“DNA TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA” AND “THE SHAPE OF INFECTIUS PRIONS” Manuela Diaz Valenzuela Medicine Student III Semester Molecular Biology
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
“DNA TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA” AND “THE
SHAPE OF INFECTIUS PRIONS”
Manuela Diaz ValenzuelaMedicine Student
III Semester
Molecular Biology
FOLDING
FOLDING
INTRODUCTION
For the synthesis of proteins wich are essential for life we should know the process that synthesized it what is called CENTRAL DOGMA that explains how the DNA is replicated in the nucleus in a process called replication, then the DNA is converted into mRNA through transcription in order to leave the nucleus to finalize in the cytoplasm where the proteins are synthesized. There are exceptions to this dogma as is the inverse transcription which basically is characteristic of virus which contain RNA as genetic materials. Retroviruses and prions are the only ones that no obey to this dogma.
“DNA TECHNOLOGY
AND EVOLUTION OF THE CENTRAL
DOGMA”January 2014
The news talks about how after a long time of understanding and comprenhension of the central dogma, this has evolved and has taken a new step as it is digitalization of biological information wich has reduced time and distances in the development and synthesis of DNA
“DNA TECHNOLOGY AND EVOLUTION OF THE CENTRAL
DOGMA”January 2014.
Scanning DNA sequences have been useful for the reconstruction of the genome and the acceleration of new DNA sequencing methods such as:
• The nanopore sequencing
• The complex DNA syntheses
“DNA TECHNOLOGY AND EVOLUTION OF THE CENTRAL
DOGMA”January 2014
They let us know how the new extension of the central dogma contributes and benefits from wildlife ecosystem.
It is an incentive to follow continuously advancing and understanding of molecular biology, because of this depends the continuity of these projects.
“DNA TECHNOLOGY AND EVOLUTION OF THE CENTRAL
DOGMA”January 2014
PERSONAL OBSERVATION
I think that is very interesting the progress that has been made in these aspects of molecular biology that facilitate and accelerate the development and synthesis of DNA, besides to help the reconstruction of the genome.
“THE SHAPE OF INFECTIUS PRIONS”
January 2014
The structure of prions when they are healthy is spherical and when they are infected are as cubes.
Prions are unique infective agents -unlike viruses, bacteria, fungi and other parasites, prions do not contain either DNA or RNA.
“THE SHAPE OF INFECTIUS PRIONS”
January 2014
They can propagate their pathological effects like wildfire, by "infecting" normal proteins.
PrPSc (the pathological form of the prion protein) can induce normal prion proteins (PrPC) to acquire the wrong conformation and become a disease-causing agents.
“THE SHAPE OF INFECTIUS PRIONS”
January 2014
Prions are misfolded proteins (n have their terminus misconfigured and normal terminal c) causing incurable neurodegenerative diseases like spongiform encephalopathies and creutzfeldt-jacob disease.
“THE SHAPE OF INFECTIUS PRIONS”
January 2014
Personal Observation
For me, the study of prions is very important for the future development of drugs and therapeutic strategies against incurable neurodegenerative diseases.
Medical Utility
With the digitization of the biological information has also facilitated access to this that allows all health professionals may have the availability
Medical Utility
It may be useful in the reconstruction of the genome and the acceleration of new DNA sequencing methods, also in the reliability
Medical Utility
Studies like this will help us to manufacture new drugs that help improve serious degenerative diseases.
Medical Utility
Know the point at which prions are misconfigured is important in the medical sphere, because knowing the target site of the defect is easier to find strategies to combat it.
BIBLIOGRAPHY
MARTINEZ SÁNCHEZ. Lina Maria. Biologia Molecular. 7 Ed. Medellin: UPB. Fac. De Medicina, 2012.74-77 pp.
*DNA technology and evolution of the Central Dogma. Cell Press (online magazine) Volume 29, Issue 1, January 2014, Pages 1–2
Avaliable at: http://www.sciencedirect.com/science/article/pii/S0169534713002498 `
*The shape of Infectius Prions. Journal of the American Chemical Society(online magazine) , January 2014; 136 (3) :937. Avaliable at http//www.sciencedaily.com/releases/2014/01/140124082602.htm
Related Documents
