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Han et al 1 8/16/13
Piperlongumine Chemosensitizes Tumor Cells Through Interaction with
Cysteine 179 of IκBα Kinase, Leading to Suppression of NF-κB –regulated
Gene Products
Jia Gang Han1, 2, Subash C. Gupta1, 3, Sahdeo Prasad1 and Bharat B. Aggarwal1
1Cytokine Research Laboratory, Department of Experimental Therapeutics,
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
3 University of Mississippi Medical Center, Arthur C. Guyton Research Complex, 2500 North
State Street Jackson, MS 39216, USA
Running title: Regulation of NF-κB Activation by Piperlongumine
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171
Published OnlineFirst July 31, 2014.Mol Cancer Ther Jia Gang Han, Subash C. Gupta, Sahdeo Prasad, et al. to Suppression of NF-kappaB -regulated Gene ProductsInteraction with Cysteine 179 of IkappaBalpha Kinase, Leading Piperlongumine Chemosensitizes Tumor Cells Through
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on July 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0171