Pine Biotech

Elia BrodskyCEO & Co-founder

Boston • New Orleans • pine-biotech.com • @PineBiotech • [email protected]

Transforming biomedical data analysis

Omics data on many diseases exists or can be generated, a good integration approach is needed to make it actionable

For researches and clinicians that need to make decisions based on multivariate data analysis, T-Bio is an analysis and discovery tool that modularly conforms to the users needs,

informs with precision metrics, and combines dozens of data types (i.e. molecular data).

We merge big -omics data analysis with clinical care and precision applications for Real World Evidence: research & development of new targets and therapeutics, stratified clinical

trials, and development of biomarkers for early detection and companion diagnostics. We want to improve patient outcomes and provide tools for researchers and clinicians to have an

impact on healthcare.

EarlyDetection• Detectingbiomarkersleadingtorisk• Predictivemodelingofdisease

ClinicalTrials• Identifyingtherightmatch• DevelopingCompanionDiagnostics

DiseaseManagement• Avoidingcostlymistakes• Improvingdecisions

The Problem Healthcare Decision Makers Face

Research&Development• Identifyingnewmoleculartargets• Biosimilars andgenerics

IN THE LAB IN THE CLINIC

Stratification in Clinical Trials• Utilize data from failed or closed projects• Using Omics features for recruitment • Molecular markers linked to responders

Molecular indicators in Clinical Decision Support

• known molecular indicators • prognostic clues • acute chronic disease management• Integration with clinical records• Integration with phenotypic data • Big data machine learning and

advanced algorithmic development

Pine Biotech Solutions and Use Cases

Research & Precision Medicine Clinical Management Platform

Targets for therapeutics• Detection of actionable pathways • Early detection of adverse effects• Multi-lab collaborative discovery projects

IN THE LAB IN THE CLINIC

How We’re Unique

Flexible/COMPREHENSIVE

Fixed/CLOSED

Hard to Install, Update and Use

Internally developed Tools or Open-source tools

T-Bio

USER-FRIENDLY

Alpha DevelopmentInternal launch of the first alpha

version

Today

Academic Pilots10 academic pilot projects

First Commercial ProjectACORDA Clinical Trial

DARPA ProjectTherapeutic design: virology

Clinical Trials Started3 validation with clinical cases

Our Traction to Date

2015

2016

2017

Case Study

Identifying biomarkers for multiple sclerosis remission patients based on lipidomics data

Patient Stratification

• New analysis of data• Correlation with clinical indicatorsActions

Our analysis of lipidomics data helped re-organize the recruitment for this clinical trial because we found artifacts in clinical data and identified candidates for companion diagnostics that would help improve the precise patient selection based on molecular features

Results

Case Study

Identifying relationships between low-frequency mutations in virus populations and it’s impact on the spread of infection. Identification of actionable methods to deliver a new therapeutic framework

Proposed Clinical Validation Projects

Patient Stratification

Clinical Decision Support

In the intersection of research, clinical trials, and healthcare there is a gap of incorporating omics data into precise diagnostics and therapeutics development to improve and implement the precision medicine component of the local population health management

Description:

Clinical Trials

Business Model

• Pharma companies and large organizations pay $20k-50k per year• (if applicable) a one time installation fee of $150k

Data Analysis Layer Platform

• Primary Investigators pay based on algorithm access per cycle (cost plus) and user types

• Integration of new methods or adaptation is separate cost

Research Lab Access

• Precision Medicine Centers pay $150,000 per year• Installation is a one time fee of $250k - $500k

Clinical Integration

• Pharma Companies pay a custom price based on “packages”• HPC, Private Cloud and Hybrid Cloud configurations

Pharma Department Solution

ENG

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API

Acc

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Plat

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OurTeam

Harvard,BUMedical,Brigham,

others

AlfredTauberCo-Founder

HaifaUniversity,MoscowStateUniversity

LeonidBrodskyCSO&Co-Founder

VariousStartups,Bar-IlanUniversity,

HarvardHBX

EliaBrodskyCEO&Co-Founder

NeilGibbons,MBACFO,xpartnerValmiki

Capital,Propeller,startups

KeithToussaintCTO,Amazon,Microsoft,

MayoClinic

DavidKulick,MPHCBD, advisoratOcshner,JohnHopkins,startups

Priyal deZoysa,Ph.D.workedatSevenBridges,ThermoFisher,Pfizer

ThankYou

Boston • New Orleans • pine-biotech.com • @PineBiotech • [email protected]

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