under consideration

17

Polyoxin D Zinc Salt (5%SC) Blueberry / Mummyberry

(KAK-2016-Blueberry-WA-Conv)

0 10 20

Oso (13 fl oz/A)

Oso (6.5 fl oz/A)

Control IncidenceMummies

IncidenceFlower,Leaf Strikes

18

Polyoxin D Zinc Salt (5%SC) Sweet Cherry / Brown Rot

(Oregon, 2015) (PDMR 10:STF009)

0 5 10 15 20

Luna Sensation

Oso (6.5 fl oz/A) +Induce

Untreated Control Post-harvestFruit BrownRot (%)

BlossomBlight (%)

19

Polyoxin D Zinc Salt (5%SC) Grapes / Powdery Mildew

(California, 2012) (CER-2012-069)

20 * Pristine, Rally, Quintec, Elite (FRAC 7+11, 3, 13, 3)

Polyoxin D Zinc Salt (5%SC) Tomatoes / Powdery Mildew

(Greenhouse, Inoculated) (BCGGA-2015-03)

21

Polyoxin D Zinc Salt (5%SC) Strawberries / Botrytis Fruit Rot

(KAK-2016-Sberry-MI)

0 5 10 15 20 25 30 35 40

Oso (13 fl oz/A)

Oso (6.5 fl oz/A)

Untreated Control

Fruit Rot Incidence (%)

22

Polyoxin D Zinc Salt (5%SC) Organic Strawberries / Botrytis

(KAK-2016-Sberry-MD) (PDMR 11:SMF020)

0 5 10 15 20 25

Oso (13.0 fl oz/A)

Oso (6.5 fl oz/A)

Organic Standard*

Water ControlInfected Fruit Weight

23

*[Regalia + Actinovate + Silwet] rotated with [Regalia + Serenade ASO + Silwet]

Polyoxin D Zinc Salt (5%SC) Cucumber / Gummy Stem Blight

(BCGGA-2015-02) (Greenhouse, Inoculated)

0 100 200 300 400 500 600

Pristine, Nova

Oso (13.7 fl oz/A)

Oso (6.8 fl oz/A)

Untreated ControlSeverity(AUDPC)

Incidence(AUDPC)

24

Polyoxin D Zinc Salt Organic Use Pending

National Organic Program petition Oso 5%SC only

2019 to 2020 launch, if approved Grower support is necessary

25

Questions?

Contact: Cynthia Smith Regulatory Consultant for Kaken Conn & Smith, Inc. 703-339-1117 [email protected]

26