Plegable biologia molecular

THE BEST OFFENSE AGAINST BACTERIA IS A GOOD DEFENSE.

 NEW DRUG DESING ENHANCES BRAIN

SIGNALING BY A FACTOR OF 1,000. 

Manuela Posada Muñoz.Medical student.

III Semester

INTRODUCCIÒN.

Between drugs and bacteria exists a relationship with its structures and proteins, which regulate how a pathogen acts in the body, because this can inactivate it generating a structural change.

The actors explained in this article the existence of proteins that inactivate bacterial toxins by modifying their structures.

THE BEST OFFENSE AGAINSTBACTERIA IS A GOOD DEFENSE.

They say that the toxins released by bacteria, have malleable surfaces that allow them move through by the porous of the host cells to pave the way for bacteria to stay alive, and say that this property make the bacteria resistant, on the other hand they say that this make the toxin vulnerable to the immune system protein.

they talked about the two ways of acting toxins, the first one is destabilizing the host cells and they can`t response against the bacteria and the second one by joining the toxin and inactivating

Toxins.

The researches were made with a single defensin who attacked a variety of toxins, demonstrating the universality of its activity.

I think this new is very important because now all the people who work in the health area will focus on increasing defensins, because they are able to attack as much bacteria than other proteins of the immune response.

PERSONAL COMMENT.

Proteins play an important role in almost all biological processes, their structures and functions are controlled by the genetic code and some Biopharmaceuticals are trying to modified this property.

NEW DRUG DESING ENHANCESBRAIN SIGNALING BY A FACTOROF 1,000.

In this study, the scientific are trying to modulate the receptors, and disigned new compounds, to evaluated the interaction between receptors and gephyrin.

Its a protein that anchors inhibitory neutrotransmitter receptors to the postsynaptic cytoskeleton.

Gephyrin.

among other things, they studied the GABA receptors which are important targets for drugs for the treatment of mental disorders like hyperkplexia.

This study ir very important because with all the new information we can work to solve problems of SNC that affect many people and its very hard their treatment.

PERSONAL COMMENT.

These drugs interact with particular target sites or receptors found in the nervous system to induce changes in physiological or psychological functions, for example in the hiperkplexia.

MEDICAL UTILITY.

Some defensis can modify HIV treatment will lead to a whole new perspective. Pharmaceutical business will change some components from the treatment and make it more permeable in cells.

MEDICAL UTILITY.

The growing problem of antibiotic resistance in bacteria, has led the way towards finfing news treatements for combating these organisms. The proposed to finding and producing new defensins already described like a potential drugs against microorganisms, has been used for the production of sinthetic drugs.

MEDICAL UTILITY.

Thanks to molecular biology can make a modification to DNA causing changes in the proteins that can modulate the interaction between the drug and bacteria, enhancing the effect of this drug.

MEDICAL UTILITY.

Elena Kudryashova, Royston Quintyn, Stephanie Seveau, Wuyuan Lu, Vicki H. Wysocki, Dmitri S. Kudryashov. Human Defensins Facilitate Local Unfolding of Thermodynamically Unstable Regions of Bacterial Protein Toxins. http://www.sciencedaily.com/releases/2015/01/150107100953.htm

Hans Michael Maric, Vikram Babu Kasaragod, Torben Johann Hausrat, Matthias Kneussel, Verena Tretter, Kristian Strømgaard, Hermann Schindelin. Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin http://www.sciencedaily.com/releases/2015/01/150106091701.htm

BIBLIOGRAPHY.

THANKS.